Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr14 | 90433729 | . | G | A | CCDS9888.1:NM_001008744.1:c.622Gtg>Atg_NP_001008744.1:p.208V>M | Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 1qzq | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2004-05-11 | VAL | A:83 | A:208 | 1.0 | 0.006 | H | -58.9 | -45.8 | 1.0 | 0.006 | 0.0 |
HOH |
3.365 |
N |
O |
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| VAL | B:83 | B:208 | 0.0 | 0.0 | H | -54.1 | -44.8 | 0.0 | 0.0 | 0.0 |
HOH |
3.349 |
N |
O |
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| 6dhu | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | VAL | A:61 | A:208 | 0.0 | 0.0 | H | -68.4 | -42.1 | 0.0 | 0.0 | 0.0 |
HOH |
3.429 |
N |
O |
||
| VAL | B:61 | B:208 | 0.0 | 0.0 | H | -68.2 | -40.1 | NA | NA | NA | |||||||||||||
| 6die | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | VAL | A:61 | A:208 | 0.0 | 0.0 | H | -71.8 | -40.7 | 0.0 | 0.0 | 0.0 |
HOH |
3.295 |
N |
O |
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| VAL | B:61 | B:208 | 0.0 | 0.0 | H | -70.6 | -41.3 | NA | NA | NA | |||||||||||||
| 6dih | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | VAL | A:61 | A:208 | 0.0 | 0.0 | H | -68.6 | -39.4 | 0.0 | 0.0 | 0.0 |
HOH |
3.404 |
N |
O |
||
| VAL | B:61 | B:208 | 0.0 | 0.0 | H | -69.6 | -40.7 | NA | NA | NA | |||||||||||||
| 6dim | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | VAL | A:61 | A:208 | 0.0 | 0.0 | H | -69.0 | -39.8 | 0.0 | 0.0 | 0.0 |
HOH |
3.371 |
N |
O |
||
| VAL | B:61 | B:208 | 0.0 | 0.0 | H | -69.1 | -40.4 | NA | NA | NA | |||||||||||||
| 6djd | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | VAL | A:61 | A:208 | 0.0 | 0.0 | H | -68.2 | -41.4 | 0.0 | 0.0 | 0.0 |
HOH |
3.452 |
N |
O |
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| VAL | B:61 | B:208 | 0.0 | 0.0 | H | -66.2 | -39.5 | NA | NA | NA | |||||||||||||
| 6dje | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | VAL | A:61 | A:208 | 0.0 | 0.0 | H | -68.0 | -39.4 | 0.0 | 0.0 | 0.0 |
HOH |
3.337 |
N |
O |
||
| VAL | B:61 | B:208 | 0.0 | 0.0 | H | -69.8 | -40.8 | NA | NA | NA | |||||||||||||
| 6djf | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | VAL | A:61 | A:208 | 0.0 | 0.0 | H | -69.0 | -39.9 | 0.0 | 0.0 | 0.0 |
HOH |
3.398 |
N |
O |
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| VAL | B:61 | B:208 | 0.0 | 0.0 | H | -66.7 | -40.6 | NA | NA | NA | |||||||||||||
| 6djg | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | VAL | A:61 | A:208 | 0.0 | 0.0 | H | -68.0 | -39.9 | 0.0 | 0.0 | 0.0 |
HOH |
3.385 |
N |
O |
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| VAL | B:61 | B:208 | 0.0 | 0.0 | H | -68.7 | -42.0 | NA | NA | NA | |||||||||||||
| 6djh | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | VAL | A:61 | A:208 | 0.0 | 0.0 | H | -70.6 | -40.9 | 0.0 | 0.0 | 0.0 |
HOH |
3.319 |
N |
O |
||
| VAL | B:61 | B:208 | 0.0 | 0.0 | H | -67.8 | -38.6 | NA | NA | NA | |||||||||||||
| 6dji | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | VAL | A:61 | A:208 | 0.0 | 0.0 | H | -68.3 | -39.8 | 0.0 | 0.0 | 0.0 |
HOH |
3.463 |
N |
O |
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| VAL | B:61 | B:208 | 0.0 | 0.0 | H | -68.9 | -40.6 | NA | NA | NA | |||||||||||||
| 6djj | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | VAL | A:61 | A:208 | 0.0 | 0.0 | H | -68.6 | -42.0 | 0.0 | 0.0 | 0.0 |
HOH |
3.429 |
N |
O |
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| VAL | B:61 | B:208 | 0.0 | 0.0 | H | -68.3 | -40.0 | NA | NA | NA | |||||||||||||
| 6myz | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-06 | VAL | A:61 | A:208 | 0.0 | 0.0 | H | -70.3 | -39.6 | 0.0 | 0.0 | 0.0 |
HOH |
3.367 |
N |
