Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr14 90433762 . T A CCDS9888.1:NM_001008744.1:c.655Ttc>Atc_NP_001008744.1:p.219F>I Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1qzq 1 Q9NUW8 100.0 0.0 X-RAY
 2004-05-11 PHE A:94 A:219 15.0 0.071 G -110.0 1.7 15.0 0.071 0.0 HOH
 2.933
 O
 O
PHE B:94 B:219 14.0 0.067 G -87.6 -6.1 14.0 0.067 0.0 HOH
 4.732
 O
 O
6dhu 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 PHE A:72 A:219 15.0 0.071 G -105.5 2.6 15.0 0.071 0.0 HOH
 2.726
 O
 O
PHE B:72 B:219 14.0 0.067 G -109.4 2.5 NA NA NA
6die 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 PHE A:72 A:219 15.0 0.071 G -106.6 3.7 15.0 0.071 0.0 HOH
 2.767
 O
 O
PHE B:72 B:219 13.0 0.062 G -103.6 -0.4 NA NA NA
6dih 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 PHE A:72 A:219 15.0 0.071 G -110.7 1.7 15.0 0.071 0.0 HOH
 2.776
 O
 O
PHE B:72 B:219 12.0 0.057 G -108.1 3.5 NA NA NA
6dim 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 PHE A:72 A:219 15.0 0.071 G -106.9 3.9 15.0 0.071 0.0 HOH
 2.827
 O
 O
PHE B:72 B:219 14.0 0.067 G -105.6 -0.7 NA NA NA
6djd 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 PHE A:72 A:219 13.0 0.062 G -106.1 3.2 13.0 0.062 0.0 HOH
 2.804
 O
 O
PHE B:72 B:219 14.0 0.067 G -100.0 0.4 NA NA NA
6dje 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 PHE A:72 A:219 15.0 0.071 G -105.2 2.8 15.0 0.071 0.0 HOH
 2.814
 O
 O
PHE B:72 B:219 12.0 0.057 G -106.6 3.1 NA NA NA
6djf 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 PHE A:72 A:219 14.0 0.067 G -106.2 3.6 14.0 0.067 0.0 HOH
 2.709
 O
 O
PHE B:72 B:219 12.0 0.057 G -110.7 -3.1 NA NA NA
6djg 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 PHE A:72 A:219 13.0 0.062 G -108.4 1.0 13.0 0.062 0.0 HOH
 2.773
 O
 O
PHE B:72 B:219 13.0 0.062 G -106.3 -1.6 NA NA NA
6djh 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 PHE A:72 A:219 14.0 0.067 G -105.9 0.5 14.0 0.067 0.0 HOH
 2.778
 O
 O
PHE B:72 B:219 15.0 0.071 G -92.9 2.8 NA NA NA
6dji 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 PHE A:72 A:219 17.0 0.081 G -103.1 0.7 17.0 0.081 0.0 HOH
 2.776
 O
 O
PHE B:72 B:219 13.0 0.062 G -115.5 -2.2 NA NA NA
6djj 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 PHE A:72 A:219 14.0 0.067 G -107.3 2.8 14.0 0.067 0.0 HOH
 2.688
 O
 O
PHE B:72 B:219 14.0 0.067 G -103.7 2.4 NA NA NA
6myz 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-06 PHE A:72 A:219 14.0 0.067 G -105.7 1.6 14.0 0.067 0.0 HOH
 2.696
 O
 O
PHE B:72 B:219 11.0 0.052 G -98.4 1.2 NA NA NA
6mz0 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-06 PHE A:72 A:219 15.0 0.071 G -110.9 1.7 15.0 0.071 0.0 HOH
 2.675
 O
 O
PHE B:72 B:219 12.0 0.057 G -107.2 -1.0 NA NA NA
6n0d 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 PHE A:72 A:219 15.0 0.071 G -108.7 2.2 15.0 0.071 0.0 HOH
 2.736
 O
 O
PHE B:72 B:219 13.0 0.062 G -102.0 1.6 NA NA NA
6n0n 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 PHE A:72 A:219 12.0 0.057 G -102.4 0.7 12.0 0.057 0.0 HOH
 2.741
 O
 O
PHE B:72 B:219 14.0 0.067 G -108.8 3.8 NA NA NA
6n0o 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 PHE A:72 A:219 14.0 0.067 G -106.0 2.2 14.0 0.067 0.0 HOH
 2.793
 O
 O
PHE B:72 B:219 12.0 0.057 G -95.5 1.4 NA NA NA
6n0r 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 PHE A:72 A:219 14.0 0.067 G -107.9 2.1 14.0 0.067 0.0 HOH
 2.708
 O
 O
PHE B:72 B:219 13.0 0.062 G -105.3 -0.0 NA NA NA
