Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr14 | 90451011 | . | G | A | CCDS9888.1:NM_001008744.1:c.1036Gat>Aat_NP_001008744.1:p.346D>N | Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 1qzq | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2004-05-11 | ASP | A:221 | A:346 | 29.0 | 0.193 | -99.2 | 106.0 | 29.0 | 0.193 | 0.0 |
HOH |
2.931 |
O |
O |
|||
| ASP | B:221 | B:346 | 32.0 | 0.213 | -98.1 | 103.7 | 32.0 | 0.213 | 0.0 |
HOH |
2.685 |
O |
O |
||||||||||
| 6dhu | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ASP | A:199 | A:346 | 26.0 | 0.173 | -97.6 | 107.5 | 26.0 | 0.173 | 0.0 |
EDO HOH |
6.771 2.697 |
N OD2 |
O2 O |
|||
| ASP | B:199 | B:346 | 30.0 | 0.2 | -96.9 | 104.7 | NA | NA | NA | ||||||||||||||
| 6die | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ASP | A:199 | A:346 | 29.0 | 0.193 | -99.9 | 107.9 | 29.0 | 0.193 | 0.0 |
HOH |
2.619 |
OD2 |
O |
|||
| ASP | B:199 | B:346 | 31.0 | 0.207 | -97.4 | 106.4 | NA | NA | NA | ||||||||||||||
| 6dih | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ASP | A:199 | A:346 | 29.0 | 0.193 | -98.2 | 106.2 | 29.0 | 0.193 | 0.0 |
EDO HOH |
6.916 2.570 |
N OD2 |
O1 O |
|||
| ASP | B:199 | B:346 | 30.0 | 0.2 | -95.9 | 104.9 | NA | NA | NA | ||||||||||||||
| 6dim | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ASP | A:199 | A:346 | 29.0 | 0.193 | -95.6 | 109.1 | 29.0 | 0.193 | 0.0 |
EDO HOH |
6.799 2.703 |
N OD2 |
O1 O |
|||
| ASP | B:199 | B:346 | 30.0 | 0.2 | -99.2 | 105.0 | NA | NA | NA | ||||||||||||||
| 6djd | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ASP | A:199 | A:346 | 29.0 | 0.193 | -96.6 | 109.3 | 29.0 | 0.193 | 0.0 |
EDO HOH |
6.907 2.666 |
N OD2 |
O1 O |
|||
| ASP | B:199 | B:346 | 31.0 | 0.207 | -95.6 | 105.0 | NA | NA | NA | ||||||||||||||
| 6dje | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ASP | A:199 | A:346 | 28.0 | 0.187 | -96.9 | 107.9 | 28.0 | 0.187 | 0.0 |
EDO HOH |
6.743 2.586 |
N OD2 |
O2 O |
|||
| ASP | B:199 | B:346 | 30.0 | 0.2 | -95.3 | 105.2 | NA | NA | NA | ||||||||||||||
| 6djf | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ASP | A:199 | A:346 | 36.0 | 0.24 | -96.2 | 108.6 | 36.0 | 0.24 | 0.0 |
HOH |
2.790 |
OD2 |
O |
|||
| ASP | B:199 | B:346 | 29.0 | 0.193 | -98.7 | 104.2 | NA | NA | NA | ||||||||||||||
| 6djg | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ASP | A:199 | A:346 | 30.0 | 0.2 | -98.2 | 108.0 | 30.0 | 0.2 | 0.0 |
HOH |
2.598 |
OD2 |
O |
|||
| ASP | B:199 | B:346 | 30.0 | 0.2 | -96.9 | 106.4 | NA | NA | NA | ||||||||||||||
| 6djh | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ASP | A:199 | A:346 | 33.0 | 0.22 | -95.1 | 110.0 | 33.0 | 0.22 | 0.0 |
HOH |
2.754 |
OD2 |
O |
|||
| ASP | B:199 | B:346 | 27.0 | 0.18 | -94.7 | 103.9 | NA | NA | NA | ||||||||||||||
| 6dji | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ASP | A:199 | A:346 | 31.0 | 0.207 | -98.4 | 108.3 | 31.0 | 0.207 | 0.0 |
