Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr14 55895574 . A C CCDS9724.1:NM_199047.2:c.907Ttt>Gtt_NP_950248.1:p.303F>V Homo sapiens TATA-box binding protein like 2 (TBPL2), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
5fur 1 P20226 85.12 2e-126 EM
 2016-04-06 PHE A:266 A:266 8.0 0.038 S -156.3 150.9 8.0 0.038 0.0 DA
 9.380
 O
 OP1
5iy6 16 P20226 85.12 2e-126 EM
 2016-05-18 PHE P:266 P:266 17.0 0.081 S -148.3 144.5 17.0 0.081 0.0 DA
 9.304
 O
 OP1
5iy7 16 P20226 85.12 2e-126 EM
 2016-05-18 PHE P:266 P:266 7.0 0.033 S -146.4 147.5 7.0 0.033 0.0 DA
 9.611
 O
 OP1
5iy8 16 P20226 85.12 2e-126 EM
 2016-05-18 PHE P:266 P:266 9.0 0.043 S -158.7 146.4 9.0 0.043 0.0
5iy9 16 P20226 85.12 2e-126 EM
 2016-05-18 PHE P:266 P:266 6.0 0.029 S -150.6 151.7 6.0 0.029 0.0
5iya 16 P20226 85.12 2e-126 EM
 2016-05-18 PHE P:266 P:266 18.0 0.086 S -148.2 144.5 18.0 0.086 0.0 DA
 9.647
 O
 OP1
5iyb 16 P20226 85.12 2e-126 EM
 2016-05-18 PHE P:266 P:266 8.0 0.038 S -146.4 147.5 8.0 0.038 0.0 DA
 9.612
 O
 OP1
5iyc 16 P20226 85.12 2e-126 EM
 2016-05-18 PHE P:266 P:266 8.0 0.038 S -158.7 146.4 8.0 0.038 0.0
5iyd 16 P20226 85.12 2e-126 EM
 2016-05-18 PHE P:266 P:266 6.0 0.029 S -150.6 151.7 6.0 0.029 0.0
6mzd 11 P20226 85.12 2e-126 EM
 2018-11-28 PHE K:266 T:266 14.0 0.067 S -154.6 146.6 14.0 0.067 0.0
6mzl 15 P20226 85.12 2e-126 EM
 2018-11-28 PHE T:266 T:266 14.0 0.067 S -154.6 146.6 14.0 0.067 0.0
6mzm 12 P20226 85.12 2e-126 EM
 2018-11-28 PHE L:266 T:266 16.0 0.076 S -154.8 152.8 16.0 0.076 0.0 DA
 9.163
 O
 OP1
6o9l 16 P20226 85.12 2e-126 EM
 2019-05-29 PHE P:266 P:266 21.0 0.1 S -157.5 139.0 21.0 0.1 0.0
7edx 12 P20226 85.12 2e-126 EM
 2021-05-05 PHE L:266 P:266 6.0 0.029 S -132.7 149.3 6.0 0.029 0.0
7eg7 12 P20226 85.12 2e-126 EM
 2021-05-05 PHE L:266 P:266 6.0 0.029 S -132.6 149.4 6.0 0.029 0.0
7eg8 12 P20226 85.12 2e-126 EM
 2021-05-05 PHE L:266 P:266 8.0 0.038 S -132.7 149.3 8.0 0.038 0.0
7eg9 12 P20226 85.12 2e-126 EM
 2021-05-05 PHE L:266 P:266 9.0 0.043 S -132.6 149.3 9.0 0.043 0.0 DT
DA
 8.993
9.492
 O
O
 OP1
OP1
7ega 12 P20226 85.12 2e-126 EM
 2021-05-05 PHE L:266 P:266 6.0 0.029 S -132.7 149.3 6.0 0.029 0.0
7egb 22 P20226 85.12 2e-126 EM
 2021-05-05 PHE V:266 P:266 18.0 0.086 S -151.5 155.9 18.0 0.086 0.0 DA
 9.449
 O
 OP1
7egc 22 P20226 85.12 2e-126 EM
 2021-05-12 PHE V:266 P:266 17.0 0.081 S -139.6 154.1 17.0 0.081 0.0 DA
