Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr14 90432500 . C A CCDS9888.1:NM_001008744.1:c.569tCt>tAt_NP_001008744.1:p.190S>Y Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1qzq 1 Q9NUW8 100.0 0.0 X-RAY
 2004-05-11 SER A:65 A:190 20.0 0.174 S -66.8 149.6 20.0 0.174 0.0 HOH
 3.280
 O
 O
SER B:65 B:190 22.0 0.191 -54.2 151.3 22.0 0.191 0.0
6dhu 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 SER A:43 A:190 20.0 0.174 S -66.4 152.0 20.0 0.174 0.0 HOH
 3.104
 O
 O
SER B:43 B:190 22.0 0.191 S -63.6 154.5 NA NA NA
6die 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 SER A:43 A:190 20.0 0.174 S -64.5 154.1 20.0 0.174 0.0 HOH
 2.956
 OG
 O
SER B:43 B:190 21.0 0.183 S -65.3 153.3 NA NA NA
6dih 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 SER A:43 A:190 20.0 0.174 S -72.6 156.7 20.0 0.174 0.0 HOH
 2.902
 OG
 O
SER B:43 B:190 20.0 0.174 S -63.9 153.5 NA NA NA
6dim 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 SER A:43 A:190 22.0 0.191 S -62.9 153.1 22.0 0.191 0.0 HOH
 3.042
 O
 O
SER B:43 B:190 20.0 0.174 S -54.8 150.8 NA NA NA
6djd 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 SER A:43 A:190 19.0 0.165 S -65.9 151.6 19.0 0.165 0.0 HOH
 3.055
 O
 O
SER B:43 B:190 22.0 0.191 S -65.8 152.6 NA NA NA
6dje 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 SER A:43 A:190 19.0 0.165 S -71.5 154.5 19.0 0.165 0.0 HOH
 3.124
 O
 O
SER B:43 B:190 22.0 0.191 S -65.0 154.7 NA NA NA
6djf 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 SER A:43 A:190 21.0 0.183 S -67.6 153.2 21.0 0.183 0.0 HOH
 2.986
 O
 O
SER B:43 B:190 22.0 0.191 S -65.6 154.6 NA NA NA
6djg 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 SER A:43 A:190 19.0 0.165 S -62.7 152.0 19.0 0.165 0.0 HOH
 3.063
 O
 O
SER B:43 B:190 21.0 0.183 S -61.2 153.0 NA NA NA
6djh 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 SER A:43 A:190 18.0 0.157 S -61.5 153.6 18.0 0.157 0.0 HOH
 3.023
 O
 O
SER B:43 B:190 23.0 0.2 S -67.7 154.2 NA NA NA
6dji 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 SER A:43 A:190 18.0 0.157 S -65.2 151.2 18.0 0.157 0.0 HOH
 3.017
 O
 O
SER B:43 B:190 21.0 0.183 S -62.5 151.2 NA NA NA
6djj 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 SER A:43 A:190 21.0 0.183 S -63.3 156.9 21.0 0.183 0.0 HOH
 2.891
 O
 O
SER B:43 B:190 21.0 0.183 S -65.2 153.7 NA NA NA
6myz 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-06 SER A:43 A:190 23.0 0.2 S -64.5 153.1 23.0 0.2 0.0 HOH
 3.048
 O
 O
SER B:43 B:190 22.0 0.191 S -58.4 154.7 NA NA NA
6mz0 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-06 SER A:43 A:190 20.0 0.174 S -52.1 150.3 20.0 0.174 0.0 HOH
 2.913
 O
 O
SER B:43 B:190 22.0 0.191 S -59.7 151.9 NA NA NA
6n0d 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 SER A:43 A:190 20.0 0.174 S -64.4 154.2 20.0 0.174 0.0 HOH
 2.801
 OG
 O
SER B:43 B:190 20.0 0.174 S -62.0 154.0 NA NA NA
6n0n 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 SER A:43 A:190 22.0 0.191 S -61.6 152.4 22.0 0.191 0.0 HOH
 2.680
 OG
 O
SER B:43 B:190 21.0 0.183 S -64.2 153.5 NA NA NA
6n0o 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 SER A:43 A:190 19.0 0.165 S -59.4 150.9 19.0 0.165 0.0 HOH
 3.098
 O
 O
SER B:43 B:190 21.0 0.183 S -61.3 152.5 NA NA NA
6n0r 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 SER A:43 A:190 18.0 0.157 S -62.1 152.2 18.0 0.157 0.0 HOH
 2.970
 O
 O
SER B:43 B:190 21.0 0.183 S -61.8 153.2 NA NA NA