O |
||
| VAL | B:61 | B:208 | 0.0 | 0.0 | H | -66.5 | -40.9 | NA | NA | NA | |||||||||||||
| 6mz0 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-06 | VAL | A:61 | A:208 | 0.0 | 0.0 | H | -69.6 | -41.4 | 0.0 | 0.0 | 0.0 |
HOH |
3.433 |
N |
O |
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| VAL | B:61 | B:208 | 0.0 | 0.0 | H | -68.1 | -41.3 | NA | NA | NA | |||||||||||||
| 6n0d | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | VAL | A:61 | A:208 | 0.0 | 0.0 | H | -70.0 | -40.5 | 0.0 | 0.0 | 0.0 |
HOH |
3.401 |
N |
O |
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| VAL | B:61 | B:208 | 0.0 | 0.0 | H | -68.8 | -41.4 | NA | NA | NA | |||||||||||||
| 6n0n | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | VAL | A:61 | A:208 | 0.0 | 0.0 | H | -68.3 | -42.2 | 0.0 | 0.0 | 0.0 |
HOH |
3.465 |
N |
O |
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| VAL | B:61 | B:208 | 0.0 | 0.0 | H | -69.0 | -41.4 | NA | NA | NA | |||||||||||||
| 6n0o | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | VAL | A:61 | A:208 | 0.0 | 0.0 | H | -69.8 | -39.2 | 0.0 | 0.0 | 0.0 |
HOH |
3.473 |
N |
O |
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| VAL | B:61 | B:208 | 0.0 | 0.0 | H | -67.8 | -39.5 | NA | NA | NA | |||||||||||||
| 6n0r | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | VAL | A:61 | A:208 | 0.0 | 0.0 | H | -69.6 | -41.9 | 0.0 | 0.0 | 0.0 |
HOH |
3.454 |
N |
O |
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| VAL | B:61 | B:208 | 0.0 | 0.0 | H | -68.9 | -41.5 | NA | NA | NA | |||||||||||||
| 6n17 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | VAL | A:61 | A:208 | 0.0 | 0.0 | H | -67.6 | -42.1 | 0.0 | 0.0 | 0.0 |
HOH |
3.490 |
N |
O |
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| VAL | B:61 | B:208 | 0.0 | 0.0 | H | -68.2 | -40.2 | NA | NA | NA | |||||||||||||
| 6n19 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | VAL | A:61 | A:208 | 0.0 | 0.0 | H | -68.3 | -41.9 | 0.0 | 0.0 | 0.0 |
HOH |
3.487 |
N |
O |
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| VAL | B:61 | B:208 | 0.0 | 0.0 | H | -69.5 | -41.1 | NA | NA | NA | |||||||||||||
| 6w4r | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-17 | VAL | A:61 | A:208 | 0.0 | 0.0 | H | -66.0 | -41.1 | 0.0 | 0.0 | 0.0 |
HOH |
3.412 |
N |
O |
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| VAL | B:61 | B:208 | 0.0 | 0.0 | H | -64.1 | -42.3 | NA | NA | NA | |||||||||||||
| 6w7j | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | VAL | A:61 | A:208 | 0.0 | 0.0 | H | -68.4 | -41.4 | 0.0 | 0.0 | 0.0 |
HOH |
3.431 |
N |
O |
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| VAL | B:61 | B:208 | 0.0 | 0.0 | H | -67.0 | -41.9 | NA | NA | NA | |||||||||||||
| 6w7k | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | VAL | A:61 | A:208 | 0.0 | 0.0 | H | -68.1 | -41.2 | 0.0 | 0.0 | 0.0 |
HOH |
3.443 |
N |
O |
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| VAL | B:61 | B:208 | 0.0 | 0.0 | H | -69.1 | -40.2 | NA | NA | NA | |||||||||||||
| 6w7l | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | VAL | A:61 | A:208 | 0.0 | 0.0 | H | -67.1 | -42.8 | 0.0 | 0.0 | 0.0 |
HOH |
3.406 |
N |
O |
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| VAL | B:61 | B:208 | 0.0 | 0.0 | H | -59.6 | -41.9 | NA | NA | NA | |||||||||||||
| 6mj5 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | VAL | A:60 | A:208 | 0.0 | 0.0 | H | -70.5 | -41.3 | 0.0 | 0.0 | 0.0 |
HOH |
3.345 |
N |
O |
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| VAL | B:60 | B:208 | 0.0 | 0.0 | H | -66.5 | -42.3 | NA | NA | NA | |||||||||||||
| 1jy1 | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2002-02-20 | VAL | A:64 | A:208 | 0.0 | 0.0 | H | -66.7 | -43.2 | 0.0 | 0.0 | 0.0 |
