Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr14 | 90446918 | . | C | A | CCDS9888.1:NM_001008744.1:c.826Cgg>Agg_NP_001008744.1:p.276R>R | Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 1qzq | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2004-05-11 | ARG | A:151 | A:276 | 26.0 | 0.116 | E | -128.7 | 141.6 | 26.0 | 0.116 | 0.0 |
HOH |
2.977 |
NH2 |
O |
||
| ARG | B:151 | B:276 | 28.0 | 0.124 | E | -131.6 | 147.2 | 28.0 | 0.124 | 0.0 |
HOH |
3.639 |
NH1 |
O |
|||||||||
| 6dhu | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:129 | A:276 | 30.0 | 0.133 | E | -129.6 | 146.2 | 30.0 | 0.133 | 0.0 |
HOH |
3.035 |
NH1 |
O |
||
| ARG | B:129 | B:276 | 29.0 | 0.129 | E | -128.8 | 144.0 | NA | NA | NA | |||||||||||||
| 6die | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:129 | A:276 | 28.0 | 0.124 | E | -128.9 | 144.6 | 28.0 | 0.124 | 0.0 |
HOH |
3.044 |
NH2 |
O |
||
| ARG | B:129 | B:276 | 30.0 | 0.133 | E | -129.7 | 146.7 | NA | NA | NA | |||||||||||||
| 6dih | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:129 | A:276 | 30.0 | 0.133 | E | -129.1 | 144.6 | 30.0 | 0.133 | 0.0 |
HOH |
3.030 |
NH2 |
O |
||
| ARG | B:129 | B:276 | 30.0 | 0.133 | E | -131.6 | 144.5 | NA | NA | NA | |||||||||||||
| 6dim | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:129 | A:276 | 30.0 | 0.133 | E | -128.8 | 144.6 | 30.0 | 0.133 | 0.0 |
HOH |
2.805 |
NH2 |
O |
||
| ARG | B:129 | B:276 | 32.0 | 0.142 | E | -131.7 | 141.5 | NA | NA | NA | |||||||||||||
| 6djd | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:129 | A:276 | 30.0 | 0.133 | E | -127.0 | 145.3 | 30.0 | 0.133 | 0.0 |
HOH |
2.931 |
NH2 |
O |
||
| ARG | B:129 | B:276 | 29.0 | 0.129 | E | -129.9 | 144.5 | NA | NA | NA | |||||||||||||
| 6dje | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:129 | A:276 | 30.0 | 0.133 | E | -128.4 | 144.8 | 30.0 | 0.133 | 0.0 |
HOH |
2.907 |
NH1 |
O |
||
| ARG | B:129 | B:276 | 29.0 | 0.129 | E | -133.5 | 142.8 | NA | NA | NA | |||||||||||||
| 6djf | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:129 | A:276 | 30.0 | 0.133 | E | -130.9 | 145.8 | 30.0 | 0.133 | 0.0 |
HOH |
3.779 |
NH1 |
O |
||
| ARG | B:129 | B:276 | 30.0 | 0.133 | E | -130.7 | 144.7 | NA | NA | NA | |||||||||||||
| 6djg | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:129 | A:276 | 26.0 | 0.116 | E | -125.1 | 145.4 | 26.0 | 0.116 | 0.0 |
HOH |
2.681 |
NH2 |
O |
||
| ARG | B:129 | B:276 | 31.0 | 0.138 | E | -128.1 | 145.3 | NA | NA | NA | |||||||||||||
| 6djh | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:129 | A:276 | 30.0 | 0.133 | E | -128.5 | 146.2 | 30.0 | 0.133 | 0.0 |
HOH |
2.825 |
NH1 |
O |
||
| ARG | B:129 | B:276 | 29.0 | 0.129 | E | -131.6 | 142.3 | NA | NA | NA | |||||||||||||
| 6dji | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:129 | A:276 | 23.0 | 0.102 | E | -127.3 | 146.2 | 23.0 | 0.102 | 0.0 |
HOH |
3.017 |
NH1 |
O |
||
| ARG | B:129 | B:276 | 29.0 | 0.129 | E | -130.5 | 142.4 | NA | NA | NA | |||||||||||||
| 6djj | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:129 | A:276 | 29.0 | 0.129 | E | -131.3 | 143.4 | 29.0 | 0.129 | 0.0 |
HOH |
2.840 |
NH1 |
O |
||
| ARG | B:129 | B:276 | 30.0 | 0.133 | E | -129.5 | 144.9 | NA | NA | NA | |||||||||||||
| 6myz | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:129 | A:276 | 22.0 | 0.098 | E | -128.8 | 144.9 | 22.0 | 0.098 | 0.0 |
HOH |
2.704 |
NH2 |
O |
||
| ARG | B:129 | B:276 | 29.0 | 0.129 | E | -132.2 | 143.2 | NA | NA | NA | |||||||||||||
| 6mz0 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:129 | A:276 | 27.0 | 0.12 | E | -127.7 | 142.2 | 27.0 | 0.12 | 0.0 |
