Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 6128668 . G A CCDS8539.1:NM_000552.3:c.3916Cgg>Tgg_NP_000543.2:p.1306R>W Homo sapiens von Willebrand factor (VWF), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
5bv8 1 P04275 99.11 3e-149 X-RAY
 2015-12-23 ARG A:81 A:1306 31.0 0.138 T -105.9 20.0 31.0 0.138 0.0 HOH
 2.943
 NH1
 O
7f49 1 P04275 99.05 2e-140 X-RAY
 2021-07-07 ARG A:48 A:543 53.0 0.236 T -106.7 14.7 53.0 0.236 0.0
1uex 3 P04275 99.52 3e-140 X-RAY
 2003-09-30 ARG C:47 C:543 20.0 0.089 T -122.6 22.7 20.0 0.089 0.0 HOH
 6.538
 NH1
 O
3hxo 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 ARG A:47 A:543 52.0 0.231 T -99.1 17.8 52.0 0.231 0.0 HOH
 4.948
 N
 O
3hxq 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 ARG A:47 A:543 52.0 0.231 T -107.4 16.0 52.0 0.231 0.0 HOH
 3.084
 NH2
 O
7eow 1 P04275 100.0 7e-140 X-RAY
 2021-07-07 ARG A:70 A:70 24.0 0.107 T -101.0 9.1 24.0 0.107 0.0 HOH
 2.741
 NE
 O
1auq 1 P04275 99.52 1e-139 X-RAY
 1998-10-14 ARG A:46 A:543 35.0 0.156 T -96.8 29.1 35.0 0.156 0.0 HOH
 3.459
 NE
 O
1u0n 1 P04275 99.52 1e-139 X-RAY
 2005-04-19 ARG A:46 A:543 18.0 0.08 T -99.0 31.1 18.0 0.08 0.0
1m10 1 P04275 99.04 7e-139 X-RAY
 2002-08-28 GLN A:46 A:543 6.0 0.033 T -66.5 27.5 6.0 0.033 0.0
7a6o 1 L8E853 99.51 5e-137 X-RAY
 2021-03-03 ARG A:45 AAA:1306 25.0 0.111 T -105.9 14.1 25.0 0.111 0.0 SO4
HOH
 3.516
2.069
 HH21
HE
 O2
O
1ijb 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 ARG A:44 A:543 29.0 0.129 T -101.8 24.7 29.0 0.129 0.0 HOH
 2.753
 NE
 O
1ijk 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 ARG A:44 A:543 21.0 0.093 T -109.6 21.6 21.0 0.093 0.0 HOH
 3.922
 NH2
 O
1sq0 1 P04275 99.01 5e-134 X-RAY
 2004-04-13 ARG A:48 A:543 14.0 0.062 H -59.6 -40.7 14.0 0.062 0.0 HOH
 5.790
 N
 O
4c2a 1 P04275 98.48 3e-130 X-RAY
 2014-01-08 GLN A:44 A:1306 0.0 0.0 H -60.2 -37.8 0.0 0.0 0.0 CAC
ACT
CA
HOH
 5.847
5.646
9.141
3.709
 CD
O
OE1
NE2
 O2
CH3
CA
O
1oak 3 P04275 99.49 1e-128 X-RAY
 1998-10-21 ARG C:37 A:543 60.0 0.267 T -102.3 19.9 60.0 0.267 0.0 HOH
 3.226
 NH2
 O
1fns 3 P04275 98.97 2e-128 X-RAY
 2000-10-18 ARG C:37 A:543 52.0 0.231 T -102.3 17.4 52.0 0.231 0.0 HOH
 2.964
 NH1
 O
4c29 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 ARG A:44 A:1306 24.0 0.107 T -97.8 9.8 24.0 0.107 0.0 HOH
 3.315
 NH2
 O
ARG B:44 B:1306 55.0 0.244 T -98.6 8.7 NA NA NA
4c2b 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 ARG A:44 A:1306 71.0 0.316 T -100.1 2.6 71.0 0.316 0.0 MES
HOH
 9.642
9.359
 N
O
 O1S
O
ARG C:44 C:1306 45.0 0.2 H -80.5 -37.3 NA NA NA
ARG E:44 E:1306 77.0 0.342 S -95.0 3.3 NA NA NA
ARG G:44 G:1306 109.0 0.484 S -101.9 2.2 NA NA NA
1u0o 3 Q8CIZ8 87.02 2e-119 X-RAY
 2005-04-19 ARG C:46 C:543 68.0 0.302 T -104.0 6.1 68.0 0.302 0.0 HOH
 6.346
 N
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p04275-f1 1 P04275 99.93 0.0 ARG A:1306 A:1306 119.0 0.529 T -94.7 -2.8
af-p04275-f2 1 P04275 99.93 0.0 ARG A:1106 A:1106 62.0 0.276 S -86.4 -3.3
af-p04275-f3 1 P04275 99.93 0.0 ARG A:906 A:906 39.0 0.173 T -85.6 -0.4
af-p04275-f6 1 P04275 100.0 0.0 ARG A:306 A:306 47.0 0.209 H -84.1 -8.1
af-p04275-f5 1 P04275 99.93 0.0 ARG A:506 A:506 62.0 0.276 T -87.7 -5.4
af-p04275-f7 1 P04275 100.0 0.0 ARG A:106 A:106 59.0 0.262 S -84.6 -4.2
af-p04275-f4 1 P04275 99.93 0.0 ARG A:706 A:706 55.0 0.244 S -85.9 -5.7