Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr14 65521295 . C A CCDS9769.1:NM_002028.3:c.1070tCg>tAg_NP_002019.1:p.357S>* Homo sapiens farnesyltransferase, CAAX box, beta (FNTB), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1jcq 2 P49356 100.0 0.0 X-RAY
 2001-11-02 SER B:357 B:357 103.0 0.896 -80.6 146.9 103.0 0.896 0.0 ZN
739
HOH
 8.837
9.150
3.051
 O
O
O
 ZN
SCC
O
1ld7 2 P49356 100.0 0.0 X-RAY
 2002-06-19 SER B:357 B:857 102.0 0.887 -84.7 150.3 102.0 0.887 0.0 ZN
U66
HOH
 8.633
8.796
2.611
 O
O
O
 ZN
C29
O
1ld8 2 P49356 100.0 0.0 X-RAY
 2002-06-19 SER B:357 B:857 96.0 0.835 -93.3 153.1 96.0 0.835 0.0 ZN
U49
HOH
 8.790
8.976
2.759
 O
O
O
 ZN
C31
O
1mzc 2 P49356 100.0 0.0 X-RAY
 2003-07-08 SER B:357 B:857 98.0 0.852 -91.8 153.2 98.0 0.852 0.0 ZN
BNE
HOH
 8.828
9.144
2.679
 O
O
N
 ZN
C32
O
1s63 2 P49356 100.0 0.0 X-RAY
 2004-07-27 SER B:357 B:357 95.0 0.826 -97.7 152.6 95.0 0.826 0.0 ZN
778
HOH
 8.805
8.856
2.732
 O
O
O
 ZN
C12
O
1sa4 2 P49356 100.0 0.0 X-RAY
 2004-06-08 SER B:357 B:357 98.0 0.852 -92.4 152.9 98.0 0.852 0.0 ZN
JAN
HOH
 9.017
6.177
2.726
 O
O
O
 ZN
C18
O
1tn6 2 P49356 100.0 0.0 X-RAY
 2004-11-02 SER B:357 B:857 98.0 0.852 -90.2 153.9 50.0 0.435 0.417 C:None:0.417
 ZN
ACY
HOH
 8.905
8.937
2.719
 O
OG
O
 ZN
CH3
O
2f0y 2 P49356 100.0 0.0 X-RAY
 2006-11-14 SER B:357 B:357 104.0 0.904 -83.4 136.6 104.0 0.904 0.0 ZN
3MN
HOH
 9.365
6.650
2.715
 O
O
N
 ZN
C23
O
2h6f 2 P49356 100.0 0.0 X-RAY
 2006-08-29 SER B:357 B:857 96.0 0.835 -91.0 153.2 96.0 0.835 0.0 ZN
ACY
ACY
HOH
 8.666
5.144
8.910
2.770
 O
OG
OG
O
 ZN
CH3
CH3
O
2iej 2 P49356 100.0 0.0 X-RAY
 2007-01-23 SER B:357 B:857 102.0 0.887 -84.2 144.6 102.0 0.887 0.0 ZN
S48
HOH
 8.786
7.160
2.743
 O
O
O
 ZN
CAK
O
3e37 2 P49356 100.0 0.0 X-RAY
 2009-03-10 SER B:357 B:359 100.0 0.87 -96.1 151.8 100.0 0.87 0.0 ED5
ZN
HOH
 7.454
8.815
2.720
 O
O
O
 CAO
ZN
O
2h6h 2 P49356 99.77 0.0 X-RAY
 2006-08-29 SER B:357 B:857 99.0 0.861 -84.6 154.9 37.0 0.322 0.539 C:None:0.539
 ZN
HOH
 8.899
2.723
 O
O
 ZN
O
2h6g 2 P49356 99.77 0.0 X-RAY
 2006-08-29 SER B:357 B:857 97.0 0.843 -95.7 154.5 97.0 0.843 0.0 ZN
HOH
 8.705
2.739
 O
O
 ZN
O
2h6i 2 P49356 99.54 0.0 X-RAY