 9.951
 O
 OP1
7egd 12 P20226 85.12 2e-126 EM
 2021-05-12 PHE L:266 P:266 19.0 0.09 S -151.6 155.9 19.0 0.09 0.0
7ege 11 P20226 85.12 2e-126 EM
 2021-05-12 PHE K:266 P:266 20.0 0.095 S -151.6 156.0 20.0 0.095 0.0
7egf 1 P20226 85.12 2e-126 EM
 2021-05-05 PHE A:266 P:266 21.0 0.1 S -151.6 156.0 21.0 0.1 0.0
7egi 12 P20226 85.12 2e-126 EM
 2021-05-12 PHE L:266 P:266 20.0 0.095 S -151.6 155.9 20.0 0.095 0.0
7egj 12 P20226 85.12 2e-126 EM
 2021-05-12 PHE L:266 P:266 20.0 0.095 S -151.5 155.9 20.0 0.095 0.0
7ena 5 P20226 85.12 2e-126 EM
 2021-05-26 PHE E:266 DP:266 8.0 0.038 S -132.7 149.3 8.0 0.038 0.0 DA
 9.665
 O
 OP1
7enc 49 P20226 85.12 2e-126 EM
 2021-05-26 PHE CB:266 DP:266 16.0 0.076 S -131.7 146.0 16.0 0.076 0.0 DA
 9.729
 O
 OP1
7lbm 20 P20226 85.12 2e-126 EM
 2021-03-24 PHE T:266 P:266 17.0 0.081 S -142.7 143.4 17.0 0.081 0.0 DA
 9.880
 O
 OP1
7nvr 25 P20226 85.12 2e-126 EM
 2021-05-05 PHE Y:266 O:266 17.0 0.081 S -165.3 145.0 17.0 0.081 0.0 DA
 9.489
 O
 OP1
7nvs 15 P20226 85.12 2e-126 EM
 2021-05-05 PHE O:266 O:266 17.0 0.081 S -168.1 148.6 17.0 0.081 0.0 DA
 9.273
 O
 OP1
7nvt 15 P20226 85.12 2e-126 EM
 2021-05-05 PHE O:266 O:266 19.0 0.09 S -166.7 149.0 19.0 0.09 0.0 DA
 9.299
 O
 OP1
7nvu 15 P20226 85.12 2e-126 EM
 2021-05-05 PHE O:266 O:266 20.0 0.095 S -161.1 146.0 20.0 0.095 0.0 DA
 9.541
 O
 OP1
7nvy 23 P20226 85.12 2e-126 EM
 2021-05-05 PHE W:266 O:266 18.0 0.086 S -166.8 148.9 18.0 0.086 0.0 DA
 9.254
 O
 OP1
7nvz 23 P20226 85.12 2e-126 EM
 2021-05-05 PHE W:266 O:266 18.0 0.086 S -167.0 149.4 18.0 0.086 0.0 DA
 9.338
 O
 OP1
7nw0 23 P20226 85.12 2e-126 EM
 2021-05-05 PHE W:266 O:266 19.0 0.09 S -161.6 146.4 19.0 0.09 0.0 DA
 9.497
 O
 OP1
1jfi 5 P20226 92.86 8e-123 X-RAY
 2001-07-11 PHE E:112 C:466 14.0 0.067 S 178.3 134.0 14.0 0.067 0.0 DA
 9.296
 O
 OP1
1tgh 2 P20226 92.86 1e-122 X-RAY
 1996-08-01 PHE C:112 A:262 25.0 0.119 S 165.5 148.6 25.0 0.119 0.0 DA
 8.637
 H
 OP1
1nvp 3 P20226 94.38 1e-122 X-RAY
 2003-10-21 PHE C:108 A:266 7.0 0.033 S -156.2 151.0 7.0 0.033 0.0 DA
HOH
 9.283
4.065
 O
CD2
 OP1
O
1c9b 4 P20226 94.38 2e-122 X-RAY
 2000-01-10 PHE L:109 B:266 12.0 0.057 S -151.5 148.8 12.0 0.057 0.0 DA
HOH
 9.459
9.777
 O
N
 OP1
O
PHE N:109 F:266 15.0 0.071 S -148.4 148.1 NA NA NA
PHE P:109 J:266 12.0 0.057 S -150.3 147.3 NA NA NA
