Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr12 6979519 . T A CCDS53740.1:NM_001159287.1:c.833tTc>tAc_NP_001152759.1:p.278F>Y Homo sapiens triosephosphate isomerase 1 (TPI1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6up1 1 P60174 100.0 0.0 X-RAY
 2020-07-01 PHE A:244 A:240 0.0 0.0 H -50.3 -36.5 0.0 0.0 0.0 HOH
 3.234
 CD2
 O
PHE B:244 B:240 0.0 0.0 H -52.3 -33.2 0.0 0.0 0.0 HOH
 3.311
 CB
 O
6up5 1 P60174 100.0 0.0 X-RAY
 2020-07-01 PHE A:244 A:240 0.0 0.0 H -48.7 -36.3 0.0 0.0 0.0 HOH
 3.324
 CE2
 O
PHE B:244 B:240 2.0 0.01 H -56.3 -36.1 2.0 0.01 0.0 PGA
HOH
 8.814
3.339
 CD1
CB
 O3P
O
4poc 1 P60174 100.0 0.0 X-RAY
 2015-01-14 PHE A:246 A:240 0.0 0.0 H -56.6 -32.4 0.0 0.0 0.0 HOH
 3.333
 CD2
 O
PHE B:246 B:240 2.0 0.01 H -59.9 -33.1 2.0 0.01 0.0 PO4
BR
HOH
 8.412
8.822
2.705
 HD1
HE1
HB3
 O1
BR
O
6c2g 1 P60174 99.6 0.0 X-RAY
 2018-03-21 PHE A:241 A:240 0.0 0.0 H -52.3 -35.6 0.0 0.0 0.0 HOH
 3.146
 CE2
 O
PHE B:241 B:240 1.0 0.005 H -52.4 -35.5 NA NA NA
PHE C:241 C:240 0.0 0.0 H -52.4 -35.7 NA NA NA
PHE D:241 D:240 0.0 0.0 H -52.5 -35.7 NA NA NA
4pod 1 P60174 99.6 0.0 X-RAY
 2015-01-14 PHE A:246 A:240 0.0 0.0 H -56.5 -36.8 0.0 0.0 0.0 HOH
 5.379
 H
 O
PHE B:246 B:240 3.0 0.014 H -57.4 -35.6 3.0 0.014 0.0 PO4
BR
HOH
 8.377
8.728
4.992
 HD1
HE1
H
 O3
BR
O
1wyi 1 P60174 100.0 0.0 X-RAY
 2005-04-12 PHE A:242 A:240 0.0 0.0 H -55.3 -34.1 0.0 0.0 0.0 HOH
 2.844
 CE1
 O
PHE B:242 B:240 0.0 0.0 H -79.3 -24.9 0.0 0.0 0.0 HOH
 3.334
 CE1
 O
2jk2 1 P60174 100.0 0.0 X-RAY
 2008-07-01 PHE A:242 A:240 0.0 0.0 H -56.6 -35.6 0.0 0.0 0.0 HOH
 3.324
 CE2
 O
PHE B:242 B:240 0.0 0.0 H -57.9 -38.7 0.0 0.0 0.0 HOH
 3.159
 CB
 O
6up8 1 P60174 99.6 0.0 X-RAY
 2020-07-01 LEU A:244 A:240 0.0 0.0 H -47.2 -37.9 0.0 0.0 0.0 HOH
 5.774
 N
 O
LEU B:244 B:240 1.0 0.006 H -59.7 -36.4 1.0 0.006 0.0 HOH
 5.917
 N
 O
6upf 1 P60174 99.6 0.0 X-RAY
 2020-07-01 LEU A:244 A:240 1.0 0.006 H -53.7 -36.3 1.0 0.006 0.0 PGA
HOH
 8.833
5.697
 CD1
N
 O3P
O
LEU B:244 B:240 4.0 0.024 H -53.7 -38.0 4.0 0.024 0.0 PGA
HOH
 8.950
5.519
 CD1
N
 O4P
O
1hti 1 P60174 100.0 0.0 X-RAY
 1995-01-26 PHE A:240 A:240 1.0 0.005 H -47.9 -37.3 1.0 0.005 0.0
