Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 6978905 . A C CCDS53740.1:NM_001159287.1:c.622Att>Ctt_NP_001152759.1:p.208I>L Homo sapiens triosephosphate isomerase 1 (TPI1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6up1 1 P60174 100.0 0.0 X-RAY
 2020-07-01 ILE A:174 A:170 102.0 0.583 S -97.0 95.4 102.0 0.583 0.0 HOH
 2.935
 O
 O
ILE B:174 B:170 75.0 0.429 S -138.6 106.5 75.0 0.429 0.0 HOH
 3.432
 CD1
 O
6up5 1 P60174 100.0 0.0 X-RAY
 2020-07-01 ILE A:174 A:170 101.0 0.577 S -89.7 95.8 101.0 0.577 0.0 GOL
HOH
 3.290
3.001
 CD1
CG1
 O1
O
ILE B:174 B:170 26.0 0.149 T -79.9 114.3 26.0 0.149 0.0 PGA
HOH
 3.484
2.549
 CA
O
 O4P
O
4poc 1 P60174 100.0 0.0 X-RAY
 2015-01-14 ILE A:176 A:170 62.0 0.354 S -120.3 106.6 62.0 0.354 0.0 NA
HOH
 3.701
2.816
 HA
O
 NA
O
ILE B:176 B:170 23.0 0.131 T -82.0 113.4 23.0 0.131 0.0 PO4
BR
HOH
 2.611
4.464
2.791
 HA
HG23
O
 O4
BR
O
6c2g 1 P60174 99.6 0.0 X-RAY
 2018-03-21 ILE A:171 A:170 68.0 0.389 S -81.3 110.0 68.0 0.389 0.0 HOH
 4.108
 CG2
 O
ILE B:171 B:170 59.0 0.337 S -81.1 110.3 NA NA NA
ILE C:171 C:170 70.0 0.4 -81.2 115.2 NA NA NA
ILE D:171 D:170 60.0 0.343 T -82.1 115.5 NA NA NA
4pod 1 P60174 99.6 0.0 X-RAY
 2015-01-14 VAL A:176 A:170 106.0 0.684 S -85.0 107.0 106.0 0.684 0.0 HOH
 2.898
 HG21
 O
VAL B:176 B:170 18.0 0.116 T -84.0 109.9 18.0 0.116 0.0 PO4
BR
HOH
 2.709
4.297
2.512
 HA
HG13
HB
 O4
BR
O
1wyi 1 P60174 100.0 0.0 X-RAY
 2005-04-12 ILE A:172 A:170 78.0 0.446 S -104.0 112.7 78.0 0.446 0.0 HOH
 2.897
 CD1
 O
ILE B:172 B:170 71.0 0.406 -144.0 139.4 71.0 0.406 0.0 HOH
 2.866
 CG2
 O
2jk2 1 P60174 100.0 0.0 X-RAY
 2008-07-01 ILE A:172 A:170 94.0 0.537 S -92.6 101.4 94.0 0.537 0.0 HOH
 2.940
 O
 O
ILE B:172 B:170 79.0 0.451 T -74.6 113.1 79.0 0.451 0.0 HOH
 4.105
 CD1
 O
6up8 1 P60174 99.6 0.0 X-RAY
 2020-07-01 ILE A:174 A:170 93.0 0.531 S -100.9 111.2 93.0 0.531 0.0 IPA
HOH
 9.631
3.210
 N
CD1
 O2
O
ILE B:174 B:170 60.0 0.343 S -135.7 117.2 60.0 0.343 0.0 HOH
 3.275
 CG2
 O
6upf 1 P60174 99.6 0.0 X-RAY
 2020-07-01 ILE A:174 A:170 26.0 0.149 S -80.0 111.4 26.0 0.149 0.0 PGA
HOH
 3.218
2.676
 CG2
O
 O1
O
ILE B:174 B:170 26.0 0.149 S -83.9 112.6 26.0 0.149 0.0 PGA
HOH
 3.211
2.619
 CA
O
 O2P
O
1hti 1 P60174 100.0 0.0 X-RAY