 2006-08-29 SER B:357 B:857 99.0 0.861 -98.5 154.5 99.0 0.861 0.0 ZN
 8.831
 O
 ZN
1o1r 2 Q02293 98.12 0.0 X-RAY
 2003-05-06 SER B:357 B:357 100.0 0.87 -92.0 150.1 100.0 0.87 0.0 ZN
HOH
 8.729
2.545
 O
O
 ZN
O
1o1s 2 Q02293 98.12 0.0 X-RAY
 2003-05-06 SER B:357 B:357 103.0 0.896 -90.8 146.0 103.0 0.896 0.0 ZN
HOH
 8.704
2.681
 O
O
 ZN
O
1o1t 2 Q02293 98.12 0.0 X-RAY
 2003-05-06 SER B:357 B:357 101.0 0.878 -93.9 150.1 101.0 0.878 0.0 ZN
2NH
HOH
 8.555
7.616
2.570
 O
O
O
 ZN
CA
O
3eu5 2 Q02293 98.12 0.0 X-RAY
 2009-07-07 SER B:357 B:357 94.0 0.817 -100.1 144.1 94.0 0.817 0.0 ZN
HOH
 8.941
2.706
 O
O
 ZN
O
4gtm 2 Q02293 98.12 0.0 X-RAY
 2012-10-24 SER B:357 B:357 100.0 0.87 -90.2 143.7 100.0 0.87 0.0 ZN
7TM
DMS
HOH
 8.628
7.083
5.453
2.778
 O
O
CB
O
 ZN
CAI
C1
O
4gto 2 Q02293 98.12 0.0 X-RAY
 2012-10-24 SER B:357 B:357 101.0 0.878 -93.0 151.3 101.0 0.878 0.0 ZN
7TO
DMS
HOH
 8.936
7.897
5.910
2.657
 O
O
OG
OG
 ZN
CAL
C2
O
4gtp 2 Q02293 98.12 0.0 X-RAY
 2012-10-24 SER B:357 B:357 94.0 0.817 -99.7 144.4 94.0 0.817 0.0 ZN
7TP
HOH
 8.678
7.025
2.720
 O
O
N
 ZN
CAO
O
4gtq 2 Q02293 98.12 0.0 X-RAY
 2012-10-24 SER B:357 B:357 95.0 0.826 -113.3 151.3 95.0 0.826 0.0 ZN
7TQ
HOH
 8.837
7.050
2.867
 O
O
O
 ZN
CAM
O
4gtr 2 Q02293 98.12 0.0 X-RAY
 2012-10-24 SER B:357 B:357 96.0 0.835 -97.0 151.6 96.0 0.835 0.0 ZN
7TR
DMS
HOH
 8.774
6.607
4.668
2.755
 O
OG
OG
O
 ZN
CAC
C1
O
3pz4 2 Q02293 98.11 0.0 X-RAY
 2011-05-11 SER B:356 B:357 100.0 0.87 -92.0 146.5 100.0 0.87 0.0 ZN
3PZ
HOH
 8.964
7.229
2.607
 O
O
O
 ZN
C28
O
1d8d 2 Q02293 96.57 0.0 X-RAY
 2000-02-09 SER B:357 B:357 95.0 0.826 -99.3 155.4 66.0 0.574 0.252 C:P01116:0.252
 ACT
ACT
ACT
ACT
ZN
HOH
 7.304
8.494
9.551
5.304
8.754
2.809
 OG
O
OG
OG
O
O
 CH3
O
O
OXT
ZN
O
1d8e 2 Q02293 96.57 0.0 X-RAY
 2000-03-20 SER B:357 B:357 100.0 0.87 -87.8 151.5 87.0 0.757 0.113 C:P01116:0.113
 ACT
HOH
 9.908
6.180
 OG
C
 O
O
1fpp 1 Q02293 96.57 0.0 X-RAY
 1999-06-08 SER A:357 B:357 102.0 0.887 -79.5 152.5 102.0 0.887 0.0 ZN
FPP
HOH
 8.776
8.578
9.771
 O
O
O
 ZN
O2A
O
1ft1 2 Q02293 96.57 0.0 X-RAY
 1998-03-18 SER B:357 B:357 50.0 0.435 60.9 78.0 50.0 0.435 0.0 ZN
HOH
 6.242
2.601
 CB
OG
 ZN
O
1jcr 2 Q02293 96.57 0.0 X-RAY
