Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 6128479 . A C CCDS8539.1:NM_000552.3:c.4105Ttc>Gtc_NP_000543.2:p.1369F>V Homo sapiens von Willebrand factor (VWF), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
5bv8 1 P04275 99.11 3e-149 X-RAY
 2015-12-23 PHE A:144 A:1369 4.0 0.019 S -106.7 34.6 4.0 0.019 0.0 HOH
 3.581
 CD1
 O
7f49 1 P04275 99.05 2e-140 X-RAY
 2021-07-07 PHE A:111 A:606 4.0 0.019 T -109.4 34.8 4.0 0.019 0.0 A2M
A2M
OMG
A2M
HOH
 9.792
5.842
5.114
9.523
3.526
 O
O
O
C
CD1
 C2
C2
N7
N7
O
1uex 3 P04275 99.52 3e-140 X-RAY
 2003-09-30 PHE C:110 C:606 3.0 0.014 T -108.0 31.2 3.0 0.014 0.0 HOH
 4.427
 C
 O
3hxo 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 PHE A:110 A:606 6.0 0.029 T -103.5 40.9 6.0 0.029 0.0 DT
HOH
 7.071
3.738
 O
CD1
 O4
O
3hxq 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 PHE A:110 A:606 1.0 0.005 S -107.1 36.7 1.0 0.005 0.0 DT
HOH
 7.336
5.838
 O
O
 O4
O
7eow 1 P04275 100.0 7e-140 X-RAY
 2021-07-07 PHE A:133 A:133 2.0 0.01 T -106.8 34.3 2.0 0.01 0.0 HOH
 3.333
 CD1
 O
1auq 1 P04275 99.52 1e-139 X-RAY
 1998-10-14 PHE A:109 A:606 4.0 0.019 S -116.2 43.9 4.0 0.019 0.0 HOH
 4.649
 O
 O
1u0n 1 P04275 99.52 1e-139 X-RAY
 2005-04-19 PHE A:109 A:606 4.0 0.019 T -118.3 31.7 4.0 0.019 0.0
1m10 1 P04275 99.04 7e-139 X-RAY
 2002-08-28 PHE A:109 A:606 6.0 0.029 S -109.7 39.6 6.0 0.029 0.0
7a6o 1 L8E853 99.51 5e-137 X-RAY
 2021-03-03 PHE A:108 AAA:1369 4.0 0.019 S -106.4 33.4 4.0 0.019 0.0 HOH
 3.106
 HD1
 O
1ijb 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 PHE A:107 A:606 4.0 0.019 S -112.3 32.5 4.0 0.019 0.0 HOH
 3.656
 CD1
 O
1ijk 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 PHE A:107 A:606 4.0 0.019 T -118.4 38.8 4.0 0.019 0.0 HOH
 3.264
 C
 O
1sq0 1 P04275 99.01 5e-134 X-RAY
 2004-04-13 PHE A:111 A:606 1.0 0.005 S -103.1 33.6 1.0 0.005 0.0 HOH
 4.707
 CD2
 O
4c2a 1 P04275 98.48 3e-130 X-RAY
 2014-01-08 PHE A:107 A:1369 7.0 0.033 S -105.5 28.8 7.0 0.033 0.0 HOH
 4.058
 CA
 O
1oak 3 P04275 99.49 1e-128 X-RAY
 1998-10-21 PHE C:100 A:606 4.0 0.019 T -104.5 37.6 4.0 0.019 0.0 HOH
 5.003
 CD1
 O
1fns 3 P04275 98.97 2e-128 X-RAY
 2000-10-18 PHE C:100 A:606 4.0 0.019 T -108.3 34.3 4.0 0.019 0.0 HOH
 3.766
 C
 O
4c29 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 PHE A:107 A:1369 3.0 0.014 T -114.5 37.0 3.0 0.014 0.0 HOH
 5.142
 CE1
 O
PHE B:107 B:1369 4.0 0.019 T -114.5 36.1 NA NA NA
4c2b 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 PHE A:107 A:1369 2.0 0.01 S -110.0 53.6 2.0 0.01 0.0
PHE C:107 C:1369 10.0 0.048 S -115.9 58.5 NA NA NA
PHE E:107 E:1369 1.0 0.005 S -115.7 56.4 NA NA NA
PHE G:107 G:1369 13.0 0.062 S -116.4 48.7 NA NA NA
1u0o 3 Q8CIZ8 87.02 2e-119 X-RAY
 2005-04-19 PHE C:109 C:606 2.0 0.01 T -105.8 29.3 2.0 0.01 0.0 HOH
 6.121
 N
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p04275-f1 1 P04275 99.93 0.0 PHE A:1369 A:1369 16.0 0.076 I -81.5 -33.7
af-p04275-f2 1 P04275 99.93 0.0 PHE A:1169 A:1169 3.0 0.014 S -98.7 29.0
af-p04275-f3 1 P04275 99.93 0.0 PHE A:969 A:969 5.0 0.024 S -95.7 26.1
af-p04275-f6 1 P04275 100.0 0.0 PHE A:369 A:369 5.0 0.024 S -102.3 23.3
af-p04275-f5 1 P04275 99.93 0.0 PHE A:569 A:569 4.0 0.019 S -97.9 29.6
af-p04275-f7 1 P04275 100.0 0.0 PHE A:169 A:169 4.0 0.019 T -85.4 30.8
af-p04275-f4 1 P04275 99.93 0.0 PHE A:769 A:769 3.0 0.014 S -98.5 32.8