PHE B:240 B:240 1.0 0.005 H -53.4 -35.2 1.0 0.005 0.0 PGA
 9.106
 CD1
 O4P
4zvj 1 P60174 99.6 0.0 X-RAY
 2016-03-09 PHE A:246 A:240 0.0 0.0 H -58.5 -32.4 0.0 0.0 0.0 HOH
 3.354
 CD2
 O
PHE B:246 B:240 0.0 0.0 H -59.7 -34.5 0.0 0.0 0.0 HOH
 2.633
 HB3
 O
2vom 1 P60174 99.6 0.0 X-RAY
 2008-06-17 PHE A:242 A:240 0.0 0.0 H -56.8 -35.2 0.0 0.0 0.0 HOH
 3.121
 CE2
 O
PHE B:242 B:240 3.0 0.014 H -53.0 -43.7 3.0 0.014 0.0 HOH
 5.403
 N
 O
PHE C:242 C:240 0.0 0.0 H -51.2 -38.1 NA NA NA
PHE D:242 D:240 0.0 0.0 H -67.1 -36.5 NA NA NA
4unk 1 P60174 99.6 0.0 X-RAY
 2015-02-04 PHE A:242 A:240 1.0 0.005 H -60.5 -36.1 1.0 0.005 0.0 HOH
 5.442
 N
 O
PHE B:242 B:240 1.0 0.005 H -58.7 -37.0 1.0 0.005 0.0 HOH
 5.329
 N
 O
4unl 1 P60174 99.6 0.0 X-RAY
 2015-02-04 PHE A:240 A:240 0.0 0.0 H -57.6 -37.3 0.0 0.0 0.0 HOH
 3.204
 CE2
 O
PHE B:240 B:240 0.0 0.0 H -56.5 -33.3 0.0 0.0 0.0 HOH
 3.312
 CE2
 O
4br1 1 P60174 100.0 0.0 X-RAY
 2013-06-12 PHE A:238 A:240 0.0 0.0 H -63.3 -34.5 0.0 0.0 0.0 HOH
 3.004
 CB
 O
PHE B:238 B:240 0.0 0.0 H -56.1 -34.2 0.0 0.0 0.0 HOH
 3.118
 CB
 O
6d43 1 P60174 100.0 0.0 X-RAY
 2018-05-16 PHE A:238 A:240 0.0 0.0 H -49.5 -38.1 0.0 0.0 0.0 HOH
 3.142
 CE2
 O
6d43 2 P60174 100.0 0.0 X-RAY
 2018-05-16 PHE B:238 B:240 0.0 0.0 H -55.1 -36.8 0.0 0.0 0.0 HOH
 3.363
 CE2
 O
1r2r 1 P00939 98.39 0.0 X-RAY
 2003-12-23 PHE A:240 A:240 0.0 0.0 H -52.2 -36.7 0.0 0.0 0.0 HOH
 3.304
 CE2
 O
PHE B:240 B:240 0.0 0.0 H -56.8 -37.2 0.0 0.0 0.0 HOH
 3.209
 CE2
 O
PHE C:240 C:240 0.0 0.0 H -55.4 -38.3 NA NA NA
PHE D:240 D:240 0.0 0.0 H -50.6 -36.8 NA NA NA
1r2s 1 P00939 98.39 0.0 X-RAY
 2003-12-23 PHE A:240 A:240 0.0 0.0 H -61.1 -37.5 0.0 0.0 0.0
PHE B:240 B:240 0.0 0.0 H -58.8 -40.5 0.0 0.0 0.0 HOH
 9.351
 CD1
 O
PHE C:240 C:240 1.0 0.005 H -54.7 -43.3 NA NA NA
PHE D:240 D:240 1.0 0.005 H -59.3 -41.0 NA NA NA
1r2t 1 P00939 98.39 0.0 X-RAY
 2003-12-23 PHE A:240 A:240 0.0 0.0 H -59.4 -32.8 0.0 0.0 0.0 HOH
 3.171
 CD2
 O
PHE B:240 B:240 0.0 0.0 H -59.0 -33.4 0.0 0.0 0.0 HOH
 3.290
 CD2
 O
4owg 1 P00939 98.39 0.0 X-RAY
 2014-03-05 PHE A:240 A:240 1.0 0.005 H -53.4 -36.2 1.0 0.005 0.0 PEP
HOH
 8.857
3.413
 CD1
CE2
 O1P
O
