Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr14 | 90446959 | . | G | A | CCDS9888.1:NM_001008744.1:c.867tgG>tgA_NP_001008744.1:p.289W>* | Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 1qzq | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2004-05-11 | TRP | A:164 | A:289 | 4.0 | 0.016 | G | -116.8 | 8.0 | 4.0 | 0.016 | 0.0 |
HOH |
2.866 |
O |
O |
||
| TRP | B:164 | B:289 | 6.0 | 0.024 | G | -116.0 | 13.9 | 6.0 | 0.024 | 0.0 |
HOH |
2.972 |
O |
O |
|||||||||
| 6dhu | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TRP | A:142 | A:289 | 2.0 | 0.008 | G | -111.5 | 7.9 | 2.0 | 0.008 | 0.0 |
HOH |
2.839 |
O |
O |
||
| TRP | B:142 | B:289 | 2.0 | 0.008 | G | -111.8 | 9.6 | NA | NA | NA | |||||||||||||
| 6die | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TRP | A:142 | A:289 | 2.0 | 0.008 | G | -111.6 | 7.5 | 2.0 | 0.008 | 0.0 |
HOH |
2.999 |
O |
O |
||
| TRP | B:142 | B:289 | 2.0 | 0.008 | G | -109.8 | 10.8 | NA | NA | NA | |||||||||||||
| 6dih | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TRP | A:142 | A:289 | 1.0 | 0.004 | G | -113.0 | 7.8 | 1.0 | 0.004 | 0.0 |
HOH |
2.952 |
O |
O |
||
| TRP | B:142 | B:289 | 2.0 | 0.008 | G | -113.7 | 11.7 | NA | NA | NA | |||||||||||||
| 6dim | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TRP | A:142 | A:289 | 1.0 | 0.004 | G | -111.8 | 7.5 | 1.0 | 0.004 | 0.0 |
HOH |
2.949 |
O |
O |
||
| TRP | B:142 | B:289 | 2.0 | 0.008 | G | -112.4 | 13.6 | NA | NA | NA | |||||||||||||
| 6djd | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TRP | A:142 | A:289 | 4.0 | 0.016 | G | -111.5 | 5.4 | 4.0 | 0.016 | 0.0 |
HOH |
2.881 |
O |
O |
||
| TRP | B:142 | B:289 | 2.0 | 0.008 | G | -110.7 | 11.1 | NA | NA | NA | |||||||||||||
| 6dje | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TRP | A:142 | A:289 | 1.0 | 0.004 | G | -111.0 | 9.0 | 1.0 | 0.004 | 0.0 |
HOH |
2.853 |
O |
O |
||
| TRP | B:142 | B:289 | 2.0 | 0.008 | G | -108.6 | 11.6 | NA | NA | NA | |||||||||||||
| 6djf | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TRP | A:142 | A:289 | 2.0 | 0.008 | G | -112.6 | 9.4 | 2.0 | 0.008 | 0.0 |
HOH |
2.863 |
O |
O |
||
| TRP | B:142 | B:289 | 2.0 | 0.008 | G | -110.9 | 9.8 | NA | NA | NA | |||||||||||||
| 6djg | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TRP | A:142 | A:289 | 1.0 | 0.004 | G | -112.2 | 6.1 | 1.0 | 0.004 | 0.0 |
HOH |
2.953 |
O |
O |
||
| TRP | B:142 | B:289 | 2.0 | 0.008 | G | -109.4 | 9.3 | NA | NA | NA | |||||||||||||
| 6djh | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TRP | A:142 | A:289 | 1.0 | 0.004 | G | -108.3 | 9.3 | 1.0 | 0.004 | 0.0 |
HOH |
2.887 |
O |
O |
||
| TRP | B:142 | B:289 | 3.0 | 0.012 | G | -108.2 | 10.3 | NA | NA | NA | |||||||||||||
| 6dji | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TRP | A:142 | A:289 | 1.0 | 0.004 | G | -111.0 | 9.0 | 1.0 | 0.004 | 0.0 |
HOH |
2.904 |
O |
O |
||
| TRP | B:142 | B:289 | 3.0 | 0.012 | G | -113.1 | 10.0 | NA | NA | NA | |||||||||||||
| 6djj | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TRP | A:142 | A:289 | 1.0 | 0.004 | G | -111.0 | 8.4 | 1.0 | 0.004 | 0.0 |
HOH |
2.969 |
O |
O |
||
| TRP | B:142 | B:289 | 6.0 | 0.024 | G | -110.7 | 9.6 | NA | NA | NA | |||||||||||||
| 6myz | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-06 | TRP | A:142 | A:289 | 2.0 | 0.008 | G | -111.0 | 9.0 | 2.0 | 0.008 | 0.0 |
HOH |
2.802 |
O |
O |
||
| TRP | B:142 | B:289 | 2.0 | 0.008 | G | -112.3 | 9.8 | NA | NA | NA | |||||||||||||
| 6mz0 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-06 | TRP | A:142 | A:289 | 2.0 | 0.008 | G | -113.7 | 10.4 | 2.0 | 0.008 | 0.0 |
