Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr14 | 90437594 | . | C | A | CCDS9888.1:NM_001008744.1:c.735taC>taA_NP_001008744.1:p.245Y>* | Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 1qzq | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2004-05-11 | TYR | A:120 | A:245 | 52.0 | 0.226 | -104.0 | 108.4 | 52.0 | 0.226 | 0.0 |
HOH |
2.496 |
OH |
O |
|||
| TYR | B:120 | B:245 | 59.0 | 0.257 | -90.7 | 106.3 | 59.0 | 0.257 | 0.0 |
HOH |
2.507 |
OH |
O |
||||||||||
| 6dhu | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TYR | A:98 | A:245 | 54.0 | 0.235 | -110.9 | 106.3 | 54.0 | 0.235 | 0.0 |
HOH |
2.980 |
OH |
O |
|||
| TYR | B:98 | B:245 | 47.0 | 0.204 | -109.1 | 108.6 | NA | NA | NA | ||||||||||||||
| 6die | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TYR | A:98 | A:245 | 56.0 | 0.243 | -109.8 | 105.5 | 56.0 | 0.243 | 0.0 |
HOH |
2.936 |
O |
O |
|||
| TYR | B:98 | B:245 | 50.0 | 0.217 | -111.2 | 104.0 | NA | NA | NA | ||||||||||||||
| 6dih | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TYR | A:98 | A:245 | 54.0 | 0.235 | -111.2 | 104.4 | 54.0 | 0.235 | 0.0 |
HOH |
2.892 |
OH |
O |
|||
| TYR | B:98 | B:245 | 51.0 | 0.222 | -107.7 | 107.5 | NA | NA | NA | ||||||||||||||
| 6dim | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TYR | A:98 | A:245 | 56.0 | 0.243 | -109.6 | 104.4 | 56.0 | 0.243 | 0.0 |
HOH |
2.516 |
O |
O |
|||
| TYR | B:98 | B:245 | 52.0 | 0.226 | -108.9 | 108.5 | NA | NA | NA | ||||||||||||||
| 6djd | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TYR | A:98 | A:245 | 54.0 | 0.235 | -107.7 | 104.0 | 54.0 | 0.235 | 0.0 |
HOH |
2.886 |
OH |
O |
|||
| TYR | B:98 | B:245 | 52.0 | 0.226 | -108.9 | 115.9 | NA | NA | NA | ||||||||||||||
| 6dje | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TYR | A:98 | A:245 | 52.0 | 0.226 | -110.5 | 104.4 | 52.0 | 0.226 | 0.0 |
HOH |
2.837 |
OH |
O |
|||
| TYR | B:98 | B:245 | 51.0 | 0.222 | -109.5 | 107.2 | NA | NA | NA | ||||||||||||||
| 6djf | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TYR | A:98 | A:245 | 54.0 | 0.235 | -112.2 | 105.2 | 54.0 | 0.235 | 0.0 |
HOH |
2.970 |
OH |
O |
|||
| TYR | B:98 | B:245 | 53.0 | 0.23 | -112.6 | 110.4 | NA | NA | NA | ||||||||||||||
| 6djg | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TYR | A:98 | A:245 | 54.0 | 0.235 | -109.8 | 103.6 | 54.0 | 0.235 | 0.0 |
HOH |
2.764 |
OH |
O |
|||
| TYR | B:98 | B:245 | 47.0 | 0.204 | -112.5 | 110.2 | NA | NA | NA | ||||||||||||||
| 6djh | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TYR | A:98 | A:245 | 50.0 | 0.217 | -111.3 | 108.4 | 50.0 | 0.217 | 0.0 |
HOH |
2.943 |
OH |
O |
|||
| TYR | B:98 | B:245 | 58.0 | 0.252 | -111.1 | 114.9 | NA | NA | NA | ||||||||||||||
| 6dji | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TYR | A:98 | A:245 | 54.0 | 0.235 | -108.1 | 104.2 | 54.0 | 0.235 | 0.0 |
HOH |
2.830 |
OH |
O |
|||
| TYR | B:98 | B:245 | 50.0 | 0.217 | -105.5 | 107.1 | NA | NA | NA | ||||||||||||||
| 6djj | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TYR | A:98 | A:245 | 53.0 | 0.23 | -110.9 | 104.7 | 53.0 | 0.23 | 0.0 |
HOH |
2.941 |
OH |
O |
|||
| TYR | B:98 | B:245 | 51.0 | 0.222 | -109.1 | 105.5 | NA | NA | NA | ||||||||||||||
| 6myz | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-06 | TYR | A:98 | A:245 | 51.0 | 0.222 | -110.0 | 102.8 | 51.0 | 0.222 | 0.0 |
