Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr14 90446931 . A C CCDS9888.1:NM_001008744.1:c.839cAc>cCc_NP_001008744.1:p.280H>P Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1qzq 1 Q9NUW8 100.0 0.0 X-RAY
 2004-05-11 HIS A:155 A:280 3.0 0.015 E -140.7 -168.4 3.0 0.015 0.0 HOH
 2.907
 NE2
 O
HIS B:155 B:280 3.0 0.015 E -145.1 -164.8 3.0 0.015 0.0 HOH
 2.871
 O
 O
6dhu 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:133 A:280 2.0 0.01 E -148.4 -171.5 2.0 0.01 0.0 GHM
EDO
HOH
 8.590
9.327
2.894
 O
O
NE2
 O3
O2
O
HIS B:133 B:280 3.0 0.015 E -149.1 -171.4 NA NA NA
6die 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:133 A:280 3.0 0.015 E -149.4 -172.8 3.0 0.015 0.0 GHM
EDO
HOH
 8.722
9.380
2.936
 O
O
ND1
 O4
O2
O
HIS B:133 B:280 2.0 0.01 E -149.0 -174.5 NA NA NA
6dih 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:133 A:280 3.0 0.015 E -147.5 -172.9 3.0 0.015 0.0 GJS
EDO
HOH
 8.575
9.383
2.879
 O
O
NE2
 O03
O1
O
HIS B:133 B:280 2.0 0.01 E -146.4 -171.9 NA NA NA
6dim 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:133 A:280 2.0 0.01 E -148.3 -173.3 2.0 0.01 0.0 GJP
EDO
HOH
 8.329
9.290
2.835
 O
O
NE2
 O2
O1
O
HIS B:133 B:280 3.0 0.015 E -148.0 -170.8 NA NA NA
6djd 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:133 A:280 2.0 0.01 E -149.3 -170.7 2.0 0.01 0.0 GJP
EDO
HOH
 8.381
9.215
2.888
 O
O
NE2
 O2
O2
O
HIS B:133 B:280 3.0 0.015 E -146.2 -170.2 NA NA NA
6dje 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:133 A:280 2.0 0.01 E -146.5 -172.2 2.0 0.01 0.0 EDO
GNY
HOH
 9.259
8.322
2.900
 O
O
NE2
 O2
O13
O
HIS B:133 B:280 2.0 0.01 E -146.9 -171.2 NA NA NA
6djf 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:133 A:280 2.0 0.01 E -149.6 -169.9 2.0 0.01 0.0 EDO
GNV
HOH
 9.181
8.392
2.925
 O
O
NE2
 O2
O01
O
HIS B:133 B:280 3.0 0.015 E -150.4 -170.5 NA NA NA
6djg 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:133 A:280 2.0 0.01 E -148.7 -170.9 2.0 0.01 0.0 GNJ
HOH
 8.242
2.935
 O
NE2
 O01
O
HIS B:133 B:280 2.0 0.01 E -147.8 -171.9 NA NA NA
6djh 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:133 A:280 2.0 0.01 E -146.1 -171.7 2.0 0.01 0.0 GNM
EDO
HOH
 8.327
9.206
2.802
 O
O
NE2
 O01
O2
O
HIS B:133 B:280 3.0 0.015 E -146.2 -171.2 NA NA NA
6dji 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:133 A:280 3.0 0.015 E -147.9 -171.4 3.0 0.015 0.0 GOG
EDO
HOH
 8.492
9.370
2.881
 O
O
NE2
 O03
O2
O
HIS B:133 B:280 3.0 0.015 E -149.3 -172.4 NA NA NA
6djj 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:133 A:280 3.0 0.015 E -147.9 -171.8 3.0 0.015 0.0 GM7
EDO
HOH
 8.773
9.355
2.902
 O
O
ND1
 O11
O2
O
HIS B:133 B:280 1.0 0.005 E -147.6 -173.4 NA NA NA