 2001-11-02 SER B:357 B:357 100.0 0.87 -89.1 151.0 100.0 0.87 0.0 ZN
ACY
HOH
 8.884
9.490
2.783
 O
CB
O
 ZN
O
O
1jcs 2 Q02293 96.57 0.0 X-RAY
 2001-11-02 SER B:357 B:357 101.0 0.878 -85.4 148.2 82.0 0.713 0.165 C:None:0.165
 ZN
ACY
ACY
HOH
 8.792
9.332
4.833
2.711
 O
CB
CB
O
 ZN
O
CH3
O
1kzo 2 Q02293 96.57 0.0 X-RAY
 2002-10-16 SER B:357 B:357 102.0 0.887 -86.3 148.3 102.0 0.887 0.0 ZN
FAR
ACY
HOH
 8.775
3.327
9.044
2.865
 O
OG
OG
N
 ZN
C14
O
O
1kzp 2 Q02293 96.57 0.0 X-RAY
 2002-10-16 SER B:357 B:357 100.0 0.87 -93.2 152.5 100.0 0.87 0.0 ZN
ACY
ACY
HOH
 8.678
9.590
5.542
2.611
 O
CB
CB
O
 ZN
O
CH3
O
1o5m 2 Q02293 96.57 0.0 X-RAY
 2003-10-21 SER B:357 B:357 103.0 0.896 -86.5 149.2 103.0 0.896 0.0 ZN
336
HOH
 8.635
3.817
2.530
 O
CB
O
 ZN
N56
O
1qbq 2 Q02293 96.57 0.0 X-RAY
 1999-06-18 SER B:357 B:357 102.0 0.887 -84.7 161.6 102.0 0.887 0.0 ZN
HOH
 8.471
2.687
 O
O
 ZN
O
1sa5 2 Q02293 96.57 0.0 X-RAY
 2004-06-08 SER B:357 B:357 101.0 0.878 -87.5 151.3 101.0 0.878 0.0 ZN
BMV
ACY
HOH
 8.875
7.570
9.034
2.761
 O
O
OG
O
 ZN
CAM
O
O
1tn7 2 Q02293 96.57 0.0 X-RAY
 2004-11-02 SER B:357 B:857 98.0 0.852 -94.5 153.8 88.0 0.765 0.087 C:None:0.087
 ZN
ACY
HOH
 8.764
9.536
2.883
 O
OG
O
 ZN
O
O
1tn8 2 Q02293 96.57 0.0 X-RAY
 2004-11-02 SER B:357 B:857 102.0 0.887 -92.2 150.6 102.0 0.887 0.0 ZN
ACY
HOH
 8.850
9.364
2.794
 O
CB
O
 ZN
O
O
3dpy 2 Q02293 96.57 0.0 X-RAY
 2008-09-30 SER B:357 B:357 99.0 0.861 -100.0 147.6 99.0 0.861 0.0 ZN
ACY
HOH
 8.974
9.190
5.820
 O
OG
C
 ZN
O
O
3e30 2 Q02293 96.57 0.0 X-RAY
 2009-03-10 SER B:357 B:357 98.0 0.852 -99.8 157.3 98.0 0.852 0.0 ZN
ED4
HOH
 8.962
7.222
2.784
 O
O
O
 ZN
CAK
O
3e32 2 Q02293 96.57 0.0 X-RAY
 2009-03-10 SER B:357 B:357 97.0 0.843 -96.5 151.4 97.0 0.843 0.0 ZN
ED2
HOH
 8.950
7.449
3.054
 O
O
O
 ZN
CAM
O
3e33 2 Q02293 96.57 0.0 X-RAY
 2009-03-10 SER B:357 B:357 96.0 0.835 -91.9 155.1 96.0 0.835 0.0 ZN
ED7
HOH
 8.805
7.144
2.667
 O
O
O
 ZN
CAO
O
3e34 2 Q02293 96.57 0.0 X-RAY
 2009-03-10 SER B:357 B:357 96.0 0.835 -93.1 155.3 96.0 0.835 0.0 ZN
ED1
HOH
 8.750
7.104
2.784
 O
O
O
 ZN
CAR
O
3ksl 2 Q02293 96.57 0.0 X-RAY
 2009-12-22 SER B:357 B:357 100.0 0.87 -90.1 152.6 100.0 0.87 0.0 ZN
HOH
 8.886
2.763
 O
O
 ZN
O
