Variant
Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr12 | 6128593 | . | G | A | CCDS8539.1:NM_000552.3:c.3991Ctc>Ttc_NP_000543.2:p.1331L>F | Homo sapiens von Willebrand factor (VWF), mRNA. |
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PDB
Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
5bv8 | 1 | P04275 | 99.11 | 3e-149 |
X-RAY |
2015-12-23 | LEU | A:106 | A:1331 | 17.0 | 0.1 | T | -56.5 | -31.7 | 17.0 | 0.1 | 0.0 |
HOH |
2.863 |
N |
O |
||
7f49 | 1 | P04275 | 99.05 | 2e-140 |
X-RAY |
2021-07-07 | LEU | A:73 | A:568 | 20.0 | 0.118 | T | -61.2 | -34.0 | 20.0 | 0.118 | 0.0 |
HOH |
2.937 |
O |
O |
||
1uex | 3 | P04275 | 99.52 | 3e-140 |
X-RAY |
2003-09-30 | LEU | C:72 | C:568 | 11.0 | 0.065 | T | -55.7 | -25.4 | 11.0 | 0.065 | 0.0 |
HOH |
6.957 |
CD1 |
O |
||
3hxo | 1 | P04275 | 99.52 | 3e-140 |
X-RAY |
2009-11-17 | LEU | A:72 | A:568 | 17.0 | 0.1 | T | -66.3 | -28.6 | 17.0 | 0.1 | 0.0 |
HOH |
2.849 |
O |
O |
||
3hxq | 1 | P04275 | 99.52 | 3e-140 |
X-RAY |
2009-11-17 | LEU | A:72 | A:568 | 15.0 | 0.088 | T | -56.1 | -35.3 | 15.0 | 0.088 | 0.0 |
HOH |
2.506 |
O |
O |
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7eow | 1 | P04275 | 100.0 | 7e-140 |
X-RAY |
2021-07-07 | LEU | A:95 | A:95 | 17.0 | 0.1 | T | -55.1 | -38.6 | 17.0 | 0.1 | 0.0 |
HOH |
2.777 |
O |
O |
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1auq | 1 | P04275 | 99.52 | 1e-139 |
X-RAY |
1998-10-14 | LEU | A:71 | A:568 | 17.0 | 0.1 | T | -53.8 | -40.2 | 17.0 | 0.1 | 0.0 |
HOH |
2.889 |
N |
O |
||
1u0n | 1 | P04275 | 99.52 | 1e-139 |
X-RAY |
2005-04-19 | LEU | A:71 | A:568 | 23.0 | 0.135 | T | -52.2 | -35.1 | 23.0 | 0.135 | 0.0 | ||||||
1m10 | 1 | P04275 | 99.04 | 7e-139 |
X-RAY |
2002-08-28 | LEU | A:71 | A:568 | 23.0 | 0.135 | T | -52.5 | -41.0 | 23.0 | 0.135 | 0.0 | ||||||
7a6o | 1 | L8E853 | 99.51 | 5e-137 |
X-RAY |
2021-03-03 | LEU | A:70 | AAA:1331 | 18.0 | 0.106 | T | -51.2 | -32.4 | 18.0 | 0.106 | 0.0 |
HOH |
3.101 |
O |
O |
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1ijb | 1 | P04275 | 99.01 | 4e-134 |
X-RAY |
2002-07-10 | LEU | A:69 | A:568 | 14.0 | 0.082 | T | -50.3 | -37.2 | 14.0 | 0.082 | 0.0 |
HOH |
2.762 |
O |
O |
||
1ijk | 1 | P04275 | 99.01 | 4e-134 |
X-RAY |
2002-07-10 | LEU | A:69 | A:568 | 15.0 | 0.088 | T | -55.0 | -36.7 | 15.0 | 0.088 | 0.0 |
HOH |
2.878 |