 1995-01-26 ILE A:170 A:170 99.0 0.566 T -72.1 153.8 99.0 0.566 0.0
ILE B:170 B:170 46.0 0.263 S -82.4 125.9 45.0 0.257 0.006 A:P60174:0.006
 PGA
 3.061
 CA
 O2P
4zvj 1 P60174 99.6 0.0 X-RAY
 2016-03-09 ILE A:176 A:170 93.0 0.531 S -96.0 98.5 93.0 0.531 0.0 HOH
 2.852
 HD11
 O
ILE B:176 B:170 75.0 0.429 S -118.8 110.7 75.0 0.429 0.0 HOH
 2.627
 HD13
 O
2vom 1 P60174 99.6 0.0 X-RAY
 2008-06-17 ILE A:172 A:170 93.0 0.531 S -97.1 106.3 93.0 0.531 0.0 HOH
 2.685
 O
 O
ILE B:172 B:170 72.0 0.411 T -46.2 113.0 72.0 0.411 0.0 HOH
 4.312
 CD1
 O
ILE C:172 C:170 74.0 0.423 T -65.4 103.1 NA NA NA
ILE D:172 D:170 82.0 0.469 T -69.8 111.2 NA NA NA
4unk 1 P60174 99.6 0.0 X-RAY
 2015-02-04 ILE A:172 A:170 76.0 0.434 S -123.9 108.9 76.0 0.434 0.0 HOH
 2.544
 O
 O
ILE B:172 B:170 77.0 0.44 S -136.1 122.9 77.0 0.44 0.0 HOH
 3.067
 CG2
 O
4unl 1 P60174 99.6 0.0 X-RAY
 2015-02-04 ILE A:170 A:170 74.0 0.423 T -88.6 102.8 74.0 0.423 0.0 HOH
 2.980
 CD1
 O
ILE B:170 B:170 96.0 0.549 S -91.9 101.6 96.0 0.549 0.0 HOH
 2.941
 O
 O
4br1 1 P60174 100.0 0.0 X-RAY
 2013-06-12 ILE A:168 NA:NA DO NA DO DO DO NA NA NA
ILE B:168 B:170 85.0 0.486 S -99.4 105.4 85.0 0.486 0.0 HOH
 3.744
 CD1
 O
6d43 1 P60174 100.0 0.0 X-RAY
 2018-05-16 ILE A:168 A:170 106.0 0.606 S -92.3 93.7 106.0 0.606 0.0 HOH
 3.310
 CD1
 O
6d43 2 P60174 100.0 0.0 X-RAY
 2018-05-16 ILE B:168 B:170 70.0 0.4 S -123.6 116.3 70.0 0.4 0.0 HOH
 3.237
 CD1
 O
1r2r 1 P00939 98.39 0.0 X-RAY
 2003-12-23 ILE A:170 A:170 88.0 0.503 S -100.8 107.1 88.0 0.503 0.0 HOH
 3.073
 CD1
 O
ILE B:170 B:170 27.0 0.154 S -90.3 114.4 26.0 0.149 0.005 A:P00939:0.006
 HOH
 2.600
 O
 O
ILE C:170 C:170 125.0 0.714 T -79.1 122.1 NA NA NA
ILE D:170 D:170 65.0 0.371 S -99.8 109.3 NA NA NA
1r2s 1 P00939 98.39 0.0 X-RAY
 2003-12-23 ILE A:170 A:170 81.0 0.463 S -120.3 115.7 81.0 0.463 0.0 HOH
 4.710
 CD1
 O
ILE B:170 B:170 83.0 0.474 S -122.9 114.9 83.0 0.474 0.0 HOH
 3.395
 CG2
 O
ILE C:170 C:170 83.0 0.474 S -119.6 115.0 NA NA NA
ILE D:170 D:170 81.0 0.463 S -120.6 114.7 NA NA NA
1r2t 1 P00939 98.39 0.0 X-RAY
 2003-12-23 ILE A:170 A:170 95.0 0.543 S -86.0 104.1 95.0 0.543 0.0 HOH
 2.758
 O
 O
ILE B:170 B:170 96.0 0.549 S -101.3 115.7 96.0 0.549 0.0 HOH
 3.337
 CG1
 O
4owg 1 P00939 98.39 0.0 X-RAY
