Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr14 | 90433753 | . | C | A | CCDS9888.1:NM_001008744.1:c.646Cca>Aca_NP_001008744.1:p.216P>T | Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 1qzq | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2004-05-11 | PRO | A:91 | A:216 | 15.0 | 0.103 | -69.5 | 144.6 | 15.0 | 0.103 | 0.0 |
HOH |
3.312 |
CG |
O |
|||
| PRO | B:91 | B:216 | 15.0 | 0.103 | -61.5 | 143.1 | 15.0 | 0.103 | 0.0 |
HOH |
8.404 |
CD |
O |
||||||||||
| 6dhu | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | PRO | A:69 | A:216 | 16.0 | 0.11 | -60.7 | 146.0 | 16.0 | 0.11 | 0.0 |
HOH |
3.302 |
CD |
O |
|||
| PRO | B:69 | B:216 | 16.0 | 0.11 | -57.1 | 150.6 | NA | NA | NA | ||||||||||||||
| 6die | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | PRO | A:69 | A:216 | 15.0 | 0.103 | -60.0 | 145.4 | 15.0 | 0.103 | 0.0 |
HOH |
3.292 |
CD |
O |
|||
| PRO | B:69 | B:216 | 16.0 | 0.11 | -59.7 | 149.8 | NA | NA | NA | ||||||||||||||
| 6dih | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | PRO | A:69 | A:216 | 15.0 | 0.103 | -57.3 | 145.2 | 15.0 | 0.103 | 0.0 |
HOH |
3.252 |
CD |
O |
|||
| PRO | B:69 | B:216 | 17.0 | 0.117 | -59.3 | 149.1 | NA | NA | NA | ||||||||||||||
| 6dim | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | PRO | A:69 | A:216 | 16.0 | 0.11 | -59.2 | 145.2 | 16.0 | 0.11 | 0.0 |
HOH |
3.298 |
CD |
O |
|||
| PRO | B:69 | B:216 | 16.0 | 0.11 | -59.8 | 151.9 | NA | NA | NA | ||||||||||||||
| 6djd | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | PRO | A:69 | A:216 | 16.0 | 0.11 | -58.7 | 146.5 | 16.0 | 0.11 | 0.0 |
HOH |
3.333 |
CD |
O |
|||
| PRO | B:69 | B:216 | 16.0 | 0.11 | -60.6 | 150.6 | NA | NA | NA | ||||||||||||||
| 6dje | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | PRO | A:69 | A:216 | 16.0 | 0.11 | -59.2 | 146.9 | 16.0 | 0.11 | 0.0 |
HOH |
3.343 |
CD |
O |
|||
| PRO | B:69 | B:216 | 16.0 | 0.11 | -61.8 | 154.3 | NA | NA | NA | ||||||||||||||
| 6djf | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | PRO | A:69 | A:216 | 16.0 | 0.11 | -61.0 | 148.4 | 16.0 | 0.11 | 0.0 |
HOH |
3.389 |
CG |
O |
|||
| PRO | B:69 | B:216 | 16.0 | 0.11 | -60.9 | 152.1 | NA | NA | NA | ||||||||||||||
| 6djg | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | PRO | A:69 | A:216 | 15.0 | 0.103 | -57.6 | 146.8 | 15.0 | 0.103 | 0.0 |
HOH |
3.294 |
CD |
O |
|||
| PRO | B:69 | B:216 | 16.0 | 0.11 | -60.8 | 149.0 | NA | NA | NA | ||||||||||||||
| 6djh | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | PRO | A:69 | A:216 | 15.0 | 0.103 | -60.6 | 146.0 | 15.0 | 0.103 | 0.0 |
HOH |
3.335 |
CD |
O |
|||
| PRO | B:69 | B:216 | 17.0 | 0.117 | -65.0 | 155.4 | NA | NA | NA | ||||||||||||||
| 6dji | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | PRO | A:69 | A:216 | 15.0 | 0.103 | -55.8 | 143.5 | 15.0 | 0.103 | 0.0 |
HOH |
3.259 |
CD |
O |
|||
| PRO | B:69 | B:216 | 16.0 | 0.11 | -59.2 | 147.1 | NA | NA | NA | ||||||||||||||
| 6djj | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | PRO | A:69 | A:216 | 15.0 | 0.103 | -59.1 | 143.8 | 15.0 | 0.103 | 0.0 |
HOH |
3.289 |
CD |
O |
|||
| PRO | B:69 | B:216 | 17.0 | 0.117 | -57.1 | 146.7 | NA | NA | NA | ||||||||||||||
| 6myz | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-06 | PRO | A:69 | A:216 | 15.0 | 0.103 | -61.2 | 147.2 | 15.0 | 0.103 | 0.0 |
HOH |
3.343 |