HOH |
2.904 |
O |
O |
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| TRP | B:142 | B:289 | 1.0 | 0.004 | G | -109.2 | 11.5 | NA | NA | NA | |||||||||||||
| 6n0d | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | TRP | A:142 | A:289 | 1.0 | 0.004 | G | -111.2 | 7.1 | 1.0 | 0.004 | 0.0 |
HOH |
2.866 |
O |
O |
||
| TRP | B:142 | B:289 | 2.0 | 0.008 | G | -113.1 | 10.3 | NA | NA | NA | |||||||||||||
| 6n0n | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | TRP | A:142 | A:289 | 2.0 | 0.008 | G | -112.0 | 9.9 | 2.0 | 0.008 | 0.0 |
HOH |
2.918 |
O |
O |
||
| TRP | B:142 | B:289 | 2.0 | 0.008 | G | -111.9 | 8.3 | NA | NA | NA | |||||||||||||
| 6n0o | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | TRP | A:142 | A:289 | 2.0 | 0.008 | G | -110.3 | 7.0 | 2.0 | 0.008 | 0.0 |
HOH |
2.869 |
O |
O |
||
| TRP | B:142 | B:289 | 3.0 | 0.012 | G | -111.2 | 8.4 | NA | NA | NA | |||||||||||||
| 6n0r | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | TRP | A:142 | A:289 | 2.0 | 0.008 | G | -111.2 | 9.3 | 2.0 | 0.008 | 0.0 |
HOH |
2.887 |
O |
O |
||
| TRP | B:142 | B:289 | 2.0 | 0.008 | G | -111.8 | 10.2 | NA | NA | NA | |||||||||||||
| 6n17 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | TRP | A:142 | A:289 | 1.0 | 0.004 | G | -111.1 | 7.5 | 1.0 | 0.004 | 0.0 |
HOH |
2.845 |
O |
O |
||
| TRP | B:142 | B:289 | 2.0 | 0.008 | G | -113.8 | 10.6 | NA | NA | NA | |||||||||||||
| 6n19 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | TRP | A:142 | A:289 | 1.0 | 0.004 | G | -111.2 | 7.7 | 1.0 | 0.004 | 0.0 |
HOH |
2.884 |
O |
O |
||
| TRP | B:142 | B:289 | 1.0 | 0.004 | G | -112.2 | 11.6 | NA | NA | NA | |||||||||||||
| 6w4r | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-17 | TRP | A:142 | A:289 | 1.0 | 0.004 | G | -111.0 | 8.2 | 1.0 | 0.004 | 0.0 |
HOH |
2.913 |
O |
O |
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| TRP | B:142 | B:289 | 2.0 | 0.008 | G | -107.8 | 13.5 | NA | NA | NA | |||||||||||||
| 6w7j | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | TRP | A:142 | A:289 | 2.0 | 0.008 | G | -109.7 | 8.1 | 2.0 | 0.008 | 0.0 |
HOH |
2.919 |
O |
O |
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| TRP | B:142 | B:289 | 3.0 | 0.012 | G | -109.8 | 10.6 | NA | NA | NA | |||||||||||||
| 6w7k | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | TRP | A:142 | A:289 | 2.0 | 0.008 | G | -111.2 | 8.1 | 2.0 | 0.008 | 0.0 |
HOH |
2.904 |
O |
O |
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| TRP | B:142 | B:289 | 2.0 | 0.008 | G | -111.8 | 12.1 | NA | NA | NA | |||||||||||||
| 6w7l | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | TRP | A:142 | A:289 | 2.0 | 0.008 | G | -110.8 | 11.8 | 2.0 | 0.008 | 0.0 |
HOH |
2.912 |
O |
O |
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| TRP | B:142 | B:289 | 2.0 | 0.008 | G | -111.1 | 16.3 | NA | NA | NA | |||||||||||||
| 6mj5 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | TRP | A:141 | A:289 | 3.0 | 0.012 | G | -110.8 | 9.5 | 3.0 | 0.012 | 0.0 |
HOH |
2.845 |
O |
O |
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| TRP | B:141 | B:289 | 2.0 | 0.008 | G | -107.2 | 12.1 | NA | NA | NA | |||||||||||||
| 1jy1 | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2002-02-20 | TRP | A:145 | A:289 | 2.0 | 0.008 | G | -118.5 | 13.3 | 2.0 | 0.008 | 0.0 |
HOH |
2.946 |
O |
O |
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| 1mu7 | 1 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-01-07 | TRP | A:166 | A:289 | 2.0 | 0.008 | G | -115.1 | 7.9 | 2.0 | 0.008 | 0.0 |
