Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr14 | 90450906 | . | A | C | CCDS9888.1:NM_001008744.1:c.931Aaa>Caa_NP_001008744.1:p.311K>Q | Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 1qzq | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2004-05-11 | LYS | A:186 | A:311 | 123.0 | 0.615 | -130.5 | 156.3 | 123.0 | 0.615 | 0.0 |
HOH |
3.571 |
NZ |
O |
|||
| LYS | B:186 | B:311 | 133.0 | 0.665 | -176.0 | 141.9 | 133.0 | 0.665 | 0.0 |
HOH |
3.173 |
CD |
O |
||||||||||
| 6dhu | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | LYS | A:164 | A:311 | 118.0 | 0.59 | -145.9 | 163.2 | 118.0 | 0.59 | 0.0 |
EDO HOH |
2.669 2.527 |
O NZ |
O2 O |
|||
| LYS | B:164 | B:311 | 121.0 | 0.605 | -141.1 | 162.2 | NA | NA | NA | ||||||||||||||
| 6die | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | LYS | A:164 | A:311 | 124.0 | 0.62 | -142.3 | 160.3 | 124.0 | 0.62 | 0.0 |
HOH |
2.739 |
O |
O |
|||
| LYS | B:164 | B:311 | 124.0 | 0.62 | -140.2 | 162.6 | NA | NA | NA | ||||||||||||||
| 6dih | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | LYS | A:164 | A:311 | 119.0 | 0.595 | -148.8 | 159.2 | 119.0 | 0.595 | 0.0 |
EDO HOH |
2.750 3.055 |
O NZ |
O1 O |
|||
| LYS | B:164 | B:311 | 122.0 | 0.61 | -138.7 | 162.3 | NA | NA | NA | ||||||||||||||
| 6dim | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | LYS | A:164 | A:311 | 122.0 | 0.61 | -141.2 | 159.4 | 122.0 | 0.61 | 0.0 |
EDO HOH |
2.771 3.167 |
O O |
O1 O |
|||
| LYS | B:164 | B:311 | 124.0 | 0.62 | -140.7 | 162.7 | NA | NA | NA | ||||||||||||||
| 6djd | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | LYS | A:164 | A:311 | 118.0 | 0.59 | -145.2 | 159.5 | 118.0 | 0.59 | 0.0 |
EDO HOH |
2.753 3.239 |
O NZ |
O1 O |
|||
| LYS | B:164 | B:311 | 122.0 | 0.61 | -138.4 | 164.1 | NA | NA | NA | ||||||||||||||
| 6dje | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | LYS | A:164 | A:311 | 116.0 | 0.58 | -144.8 | 160.1 | 116.0 | 0.58 | 0.0 |
EDO HOH |
2.687 2.962 |
O NZ |
O2 O |
|||
| LYS | B:164 | B:311 | 120.0 | 0.6 | -138.7 | 160.5 | NA | NA | NA | ||||||||||||||
| 6djf | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | LYS | A:164 | A:311 | 111.0 | 0.555 | -128.6 | 154.5 | 111.0 | 0.555 | 0.0 |
HOH |
2.433 |
NZ |
O |
|||
| LYS | B:164 | B:311 | 122.0 | 0.61 | -138.5 | 161.6 | NA | NA | NA | ||||||||||||||
| 6djg | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | LYS | A:164 | A:311 | 122.0 | 0.61 | -141.1 | 160.2 | 122.0 | 0.61 | 0.0 |
HOH |
3.257 |
O |
O |
|||
| LYS | B:164 | B:311 | 122.0 | 0.61 | -142.8 | 160.3 | NA | NA | NA | ||||||||||||||
| 6djh | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | LYS | A:164 | A:311 | 106.0 | 0.53 | -141.9 | 161.5 | 106.0 | 0.53 | 0.0 |
HOH |
2.669 |
NZ |
O |
|||
| LYS | B:164 | B:311 | 121.0 | 0.605 | -133.8 | 159.1 | NA | NA | NA | ||||||||||||||
| 6dji | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | LYS | A:164 | A:311 | 122.0 | 0.61 | -144.6 | 159.6 | 122.0 | 0.61 | 0.0 |
EDO HOH |
2.814 3.138 |
O O |
O2 O |
|||
| LYS | B:164 | B:311 | 121.0 | 0.605 | -135.5 | 162.6 | NA | NA | NA | ||||||||||||||
| 6djj | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | LYS | A:164 | A:311 | 123.0 | 0.615 | -141.8 | 162.3 | 123.0 | 0.615 | 0.0 |
HOH |
3.196 |
O |
O |
|||
| LYS | B:164 | B:311 | 124.0 | 0.62 | -138.8 | 161.6 | NA | NA | NA | ||||||||||||||
| 6myz | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-06 | LYS | A:164 | A:311 | 102.0 | 0.51 | -137.3 | 157.5 | 102.0 | 0.51 | 0.0 |
