Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 6128502 . A C CCDS8539.1:NM_000552.3:c.4082tTg>tGg_NP_000543.2:p.1361L>W Homo sapiens von Willebrand factor (VWF), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
5bv8 1 P04275 99.11 3e-149 X-RAY
 2015-12-23 LEU A:136 A:1361 0.0 0.0 H -71.9 -36.2 0.0 0.0 0.0 HOH
 6.278
 N
 O
7f49 1 P04275 99.05 2e-140 X-RAY
 2021-07-07 LEU A:103 A:598 0.0 0.0 H -72.1 -42.6 0.0 0.0 0.0 A2M
OMG
A2M
A2M
OMC
HOH
 8.792
9.290
8.233
9.245
8.874
6.913
 O
O
C
C
C
C
 N1
O6
N1
CM'
OP2
O
1uex 3 P04275 99.52 3e-140 X-RAY
 2003-09-30 LEU C:102 C:598 0.0 0.0 H -72.6 -26.8 0.0 0.0 0.0 HOH
 8.186
 CD1
 O
3hxo 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 LEU A:102 A:598 0.0 0.0 H -75.8 -36.4 0.0 0.0 0.0 DT
DT
HOH
 8.726
9.871
6.947
 C
CD1
C
 OP2
O4
O
3hxq 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 LEU A:102 A:598 0.0 0.0 H -63.3 -30.5 0.0 0.0 0.0 DT
DT
HOH
 8.654
9.343
6.037
 C
CD1
N
 OP2
O4
O
7eow 1 P04275 100.0 7e-140 X-RAY
 2021-07-07 LEU A:125 A:125 0.0 0.0 H -74.1 -34.6 0.0 0.0 0.0 HOH
 5.581
 N
 O
1auq 1 P04275 99.52 1e-139 X-RAY
 1998-10-14 LEU A:101 A:598 0.0 0.0 H -75.7 -28.2 0.0 0.0 0.0 HOH
 6.949
 CD2
 O
1u0n 1 P04275 99.52 1e-139 X-RAY
 2005-04-19 LEU A:101 A:598 0.0 0.0 H -76.2 -42.9 0.0 0.0 0.0
1m10 1 P04275 99.04 7e-139 X-RAY
 2002-08-28 LEU A:101 A:598 0.0 0.0 H -82.2 -30.8 0.0 0.0 0.0
7a6o 1 L8E853 99.51 5e-137 X-RAY
 2021-03-03 LEU A:100 AAA:1361 0.0 0.0 H -71.3 -36.6 0.0 0.0 0.0 HOH
 6.876
 HD13
 O
1ijb 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 LEU A:99 A:598 0.0 0.0 H -75.1 -32.2 0.0 0.0 0.0 HOH
 5.856
 N
 O
1ijk 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 LEU A:99 A:598 0.0 0.0 H -82.6 -34.3 0.0 0.0 0.0 HOH
 6.583
 N
 O
1sq0 1 P04275 99.01 5e-134 X-RAY
 2004-04-13 LEU A:103 A:598 0.0 0.0 H -66.0 -46.2 0.0 0.0 0.0 HOH
 6.864
 N
 O
4c2a 1 P04275 98.48 3e-130 X-RAY
 2014-01-08 LEU A:99 A:1361 0.0 0.0 H -74.5 -35.4 0.0 0.0 0.0 HOH
 5.581
 N
 O
1oak 3 P04275 99.49 1e-128 X-RAY
 1998-10-21 LEU C:92 A:598 0.0 0.0 H -66.5 -42.2 0.0 0.0 0.0 HOH
 6.717
 N
 O
1fns 3 P04275 98.97 2e-128 X-RAY
 2000-10-18 LEU C:92 A:598 0.0 0.0 H -70.0 -37.0 0.0 0.0 0.0 HOH
 5.960
 N
 O
4c29 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 LEU A:99 A:1361 0.0 0.0 H -71.3 -32.9 0.0 0.0 0.0 PEG
HOH
 9.288
6.419
 CD1
N
 O4
O
LEU B:99 B:1361 0.0 0.0 H -72.5 -33.2 NA NA NA
4c2b 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 LEU A:99 A:1361 1.0 0.006 H -81.5 -31.2 1.0 0.006 0.0 HOH
 9.475
 CD1
 O
LEU C:99 C:1361 0.0 0.0 H -81.8 -28.0 NA NA NA
LEU E:99 E:1361 0.0 0.0 H -81.7 -30.6 NA NA NA
LEU G:99 G:1361 0.0 0.0 H -80.6 -27.4 NA NA NA
1u0o 3 Q8CIZ8 87.02 2e-119 X-RAY
 2005-04-19 LEU C:101 C:598 0.0 0.0 H -83.4 -31.8 0.0 0.0 0.0 HOH
 9.200
 N
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p04275-f1 1 P04275 99.93 0.0 LEU A:1361 A:1361 55.0 0.324 H -67.9 -41.0
af-p04275-f2 1 P04275 99.93 0.0 LEU A:1161 A:1161 0.0 0.0 H -70.5 -34.0
af-p04275-f3 1 P04275 99.93 0.0 LEU A:961 A:961 0.0 0.0 H -69.7 -35.4
af-p04275-f6 1 P04275 100.0 0.0 LEU A:361 A:361 0.0 0.0 H -70.0 -31.7
af-p04275-f5 1 P04275 99.93 0.0 LEU A:561 A:561 0.0 0.0 H -66.8 -33.0
af-p04275-f7 1 P04275 100.0 0.0 LEU A:161 A:161 0.0 0.0 H -66.5 -28.2
af-p04275-f4 1 P04275 99.93 0.0 LEU A:761 A:761 0.0 0.0 H -67.9 -34.2