6myz 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-06 HIS A:133 A:280 3.0 0.015 E -148.6 -170.8 3.0 0.015 0.0 K7D
EDO
HOH
 8.482
9.247
2.917
 O
O
NE2
 O01
O1
O
HIS B:133 B:280 3.0 0.015 E -147.6 -170.1 NA NA NA
6mz0 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-06 HIS A:133 A:280 3.0 0.015 E -145.0 -168.7 3.0 0.015 0.0 K7A
EDO
HOH
 8.539
9.143
2.941
 O
O
ND1
 O12
O2
O
HIS B:133 B:280 2.0 0.01 E -148.5 -172.2 NA NA NA
6n0d 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 HIS A:133 A:280 2.0 0.01 E -147.2 -170.6 2.0 0.01 0.0 K8J
EDO
HOH
 8.798
9.337
2.924
 O
O
ND1
 O01
O1
O
HIS B:133 B:280 2.0 0.01 E -147.1 -170.6 NA NA NA
6n0n 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 HIS A:133 A:280 2.0 0.01 E -146.6 -171.6 2.0 0.01 0.0 KAY
EDO
HOH
 8.742
9.336
2.938
 O
O
ND1
 O07
O1
O
HIS B:133 B:280 2.0 0.01 E -148.0 -171.7 NA NA NA
6n0o 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 HIS A:133 A:280 2.0 0.01 E -147.4 -170.9 2.0 0.01 0.0 EDO
K8G
HOH
 9.397
8.661
2.792
 O
O
NE2
 O2
O03
O
HIS B:133 B:280 2.0 0.01 E -141.2 -169.4 NA NA NA
6n0r 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 HIS A:133 A:280 3.0 0.015 E -148.4 -169.6 3.0 0.015 0.0 K8D
EDO
HOH
 8.812
9.321
2.936
 O
O
ND1
 O08
O2
O
HIS B:133 B:280 2.0 0.01 E -146.8 -171.4 NA NA NA
6n17 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 HIS A:133 A:280 3.0 0.015 E -147.8 -170.3 3.0 0.015 0.0 K8Y
EDO
HOH
 8.766
9.371
2.911
 O
O
NE2
 O15
O1
O
HIS B:133 B:280 2.0 0.01 E -147.2 -171.3 NA NA NA
6n19 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 HIS A:133 A:280 3.0 0.015 E -148.9 -170.8 3.0 0.015 0.0 K8V
EDO
HOH
 8.810
9.337
2.893
 O
O
ND1
 O16
O2
O
HIS B:133 B:280 2.0 0.01 E -147.9 -170.9 NA NA NA
6w4r 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-17 HIS A:133 A:280 2.0 0.01 E -149.6 -172.1 2.0 0.01 0.0 SZV
EDO
HOH
 8.610
9.316
2.939
 O
O
ND1
 O29
O2
O
HIS B:133 B:280 2.0 0.01 E -149.8 -173.3 NA NA NA
6w7j 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 HIS A:133 A:280 2.0 0.01 E -147.1 -170.8 2.0 0.01 0.0 TGM
EDO
HOH
 8.685
9.352
2.915
 O
O
NE2
 O28
O2
O
HIS B:133 B:280 2.0 0.01 E -148.1 -172.2 NA NA NA
6w7k 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 HIS A:133 A:280 2.0 0.01 E -147.3 -170.9 2.0 0.01 0.0 TG7
EDO
HOH
 8.576
9.265
2.877
 O
O
NE2
 O27
O2
O
HIS B:133 B:280 3.0 0.015 E -147.5 -171.2 NA NA NA
6w7l 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 HIS A:133 A:280 3.0 0.015 E -149.2 -171.8 3.0 0.015 0.0 TGV
EDO
HOH
 8.669
9.412
2.984
 O
O
NE2
 O27
O2
O
HIS B:133 B:280 3.0 0.015 E -146.2 -173.8 NA NA NA
6mj5 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 HIS A:132 A:280 3.0 0.015 E -147.1 -171.6 3.0 0.015 0.0 EDO