CD |
O |
|||
| PRO | B:69 | B:216 | 18.0 | 0.124 | -62.6 | 155.0 | NA | NA | NA | ||||||||||||||
| 6mz0 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-06 | PRO | A:69 | A:216 | 14.0 | 0.097 | -60.0 | 143.2 | 14.0 | 0.097 | 0.0 |
HOH |
3.190 |
CD |
O |
|||
| PRO | B:69 | B:216 | 16.0 | 0.11 | -60.0 | 147.2 | NA | NA | NA | ||||||||||||||
| 6n0d | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | PRO | A:69 | A:216 | 15.0 | 0.103 | -57.3 | 144.4 | 15.0 | 0.103 | 0.0 |
HOH |
3.241 |
CD |
O |
|||
| PRO | B:69 | B:216 | 17.0 | 0.117 | -58.2 | 149.5 | NA | NA | NA | ||||||||||||||
| 6n0n | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | PRO | A:69 | A:216 | 16.0 | 0.11 | -57.9 | 149.0 | 16.0 | 0.11 | 0.0 |
HOH |
3.274 |
CD |
O |
|||
| PRO | B:69 | B:216 | 15.0 | 0.103 | -57.0 | 143.1 | NA | NA | NA | ||||||||||||||
| 6n0o | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | PRO | A:69 | A:216 | 15.0 | 0.103 | -58.2 | 146.9 | 15.0 | 0.103 | 0.0 |
HOH |
3.347 |
CD |
O |
|||
| PRO | B:69 | B:216 | 17.0 | 0.117 | -61.3 | 152.4 | NA | NA | NA | ||||||||||||||
| 6n0r | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | PRO | A:69 | A:216 | 14.0 | 0.097 | -57.6 | 141.9 | 14.0 | 0.097 | 0.0 |
HOH |
3.218 |
CD |
O |
|||
| PRO | B:69 | B:216 | 17.0 | 0.117 | -58.5 | 148.9 | NA | NA | NA | ||||||||||||||
| 6n17 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | PRO | A:69 | A:216 | 14.0 | 0.097 | -57.9 | 146.1 | 14.0 | 0.097 | 0.0 |
HOH |
3.304 |
CD |
O |
|||
| PRO | B:69 | B:216 | 17.0 | 0.117 | -60.3 | 150.4 | NA | NA | NA | ||||||||||||||
| 6n19 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | PRO | A:69 | A:216 | 14.0 | 0.097 | -59.0 | 144.3 | 14.0 | 0.097 | 0.0 |
HOH |
3.212 |
CD |
O |
|||
| PRO | B:69 | B:216 | 16.0 | 0.11 | -58.8 | 149.6 | NA | NA | NA | ||||||||||||||
| 6w4r | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-17 | PRO | A:69 | A:216 | 14.0 | 0.097 | -62.3 | 147.0 | 14.0 | 0.097 | 0.0 |
HOH |
3.299 |
CD |
O |
|||
| PRO | B:69 | B:216 | 17.0 | 0.117 | -61.9 | 151.7 | NA | NA | NA | ||||||||||||||
| 6w7j | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | PRO | A:69 | A:216 | 15.0 | 0.103 | -57.7 | 144.3 | 15.0 | 0.103 | 0.0 |
HOH |
3.237 |
CD |
O |
|||
| PRO | B:69 | B:216 | 15.0 | 0.103 | -57.5 | 148.8 | NA | NA | NA | ||||||||||||||
| 6w7k | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | PRO | A:69 | A:216 | 16.0 | 0.11 | -60.7 | 146.5 | 16.0 | 0.11 | 0.0 |
HOH |
3.358 |
CD |
O |
|||
| PRO | B:69 | B:216 | 16.0 | 0.11 | -62.3 | 150.7 | NA | NA | NA | ||||||||||||||
| 6w7l | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | PRO | A:69 | A:216 | 15.0 | 0.103 | -64.1 | 143.1 | 15.0 | 0.103 | 0.0 |
HOH |
3.535 |
CA |
O |
|||
| PRO | B:69 | B:216 | 17.0 | 0.117 | -58.2 | 148.4 | NA | NA | NA | ||||||||||||||
| 6mj5 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | PRO | A:68 | A:216 | 16.0 | 0.11 | -62.7 | 149.5 | 16.0 | 0.11 | 0.0 |
HOH |
3.450 |
CD |
O |
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| PRO | B:68 | B:216 | 18.0 | 0.124 | -62.0 | 154.8 | NA | NA | NA | ||||||||||||||
| 1jy1 | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2002-02-20 | PRO | A:72 | A:216 | 14.0 | 0.097 | -58.0 | 142.1 | 14.0 | 0.097 | 0.0 |
HOH |
3.180 |
CD |
O |
|||