PHE R:109 N:266 20.0 0.095 S -150.1 144.4 NA NA NA
PHE T:109 R:266 16.0 0.076 S -154.0 147.5 NA NA NA
5n9g 2 P20226 94.38 2e-122 X-RAY
 2017-06-14 PHE B:127 B:266 52.0 0.248 S -154.9 148.5 49.0 0.233 0.015 A:Q9HAW0:0.014
 A
HOH
 9.207
3.880
 O
CG
 OP1
O
PHE G:127 G:266 50.0 0.238 S -153.4 149.2 NA NA NA
4roc 2 P20226 94.38 3e-122 X-RAY
 2015-12-30 PHE B:110 B:266 55.0 0.262 S -152.4 145.1 52.0 0.248 0.014 A:Q9HAW0:0.014
 DA
HOH
 9.316
3.883
 O
CD1
 OP1
O
4rod 2 P20226 94.38 3e-122 X-RAY
 2015-12-30 PHE B:110 B:266 56.0 0.267 S -155.7 147.2 52.0 0.248 0.019 A:Q9HAW0:0.019
 DG
HOH
 9.368
3.871
 O
CD1
 OP1
O
4roe 2 P20226 94.38 3e-122 X-RAY
 2015-12-30 PHE B:110 B:266 55.0 0.262 S -143.1 150.3 53.0 0.252 0.01 A:Q9HAW0:0.01
 DG
HOH
 9.272
4.225
 O
CD1
 OP1
O
1cdw 3 P20226 93.82 2e-121 X-RAY
 1996-12-23 PHE C:108 A:262 10.0 0.048 S -155.5 146.2 10.0 0.048 0.0 DA
HOH
 9.252
3.657
 O
CA
 OP1
O
1vtl 3 P28147 80.9 2e-104 X-RAY
 2011-07-13 PHE E:114 E:126 28.0 0.133 S -142.4 146.6 28.0 0.133 0.0 DA
 9.263
 O
 OP1
PHE F:114 F:126 20.0 0.095 S -143.8 148.0 NA NA NA
1vto 3 P28147 80.9 3e-104 X-RAY
 2011-07-13 PHE E:116 A:126 32.0 0.152 S -154.4 147.8 32.0 0.152 0.0 DA
HOH
 9.088
2.890
 O
CE2
 OP1
H2
PHE F:116 B:1126 23.0 0.11 S -157.7 147.7 NA NA NA
1qn3 1 P28147 80.9 3e-104 X-RAY
 2000-02-06 PHE A:126 A:126 30.0 0.143 S -156.3 143.5 30.0 0.143 0.0 DA
HOH
 9.142
3.280
 O
CE2
 OP1
O
PHE B:126 B:126 22.0 0.105 S -171.0 143.1 NA NA NA
1qn4 1 P28147 80.9 3e-104 X-RAY
 2000-02-06 PHE A:126 A:126 31.0 0.148 S -152.6 147.8 31.0 0.148 0.0 DA
HOH
 9.026
3.291
 O
CE2
 OP1
O
PHE B:126 B:126 17.0 0.081 S -156.0 145.9 NA NA NA
1qn5 1 P28147 80.9 3e-104 X-RAY
 2000-02-07 PHE A:126 A:126 31.0 0.148 S -155.4 141.9 31.0 0.148 0.0 DA
HOH
 9.158
3.197
 O
CE2
 OP1
O
PHE B:126 B:126 22.0 0.105 S -159.1 145.3 NA NA NA
1qn6 1 P28147 80.9 3e-104 X-RAY
 2000-02-07 PHE A:126 A:126 8.0 0.038 S -148.4 144.7 8.0 0.038 0.0 DA
HOH
 9.162
3.342
 O
CE2
 OP1
O
PHE B:126 B:126 24.0 0.114 S -170.0 145.0 NA NA NA
1qn7 1 P28147 80.9 3e-104 X-RAY
 2000-02-07 PHE A:126 A:126 28.0 0.133 S -154.5 142.5 28.0 0.133 0.0 DA
HOH
 9.175
3.145
 O
CE2
 OP1
O
PHE B:126 B:126 23.0 0.11 S -165.7 141.7 NA NA NA
1qn8 1 P28147 80.9 3e-104 X-RAY
 2000-02-07 PHE A:126 A:126 29.0 0.138 S -154.0 145.9 29.0 0.138 0.0 DA
HOH
 9.092
3.322
 O
CE2
 OP1
O
PHE B:126 B:126 26.0 0.124 S -157.7 146.9 NA NA NA