EDO HOH |
2.803 2.500 |
O NZ |
O2 O |
|||
| LYS | B:164 | B:311 | 123.0 | 0.615 | -143.8 | 161.7 | NA | NA | NA | ||||||||||||||
| 6mz0 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-06 | LYS | A:164 | A:311 | 126.0 | 0.63 | -142.0 | 162.5 | 126.0 | 0.63 | 0.0 |
HOH |
2.995 |
NZ |
O |
|||
| LYS | B:164 | B:311 | 122.0 | 0.61 | -143.8 | 160.6 | NA | NA | NA | ||||||||||||||
| 6n0d | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | LYS | A:164 | A:311 | 120.0 | 0.6 | -147.2 | 160.2 | 120.0 | 0.6 | 0.0 |
HOH |
2.793 |
O |
O |
|||
| LYS | B:164 | B:311 | 123.0 | 0.615 | -140.1 | 159.1 | NA | NA | NA | ||||||||||||||
| 6n0n | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | LYS | A:164 | A:311 | 127.0 | 0.635 | -137.2 | 156.9 | 127.0 | 0.635 | 0.0 |
HOH |
3.169 |
NZ |
O |
|||
| LYS | B:164 | B:311 | 129.0 | 0.645 | -141.0 | 158.5 | NA | NA | NA | ||||||||||||||
| 6n0o | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | LYS | A:164 | A:311 | 117.0 | 0.585 | -144.8 | 156.8 | 117.0 | 0.585 | 0.0 |
HOH |
2.903 |
O |
O |
|||
| LYS | B:164 | B:311 | 141.0 | 0.705 | -127.6 | 157.0 | NA | NA | NA | ||||||||||||||
| 6n0r | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | LYS | A:164 | A:311 | 119.0 | 0.595 | -145.5 | 162.2 | 119.0 | 0.595 | 0.0 |
EDO HOH |
2.756 3.010 |
O NZ |
O2 O |
|||
| LYS | B:164 | B:311 | 123.0 | 0.615 | -140.4 | 162.9 | NA | NA | NA | ||||||||||||||
| 6n17 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | LYS | A:164 | A:311 | 120.0 | 0.6 | -145.9 | 161.1 | 120.0 | 0.6 | 0.0 |
HOH |
2.841 |
O |
O |
|||
| LYS | B:164 | B:311 | 135.0 | 0.675 | -134.4 | 157.7 | NA | NA | NA | ||||||||||||||
| 6n19 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | LYS | A:164 | A:311 | 120.0 | 0.6 | -143.0 | 159.0 | 120.0 | 0.6 | 0.0 |
HOH |
2.829 |
O |
O |
|||
| LYS | B:164 | B:311 | 123.0 | 0.615 | -136.6 | 157.0 | NA | NA | NA | ||||||||||||||
| 6w4r | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-17 | LYS | A:164 | A:311 | 120.0 | 0.6 | -144.6 | 158.5 | 120.0 | 0.6 | 0.0 |
HOH |
3.151 |
NZ |
O |
|||
| LYS | B:164 | B:311 | 137.0 | 0.685 | -136.4 | 155.0 | NA | NA | NA | ||||||||||||||
| 6w7j | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | LYS | A:164 | A:311 | 121.0 | 0.605 | -143.0 | 161.6 | 121.0 | 0.605 | 0.0 |
HOH |
2.868 |
NZ |
O |
|||
| LYS | B:164 | B:311 | 123.0 | 0.615 | -139.8 | 160.6 | NA | NA | NA | ||||||||||||||
| 6w7k | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | LYS | A:164 | A:311 | 112.0 | 0.56 | -141.1 | 164.2 | 112.0 | 0.56 | 0.0 |
HOH |
2.405 |
NZ |
O |
|||
| LYS | B:164 | B:311 | 114.0 | 0.57 | -129.8 | 160.8 | NA | NA | NA | ||||||||||||||
| 6w7l | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | LYS | A:164 | A:311 | 159.0 | 0.795 | -132.9 | 156.7 | 159.0 | 0.795 | 0.0 |
HOH |
2.577 |
O |
O |
|||
| LYS | B:164 | B:311 | 135.0 | 0.675 | -132.0 | 149.0 | NA | NA | NA | ||||||||||||||
| 6mj5 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | LYS | A:163 | A:311 | 122.0 | 0.61 | -148.6 | 160.8 | 122.0 | 0.61 | 0.0 |
HOH |
2.870 |
O |
O |
|||
| LYS | B:163 | B:311 | 132.0 | 0.66 | -144.4 | 159.8 | NA | NA | NA | ||||||||||||||
| 1jy1 | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2002-02-20 | LYS | A:167 | A:311 | 125.0 | 0.625 | -157.9 | 164.8 | 125.0 | 0.625 | 0.0 |
HOH |
2.962 |
NZ |
O |
|||