HOH |
2.676 |
NH1 |
O |
||
| ARG | B:129 | B:276 | 27.0 | 0.12 | E | -131.1 | 144.3 | NA | NA | NA | |||||||||||||
| 6n0d | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | ARG | A:129 | A:276 | 30.0 | 0.133 | E | -130.1 | 144.4 | 30.0 | 0.133 | 0.0 |
HOH |
3.852 |
NH1 |
O |
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| ARG | B:129 | B:276 | 30.0 | 0.133 | E | -128.2 | 145.5 | NA | NA | NA | |||||||||||||
| 6n0n | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | ARG | A:129 | A:276 | 29.0 | 0.129 | E | -128.0 | 145.4 | 29.0 | 0.129 | 0.0 |
HOH |
2.756 |
NH1 |
O |
||
| ARG | B:129 | B:276 | 30.0 | 0.133 | E | -129.7 | 143.9 | NA | NA | NA | |||||||||||||
| 6n0o | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | ARG | A:129 | A:276 | 28.0 | 0.124 | E | -129.6 | 142.5 | 28.0 | 0.124 | 0.0 |
HOH |
2.828 |
NH2 |
O |
||
| ARG | B:129 | B:276 | 29.0 | 0.129 | E | -130.7 | 143.8 | NA | NA | NA | |||||||||||||
| 6n0r | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | ARG | A:129 | A:276 | 28.0 | 0.124 | E | -130.1 | 144.9 | 28.0 | 0.124 | 0.0 |
HOH |
3.866 |
NH1 |
O |
||
| ARG | B:129 | B:276 | 30.0 | 0.133 | E | -128.4 | 144.2 | NA | NA | NA | |||||||||||||
| 6n17 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | ARG | A:129 | A:276 | 30.0 | 0.133 | E | -129.3 | 144.6 | 30.0 | 0.133 | 0.0 |
HOH |
2.858 |
NH2 |
O |
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| ARG | B:129 | B:276 | 29.0 | 0.129 | E | -130.3 | 142.5 | NA | NA | NA | |||||||||||||
| 6n19 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | ARG | A:129 | A:276 | 28.0 | 0.124 | E | -129.0 | 145.0 | 28.0 | 0.124 | 0.0 |
HOH |
2.894 |
NH1 |
O |
||
| ARG | B:129 | B:276 | 30.0 | 0.133 | E | -129.1 | 145.2 | NA | NA | NA | |||||||||||||
| 6w4r | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-17 | ARG | A:129 | A:276 | 30.0 | 0.133 | E | -127.3 | 143.5 | 30.0 | 0.133 | 0.0 |
HOH |
2.931 |
NH1 |
O |
||
| ARG | B:129 | B:276 | 28.0 | 0.124 | E | -129.8 | 143.6 | NA | NA | NA | |||||||||||||
| 6w7j | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | ARG | A:129 | A:276 | 30.0 | 0.133 | E | -130.0 | 143.4 | 30.0 | 0.133 | 0.0 |
HOH |
3.004 |
NH1 |
O |
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| ARG | B:129 | B:276 | 30.0 | 0.133 | E | -128.3 | 145.0 | NA | NA | NA | |||||||||||||
| 6w7k | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | ARG | A:129 | A:276 | 28.0 | 0.124 | E | -130.1 | 145.8 | 28.0 | 0.124 | 0.0 |
HOH |
2.625 |
NH1 |
O |
||
| ARG | B:129 | B:276 | 29.0 | 0.129 | E | -131.6 | 144.9 | NA | NA | NA | |||||||||||||
| 6w7l | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | ARG | A:129 | A:276 | 32.0 | 0.142 | E | -129.6 | 143.0 | 32.0 | 0.142 | 0.0 |
HOH |
2.803 |
NH2 |
O |
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| ARG | B:129 | B:276 | 29.0 | 0.129 | E | -128.8 | 144.7 | NA | NA | NA | |||||||||||||
| 6mj5 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | ARG | A:128 | A:276 | 25.0 | 0.111 | E | -131.1 | 146.0 | 25.0 | 0.111 | 0.0 |
HOH |
2.970 |
NH1 |
O |
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| ARG | B:128 | B:276 | 29.0 | 0.129 | E | -130.4 | 146.8 | NA | NA | NA | |||||||||||||
| 1jy1 | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2002-02-20 | ARG | A:132 | A:276 | 13.0 | 0.058 | E | -123.2 | 141.3 | 13.0 | 0.058 | 0.0 |
HOH |
2.634 |
NH1 |
O |
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| 1mu7 | 1 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-01-07 | ARG | A:153 | A:276 | 32.0 | 0.142 | E | -122.5 | 143.8 | 32.0 | 0.142 | 0.0 |