1qn9 1 P28147 80.9 3e-104 X-RAY
 2000-02-07 PHE A:126 A:126 27.0 0.129 S -157.9 148.1 27.0 0.129 0.0 DA
HOH
 9.205
2.978
 O
CE2
 OP1
O
PHE B:126 B:126 25.0 0.119 S -153.4 139.9 NA NA NA
1qna 1 P28147 80.9 3e-104 X-RAY
 2000-02-07 PHE A:126 A:126 29.0 0.138 S -156.7 142.1 29.0 0.138 0.0 DA
HOH
 9.088
3.327
 O
CE2
 OP1
O
PHE B:126 B:126 22.0 0.105 S -159.6 144.4 NA NA NA
1qnb 1 P28147 80.9 3e-104 X-RAY
 2000-02-07 PHE A:126 A:126 30.0 0.143 S -149.7 150.3 30.0 0.143 0.0 DA
HOH
 9.121
3.139
 O
CE2
 OP1
O
PHE B:126 B:126 23.0 0.11 S -168.8 144.6 NA NA NA
1qnc 1 P28147 80.9 3e-104 X-RAY
 2000-02-07 PHE A:126 A:126 30.0 0.143 S -155.5 145.9 30.0 0.143 0.0 DT
HOH
 9.191
3.125
 O
CE2
 OP1
O
PHE B:126 B:126 21.0 0.1 S -162.8 145.5 NA NA NA
1qne 1 P28147 80.9 3e-104 X-RAY
 2000-02-07 PHE A:126 A:126 30.0 0.143 S -157.2 145.7 30.0 0.143 0.0 DA
HOH
 9.159
3.170
 O
CE2
 OP1
O
PHE B:126 B:126 23.0 0.11 S -159.2 148.2 NA NA NA
1vok 1 P28147 80.9 3e-104 X-RAY
 1996-11-08 PHE A:126 A:126 21.0 0.1 S -157.3 145.0 21.0 0.1 0.0 HOH
 3.584
 CB
 O
PHE B:126 B:126 8.0 0.038 S -143.1 139.6 NA NA NA
1vol 4 P28147 80.9 3e-104 X-RAY
 1996-11-08 PHE D:126 B:126 13.0 0.062 S -139.4 146.1 13.0 0.062 0.0 DA
 9.104
 O
 OP1
6ueo 1 P28147 80.9 8e-104 X-RAY
 2020-09-02 PHE A:145 A:126 33.0 0.157 S -159.4 152.9 33.0 0.157 0.0 DA
HOH
 9.223
3.383
 O
C
 OP1
O
PHE D:145 D:126 23.0 0.11 S -153.1 153.0 NA NA NA
PHE G:145 G:126 27.0 0.129 S -151.8 152.8 NA NA NA
PHE J:145 J:126 30.0 0.143 S -157.2 152.8 NA NA NA
6uep 1 P28147 80.9 8e-104 X-RAY
 2020-09-02 PHE A:145 B:126 4.0 0.019 S -155.7 150.8 4.0 0.019 0.0 DA
HOH
 9.075
3.487
 O
CE2
 OP1
O
PHE D:145 A:126 9.0 0.043 S -147.1 154.9 NA NA NA
6ueq 1 P28147 80.9 8e-104 X-RAY
 2020-09-02 PHE A:145 B:126 11.0 0.052 S -152.5 151.4 11.0 0.052 0.0 DA
HOH
 9.359
3.925
 O
CB
 OP1
O
6uer 1 P28147 80.9 8e-104 X-RAY
 2020-09-02 PHE A:145 A:126 9.0 0.043 S -106.7 140.4 9.0 0.043 0.0 DA
 9.529
 O
 OP1
PHE D:145 B:126 10.0 0.048 S -106.7 152.9 NA NA NA
6njq 1 P28147 80.9 8e-104 X-RAY
 2019-10-30 PHE A:146 B:126 26.0 0.124 S -168.8 151.9 26.0 0.124 0.0 DA
 9.052
 O
 OP1
PHE D:146 A:126 21.0 0.1 S -149.9 154.3 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q6sj96-f1 1 Q6SJ96 100.0 0.0 PHE A:303 A:303 21.0 0.1 S -147.3 147.9
af-p20226-f1 1 P20226 85.12 8e-127 PHE A:266 A:266 20.0 0.095 S -144.6 148.0