Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr14 90442154 . C A CCDS9888.1:NM_001008744.1:c.786caC>caA_NP_001008744.1:p.262H>Q Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1qzq 1 Q9NUW8 100.0 0.0 X-RAY
 2004-05-11 HIS A:137 A:262 1.0 0.005 B -95.9 90.8 1.0 0.005 0.0 HOH
 2.869
 N
 O
HIS B:137 B:262 2.0 0.01 B -97.0 91.3 2.0 0.01 0.0 HOH
 2.816
 N
 O
6dhu 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:115 A:262 1.0 0.005 B -92.8 94.4 1.0 0.005 0.0 GHM
HOH
 5.647
2.885
 O
N
 O3
O
HIS B:115 B:262 1.0 0.005 B -100.9 93.8 NA NA NA
6die 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:115 A:262 2.0 0.01 B -89.8 93.3 2.0 0.01 0.0 GHM
HOH
 5.473
2.850
 O
N
 O4
O
HIS B:115 B:262 1.0 0.005 B -95.3 92.2 NA NA NA
6dih 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:115 A:262 2.0 0.01 B -96.2 93.3 2.0 0.01 0.0 GJS
HOH
 5.546
2.776
 O
N
 O03
O
HIS B:115 B:262 2.0 0.01 B -91.6 93.6 NA NA NA
6dim 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:115 A:262 2.0 0.01 B -101.2 96.2 2.0 0.01 0.0 GJP
HOH
 6.021
2.949
 O
N
 O1
O
HIS B:115 B:262 1.0 0.005 B -99.4 96.7 NA NA NA
6djd 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:115 A:262 1.0 0.005 B -102.5 96.1 1.0 0.005 0.0 GJP
HOH
 6.131
2.881
 O
N
 O1
O
HIS B:115 B:262 1.0 0.005 B -102.5 94.0 NA NA NA
6dje 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:115 A:262 2.0 0.01 B -97.4 96.1 2.0 0.01 0.0 GNY
HOH
 6.115
2.931
 O
N
 O14
O
HIS B:115 B:262 2.0 0.01 B -97.5 94.5 NA NA NA
6djf 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:115 A:262 1.0 0.005 B -100.0 96.3 1.0 0.005 0.0 GNV
HOH
 5.758
2.872
 O
N
 O03
O
HIS B:115 B:262 1.0 0.005 B -101.5 94.6 NA NA NA
6djg 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:115 A:262 1.0 0.005 B -108.6 95.9 1.0 0.005 0.0 GNJ
HOH
 5.353
2.874
 O
N
 O03
O
HIS B:115 B:262 1.0 0.005 B -101.5 96.9 NA NA NA
6djh 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:115 A:262 1.0 0.005 B -101.0 94.4 1.0 0.005 0.0 GNM
HOH
 5.855
2.824
 O
N
 O03
O
HIS B:115 B:262 1.0 0.005 B -101.4 97.5 NA NA NA
6dji 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:115 A:262 1.0 0.005 B -94.5 93.1 1.0 0.005 0.0 GOG
HOH
 5.425
2.949
 O
N
 O03
O
HIS B:115 B:262 2.0 0.01 B -92.7 93.4 NA NA NA
6djj 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:115 A:262 2.0 0.01 B -90.8 91.7 2.0 0.01 0.0 GM7
HOH
 5.572
2.866
 O
N
 O11
O
HIS B:115 B:262 2.0 0.01 B -92.4 92.6 NA NA NA
6myz 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-06 HIS A:115 A:262 1.0 0.005 B -96.5 95.1 1.0 0.005 0.0 K7D
HOH
 6.399
2.901
 O
N
 O03
O
HIS B:115 B:262 1.0 0.005 B -101.5 91.4 NA NA NA