HOH |
3.488 |
N |
O |
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| 1mu7 | 1 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-01-07 | VAL | A:85 | A:208 | 0.0 | 0.0 | H | -66.6 | -42.8 | 0.0 | 0.0 | 0.0 |
HOH |
3.268 |
N |
O |
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| VAL | B:85 | B:208 | 0.0 | 0.0 | H | -64.1 | -46.4 | NA | NA | NA | |||||||||||||
| 1mu9 | 1 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-01-07 | VAL | A:85 | A:208 | 0.0 | 0.0 | H | -61.2 | -45.5 | 0.0 | 0.0 | 0.0 |
HOH |
3.376 |
N |
O |
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| VAL | B:85 | B:208 | 0.0 | 0.0 | H | -61.5 | -47.2 | NA | NA | NA | |||||||||||||
| 1nop | 2 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-03-11 | VAL | C:85 | A:208 | 0.0 | 0.0 | H | -61.0 | -41.3 | 0.0 | 0.0 | 0.0 | ||||||
| VAL | D:85 | B:208 | 0.0 | 0.0 | H | -66.5 | -52.5 | NA | NA | NA | |||||||||||||
| 1rff | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | VAL | C:85 | A:208 | 0.0 | 0.0 | H | -65.8 | -44.4 | 0.0 | 0.0 | 0.0 |
HOH |
3.354 |
N |
O |
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| VAL | D:85 | B:208 | 0.0 | 0.0 | H | -66.0 | -42.6 | NA | NA | NA | |||||||||||||
| 1rfi | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | VAL | C:85 | A:208 | 0.0 | 0.0 | H | -57.0 | -40.6 | 0.0 | 0.0 | 0.0 |
HOH |
3.339 |
N |
O |
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| VAL | D:85 | B:208 | 0.0 | 0.0 | H | -69.7 | -38.7 | NA | NA | NA | |||||||||||||
| 1rg1 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | VAL | C:85 | A:208 | 0.0 | 0.0 | H | -60.0 | -42.8 | 0.0 | 0.0 | 0.0 |
HOH |
3.316 |
N |
O |
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| VAL | D:85 | B:208 | 0.0 | 0.0 | H | -70.6 | -43.0 | NA | NA | NA | |||||||||||||
| 1rg2 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | VAL | C:85 | A:208 | 0.0 | 0.0 | H | -58.1 | -42.2 | 0.0 | 0.0 | 0.0 |
HOH |
3.524 |
N |
O |
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| VAL | D:85 | B:208 | 0.0 | 0.0 | H | -66.2 | -43.7 | NA | NA | NA | |||||||||||||
| 1rgt | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | VAL | C:85 | A:208 | 0.0 | 0.0 | H | -63.7 | -44.5 | 0.0 | 0.0 | 0.0 |
HOH |
3.236 |
N |
O |
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| VAL | D:85 | B:208 | 0.0 | 0.0 | H | -67.4 | -40.3 | NA | NA | NA | |||||||||||||
| 1rgu | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | VAL | C:85 | A:208 | 0.0 | 0.0 | H | -62.8 | -43.9 | 0.0 | 0.0 | 0.0 |
HOH |
7.150 |
N |
O |
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| VAL | D:85 | B:208 | 0.0 | 0.0 | H | -70.0 | -43.9 | NA | NA | NA | |||||||||||||
| 1rh0 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | VAL | C:85 | A:208 | 0.0 | 0.0 | H | -62.7 | -40.7 | 0.0 | 0.0 | 0.0 |
HOH |
3.296 |
N |
O |
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| VAL | D:85 | B:208 | 0.0 | 0.0 | H | -72.4 | -43.5 | NA | NA | NA | |||||||||||||
| 5nw9 | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2018-01-10 | VAL | A:85 | A:208 | 0.0 | 0.0 | H | -67.3 | -36.6 | 0.0 | 0.0 | 0.0 |
HOH |
9.616 |
O |
O |
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| VAL | B:85 | B:208 | 0.0 | 0.0 | H | -70.3 | -36.7 | NA | NA | NA | |||||||||||||
| 5nwa | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2018-01-10 | VAL | A:85 | A:208 | 0.0 | 0.0 | H | -74.9 | -35.4 | 0.0 | 0.0 | 0.0 | ||||||
| VAL | C:85 | B:208 | 0.0 | 0.0 | H | -78.1 | -39.4 | NA | NA | NA | |||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q9nuw8-f1 | 1 | Q9NUW8 | 100.0 | 0.0 | VAL | A:208 | A:208 | 0.0 | 0.0 | H | -67.7 | -43.2 | |