HOH |
2.858 |
OH |
O |
|||
| TYR | B:98 | B:245 | 46.0 | 0.2 | -111.8 | 108.8 | NA | NA | NA | ||||||||||||||
| 6mz0 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-06 | TYR | A:98 | A:245 | 54.0 | 0.235 | -109.8 | 102.7 | 54.0 | 0.235 | 0.0 |
HOH |
2.770 |
OH |
O |
|||
| TYR | B:98 | B:245 | 56.0 | 0.243 | -108.4 | 106.8 | NA | NA | NA | ||||||||||||||
| 6n0d | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | TYR | A:98 | A:245 | 56.0 | 0.243 | -109.4 | 100.5 | 56.0 | 0.243 | 0.0 |
HOH |
2.907 |
O |
O |
|||
| TYR | B:98 | B:245 | 46.0 | 0.2 | -109.9 | 102.3 | NA | NA | NA | ||||||||||||||
| 6n0n | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | TYR | A:98 | A:245 | 51.0 | 0.222 | -109.1 | 99.9 | 51.0 | 0.222 | 0.0 |
HOH |
2.785 |
OH |
O |
|||
| TYR | B:98 | B:245 | 50.0 | 0.217 | -110.2 | 101.1 | NA | NA | NA | ||||||||||||||
| 6n0o | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | TYR | A:98 | A:245 | 54.0 | 0.235 | -109.2 | 107.8 | 54.0 | 0.235 | 0.0 |
HOH |
2.612 |
OH |
O |
|||
| TYR | B:98 | B:245 | 47.0 | 0.204 | -109.0 | 109.0 | NA | NA | NA | ||||||||||||||
| 6n0r | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | TYR | A:98 | A:245 | 53.0 | 0.23 | -112.2 | 103.1 | 53.0 | 0.23 | 0.0 |
HOH |
2.932 |
O |
O |
|||
| TYR | B:98 | B:245 | 53.0 | 0.23 | -112.7 | 100.7 | NA | NA | NA | ||||||||||||||
| 6n17 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | TYR | A:98 | A:245 | 57.0 | 0.248 | -110.7 | 104.9 | 57.0 | 0.248 | 0.0 |
HOH |
2.832 |
O |
O |
|||
| TYR | B:98 | B:245 | 57.0 | 0.248 | -107.3 | 110.6 | NA | NA | NA | ||||||||||||||
| 6n19 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | TYR | A:98 | A:245 | 51.0 | 0.222 | -112.4 | 104.7 | 51.0 | 0.222 | 0.0 |
HOH |
2.916 |
O |
O |
|||
| TYR | B:98 | B:245 | 50.0 | 0.217 | -111.5 | 103.7 | NA | NA | NA | ||||||||||||||
| 6w4r | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-17 | TYR | A:98 | A:245 | 52.0 | 0.226 | -110.0 | 103.2 | 52.0 | 0.226 | 0.0 |
HOH |
2.722 |
OH |
O |
|||
| TYR | B:98 | B:245 | 59.0 | 0.257 | -111.6 | 106.4 | NA | NA | NA | ||||||||||||||
| 6w7j | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | TYR | A:98 | A:245 | 51.0 | 0.222 | -109.3 | 99.9 | 51.0 | 0.222 | 0.0 |
HOH |
2.843 |
OH |
O |
|||
| TYR | B:98 | B:245 | 53.0 | 0.23 | -109.9 | 99.8 | NA | NA | NA | ||||||||||||||
| 6w7k | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | TYR | A:98 | A:245 | 54.0 | 0.235 | -113.0 | 102.7 | 54.0 | 0.235 | 0.0 |
HOH |
2.927 |
O |
O |
|||
| TYR | B:98 | B:245 | 58.0 | 0.252 | -111.9 | 110.8 | NA | NA | NA | ||||||||||||||
| 6w7l | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | TYR | A:98 | A:245 | 52.0 | 0.226 | -115.8 | 101.1 | 52.0 | 0.226 | 0.0 |
HOH |
2.825 |
OH |
O |
|||
| TYR | B:98 | B:245 | 57.0 | 0.248 | -109.0 | 106.7 | NA | NA | NA | ||||||||||||||
| 6mj5 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | TYR | A:97 | A:245 | 53.0 | 0.23 | -113.1 | 101.2 | 53.0 | 0.23 | 0.0 |
HOH |
2.882 |
OH |
O |
|||
| TYR | B:97 | B:245 | 60.0 | 0.261 | -107.6 | 109.7 | NA | NA | NA | ||||||||||||||
| 1jy1 | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2002-02-20 | TYR | A:101 | A:245 | 55.0 | 0.239 | -111.4 | 99.8 | 55.0 | 0.239 | 0.0 |