| 1mu7 | 1 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-01-07 | LYS | A:188 | A:311 | 118.0 | 0.59 | -133.4 | 143.6 | 118.0 | 0.59 | 0.0 |
HOH |
2.813 |
CE |
O |
|||
| LYS | B:188 | B:311 | 115.0 | 0.575 | -128.2 | 150.2 | NA | NA | NA | ||||||||||||||
| 1mu9 | 1 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-01-07 | LYS | A:188 | A:311 | 113.0 | 0.565 | -138.2 | 149.6 | 113.0 | 0.565 | 0.0 |
HOH |
3.406 |
CB |
O |
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| LYS | B:188 | B:311 | 158.0 | 0.79 | -131.1 | 138.9 | NA | NA | NA | ||||||||||||||
| 1nop | 2 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-03-11 | LYS | C:188 | A:311 | 111.0 | 0.555 | -149.4 | 153.7 | 111.0 | 0.555 | 0.0 |
HOH |
8.121 |
O |
O |
|||
| LYS | D:188 | B:311 | 119.0 | 0.595 | -137.3 | 140.4 | NA | NA | NA | ||||||||||||||
| 1rff | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | LYS | C:188 | A:311 | 111.0 | 0.555 | -131.1 | 154.3 | 111.0 | 0.555 | 0.0 |
HOH |
3.340 |
CB |
O |
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| LYS | D:188 | B:311 | 158.0 | 0.79 | -124.8 | 144.2 | NA | NA | NA | ||||||||||||||
| 1rfi | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | LYS | C:188 | A:311 | 110.0 | 0.55 | -149.7 | 155.9 | 110.0 | 0.55 | 0.0 |
HOH |
5.487 |
O |
O |
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| LYS | D:188 | B:311 | 150.0 | 0.75 | -123.3 | 141.4 | NA | NA | NA | ||||||||||||||
| 1rg1 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | LYS | C:188 | A:311 | 117.0 | 0.585 | -154.3 | 151.8 | 117.0 | 0.585 | 0.0 |
HOH |
3.618 |
CB |
O |
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| LYS | D:188 | B:311 | 156.0 | 0.78 | -136.0 | 143.6 | NA | NA | NA | ||||||||||||||
| 1rg2 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | LYS | C:188 | A:311 | 119.0 | 0.595 | -140.5 | 157.1 | 119.0 | 0.595 | 0.0 |
HOH |
3.394 |
CB |
O |
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| LYS | D:188 | B:311 | 160.0 | 0.8 | -129.5 | 145.1 | NA | NA | NA | ||||||||||||||
| 1rgt | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | LYS | C:188 | A:311 | 122.0 | 0.61 | -143.2 | 151.8 | 122.0 | 0.61 | 0.0 |
HOH |
3.300 |
CB |
O |
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| LYS | D:188 | B:311 | 156.0 | 0.78 | -108.8 | 145.2 | NA | NA | NA | ||||||||||||||
| 1rgu | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | LYS | C:188 | A:311 | 112.0 | 0.56 | -144.3 | 152.7 | 112.0 | 0.56 | 0.0 |
HOH |
3.349 |
CB |
O |
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| LYS | D:188 | B:311 | 165.0 | 0.825 | -133.8 | 143.6 | NA | NA | NA | ||||||||||||||
| 1rh0 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | LYS | C:188 | A:311 | 105.0 | 0.525 | -152.4 | 150.9 | 105.0 | 0.525 | 0.0 |
HOH |
5.282 |
O |
O |
|||
| LYS | D:188 | B:311 | 150.0 | 0.75 | -129.4 | 143.0 | NA | NA | NA | ||||||||||||||
| 5nw9 | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2018-01-10 | LYS | A:188 | A:311 | 128.0 | 0.64 | -134.4 | 159.5 | 128.0 | 0.64 | 0.0 | |||||||
| LYS | B:188 | B:311 | 130.0 | 0.65 | -138.5 | 159.9 | NA | NA | NA | ||||||||||||||
| 5nwa | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2018-01-10 | LYS | A:188 | A:311 | 138.0 | 0.69 | -146.5 | 138.0 | 138.0 | 0.69 | 0.0 | |||||||
| LYS | C:188 | B:311 | 155.0 | 0.775 | -131.0 | 128.8 | NA | NA | NA | ||||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q9nuw8-f1 | 1 | Q9NUW8 | 100.0 | 0.0 | LYS | A:311 | A:311 | 147.0 | 0.735 | -76.8 | 129.8 | ||