6mz0 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-06 HIS A:115 A:262 1.0 0.005 B -89.6 94.7 1.0 0.005 0.0 K7A
HOH
 7.912
2.913
 O
N
 O12
O
HIS B:115 B:262 1.0 0.005 B -89.6 90.1 NA NA NA
6n0d 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 HIS A:115 A:262 2.0 0.01 B -86.9 93.8 2.0 0.01 0.0 K8J
HOH
 5.775
2.854
 O
N
 O01
O
HIS B:115 B:262 1.0 0.005 B -90.9 94.3 NA NA NA
6n0n 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 HIS A:115 A:262 2.0 0.01 B -87.2 92.6 2.0 0.01 0.0 KAY
HOH
 5.668
2.847
 O
N
 O07
O
HIS B:115 B:262 2.0 0.01 B -87.3 90.7 NA NA NA
6n0o 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 HIS A:115 A:262 2.0 0.01 B -90.8 92.8 2.0 0.01 0.0 K8G
HOH
 6.249
2.808
 O
N
 O03
O
HIS B:115 B:262 1.0 0.005 B -89.8 88.5 NA NA NA
6n0r 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 HIS A:115 A:262 2.0 0.01 B -96.1 94.4 2.0 0.01 0.0 K8D
HOH
 5.900
2.867
 O
N
 O08
O
HIS B:115 B:262 1.0 0.005 B -91.9 94.9 NA NA NA
6n17 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 HIS A:115 A:262 2.0 0.01 B -99.9 92.4 2.0 0.01 0.0 K8Y
HOH
 5.488
2.882
 O
N
 O15
O
HIS B:115 B:262 2.0 0.01 B -89.4 90.7 NA NA NA
6n19 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 HIS A:115 A:262 2.0 0.01 B -88.9 94.1 2.0 0.01 0.0 K8V
HOH
 5.719
2.841
 O
N
 O16
O
HIS B:115 B:262 2.0 0.01 B -91.3 96.6 NA NA NA
6w4r 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-17 HIS A:115 A:262 2.0 0.01 B -92.8 92.4 2.0 0.01 0.0 MPO
SZV
HOH
 7.919
5.473
2.887
 N
O
N
 O3
O29
O
HIS B:115 B:262 2.0 0.01 B -93.7 92.9 NA NA NA
6w7j 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 HIS A:115 A:262 1.0 0.005 B -90.2 96.8 1.0 0.005 0.0 TGM
HOH
 5.578
2.830
 O
N
 O28
O
HIS B:115 B:262 2.0 0.01 B -92.9 93.9 NA NA NA
6w7k 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 HIS A:115 A:262 2.0 0.01 B -92.7 97.2 2.0 0.01 0.0 TG7
HOH
 5.891
2.802
 O
N
 O27
O
HIS B:115 B:262 2.0 0.01 B -94.3 94.3 NA NA NA
6w7l 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 HIS A:115 A:262 2.0 0.01 B -96.4 94.0 2.0 0.01 0.0 TGV
HOH
 5.260
2.802
 O
N
 O27
O
HIS B:115 B:262 2.0 0.01 B -95.3 92.3 NA NA NA
6mj5 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 HIS A:114 A:262 2.0 0.01 B -100.9 96.0 2.0 0.01 0.0 JTA
HOH
 5.612
2.773
 O
N
 O01
O
HIS B:114 B:262 1.0 0.005 B -103.3 99.7 NA NA NA
1jy1 1 Q9NUW8 98.92 0.0 X-RAY
 2002-02-20 HIS A:118 A:262 2.0 0.01 B -97.9 97.4 2.0 0.01 0.0 HOH
 2.857
 N
 O
1mu7 1 20127586 98.92 0.0 X-RAY
 2003-01-07 HIS A:139 A:262 1.0 0.005 B -89.9 94.5 1.0 0.005 0.0 WO4
GOL
HOH
 7.118
6.663
2.890
 O
N
N
 O1
O3
O
HIS B:139 B:262 1.0 0.005 B -90.6 93.8 NA NA NA