N |
O |
||
1sq0 | 1 | P04275 | 99.01 | 5e-134 |
X-RAY |
2004-04-13 | LEU | A:73 | A:568 | 20.0 | 0.118 | T | -54.8 | -45.5 | 20.0 | 0.118 | 0.0 |
HOH |
3.189 |
N |
O |
||
4c2a | 1 | P04275 | 98.48 | 3e-130 |
X-RAY |
2014-01-08 | LEU | A:69 | A:1331 | 20.0 | 0.118 | T | -55.8 | -29.3 | 20.0 | 0.118 | 0.0 |
HOH |
2.949 |
N |
O |
||
1oak | 3 | P04275 | 99.49 | 1e-128 |
X-RAY |
1998-10-21 | LEU | C:62 | A:568 | 17.0 | 0.1 | T | -55.3 | -26.1 | 17.0 | 0.1 | 0.0 |
HOH |
2.993 |
N |
O |
||
1fns | 3 | P04275 | 98.97 | 2e-128 |
X-RAY |
2000-10-18 | LEU | C:62 | A:568 | 15.0 | 0.088 | T | -52.5 | -32.8 | 15.0 | 0.088 | 0.0 |
HOH |
3.024 |
N |
O |
||
4c29 | 1 | P04275 | 98.48 | 4e-128 |
X-RAY |
2014-01-08 | LEU | A:69 | A:1331 | 11.0 | 0.065 | T | -58.0 | -36.0 | 11.0 | 0.065 | 0.0 |
HOH |
2.949 |
N |
O |
||
LEU | B:69 | B:1331 | 9.0 | 0.053 | T | -57.4 | -34.2 | NA | NA | NA | |||||||||||||
4c2b | 1 | P04275 | 98.48 | 4e-128 |
X-RAY |
2014-01-08 | LEU | A:69 | A:1331 | 21.0 | 0.124 | T | -69.0 | -28.3 | 21.0 | 0.124 | 0.0 | ||||||
LEU | C:69 | C:1331 | 16.0 | 0.094 | T | -67.4 | -41.1 | NA | NA | NA | |||||||||||||
LEU | E:69 | E:1331 | 17.0 | 0.1 | T | -62.7 | -43.8 | NA | NA | NA | |||||||||||||
LEU | G:69 | G:1331 | 14.0 | 0.082 | T | -69.7 | -24.1 | NA | NA | NA | |||||||||||||
1u0o | 3 | Q8CIZ8 | 87.02 | 2e-119 |
X-RAY |
2005-04-19 | LEU | C:71 | C:568 | 17.0 | 0.1 | S | -58.9 | -49.7 | 17.0 | 0.1 | 0.0 |
HOH |
2.821 |
O |
O |
AlphaFold DB
Entity | Residue | Monomer | View | ||||||||||
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ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
af-p04275-f1 | 1 | P04275 | 99.93 | 0.0 | LEU | A:1331 | A:1331 | 4.0 | 0.024 | T | -59.4 | -24.1 | |
af-p04275-f2 | 1 | P04275 | 99.93 | 0.0 | LEU | A:1131 | A:1131 | 13.0 | 0.076 | T | -57.2 | -27.2 | |
af-p04275-f3 | 1 | P04275 | 99.93 | 0.0 | LEU | A:931 | A:931 | 16.0 | 0.094 | T | -57.4 | -24.2 | |
af-p04275-f6 | 1 | P04275 | 100.0 | 0.0 | LEU | A:331 | A:331 | 16.0 | 0.094 | T | -56.9 | -26.2 | |
af-p04275-f5 | 1 | P04275 | 99.93 | 0.0 | LEU | A:531 | A:531 | 16.0 | 0.094 | T | -58.9 | -25.2 | |
af-p04275-f7 | 1 | P04275 | 100.0 | 0.0 | LEU | A:131 | A:131 | 14.0 | 0.082 | T | -56.1 | -18.5 | |
af-p04275-f4 | 1 | P04275 | 99.93 | 0.0 | LEU | A:731 | A:731 | 16.0 | 0.094 | T | -58.5 | -23.7 |