Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr14 | 90450886 | . | G | A | CCDS9888.1:NM_001008744.1:c.911cGa>cAa_NP_001008744.1:p.304R>Q | Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1, mRNA. |
|---|---|---|---|---|---|---|---|
|
|
|
|
|
PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 1qzq | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2004-05-11 | ARG | A:179 | A:304 | 114.0 | 0.507 | B | -71.1 | 140.6 | 114.0 | 0.507 | 0.0 |
HOH |
2.863 |
N |
O |
||
| ARG | B:179 | B:304 | 130.0 | 0.578 | B | -74.0 | 142.3 | 130.0 | 0.578 | 0.0 |
HOH |
3.108 |
NH1 |
O |
|||||||||
| 6dhu | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:157 | A:304 | 120.0 | 0.533 | B | -75.4 | 142.6 | 120.0 | 0.533 | 0.0 |
EDO HOH |
8.654 2.797 |
C O |
O2 O |
||
| ARG | B:157 | B:304 | 115.0 | 0.511 | B | -75.8 | 143.0 | NA | NA | NA | |||||||||||||
| 6die | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:157 | A:304 | 132.0 | 0.587 | B | -76.6 | 145.8 | 132.0 | 0.587 | 0.0 |
HOH |
2.498 |
O |
O |
||
| ARG | B:157 | B:304 | 130.0 | 0.578 | B | -78.4 | 141.8 | NA | NA | NA | |||||||||||||
| 6dih | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:157 | A:304 | 114.0 | 0.507 | B | -75.1 | 144.4 | 114.0 | 0.507 | 0.0 |
EDO HOH |
8.768 2.887 |
C N |
O1 O |
||
| ARG | B:157 | B:304 | 133.0 | 0.591 | B | -75.0 | 142.0 | NA | NA | NA | |||||||||||||
| 6dim | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:157 | A:304 | 124.0 | 0.551 | B | -75.5 | 146.5 | 124.0 | 0.551 | 0.0 |
EDO HOH |
8.667 2.482 |
C O |
O1 O |
||
| ARG | B:157 | B:304 | 126.0 | 0.56 | B | -71.6 | 145.7 | NA | NA | NA | |||||||||||||
| 6djd | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:157 | A:304 | 124.0 | 0.551 | B | -75.4 | 143.8 | 124.0 | 0.551 | 0.0 |
EDO HOH |
8.802 2.897 |
C N |
O1 O |
||
| ARG | B:157 | B:304 | 64.0 | NA | B | -75.3 | 145.4 | NA | NA | NA | |||||||||||||
| 6dje | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:157 | A:304 | 119.0 | 0.529 | B | -75.5 | 144.8 | 119.0 | 0.529 | 0.0 |
EDO HOH |
8.637 2.526 |
C O |
O2 O |
||
| ARG | B:157 | B:304 | 65.0 | NA | B | -75.3 | 145.0 | NA | NA | NA | |||||||||||||
| 6djf | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:157 | A:304 | 114.0 | 0.507 | B | -74.9 | 143.4 | 114.0 | 0.507 | 0.0 |
HOH |
2.867 |
N |
O |
||
| ARG | B:157 | B:304 | 119.0 | 0.529 | B | -76.4 | 143.1 | NA | NA | NA | |||||||||||||
| 6djg | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:157 | A:304 | 110.0 | 0.489 | B | -74.9 | 140.3 | 110.0 | 0.489 | 0.0 |
HOH |
2.726 |
N |
O |
||
| ARG | B:157 | B:304 | 112.0 | 0.498 | B | -74.9 | 142.8 | NA | NA | NA | |||||||||||||
| 6djh | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:157 | A:304 | 123.0 | 0.547 | B | -73.1 | 141.0 | 123.0 | 0.547 | 0.0 |
HOH |
2.533 |
O |
O |
||
| ARG | B:157 | B:304 | 106.0 | 0.471 | B | -65.6 | 143.3 | NA | NA | NA | |||||||||||||
| 6dji | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:157 | A:304 | 120.0 | 0.533 | B | -75.0 | 144.3 | 120.0 | 0.533 | 0.0 |
EDO HOH |
8.737 2.652 |
C O |
O2 O |
||
| ARG | B:157 | B:304 | 118.0 | 0.524 | B | -74.5 | 143.9 | NA | NA | NA | |||||||||||||
| 6djj | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:157 | A:304 | 114.0 | 0.507 | B | -77.0 | 143.2 | 114.0 | 0.507 | 0.0 |
HOH |
2.971 |
N |
O |
||
| ARG | B:157 | B:304 | 137.0 | 0.609 | B | -76.3 | 143.4 | NA | NA | NA | |||||||||||||