PHE B:240 B:240 0.0 0.0 H -53.6 -34.5 0.0 0.0 0.0 PEP
HOH
 8.843
3.255
 CD1
CE2
 O1P
O
6nlh 1 P60174 99.59 0.0 X-RAY
 2019-06-19 PHE A:237 A:240 0.0 0.0 H -56.3 -28.9 0.0 0.0 0.0 HOH
 3.113
 CE2
 O
PHE B:237 E:240 0.0 0.0 H -56.6 -31.9 0.0 0.0 0.0 BR
PO4
HOH
 8.623
9.044
3.227
 HE1
HD1
CE2
 BR
O3
O
PHE C:237 B:240 0.0 0.0 H -54.4 -34.4 NA NA NA
PHE D:237 C:240 0.0 0.0 H -56.2 -30.9 NA NA NA
PHE E:237 D:240 0.0 0.0 H -58.3 -33.3 NA NA NA
PHE F:237 F:240 0.0 0.0 H -60.1 -32.0 NA NA NA
PHE G:237 G:240 0.0 0.0 H -55.0 -32.4 NA NA NA
PHE H:237 H:240 0.0 0.0 H -57.4 -29.4 NA NA NA
1sw3 1 P00940 89.16 1e-162 X-RAY
 2004-08-24 PHE A:240 A:240 2.0 0.01 H -52.7 -36.7 2.0 0.01 0.0 PGA
HOH
 8.968
5.765
 CD1
N
 O2P
O
PHE B:240 B:240 0.0 0.0 H -54.2 -37.6 0.0 0.0 0.0 PGA
HOH
 8.941
5.506
 CD1
N
 O2P
O
1tph 1 P00940 89.39 7e-162 X-RAY
 1994-04-30 PHE A:239 1:240 1.0 0.005 H -55.6 -33.8 1.0 0.005 0.0 PGH
HOH
 8.782
2.800
 CD1
CE2
 O4P
O
PHE B:239 2:240 1.0 0.005 H -63.4 -32.8 1.0 0.005 0.0 PGH
HOH
 8.802
3.010
 CE1
CE2
 O4P
O
8tim 1 P00940 89.39 7e-162 X-RAY
 1999-02-16 PHE A:239 A:240 1.0 0.005 H -63.5 -41.1 1.0 0.005 0.0 HOH
 8.234
 CD1
 O
PHE B:239 B:240 1.0 0.005 H -56.8 -38.4 1.0 0.005 0.0 SO4
HOH
 9.825
8.494
 CD1
CE1
 O2
O
1sw7 1 P00940 88.35 8e-162 X-RAY
 2004-08-24 PHE A:240 A:240 4.0 0.019 H -51.5 -37.2 4.0 0.019 0.0 PGA
HOH
 8.863
3.169
 CD1
CD2
 O2P
O
PHE B:240 B:240 4.0 0.019 H -56.8 -33.3 4.0 0.019 0.0 PGA
HOH
 8.893
3.154
 CD1
CE2
 O2P
O
1spq 1 P00940 89.39 1e-161 X-RAY
 2004-08-24 PHE A:239 A:240 2.0 0.01 H -52.3 -35.6 2.0 0.01 0.0 HOH
 2.735
 CE2
 O
PHE B:239 B:240 1.0 0.005 H -52.3 -37.0 1.0 0.005 0.0 HOH
 3.167
 CE2
 O
1tpb 1 P00940 88.98 2e-161 X-RAY
 1995-02-14 PHE A:239 1:240 1.0 0.005 H -57.5 -31.4 1.0 0.005 0.0 PGH
HOH
 8.727
5.691
 CD1
N
 O3P
O
PHE B:239 2:240 1.0 0.005 H -59.7 -35.2 1.0 0.005 0.0 PGH
HOH
 8.732
5.414
 CD1
N
 O3P
O
1sw0 1 P00940 88.76 6e-161 X-RAY
 2004-08-24 PHE A:240 A:240 3.0 0.014 H -49.0 -37.5 3.0 0.014 0.0 PGA
HOH
 8.960
3.205
 CD1
CE2
 O2P
O
PHE B:240 B:240 0.0 0.0 H -47.3 -39.3 0.0 0.0 0.0 PGA
HOH
 8.882
2.961
 CE1
CD2
 O2P
O
1tpw 1 P00940 88.98 8e-161 X-RAY
 1995-04-20 PHE A:239 A:240 1.0 0.005 H -55.5 -34.4 1.0 0.005 0.0 PGH