3ksq 2 Q02293 96.57 0.0 X-RAY
 2010-01-26 SER B:357 B:357 105.0 0.913 -88.3 144.7 105.0 0.913 0.0 ZN
Z96
HOH
 8.861
5.855
2.664
 O
O
O
 ZN
C22
O
7rn5 2 Q02293 96.57 0.0 X-RAY
 2021-09-08 SER B:357 B:357 105.0 0.913 -85.7 149.1 105.0 0.913 0.0 60I
ZN
HOH
 8.843
8.841
2.668
 HB2
O
O
 H6
ZN
O
7rni 2 Q02293 96.57 0.0 X-RAY
 2021-09-08 SER B:357 B:357 103.0 0.896 -90.3 148.1 103.0 0.896 0.0 60I
ZN
HOH
 8.776
8.803
2.604
 HB2
O
O
 H6
ZN
O
2zir 2 Q02293 96.57 0.0 X-RAY
 2009-02-24 SER B:360 B:357 104.0 0.904 -86.4 149.9 104.0 0.904 0.0 ZN
NH7
HOH
 8.852
5.367
2.785
 O
CB
O
 ZN
C48
O
2zis 2 Q02293 96.57 0.0 X-RAY
 2009-02-24 SER B:360 B:357 101.0 0.878 -88.7 150.4 101.0 0.878 0.0 ZN
NH8
ACY
HOH
 8.649
7.077
9.570
2.770
 O
O
CB
O
 ZN
O42
O
O
3euv 2 Q02293 97.65 0.0 X-RAY
 2009-07-07 SER B:357 B:357 96.0 0.835 -111.5 146.7 96.0 0.835 0.0 ZN
HOH
 9.262
2.698
 O
N
 ZN
O
1n95 2 Q02293 98.26 0.0 X-RAY
 2003-01-07 SER B:336 B:357 102.0 0.887 -88.0 159.9 102.0 0.887 0.0 ZN
FTH
 8.357
7.331
 O
O
 ZN
C3
1n9a 2 Q02293 98.26 0.0 X-RAY
 2003-01-07 SER B:336 B:357 101.0 0.878 -88.6 160.0 101.0 0.878 0.0 ZN
FTI
 8.556
7.587
 O
O
 ZN
C1
1ni1 2 Q02293 98.26 0.0 X-RAY
 2004-04-06 SER B:336 B:357 95.0 0.826 -110.6 163.9 95.0 0.826 0.0 ZN
2C5
 8.816
6.528
 O
O
 ZN
CL2
1nl4 2 Q02293 98.25 0.0 X-RAY
 2003-02-11 SER B:335 B:357 103.0 0.896 -74.1 164.0 103.0 0.896 0.0 ZN
FTL
 8.581
8.176
 O
O
 ZN
C13
2bed 2 Q02293 98.25 0.0 X-RAY
 2006-08-08 SER B:335 B:357 101.0 0.878 -86.5 166.1 101.0 0.878 0.0 ZN
736
HOH
 8.653
6.870
6.826
 O
O
C
 ZN
O2
O
2r2l 2 Q02293 98.25 0.0 X-RAY
 2008-03-11 SER B:335 B:357 102.0 0.887 -85.9 149.4 102.0 0.887 0.0 ZN
PB9
HOH
 8.779
7.191
2.786
 O
O
O
 ZN
C1
O
1ft2 2 Q02293 98.25 0.0 X-RAY
 1998-11-04 SER B:336 B:357 105.0 0.913 -85.2 154.7 105.0 0.913 0.0 ZN
 8.750
 O
 ZN
1n94 2 Q02293 98.24 0.0 X-RAY
 2003-01-07 SER B:336 B:357 102.0 0.887 -33.7 108.0 102.0 0.887 0.0 TIN
ZN
 7.000
9.326
 O
O
 C6
ZN
1x81 2 Q02293 98.24 0.0 X-RAY
 2004-12-21 SER B:336 B:357 91.0 0.791 79.4 130.1 91.0 0.791 0.0 ZN
JAN
 8.683
6.234
 O
O
 ZN
C18

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p49356-f1 1 P49356 100.0 0.0 SER A:357 A:357 102.0 0.887 -72.0 153.3