| 6myz | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:157 | A:304 | 117.0 | 0.52 | B | -74.9 | 144.2 | 117.0 | 0.52 | 0.0 |
EDO HOH |
8.729 2.486 |
C O |
O2 O |
||
| ARG | B:157 | B:304 | 119.0 | 0.529 | B | -76.4 | 146.6 | NA | NA | NA | |||||||||||||
| 6mz0 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:157 | A:304 | 136.0 | 0.604 | B | -73.8 | 142.3 | 136.0 | 0.604 | 0.0 |
HOH |
2.791 |
N |
O |
||
| ARG | B:157 | B:304 | 138.0 | 0.613 | B | -70.7 | 144.2 | NA | NA | NA | |||||||||||||
| 6n0d | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | ARG | A:157 | A:304 | 116.0 | 0.516 | B | -75.2 | 140.0 | 116.0 | 0.516 | 0.0 |
HOH |
2.712 |
O |
O |
||
| ARG | B:157 | B:304 | 65.0 | NA | B | -72.9 | 141.3 | NA | NA | NA | |||||||||||||
| 6n0n | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | ARG | A:157 | A:304 | 113.0 | 0.502 | B | -74.6 | 142.1 | 113.0 | 0.502 | 0.0 |
HOH |
2.891 |
N |
O |
||
| ARG | B:157 | B:304 | 111.0 | 0.493 | B | -76.5 | 141.0 | NA | NA | NA | |||||||||||||
| 6n0o | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | ARG | A:157 | A:304 | 111.0 | 0.493 | B | -72.9 | 145.9 | 111.0 | 0.493 | 0.0 |
HOH |
2.576 |
O |
O |
||
| ARG | B:157 | B:304 | 130.0 | 0.578 | B | -72.0 | 145.1 | NA | NA | NA | |||||||||||||
| 6n0r | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | ARG | A:157 | A:304 | 107.0 | 0.476 | B | -75.4 | 143.2 | 107.0 | 0.476 | 0.0 |
EDO HOH |
8.722 2.757 |
C O |
O2 O |
||
| ARG | B:157 | B:304 | 114.0 | 0.507 | B | -73.6 | 145.1 | NA | NA | NA | |||||||||||||
| 6n17 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | ARG | A:157 | A:304 | 133.0 | 0.591 | B | -75.8 | 143.2 | 133.0 | 0.591 | 0.0 |
HOH |
2.604 |
O |
O |
||
| ARG | B:157 | B:304 | 102.0 | NA | B | -74.6 | 141.8 | NA | NA | NA | |||||||||||||
| 6n19 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | ARG | A:157 | A:304 | 136.0 | 0.604 | B | -74.1 | 141.1 | 136.0 | 0.604 | 0.0 |
HOH |
2.631 |
O |
O |
||
| ARG | B:157 | B:304 | 132.0 | 0.587 | B | -75.9 | 140.5 | NA | NA | NA | |||||||||||||
| 6w4r | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-17 | ARG | A:157 | A:304 | 137.0 | 0.609 | B | -74.9 | 142.4 | 137.0 | 0.609 | 0.0 |
HOH |
2.873 |
O |
O |
||
| ARG | B:157 | B:304 | 126.0 | 0.56 | B | -76.6 | 144.1 | NA | NA | NA | |||||||||||||
| 6w7j | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | ARG | A:157 | A:304 | 118.0 | 0.524 | B | -75.4 | 140.9 | 118.0 | 0.524 | 0.0 |
HOH |
2.598 |
O |
O |
||
| ARG | B:157 | B:304 | 112.0 | 0.498 | B | -72.2 | 142.0 | NA | NA | NA | |||||||||||||
| 6w7k | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | ARG | A:157 | A:304 | 109.0 | 0.484 | B | -71.9 | 142.2 | 109.0 | 0.484 | 0.0 |
HOH |
2.565 |
O |
O |
||
| ARG | B:157 | B:304 | 140.0 | 0.622 | B | -74.5 | 148.6 | NA | NA | NA | |||||||||||||
| 6w7l | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | ARG | A:157 | A:304 | 123.0 | 0.547 | B | -72.2 | 145.9 | 123.0 | 0.547 | 0.0 |
HOH |
2.726 |
N |
O |
||
| ARG | B:157 | B:304 | 117.0 | 0.52 | B | -75.6 | 145.7 | NA | NA | NA | |||||||||||||
| 6mj5 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | ARG | A:156 | A:304 | 114.0 | 0.507 | B | -73.8 | 142.5 | 114.0 | 0.507 | 0.0 |
HOH |
2.837 |
N |
O |
||
| ARG | B:156 | B:304 | 135.0 | 0.6 | B | -76.7 | 143.4 | NA | NA | NA | |||||||||||||