HOH |
2.992 |
O |
O |
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| TRP | B:166 | B:289 | 2.0 | 0.008 | G | -117.6 | 9.5 | NA | NA | NA | |||||||||||||
| 1mu9 | 1 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-01-07 | TRP | A:166 | A:289 | 4.0 | 0.016 | G | -117.2 | 10.5 | 4.0 | 0.016 | 0.0 |
HOH |
2.981 |
O |
O |
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| TRP | B:166 | B:289 | 1.0 | 0.004 | G | -112.9 | 9.1 | NA | NA | NA | |||||||||||||
| 1nop | 2 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-03-11 | TRP | C:166 | A:289 | 3.0 | 0.012 | G | -118.8 | 9.6 | 3.0 | 0.012 | 0.0 |
HOH |
5.207 |
N |
O |
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| TRP | D:166 | B:289 | 2.0 | 0.008 | G | -114.7 | 16.3 | NA | NA | NA | |||||||||||||
| 1rff | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | TRP | C:166 | A:289 | 1.0 | 0.004 | G | -114.0 | 9.4 | 1.0 | 0.004 | 0.0 |
HOH |
2.860 |
O |
O |
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| TRP | D:166 | B:289 | 2.0 | 0.008 | G | -112.9 | 8.1 | NA | NA | NA | |||||||||||||
| 1rfi | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | TRP | C:166 | A:289 | 3.0 | 0.012 | G | -115.2 | 13.0 | 3.0 | 0.012 | 0.0 |
HOH |
2.897 |
O |
O |
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| TRP | D:166 | B:289 | 2.0 | 0.008 | G | -112.2 | 9.5 | NA | NA | NA | |||||||||||||
| 1rg1 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | TRP | C:166 | A:289 | 4.0 | 0.016 | G | -113.0 | 10.5 | 4.0 | 0.016 | 0.0 |
HOH |
2.847 |
O |
O |
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| TRP | D:166 | B:289 | 2.0 | 0.008 | G | -116.6 | 8.5 | NA | NA | NA | |||||||||||||
| 1rg2 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | TRP | C:166 | A:289 | 3.0 | 0.012 | G | -109.9 | 12.6 | 3.0 | 0.012 | 0.0 |
HOH |
2.852 |
O |
O |
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| TRP | D:166 | B:289 | 2.0 | 0.008 | G | -112.8 | 7.8 | NA | NA | NA | |||||||||||||
| 1rgt | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | TRP | C:166 | A:289 | 4.0 | 0.016 | G | -110.3 | 6.2 | 4.0 | 0.016 | 0.0 |
HOH |
2.794 |
O |
O |
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| TRP | D:166 | B:289 | 3.0 | 0.012 | G | -114.5 | 10.9 | NA | NA | NA | |||||||||||||
| 1rgu | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | TRP | C:166 | A:289 | 1.0 | 0.004 | G | -117.2 | 9.7 | 1.0 | 0.004 | 0.0 |
HOH |
2.848 |
O |
O |
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| TRP | D:166 | B:289 | 2.0 | 0.008 | G | -116.9 | 12.2 | NA | NA | NA | |||||||||||||
| 1rh0 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | TRP | C:166 | A:289 | 2.0 | 0.008 | G | -108.3 | 9.3 | 2.0 | 0.008 | 0.0 |
HOH |
3.191 |
O |
O |
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| TRP | D:166 | B:289 | 3.0 | 0.012 | G | -114.5 | 12.0 | NA | NA | NA | |||||||||||||
| 5nw9 | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2018-01-10 | TRP | A:166 | A:289 | 2.0 | 0.008 | G | -113.7 | 15.0 | 2.0 | 0.008 | 0.0 |
HOH |
3.311 |
C |
O |
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| TRP | B:166 | B:289 | 1.0 | 0.004 | G | -109.7 | 11.6 | NA | NA | NA | |||||||||||||
| 5nwa | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2018-01-10 | TRP | A:166 | A:289 | 4.0 | 0.016 | T | -107.8 | 7.6 | 4.0 | 0.016 | 0.0 | ||||||
| TRP | C:166 | B:289 | 3.0 | 0.012 | G | -106.9 | 1.5 | NA | NA | NA | |||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q9nuw8-f1 | 1 | Q9NUW8 | 100.0 | 0.0 | TRP | A:289 | A:289 | 3.0 | 0.012 | H | -106.7 | -1.7 | |