HOH
 8.977
6.773
 CD1
C
 O3P
O
PHE B:239 B:240 1.0 0.005 H -63.9 -36.3 1.0 0.005 0.0 PGH
HOH
 9.081
6.052
 CD1
N
 O3P
O
1tpu 1 P00940 88.98 1e-160 X-RAY
 1995-04-20 PHE A:239 A:240 1.0 0.005 H -53.9 -34.8 1.0 0.005 0.0 PGH
HOH
 9.285
2.938
 CD1
CE2
 O3P
O
PHE B:239 B:240 0.0 0.0 H -58.9 -34.9 0.0 0.0 0.0 PGH
HOH
 9.157
5.578
 CD1
N
 O3P
O
4p61 1 P00940 88.76 2e-160 X-RAY
 2014-08-27 PHE A:240 A:240 3.0 0.014 H -55.9 -36.4 3.0 0.014 0.0 HOH
 3.089
 CE2
 O
PHE B:240 B:240 0.0 0.0 H -53.1 -34.1 0.0 0.0 0.0 HOH
 3.119
 CE2
 O
1tpc 1 P00940 88.57 2e-160 X-RAY
 1995-02-14 PHE A:239 1:240 2.0 0.01 H -45.9 -35.0 2.0 0.01 0.0 PGH
HOH
 8.847
3.037
 CD1
CE2
 O3P
O
PHE B:239 2:240 1.0 0.005 H -56.5 -40.5 1.0 0.005 0.0 PGH
HOH
 8.942
5.329
 CD1
N
 O3P
O
1ssd 1 P00940 88.57 3e-160 X-RAY
 2004-08-24 PHE A:239 A:240 1.0 0.005 H -53.9 -37.5 1.0 0.005 0.0 SO4
HOH
 9.755
6.894
 CD1
C
 O2
O
PHE B:239 B:240 0.0 0.0 H -52.5 -34.6 0.0 0.0 0.0 SO4
HOH
 9.488
5.625
 CD1
N
 O2
O
1ssg 1 P00940 88.57 3e-160 X-RAY
 2004-08-24 PHE A:239 A:240 4.0 0.019 H -54.7 -39.6 4.0 0.019 0.0 PGA
SO4
HOH
 9.176
9.974
3.359
 CD1
N
CD2
 O2P
O1
O
PHE B:239 B:240 4.0 0.019 H -50.1 -42.1 4.0 0.019 0.0 PGA
HOH
 9.180
2.807
 CD1
CD2
 O2P
O
1sq7 1 P00940 88.98 4e-160 X-RAY
 2004-08-24 PHE A:239 A:240 0.0 0.0 H -57.2 -28.0 0.0 0.0 0.0 HOH
 5.681
 N
 O
PHE B:239 B:240 3.0 0.014 H -58.9 -29.5 3.0 0.014 0.0 HOH
 3.348
 CB
 O
1tpv 1 P00940 88.57 1e-159 X-RAY
 1995-04-20 PHE A:239 A:240 1.0 0.005 H -56.1 -33.2 1.0 0.005 0.0 PGH
HOH
 9.287
6.908
 CD1
O
 O3P
O
PHE B:239 B:240 0.0 0.0 H -59.4 -36.0 0.0 0.0 0.0 PGH
HOH
 9.182
5.534
 CE1
N
 O3P
O
1su5 1 P00940 88.57 1e-159 X-RAY
 2004-08-24 PHE A:239 A:240 4.0 0.019 H -55.8 -34.2 4.0 0.019 0.0 PGA
HOH
 8.836
2.907
 CD1
CE2
 O2P
O
PHE B:239 B:240 4.0 0.019 H -53.6 -36.5 4.0 0.019 0.0 PGA
SO4
HOH
 8.823
8.664
3.310
 CD1
CE2
CD2
 O2P
O3
O
1tim 1 P00940 86.53 5e-158 X-RAY
 1976-10-15 PHE A:239 A:240 1.0 0.005 H -45.6 -64.8 1.0 0.005 0.0
PHE B:239 B:240 3.0 0.014 H -47.1 -58.7 3.0 0.014 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p60174-f1 1 P60174 100.0 0.0 PHE A:241 A:241 0.0 0.0 H -59.8 -29.8