6n17 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 PHE A:72 A:219 15.0 0.071 G -106.1 2.3 15.0 0.071 0.0 HOH
 2.735
 O
 O
PHE B:72 B:219 12.0 0.057 G -112.6 2.0 NA NA NA
6n19 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 PHE A:72 A:219 14.0 0.067 G -108.2 2.6 14.0 0.067 0.0 HOH
 2.730
 O
 O
PHE B:72 B:219 12.0 0.057 G -105.7 -1.5 NA NA NA
6w4r 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-17 PHE A:72 A:219 14.0 0.067 G -107.6 0.6 14.0 0.067 0.0 HOH
 2.766
 O
 O
PHE B:72 B:219 13.0 0.062 G -94.8 -1.6 NA NA NA
6w7j 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 PHE A:72 A:219 15.0 0.071 G -107.2 2.4 15.0 0.071 0.0 HOH
 2.752
 O
 O
PHE B:72 B:219 12.0 0.057 G -105.6 -0.5 NA NA NA
6w7k 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 PHE A:72 A:219 14.0 0.067 G -107.4 3.5 14.0 0.067 0.0 HOH
 2.695
 O
 O
PHE B:72 B:219 11.0 0.052 G -107.8 -0.4 NA NA NA
6w7l 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 PHE A:72 A:219 13.0 0.062 G -104.0 4.5 13.0 0.062 0.0 HOH
 2.745
 O
 O
PHE B:72 B:219 13.0 0.062 G -103.8 -1.3 NA NA NA
6mj5 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 PHE A:71 A:219 14.0 0.067 G -102.4 -0.7 14.0 0.067 0.0 HOH
 2.762
 O
 O
PHE B:71 B:219 14.0 0.067 G -106.0 -1.9 NA NA NA
1jy1 1 Q9NUW8 98.92 0.0 X-RAY
 2002-02-20 PHE A:75 A:219 15.0 0.071 G -109.1 -2.2 15.0 0.071 0.0 HOH
 2.723
 O
 O
1mu7 1 20127586 98.92 0.0 X-RAY
 2003-01-07 PHE A:96 A:219 14.0 0.067 G -99.6 -2.4 14.0 0.067 0.0 HOH
 2.431
 O
 O
PHE B:96 B:219 15.0 0.071 G -108.1 0.5 NA NA NA
1mu9 1 20127586 98.92 0.0 X-RAY
 2003-01-07 PHE A:96 A:219 15.0 0.071 G -102.6 -2.1 15.0 0.071 0.0 HOH
 2.614
 O
 O
PHE B:96 B:219 15.0 0.071 G -106.3 -0.8 NA NA NA
1nop 2 20127586 98.92 0.0 X-RAY
 2003-03-11 PHE C:96 A:219 13.0 0.062 G -98.1 -3.2 13.0 0.062 0.0
PHE D:96 B:219 15.0 0.071 G -102.1 1.9 NA NA NA
1rff 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 PHE C:96 A:219 14.0 0.067 G -103.8 -2.7 14.0 0.067 0.0 HOH
 2.454
 O
 O
PHE D:96 B:219 14.0 0.067 G -110.6 0.8 NA NA NA
1rfi 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 PHE C:96 A:219 14.0 0.067 G -110.3 -2.4 14.0 0.067 0.0 HOH
 2.617
 O
 O
PHE D:96 B:219 16.0 0.076 G -107.1 2.2 NA NA NA
1rg1 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 PHE C:96 A:219 13.0 0.062 G -101.4 -8.5 13.0 0.062 0.0 HOH
 3.106
 C
 O
PHE D:96 B:219 16.0 0.076 G -107.4 -1.2 NA NA NA
1rg2 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 PHE C:96 A:219 14.0 0.067 G -99.6 -3.2 14.0 0.067 0.0 HOH
 2.996
 C
 O
PHE D:96 B:219 15.0 0.071 G -106.1 -1.4 NA NA NA
1rgt 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 PHE C:96 A:219 14.0 0.067 G -106.9 -7.4 14.0 0.067 0.0 HOH
 3.065
 C
 O
PHE D:96 B:219 15.0 0.071 G -108.5 2.0 NA NA NA
1rgu 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 PHE C:96 A:219 14.0 0.067 G -113.9 -4.3 14.0 0.067 0.0 HOH
 3.110
 C
 O
PHE D:96 B:219 14.0 0.067 G -107.3 -0.2 NA NA NA
1rh0 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 PHE C:96 A:219 14.0 0.067 G -98.4 -5.0 14.0 0.067 0.0 HOH
 2.687
 O
 O
PHE D:96 B:219 15.0 0.071 G -105.7 1.4 NA NA NA
5nw9 1 Q9NUW8 98.92 0.0 X-RAY
 2018-01-10 PHE A:96 A:219 14.0 0.067 G -107.6 -0.0 14.0 0.067 0.0 HOH
 2.847
 O
 O
PHE B:96 B:219 11.0 0.052 G -101.9 -2.0 NA NA NA
5nwa 1 Q9NUW8 98.92 0.0 X-RAY
 2018-01-10 PHE A:96 A:219 14.0 0.067 T -100.4 -15.4 14.0 0.067 0.0
PHE C:96 B:219 10.0 0.048 H -94.5 -13.0 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q9nuw8-f1 1 Q9NUW8 100.0 0.0 PHE A:219 A:219 10.0 0.048 T -102.2 -11.8