HOH |
7.143 |
NH1 |
O |
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| ARG | B:153 | B:276 | 20.0 | 0.089 | E | -122.5 | 144.9 | NA | NA | NA | |||||||||||||
| 1mu9 | 1 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-01-07 | ARG | A:153 | A:276 | 32.0 | 0.142 | E | -125.7 | 138.9 | 32.0 | 0.142 | 0.0 |
HOH |
3.575 |
NH1 |
O |
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| ARG | B:153 | B:276 | 32.0 | 0.142 | E | -129.1 | 145.9 | NA | NA | NA | |||||||||||||
| 1nop | 2 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-03-11 | ARG | C:153 | A:276 | 29.0 | 0.129 | E | -129.6 | 139.4 | 29.0 | 0.129 | 0.0 |
HOH |
9.770 |
NH1 |
O |
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| ARG | D:153 | B:276 | 29.0 | 0.129 | E | -125.4 | 140.7 | NA | NA | NA | |||||||||||||
| 1rff | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:153 | A:276 | 29.0 | 0.129 | E | -128.7 | 144.6 | 29.0 | 0.129 | 0.0 |
HOH |
2.750 |
NH2 |
O |
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| ARG | D:153 | B:276 | 31.0 | 0.138 | E | -127.4 | 145.8 | NA | NA | NA | |||||||||||||
| 1rfi | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:153 | A:276 | 27.0 | 0.12 | E | -129.7 | 141.1 | 27.0 | 0.12 | 0.0 |
HOH |
3.835 |
NH1 |
O |
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| ARG | D:153 | B:276 | 30.0 | 0.133 | E | -127.5 | 145.4 | NA | NA | NA | |||||||||||||
| 1rg1 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:153 | A:276 | 30.0 | 0.133 | E | -126.6 | 141.3 | 30.0 | 0.133 | 0.0 |
HOH |
3.608 |
NH1 |
O |
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| ARG | D:153 | B:276 | 30.0 | 0.133 | E | -128.2 | 143.7 | NA | NA | NA | |||||||||||||
| 1rg2 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:153 | A:276 | 27.0 | 0.12 | E | -127.6 | 140.9 | 27.0 | 0.12 | 0.0 |
HOH |
3.763 |
NH1 |
O |
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| ARG | D:153 | B:276 | 31.0 | 0.138 | E | -123.2 | 145.2 | NA | NA | NA | |||||||||||||
| 1rgt | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:153 | A:276 | 29.0 | 0.129 | E | -133.2 | 142.6 | 29.0 | 0.129 | 0.0 |
HOH |
4.899 |
NH1 |
O |
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| ARG | D:153 | B:276 | 29.0 | 0.129 | E | -127.3 | 143.7 | NA | NA | NA | |||||||||||||
| 1rgu | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:153 | A:276 | 29.0 | 0.129 | E | -124.0 | 140.7 | 29.0 | 0.129 | 0.0 |
HOH |
3.761 |
NH1 |
O |
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| ARG | D:153 | B:276 | 30.0 | 0.133 | E | -127.8 | 141.2 | NA | NA | NA | |||||||||||||
| 1rh0 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:153 | A:276 | 26.0 | 0.116 | E | -128.2 | 141.2 | 26.0 | 0.116 | 0.0 |
HOH |
3.569 |
NH1 |
O |
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| ARG | D:153 | B:276 | 29.0 | 0.129 | E | -123.1 | 144.7 | NA | NA | NA | |||||||||||||
| 5nw9 | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2018-01-10 | ARG | A:153 | A:276 | 28.0 | 0.124 | E | -125.3 | 144.8 | 28.0 | 0.124 | 0.0 |
HOH |
5.983 |
NE |
O |
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| ARG | B:153 | B:276 | 29.0 | 0.129 | E | -127.6 | 143.2 | NA | NA | NA | |||||||||||||
| 5nwa | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2018-01-10 | ARG | A:153 | A:276 | 29.0 | 0.129 | E | -130.5 | 127.8 | 29.0 | 0.129 | 0.0 | ||||||
| ARG | C:153 | B:276 | 24.0 | 0.107 | E | -141.1 | 146.5 | NA | NA | NA | |||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q9nuw8-f1 | 1 | Q9NUW8 | 100.0 | 0.0 | ARG | A:276 | A:276 | 15.0 | 0.067 | E | -123.8 | 141.0 | |