6n17 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 SER A:43 A:190 21.0 0.183 S -66.1 152.3 21.0 0.183 0.0 HOH
 3.072
 O
 O
SER B:43 B:190 20.0 0.174 S -63.2 151.5 NA NA NA
6n19 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 SER A:43 A:190 19.0 0.165 S -59.5 153.7 19.0 0.165 0.0 HOH
 2.838
 OG
 O
SER B:43 B:190 18.0 0.157 S -64.0 154.1 NA NA NA
6w4r 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-17 SER A:43 A:190 23.0 0.2 S -65.2 154.3 23.0 0.2 0.0 HOH
 3.050
 O
 O
SER B:43 B:190 25.0 0.217 S -60.4 153.1 NA NA NA
6w7j 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 SER A:43 A:190 21.0 0.183 S -63.2 153.2 21.0 0.183 0.0 HOH
 3.013
 O
 O
SER B:43 B:190 22.0 0.191 S -64.9 154.3 NA NA NA
6w7k 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 SER A:43 A:190 21.0 0.183 S -67.5 156.3 21.0 0.183 0.0 HOH
 2.968
 O
 O
SER B:43 B:190 19.0 0.165 S -64.0 151.8 NA NA NA
6w7l 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 SER A:43 A:190 22.0 0.191 S -68.3 155.0 22.0 0.191 0.0 HOH
 2.959
 O
 O
SER B:43 B:190 22.0 0.191 S -65.2 153.3 NA NA NA
6mj5 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 SER A:42 A:190 22.0 0.191 S -64.6 155.4 22.0 0.191 0.0 HOH
 2.974
 O
 O
SER B:42 B:190 25.0 0.217 S -67.6 152.4 NA NA NA
1jy1 1 Q9NUW8 98.92 0.0 X-RAY
 2002-02-20 SER A:46 A:190 18.0 0.157 S -63.3 151.9 18.0 0.157 0.0 HOH
 2.884
 O
 O
1mu7 1 20127586 98.92 0.0 X-RAY
 2003-01-07 SER A:67 A:190 21.0 0.183 S -66.0 152.5 21.0 0.183 0.0
SER B:67 B:190 23.0 0.2 S -64.6 146.1 NA NA NA
1mu9 1 20127586 98.92 0.0 X-RAY
 2003-01-07 SER A:67 A:190 20.0 0.174 -64.2 151.4 20.0 0.174 0.0 HOH
 4.298
 CA
 O
SER B:67 B:190 24.0 0.209 S -69.2 150.9 NA NA NA
1nop 2 20127586 98.92 0.0 X-RAY
 2003-03-11 SER C:67 A:190 23.0 0.2 S -59.7 151.0 23.0 0.2 0.0
SER D:67 B:190 25.0 0.217 S -64.3 148.9 NA NA NA
1rff 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 SER C:67 A:190 26.0 0.226 S -67.8 155.7 26.0 0.226 0.0 HOH
 3.154
 O
 O
SER D:67 B:190 23.0 0.2 S -70.5 152.1 NA NA NA
1rfi 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 SER C:67 A:190 23.0 0.2 S -63.1 155.0 23.0 0.2 0.0 HOH
 2.874
 O
 O
SER D:67 B:190 25.0 0.217 S -67.4 157.5 NA NA NA
1rg1 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 SER C:67 A:190 22.0 0.191 S -66.1 159.3 22.0 0.191 0.0 HOH
 5.617
 O
 O
SER D:67 B:190 23.0 0.2 S -63.8 149.0 NA NA NA
1rg2 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 SER C:67 A:190 24.0 0.209 S -66.7 150.9 24.0 0.209 0.0 HOH
 3.118
 O
 O
SER D:67 B:190 24.0 0.209 S -65.4 149.9 NA NA NA
1rgt 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 SER C:67 A:190 22.0 0.191 S -64.0 156.1 22.0 0.191 0.0 HOH
 2.957
 O
 O
SER D:67 B:190 24.0 0.209 S -71.6 149.7 NA NA NA
1rgu 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 SER C:67 A:190 23.0 0.2 S -61.7 154.8 23.0 0.2 0.0 HOH
 2.848
 O
 O
SER D:67 B:190 25.0 0.217 S -67.3 153.6 NA NA NA
1rh0 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 SER C:67 A:190 25.0 0.217 S -67.0 154.5 25.0 0.217 0.0 HOH
 2.890
 O
 O
SER D:67 B:190 24.0 0.209 S -67.8 157.1 NA NA NA
5nw9 1 Q9NUW8 98.92 0.0 X-RAY
 2018-01-10 SER A:67 A:190 19.0 0.165 S -53.3 145.2 19.0 0.165 0.0 HOH
 3.038
 O
 O
SER B:67 B:190 22.0 0.191 -48.2 153.0 NA NA NA
5nwa 1 Q9NUW8 98.92 0.0 X-RAY
 2018-01-10 SER A:67 A:190 21.0 0.183 -51.6 151.8 21.0 0.183 0.0
SER C:67 B:190 18.0 0.157 S -66.1 158.5 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q9nuw8-f1 1 Q9NUW8 100.0 0.0 SER A:190 A:190 25.0 0.217 -66.6 142.3