| 1mu7 | 1 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-01-07 | PRO | A:93 | A:216 | 14.0 | 0.097 | -60.6 | 144.4 | 14.0 | 0.097 | 0.0 |
HOH |
6.574 |
O |
O |
|||
| PRO | B:93 | B:216 | 15.0 | 0.103 | -63.9 | 143.0 | NA | NA | NA | ||||||||||||||
| 1mu9 | 1 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-01-07 | PRO | A:93 | A:216 | 16.0 | 0.11 | -69.4 | 147.3 | 16.0 | 0.11 | 0.0 |
HOH |
3.341 |
CG |
O |
|||
| PRO | B:93 | B:216 | 16.0 | 0.11 | -61.4 | 146.3 | NA | NA | NA | ||||||||||||||
| 1nop | 2 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-03-11 | PRO | C:93 | A:216 | 18.0 | 0.124 | -61.3 | 145.9 | 18.0 | 0.124 | 0.0 | |||||||
| PRO | D:93 | B:216 | 17.0 | 0.117 | -63.0 | 145.1 | NA | NA | NA | ||||||||||||||
| 1rff | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | PRO | C:93 | A:216 | 17.0 | 0.117 | -64.8 | 146.7 | 17.0 | 0.117 | 0.0 |
HOH |
5.632 |
CG |
O |
|||
| PRO | D:93 | B:216 | 16.0 | 0.11 | -64.5 | 148.4 | NA | NA | NA | ||||||||||||||
| 1rfi | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | PRO | C:93 | A:216 | 16.0 | 0.11 | -65.5 | 146.1 | 16.0 | 0.11 | 0.0 |
HOH |
5.595 |
CG |
O |
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| PRO | D:93 | B:216 | 16.0 | 0.11 | -59.2 | 143.9 | NA | NA | NA | ||||||||||||||
| 1rg1 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | PRO | C:93 | A:216 | 17.0 | 0.117 | -62.4 | 144.6 | 17.0 | 0.117 | 0.0 |
HOH |
5.489 |
O |
O |
|||
| PRO | D:93 | B:216 | 16.0 | 0.11 | -64.9 | 148.0 | NA | NA | NA | ||||||||||||||
| 1rg2 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | PRO | C:93 | A:216 | 17.0 | 0.117 | -64.0 | 143.2 | 17.0 | 0.117 | 0.0 |
HOH |
5.671 |
CG |
O |
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| PRO | D:93 | B:216 | 15.0 | 0.103 | -62.5 | 146.9 | NA | NA | NA | ||||||||||||||
| 1rgt | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | PRO | C:93 | A:216 | 16.0 | 0.11 | -63.6 | 142.4 | 16.0 | 0.11 | 0.0 |
HOH |
5.500 |
O |
O |
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| PRO | D:93 | B:216 | 16.0 | 0.11 | -62.3 | 147.7 | NA | NA | NA | ||||||||||||||
| 1rgu | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | PRO | C:93 | A:216 | 18.0 | 0.124 | -66.8 | 149.4 | 18.0 | 0.124 | 0.0 |
HOH |
5.459 |
O |
O |
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| PRO | D:93 | B:216 | 17.0 | 0.117 | -58.1 | 146.0 | NA | NA | NA | ||||||||||||||
| 1rh0 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | PRO | C:93 | A:216 | 19.0 | 0.131 | -68.3 | 146.0 | 19.0 | 0.131 | 0.0 |
HOH |
5.695 |
CG |
O |
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| PRO | D:93 | B:216 | 17.0 | 0.117 | -61.8 | 147.3 | NA | NA | NA | ||||||||||||||
| 5nw9 | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2018-01-10 | PRO | A:93 | A:216 | 17.0 | 0.117 | -64.9 | 145.8 | 17.0 | 0.117 | 0.0 |
HOH |
6.489 |
CD |
O |
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| PRO | B:93 | B:216 | 16.0 | 0.11 | -65.8 | 147.1 | NA | NA | NA | ||||||||||||||
| 5nwa | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2018-01-10 | PRO | A:93 | A:216 | 16.0 | 0.11 | -64.5 | 144.6 | 16.0 | 0.11 | 0.0 | |||||||
| PRO | C:93 | B:216 | 21.0 | 0.145 | -64.7 | 160.7 | NA | NA | NA | ||||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q9nuw8-f1 | 1 | Q9NUW8 | 100.0 | 0.0 | PRO | A:216 | A:216 | 21.0 | 0.145 | -63.5 | 149.7 | ||