 2014-03-05 ILE A:170 A:170 26.0 0.149 S -85.1 114.1 26.0 0.149 0.0 PEP
HOH
 3.407
2.846
 CA
O
 O2P
O
ILE B:170 B:170 27.0 0.154 S -84.7 113.0 27.0 0.154 0.0 PEP
HOH
 3.336
2.782
 CA
O
 O2P
O
6nlh 1 P60174 99.59 0.0 X-RAY
 2019-06-19 ILE A:167 A:170 95.0 0.543 S -87.3 94.1 95.0 0.543 0.0 HOH
 2.890
 HG21
 O
ILE B:167 NA:NA DO NA DO DO DO NA NA NA
ILE C:167 B:170 102.0 0.583 S -96.9 104.0 NA NA NA
ILE D:167 NA:NA DO NA DO DO DO NA NA NA
ILE E:167 D:170 97.0 0.554 S -96.4 95.2 NA NA NA
ILE F:167 NA:NA DO NA DO DO DO NA NA NA
ILE G:167 G:170 93.0 0.531 S -91.8 97.3 NA NA NA
ILE H:167 NA:NA DO NA DO DO DO NA NA NA
1sw3 1 P00940 89.16 1e-162 X-RAY
 2004-08-24 ILE A:170 A:170 25.0 0.143 S -82.2 113.7 25.0 0.143 0.0 PGA
HOH
 3.493
2.781
 CA
O
 O3P
O
ILE B:170 B:170 22.0 0.126 T -82.5 115.6 22.0 0.126 0.0 PGA
HOH
 3.562
2.883
 CA
O
 O3P
O
1tph 1 P00940 89.39 7e-162 X-RAY
 1994-04-30 ILE A:169 1:170 26.0 0.149 T -78.6 115.3 26.0 0.149 0.0 PGH
HOH
 3.342
2.832
 CG2
O
 O1
O
ILE B:169 2:170 26.0 0.149 T -77.0 114.2 26.0 0.149 0.0 PGH
HOH
 3.475
2.755
 CA
O
 O3P
O
8tim 1 P00940 89.39 7e-162 X-RAY
 1999-02-16 ILE A:169 A:170 79.0 0.451 H -21.6 -67.3 79.0 0.451 0.0 SO4
HOH
 3.613
6.349
 CB
O
 O2
O
ILE B:169 B:170 99.0 0.566 S -103.7 132.8 99.0 0.566 0.0 SO4
HOH
 5.503
2.860
 CD1
C
 O3
O
1sw7 1 P00940 88.35 8e-162 X-RAY
 2004-08-24 ILE A:170 A:170 24.0 0.137 S -80.2 110.3 24.0 0.137 0.0 PGA
HOH
 3.370
2.831
 CA
O
 O3P
O
ILE B:170 B:170 25.0 0.143 S -85.7 109.3 25.0 0.143 0.0 PGA
HOH
 3.438
2.613
 CA
O
 O3P
O
1spq 1 P00940 89.39 1e-161 X-RAY
 2004-08-24 ILE A:169 A:170 136.0 0.777 -126.0 360.0 136.0 0.777 0.0 HOH
 4.880
 CG2
 O
ILE B:169 NA:NA DO NA DO DO DO NA NA NA
1tpb 1 P00940 88.98 2e-161 X-RAY
 1995-02-14 ILE A:169 1:170 25.0 0.143 T -76.9 118.3 25.0 0.143 0.0 PGH
HOH
 3.315
2.734
 CG2
O
 O1
O
ILE B:169 2:170 25.0 0.143 T -77.1 117.1 25.0 0.143 0.0 PGH
HOH
 3.532
2.723
 CA
O
 O2P
O
1sw0 1 P00940 88.76 6e-161 X-RAY
 2004-08-24 ILE A:170 A:170 24.0 0.137 S -88.1 113.2 24.0 0.137 0.0 PGA
HOH
 3.469
2.624
 CG2
O
 O1
O
ILE B:170 B:170 23.0 0.131 T -77.0 111.9 23.0 0.131 0.0 PGA
HOH
 3.472
2.667
 CA
O
 O3P
O
1tpw 1 P00940 88.98 8e-161 X-RAY
 1995-04-20 ILE A:169 A:170 29.0 0.166 T -87.3 114.0 28.0 0.16 0.006 B:P00940:0.006
 PGH
HOH
 3.397
4.528
 CG2