1mu9 1 20127586 98.92 0.0 X-RAY
 2003-01-07 HIS A:139 A:262 1.0 0.005 B -90.6 95.0 1.0 0.005 0.0 VO4
GOL
HOH
 7.026
7.637
2.701
 O
O
N
 O3
O1
O
HIS B:139 B:262 1.0 0.005 B -92.3 92.2 NA NA NA
1nop 2 20127586 98.92 0.0 X-RAY
 2003-03-11 HIS C:139 A:262 1.0 0.005 B -88.0 90.5 1.0 0.005 0.0 DT
DT
VO4
HOH
 8.224
7.201
6.913
2.836
 N
N
O
N
 O2
C5'
O3
O
HIS D:139 B:262 1.0 0.005 B -88.5 95.3 NA NA NA
1rff 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 HIS C:139 A:262 0.0 0.0 B -87.1 95.3 0.0 0.0 0.0 DT
DT
VO4
HOH
 8.273
7.178
7.085
2.896
 N
C
O
N
 O2
C4'
O3
O
HIS D:139 B:262 1.0 0.005 B -90.7 95.1 NA NA NA
1rfi 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 HIS C:139 A:262 0.0 0.0 B -85.0 89.0 0.0 0.0 0.0 DT
DC
VO4
HOH
 8.196
7.221
7.006
2.943
 N
C
O
N
 O2
C4'
O3
O
HIS D:139 B:262 1.0 0.005 B -91.3 91.1 NA NA NA
1rg1 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 HIS C:139 A:262 1.0 0.005 B -91.5 90.7 1.0 0.005 0.0 DT
DT
VO4
OTS
HOH
 8.361
7.169
7.179
8.829
2.997
 N
N
O
O
N
 O2
C5'
O3
C3
O
HIS D:139 B:262 1.0 0.005 B -87.1 91.1 NA NA NA
1rg2 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 HIS C:139 A:262 1.0 0.005 B -92.1 87.7 1.0 0.005 0.0 DT
DA
VO4
OTS
OTR
HOH
 8.050
7.166
7.196
8.730
8.730
2.906
 N
N
O
O
O
N
 O2
C5'
O3
C3
C3
O
HIS D:139 B:262 1.0 0.005 B -87.8 92.3 NA NA NA
1rgt 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 HIS C:139 A:262 1.0 0.005 B -86.5 94.6 1.0 0.005 0.0 DT
DC
VO4
OTS
OTR
HOH
 8.106
7.171
7.151
8.769
8.769
2.929
 N
C
O
O
O
N
 O2
C4'
O3
C3
C3
O
HIS D:139 B:262 1.0 0.005 B -92.3 93.6 NA NA NA
1rgu 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 HIS C:139 A:262 0.0 0.0 B -87.0 91.8 0.0 0.0 0.0 DT
DG
VO4
OTS
HOH
 7.913
7.134
7.237
8.763
6.215
 N
C
O
O
N
 O2
C4'
O3
C3
O
HIS D:139 B:262 1.0 0.005 B -91.0 91.3 NA NA NA
1rh0 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 HIS C:139 A:262 1.0 0.005 B -88.2 92.6 1.0 0.005 0.0 DT
DT
VO4
OTS
HOH
 8.271
7.170
7.075
8.833
2.873
 N
C
O
O
N
 O2
C4'
O3
C3
O
HIS D:139 B:262 1.0 0.005 B -90.0 96.1 NA NA NA
5nw9 1 Q9NUW8 98.92 0.0 X-RAY
 2018-01-10 HIS A:139 A:262 1.0 0.005 B -83.1 85.8 1.0 0.005 0.0 DG
DT
DA
DG
DT
DA
HOH
 8.597
7.563
7.570
8.597
7.563
7.570
2.750
 N
C
O
N
C
O
N
 C2'
C4'
OP1
C2'
C4'
OP1
O
HIS B:139 B:262 1.0 0.005 B -74.5 86.8 NA NA NA
5nwa 1 Q9NUW8 98.92 0.0 X-RAY
 2018-01-10 HIS A:139 A:262 1.0 0.005 B -90.5 92.9 1.0 0.005 0.0 DT
DT
DA
 8.388
7.483
8.001
 N
C
O
 O2
C4'
OP1
HIS C:139 B:262 1.0 0.005 B -80.8 81.4 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q9nuw8-f1 1 Q9NUW8 100.0 0.0 HIS A:262 A:262 1.0 0.005 B -91.7 104.2