HOH |
2.922 |
OH |
O |
|||
| 1mu7 | 1 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-01-07 | TYR | A:122 | A:245 | 58.0 | 0.252 | -113.7 | 97.8 | 58.0 | 0.252 | 0.0 |
HOH |
2.318 |
OH |
O |
|||
| TYR | B:122 | B:245 | 57.0 | 0.248 | -107.1 | 95.0 | NA | NA | NA | ||||||||||||||
| 1mu9 | 1 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-01-07 | TYR | A:122 | A:245 | 41.0 | 0.178 | -102.8 | 93.9 | 41.0 | 0.178 | 0.0 |
HOH |
5.771 |
CE2 |
O |
|||
| TYR | B:122 | B:245 | 62.0 | 0.27 | -105.0 | 97.9 | NA | NA | NA | ||||||||||||||
| 1nop | 2 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-03-11 | TYR | C:122 | A:245 | 44.0 | 0.191 | -99.9 | 95.2 | 44.0 | 0.191 | 0.0 |
HOH |
6.893 |
O |
O |
|||
| TYR | D:122 | B:245 | 64.0 | 0.278 | -111.0 | 98.9 | NA | NA | NA | ||||||||||||||
| 1rff | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | TYR | C:122 | A:245 | 46.0 | 0.2 | -105.4 | 98.4 | 46.0 | 0.2 | 0.0 |
HOH |
3.131 |
O |
O |
|||
| TYR | D:122 | B:245 | 61.0 | 0.265 | -98.7 | 105.2 | NA | NA | NA | ||||||||||||||
| 1rfi | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | TYR | C:122 | A:245 | 44.0 | 0.191 | -105.9 | 102.8 | 44.0 | 0.191 | 0.0 |
HOH |
2.917 |
O |
O |
|||
| TYR | D:122 | B:245 | 58.0 | 0.252 | -107.2 | 99.6 | NA | NA | NA | ||||||||||||||
| 1rg1 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | TYR | C:122 | A:245 | 42.0 | 0.183 | -116.2 | 99.8 | 42.0 | 0.183 | 0.0 |
HOH |
6.222 |
CE2 |
O |
|||
| TYR | D:122 | B:245 | 60.0 | 0.261 | -103.4 | 101.9 | NA | NA | NA | ||||||||||||||
| 1rg2 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | TYR | C:122 | A:245 | 44.0 | 0.191 | -107.0 | 99.8 | 44.0 | 0.191 | 0.0 |
HOH |
2.665 |
O |
O |
|||
| TYR | D:122 | B:245 | 61.0 | 0.265 | -101.0 | 101.1 | NA | NA | NA | ||||||||||||||
| 1rgt | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | TYR | C:122 | A:245 | 44.0 | 0.191 | -104.3 | 105.4 | 44.0 | 0.191 | 0.0 |
HOH |
6.041 |
CE2 |
O |
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| TYR | D:122 | B:245 | 63.0 | 0.274 | -106.7 | 103.3 | NA | NA | NA | ||||||||||||||
| 1rgu | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | TYR | C:122 | A:245 | 47.0 | 0.204 | -104.6 | 107.0 | 47.0 | 0.204 | 0.0 |
HOH |
2.583 |
O |
O |
|||
| TYR | D:122 | B:245 | 63.0 | 0.274 | -107.3 | 99.8 | NA | NA | NA | ||||||||||||||
| 1rh0 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | TYR | C:122 | A:245 | 44.0 | 0.191 | -104.5 | 102.6 | 44.0 | 0.191 | 0.0 |
HOH |
3.077 |
O |
O |
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| TYR | D:122 | B:245 | 62.0 | 0.27 | -110.6 | 101.4 | NA | NA | NA | ||||||||||||||
| 5nw9 | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2018-01-10 | TYR | A:122 | A:245 | 53.0 | 0.23 | -109.1 | 101.6 | 53.0 | 0.23 | 0.0 |
HOH |
8.438 |
CB |
O |
|||
| TYR | B:122 | B:245 | 57.0 | 0.248 | -111.2 | 111.6 | NA | NA | NA | ||||||||||||||
| 5nwa | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2018-01-10 | TYR | A:122 | A:245 | 52.0 | 0.226 | -101.7 | 110.1 | 52.0 | 0.226 | 0.0 | |||||||
| TYR | C:122 | B:245 | 58.0 | 0.252 | -108.8 | 116.4 | NA | NA | NA | ||||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q9nuw8-f1 | 1 | Q9NUW8 | 100.0 | 0.0 | TYR | A:245 | A:245 | 45.0 | 0.196 | -114.9 | 97.5 | ||