Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 6128584 . G A CCDS8539.1:NM_000552.3:c.4000Cgg>Tgg_NP_000543.2:p.1334R>W Homo sapiens von Willebrand factor (VWF), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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label_comp_id: 
auth_asym_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
5bv8 1 P04275 99.11 3e-149 X-RAY
 2015-12-23 ARG A:109 A:1334 87.0 NA -90.1 81.2 87.0 NA NA HOH
 2.976
 N
 O
7f49 1 P04275 99.05 2e-140 X-RAY
 2021-07-07 ARG A:76 A:571 208.0 0.924 -83.1 72.5 208.0 0.924 0.0 HOH
 3.714
 O
 O
1uex 3 P04275 99.52 3e-140 X-RAY
 2003-09-30 ARG C:75 C:571 179.0 0.796 -82.7 83.4 179.0 0.796 0.0 HOH
 7.632
 NH2
 O
3hxo 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 ARG A:75 A:571 210.0 0.933 -82.0 84.2 210.0 0.933 0.0 HOH
 3.471
 O
 O
3hxq 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 ARG A:75 A:571 181.0 0.804 50.4 41.1 181.0 0.804 0.0 HOH
 4.262
 NH1
 O
7eow 1 P04275 100.0 7e-140 X-RAY
 2021-07-07 ARG A:98 A:98 205.0 0.911 -89.2 85.0 205.0 0.911 0.0 HOH
 2.838
 NE
 O
1auq 1 P04275 99.52 1e-139 X-RAY
 1998-10-14 ARG A:74 A:571 191.0 0.849 -88.7 84.0 191.0 0.849 0.0 HOH
 3.058
 NH2
 O
1u0n 1 P04275 99.52 1e-139 X-RAY
 2005-04-19 ARG A:74 A:571 213.0 0.947 -88.0 91.6 109.0 0.484 0.463 D:P07359:0.462
1m10 1 P04275 99.04 7e-139 X-RAY
 2002-08-28 ARG A:74 A:571 203.0 0.902 -94.5 105.1 114.0 0.507 0.395 B:P07359:0.396
7a6o 1 L8E853 99.51 5e-137 X-RAY
 2021-03-03 ARG A:73 AAA:1334 211.0 0.938 -81.1 84.9 211.0 0.938 0.0 HOH
 3.752
 HB3
 O
1ijb 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 ARG A:72 A:571 93.0 NA -85.0 81.9 93.0 NA NA HOH
 4.454
 CA
 O
1ijk 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 ARG A:72 A:571 87.0 NA -97.5 108.3 87.0 NA NA HOH
 6.341
 N
 O
1sq0 1 P04275 99.01 5e-134 X-RAY
 2004-04-13 ARG A:76 A:571 238.0 1.0 -106.3 89.1 87.0 0.387 0.613 B:P07359:0.671
 HOH
 2.668
 N
 O
4c2a 1 P04275 98.48 3e-130 X-RAY
 2014-01-08 ARG A:72 A:1334 241.0 1.0 -102.6 78.5 131.0 0.582 0.418 B:P07359:0.489
 HOH
 2.615
 NH1
 O
1oak 3 P04275 99.49 1e-128 X-RAY
 1998-10-21 ARG C:65 A:571 185.0 0.822 -96.4 86.8 185.0 0.822 0.0 HOH
 2.871
 N
 O
1fns 3 P04275 98.97 2e-128 X-RAY
 2000-10-18 ARG C:65 A:571 184.0 0.818 -96.2 93.5 184.0 0.818 0.0 HOH
 2.497
 N
 O
4c29 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 ARG A:72 A:1334 199.0 0.884 -87.7 55.5 199.0 0.884 0.0 HOH
 3.164
 CD
 O
ARG B:72 B:1334 197.0 0.876 -88.6 52.1 NA NA NA
4c2b 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 ARG A:72 A:1334 228.0 1.0 -106.2 74.7 125.0 0.556 0.444 B:P07359:0.458
ARG C:72 C:1334 207.0 0.92 -89.0 80.6 NA NA NA
ARG E:72 E:1334 187.0 0.831 -91.1 81.5 NA NA NA
ARG G:72 G:1334 239.0 1.0 -99.9 67.0 NA NA NA
1u0o 3 Q8CIZ8 87.02 2e-119 X-RAY
 2005-04-19 ARG C:74 C:571 244.0 1.0 -107.5 -17.3 244.0 1.0 0.0 HOH
 6.243
 N
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p04275-f1 1 P04275 99.93 0.0 ARG A:1334 A:1334 188.0 0.836 -100.4 41.0
af-p04275-f2 1 P04275 99.93 0.0 ARG A:1134 A:1134 228.0 1.0 -94.1 68.1
af-p04275-f3 1 P04275 99.93 0.0 ARG A:934 A:934 197.0 0.876 -92.3 71.2
af-p04275-f6 1 P04275 100.0 0.0 ARG A:334 A:334 172.0 0.764 -88.8 67.9
af-p04275-f5 1 P04275 99.93 0.0 ARG A:534 A:534 145.0 0.644 -96.5 69.7
af-p04275-f7 1 P04275 100.0 0.0 ARG A:134 A:134 147.0 0.653 -91.1 83.2
af-p04275-f4 1 P04275 99.93 0.0 ARG A:734 A:734 229.0 1.0 -90.1 67.9