| 1jy1 | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2002-02-20 | ARG | A:160 | A:304 | 146.0 | 0.649 | B | -79.6 | 139.4 | 146.0 | 0.649 | 0.0 |
HOH |
2.485 |
NH2 |
O |
||
| 1mu7 | 1 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-01-07 | ARG | A:181 | A:304 | 167.0 | 0.742 | B | -83.9 | 145.3 | 167.0 | 0.742 | 0.0 |
HOH |
2.555 |
CZ |
O |
||
| ARG | B:181 | B:304 | 169.0 | 0.751 | B | -73.5 | 140.1 | NA | NA | NA | |||||||||||||
| 1mu9 | 1 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-01-07 | ARG | A:181 | A:304 | 155.0 | 0.689 | B | -77.6 | 144.8 | 155.0 | 0.689 | 0.0 |
HOH |
2.656 |
NH1 |
O |
||
| ARG | B:181 | B:304 | 170.0 | 0.756 | B | -70.3 | 143.0 | NA | NA | NA | |||||||||||||
| 1nop | 2 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-03-11 | ARG | C:181 | A:304 | 132.0 | 0.587 | B | -70.2 | 144.0 | 132.0 | 0.587 | 0.0 |
HOH |
3.728 |
CG |
O |
||
| ARG | D:181 | B:304 | 171.0 | 0.76 | B | -61.1 | 143.6 | NA | NA | NA | |||||||||||||
| 1rff | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:181 | A:304 | 124.0 | 0.551 | B | -70.3 | 141.6 | 124.0 | 0.551 | 0.0 |
HOH |
2.383 |
NH2 |
O |
||
| ARG | D:181 | B:304 | 165.0 | 0.733 | B | -68.4 | 147.3 | NA | NA | NA | |||||||||||||
| 1rfi | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:181 | A:304 | 136.0 | 0.604 | B | -73.6 | 145.4 | 136.0 | 0.604 | 0.0 |
HOH |
2.833 |
N |
O |
||
| ARG | D:181 | B:304 | 164.0 | 0.729 | B | -67.6 | 143.0 | NA | NA | NA | |||||||||||||
| 1rg1 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:181 | A:304 | 122.0 | 0.542 | B | -73.1 | 143.0 | 122.0 | 0.542 | 0.0 |
HOH |
3.126 |
N |
O |
||
| ARG | D:181 | B:304 | 164.0 | 0.729 | B | -67.1 | 146.5 | NA | NA | NA | |||||||||||||
| 1rg2 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:181 | A:304 | 139.0 | 0.618 | B | -64.1 | 139.2 | 139.0 | 0.618 | 0.0 |
HOH |
2.914 |
N |
O |
||
| ARG | D:181 | B:304 | 171.0 | 0.76 | B | -67.7 | 144.2 | NA | NA | NA | |||||||||||||
| 1rgt | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:181 | A:304 | 133.0 | 0.591 | B | -69.2 | 143.3 | 133.0 | 0.591 | 0.0 |
HOH |
3.948 |
C |
O |
||
| ARG | D:181 | B:304 | 168.0 | 0.747 | B | -66.5 | 148.9 | NA | NA | NA | |||||||||||||
| 1rgu | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:181 | A:304 | 118.0 | 0.524 | B | -67.0 | 141.9 | 118.0 | 0.524 | 0.0 |
HOH |
2.794 |
N |
O |
||
| ARG | D:181 | B:304 | 174.0 | 0.773 | B | -62.9 | 149.1 | NA | NA | NA | |||||||||||||
| 1rh0 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:181 | A:304 | 139.0 | 0.618 | B | -72.1 | 143.4 | 139.0 | 0.618 | 0.0 |
HOH |
2.913 |
NE |
O |
||
| ARG | D:181 | B:304 | 172.0 | 0.764 | B | -61.4 | 141.4 | NA | NA | NA | |||||||||||||
| 5nw9 | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2018-01-10 | ARG | A:181 | A:304 | 141.0 | 0.627 | B | -73.6 | 144.9 | 141.0 | 0.627 | 0.0 | ||||||
| ARG | B:181 | B:304 | 128.0 | 0.569 | B | -83.3 | 145.9 | NA | NA | NA | |||||||||||||
| 5nwa | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2018-01-10 | ARG | A:181 | A:304 | 124.0 | 0.551 | B | -69.5 | 146.4 | 124.0 | 0.551 | 0.0 | ||||||
| ARG | C:181 | B:304 | 126.0 | 0.56 | B | -78.1 | 148.6 | NA | NA | NA | |||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q9nuw8-f1 | 1 | Q9NUW8 | 100.0 | 0.0 | ARG | A:304 | A:304 | 165.0 | 0.733 | B | -72.2 | 137.6 | |