Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 6128707 . A C CCDS8539.1:NM_000552.3:c.3877Ttt>Gtt_NP_000543.2:p.1293F>V Homo sapiens von Willebrand factor (VWF), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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label_comp_id: 
auth_asym_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
5bv8 1 P04275 99.11 3e-149 X-RAY
 2015-12-23 PHE A:68 A:1293 1.0 0.005 H -62.4 -33.5 1.0 0.005 0.0 EDO
HOH
 6.462
3.292
 N
CD1
 C1
O
7f49 1 P04275 99.05 2e-140 X-RAY
 2021-07-07 PHE A:35 A:530 1.0 0.005 H -69.7 -35.6 1.0 0.005 0.0 HOH
 3.271
 CD1
 O
1uex 3 P04275 99.52 3e-140 X-RAY
 2003-09-30 PHE C:34 C:530 1.0 0.005 H -68.7 -34.5 1.0 0.005 0.0 HOH
 3.102
 CD1
 O
3hxo 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 PHE A:34 A:530 0.0 0.0 H -73.2 -37.6 0.0 0.0 0.0 HOH
 3.108
 CD1
 O
3hxq 1 P04275 99.52 3e-140 X-RAY
 2009-11-17 PHE A:34 A:530 2.0 0.01 H -77.2 -31.0 2.0 0.01 0.0 HOH
 3.187
 CE1
 O
7eow 1 P04275 100.0 7e-140 X-RAY
 2021-07-07 PHE A:57 A:57 1.0 0.005 H -58.7 -34.8 1.0 0.005 0.0 HOH
 3.244
 CD1
 O
1auq 1 P04275 99.52 1e-139 X-RAY
 1998-10-14 PHE A:33 A:530 1.0 0.005 H -63.3 -38.9 1.0 0.005 0.0 HOH
 3.159
 CZ
 O
1u0n 1 P04275 99.52 1e-139 X-RAY
 2005-04-19 PHE A:33 A:530 1.0 0.005 H -52.4 -31.0 1.0 0.005 0.0
1m10 1 P04275 99.04 7e-139 X-RAY
 2002-08-28 PHE A:33 A:530 1.0 0.005 H -67.7 -42.3 1.0 0.005 0.0
7a6o 1 L8E853 99.51 5e-137 X-RAY
 2021-03-03 PHE A:32 AAA:1293 0.0 0.0 H -70.8 -39.9 0.0 0.0 0.0 HOH
 2.904
 HD2
 O
1ijb 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 PHE A:31 A:530 1.0 0.005 H -65.8 -33.0 1.0 0.005 0.0 HOH
 3.235
 CD1
 O
1ijk 1 P04275 99.01 4e-134 X-RAY
 2002-07-10 PHE A:31 A:530 0.0 0.0 H -65.6 -17.7 0.0 0.0 0.0 HOH
 3.109
 CE1
 O
1sq0 1 P04275 99.01 5e-134 X-RAY
 2004-04-13 PHE A:35 A:530 1.0 0.005 H -62.1 -34.3 1.0 0.005 0.0 HOH
 3.122
 CD1
 O
4c2a 1 P04275 98.48 3e-130 X-RAY
 2014-01-08 PHE A:31 A:1293 1.0 0.005 H -65.2 -33.8 1.0 0.005 0.0 HOH
 3.238
 CD2
 O
1oak 3 P04275 99.49 1e-128 X-RAY
 1998-10-21 PHE C:24 A:530 0.0 0.0 H -70.6 -23.2 0.0 0.0 0.0 HOH
 3.095
 CE1
 O
1fns 3 P04275 98.97 2e-128 X-RAY
 2000-10-18 PHE C:24 A:530 0.0 0.0 H -65.4 -34.4 0.0 0.0 0.0 HOH
 3.256
 CD2
 O
4c29 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 PHE A:31 A:1293 1.0 0.005 H -66.0 -32.1 1.0 0.005 0.0 PEG
HOH
 7.894
3.346
 CD2
CD1
 C4
O
PHE B:31 B:1293 1.0 0.005 H -66.1 -32.7 NA NA NA
4c2b 1 P04275 98.48 4e-128 X-RAY
 2014-01-08 PHE A:31 A:1293 1.0 0.005 H -73.8 -27.5 1.0 0.005 0.0
PHE C:31 C:1293 1.0 0.005 H -69.4 -27.4 NA NA NA
PHE E:31 E:1293 2.0 0.01 H -72.1 -24.3 NA NA NA
PHE G:31 G:1293 0.0 0.0 H -70.1 -25.7 NA NA NA
1u0o 3 Q8CIZ8 87.02 2e-119 X-RAY
 2005-04-19 PHE C:33 C:530 1.0 0.005 H -58.1 -46.2 1.0 0.005 0.0 HOH
 5.494
 O
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p04275-f1 1 P04275 99.93 0.0 PHE A:1293 A:1293 0.0 0.0 H -68.9 -35.4
af-p04275-f2 1 P04275 99.93 0.0 PHE A:1093 A:1093 0.0 0.0 H -68.9 -31.9
af-p04275-f3 1 P04275 99.93 0.0 PHE A:893 A:893 0.0 0.0 H -70.5 -32.6
af-p04275-f6 1 P04275 100.0 0.0 PHE A:293 A:293 0.0 0.0 H -70.2 -34.0
af-p04275-f5 1 P04275 99.93 0.0 PHE A:493 A:493 0.0 0.0 H -69.9 -33.3
af-p04275-f7 1 P04275 100.0 0.0 PHE A:93 A:93 0.0 0.0 H -73.6 -31.8
af-p04275-f4 1 P04275 99.93 0.0 PHE A:693 A:693 0.0 0.0 H -69.1 -33.3