JTA
HOH
 9.199
8.348
2.907
 O
O
NE2
 O2
O03
O
HIS B:132 B:280 3.0 0.015 E -145.9 -171.2 NA NA NA
1jy1 1 Q9NUW8 98.92 0.0 X-RAY
 2002-02-20 HIS A:136 A:280 3.0 0.015 E -154.4 -169.4 3.0 0.015 0.0 HOH
 2.928
 NE2
 O
1mu7 1 20127586 98.92 0.0 X-RAY
 2003-01-07 HIS A:157 A:280 2.0 0.01 E -146.8 -163.9 2.0 0.01 0.0 WO4
HOH
 7.904
2.959
 O
NE2
 O2
O
HIS B:157 B:280 2.0 0.01 E -144.5 -164.6 NA NA NA
1mu9 1 20127586 98.92 0.0 X-RAY
 2003-01-07 HIS A:157 A:280 2.0 0.01 E -147.6 -167.1 2.0 0.01 0.0 VO4
HOH
 7.984
2.975
 O
ND1
 O3
O
HIS B:157 B:280 3.0 0.015 E -144.5 -166.0 NA NA NA
1nop 2 20127586 98.92 0.0 X-RAY
 2003-03-11 HIS C:157 A:280 2.0 0.01 E -152.5 -168.8 2.0 0.01 0.0 VO4
HOH
 8.343
3.121
 O
O
 O3
O
HIS D:157 B:280 3.0 0.015 E -147.1 -166.7 NA NA NA
1rff 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 HIS C:157 A:280 2.0 0.01 E -147.7 -170.0 2.0 0.01 0.0 VO4
HOH
 8.343
2.871
 O
NE2
 O3
O
HIS D:157 B:280 2.0 0.01 E -148.6 -172.8 NA NA NA
1rfi 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 HIS C:157 A:280 2.0 0.01 E -149.5 -168.1 2.0 0.01 0.0 VO4
HOH
 8.260
3.018
 O
NE2
 O3
O
HIS D:157 B:280 3.0 0.015 E -143.9 -171.0 NA NA NA
1rg1 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 HIS C:157 A:280 2.0 0.01 E -147.7 -167.0 2.0 0.01 0.0 VO4
HOH
 8.320
2.957
 O
ND1
 O3
O
HIS D:157 B:280 1.0 0.005 E -150.3 -168.6 NA NA NA
1rg2 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 HIS C:157 A:280 1.0 0.005 E -149.9 -168.1 1.0 0.005 0.0 VO4
HOH
 8.315
2.940
 O
O
 O3
O
HIS D:157 B:280 3.0 0.015 E -143.3 -166.4 NA NA NA
1rgt 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 HIS C:157 A:280 1.0 0.005 E -144.5 -167.2 1.0 0.005 0.0 VO4
HOH
 8.368
2.869
 O
NE2
 O3
O
HIS D:157 B:280 2.0 0.01 E -147.0 -167.5 NA NA NA
1rgu 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 HIS C:157 A:280 2.0 0.01 E -153.4 -168.9 2.0 0.01 0.0 VO4
HOH
 8.236
2.961
 O
NE2
 O3
O
HIS D:157 B:280 2.0 0.01 E -147.7 -168.1 NA NA NA
1rh0 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 HIS C:157 A:280 2.0 0.01 E -152.6 -171.3 2.0 0.01 0.0 VO4
HOH
 8.368
2.834
 O
ND1
 O3
O
HIS D:157 B:280 3.0 0.015 E -147.8 -168.1 NA NA NA
5nw9 1 Q9NUW8 98.92 0.0 X-RAY
 2018-01-10 HIS A:157 A:280 3.0 0.015 E -153.6 -167.8 3.0 0.015 0.0 DA
DA
HOH
 8.452
8.452
3.039
 O
O
ND1
 OP1
OP1
O
HIS B:157 B:280 3.0 0.015 E -155.9 -173.2 NA NA NA
5nwa 1 Q9NUW8 98.92 0.0 X-RAY
 2018-01-10 HIS A:157 A:280 4.0 0.021 E -142.8 -173.8 4.0 0.021 0.0 DA
 8.921
 O
 OP1
HIS C:157 B:280 4.0 0.021 E -139.9 -177.3 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q9nuw8-f1 1 Q9NUW8 100.0 0.0 HIS A:280 A:280 2.0 0.01 E -138.3 173.8