CG2
 O1
O
ILE B:169 B:170 28.0 0.16 T -82.1 113.8 28.0 0.16 0.0 PGH
HOH
 3.301
3.515
 CG2
O
 O1
O
1tpu 1 P00940 88.98 1e-160 X-RAY
 1995-04-20 ILE A:169 A:170 28.0 0.16 T -93.7 122.6 27.0 0.154 0.006 B:P00940:0.006
 PGH
HOH
 3.565
2.804
 CA
O
 O4P
O
ILE B:169 B:170 27.0 0.154 T -85.9 119.9 27.0 0.154 0.0 PGH
HOH
 3.205
2.853
 CG2
O
 O1
O
4p61 1 P00940 88.76 2e-160 X-RAY
 2014-08-27 ILE A:170 A:170 141.0 0.806 T 49.2 37.1 141.0 0.806 0.0 HOH
 3.117
 CD1
 O
ILE B:170 NA:NA DO NA DO DO DO NA NA NA
1tpc 1 P00940 88.57 2e-160 X-RAY
 1995-02-14 ILE A:169 1:170 29.0 0.166 T -76.8 112.4 29.0 0.166 0.0 PGH
HOH
 3.237
2.748
 CA
O
 O2P
O
ILE B:169 2:170 26.0 0.149 T -75.5 119.0 26.0 0.149 0.0 PGH
HOH
 3.569
2.824
 CA
O
 O2P
O
1ssd 1 P00940 88.57 3e-160 X-RAY
 2004-08-24 ILE A:169 A:170 30.0 0.171 T -74.2 112.7 29.0 0.166 0.005 B:P00940:0.006
 SO4
HOH
 4.107
3.871
 CA
CD1
 O3
O
ILE B:169 B:170 28.0 0.16 T -67.9 115.9 26.0 0.149 0.011 A:P00940:0.011
 SO4
HOH
 3.504
4.103
 CA
CD1
 O4
O
1ssg 1 P00940 88.57 3e-160 X-RAY
 2004-08-24 ILE A:169 A:170 26.0 0.149 S -76.9 124.1 24.0 0.137 0.012 B:P00940:0.011
 PGA
HOH
 3.536
4.485
 CG1
CD1
 O2
O
ILE B:169 B:170 27.0 0.154 S -70.9 121.9 26.0 0.149 0.005 A:P00940:0.006
 PGA
HOH
 3.437
4.168
 CA
CG2
 O3P
O
1sq7 1 P00940 88.98 4e-160 X-RAY
 2004-08-24 ILE A:169 A:170 75.0 0.429 S -104.4 94.8 75.0 0.429 0.0 HOH
 2.810
 O
 O
ILE B:169 B:170 90.0 0.514 S -93.2 116.2 90.0 0.514 0.0 HOH
 3.027
 CD1
 O
1tpv 1 P00940 88.57 1e-159 X-RAY
 1995-04-20 ILE A:169 A:170 28.0 0.16 S -91.1 121.6 27.0 0.154 0.006 B:P00940:0.006
 PGH
HOH
 3.277
4.109
 CA
CG2
 O4P
O
ILE B:169 B:170 28.0 0.16 T -86.0 119.6 27.0 0.154 0.006 A:P00940:0.006
 PGH
HOH
 3.434
3.001
 CG2
O
 O1
O
1su5 1 P00940 88.57 1e-159 X-RAY
 2004-08-24 ILE A:169 A:170 25.0 0.143 S -77.8 119.9 25.0 0.143 0.0 PGA
HOH
 3.357
2.712
 CA
O
 O3P
O
ILE B:169 B:170 26.0 0.149 S -80.6 116.9 25.0 0.143 0.006 A:P00940:0.006
 PGA
SO4
HOH
 3.294
5.148
3.705
 CA
CD1
O
 O3P
O3
O
1tim 1 P00940 86.53 5e-158 X-RAY
 1976-10-15 ILE A:169 A:170 75.0 0.429 S -106.4 108.4 75.0 0.429 0.0
ILE B:169 B:170 94.0 0.537 S -131.0 115.1 94.0 0.537 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p60174-f1 1 P60174 100.0 0.0 ILE A:171 A:171 27.0 0.154 S -89.6 108.8