EDO HOH |
6.933 2.641 |
N OD2 |
O2 O |
|||
| ASP | B:199 | B:346 | 28.0 | 0.187 | -95.4 | 107.0 | NA | NA | NA | ||||||||||||||
| 6djj | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ASP | A:199 | A:346 | 29.0 | 0.193 | -99.4 | 106.3 | 29.0 | 0.193 | 0.0 |
HOH |
2.689 |
OD2 |
O |
|||
| ASP | B:199 | B:346 | 29.0 | 0.193 | -97.3 | 104.6 | NA | NA | NA | ||||||||||||||
| 6myz | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-06 | ASP | A:199 | A:346 | 35.0 | 0.233 | -97.6 | 107.8 | 35.0 | 0.233 | 0.0 |
EDO HOH |
6.876 2.609 |
N OD2 |
O2 O |
|||
| ASP | B:199 | B:346 | 30.0 | 0.2 | -95.9 | 106.6 | NA | NA | NA | ||||||||||||||
| 6mz0 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-06 | ASP | A:199 | A:346 | 31.0 | 0.207 | -101.7 | 109.8 | 31.0 | 0.207 | 0.0 |
HOH |
2.736 |
OD2 |
O |
|||
| ASP | B:199 | B:346 | 28.0 | 0.187 | -96.6 | 106.2 | NA | NA | NA | ||||||||||||||
| 6n0d | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | ASP | A:199 | A:346 | 29.0 | 0.193 | -100.1 | 107.1 | 29.0 | 0.193 | 0.0 |
HOH |
2.653 |
OD2 |
O |
|||
| ASP | B:199 | B:346 | 29.0 | 0.193 | -99.4 | 107.0 | NA | NA | NA | ||||||||||||||
| 6n0n | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | ASP | A:199 | A:346 | 27.0 | 0.18 | -99.7 | 106.4 | 27.0 | 0.18 | 0.0 |
HOH |
2.737 |
OD2 |
O |
|||
| ASP | B:199 | B:346 | 27.0 | 0.18 | -99.8 | 107.1 | NA | NA | NA | ||||||||||||||
| 6n0o | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | ASP | A:199 | A:346 | 29.0 | 0.193 | -98.4 | 106.3 | 29.0 | 0.193 | 0.0 |
HOH |
2.611 |
OD2 |
O |
|||
| ASP | B:199 | B:346 | 31.0 | 0.207 | -97.1 | 106.3 | NA | NA | NA | ||||||||||||||
| 6n0r | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | ASP | A:199 | A:346 | 27.0 | 0.18 | -99.2 | 107.1 | 27.0 | 0.18 | 0.0 |
EDO HOH |
6.887 2.676 |
N OD2 |
O2 O |
|||
| ASP | B:199 | B:346 | 30.0 | 0.2 | -98.6 | 105.9 | NA | NA | NA | ||||||||||||||
| 6n17 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | ASP | A:199 | A:346 | 28.0 | 0.187 | -98.2 | 108.3 | 28.0 | 0.187 | 0.0 |
HOH |
2.622 |
OD2 |
O |
|||
| ASP | B:199 | B:346 | 28.0 | 0.187 | -96.2 | 105.4 | NA | NA | NA | ||||||||||||||
| 6n19 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | ASP | A:199 | A:346 | 30.0 | 0.2 | -97.9 | 107.3 | 30.0 | 0.2 | 0.0 |
HOH |
2.712 |
OD2 |
O |
|||
| ASP | B:199 | B:346 | 25.0 | 0.167 | -99.2 | 105.3 | NA | NA | NA | ||||||||||||||
| 6w4r | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-17 | ASP | A:199 | A:346 | 27.0 | 0.18 | -101.6 | 106.8 | 27.0 | 0.18 | 0.0 |
HOH |
2.469 |
OD2 |
O |
|||
| ASP | B:199 | B:346 | 29.0 | 0.193 | -99.5 | 106.1 | NA | NA | NA | ||||||||||||||
| 6w7j | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | ASP | A:199 | A:346 | 28.0 | 0.187 | -98.6 | 107.6 | 28.0 | 0.187 | 0.0 |
HOH |
2.631 |
OD2 |
O |
|||
| ASP | B:199 | B:346 | 30.0 | 0.2 | -99.8 | 107.0 | NA | NA | NA | ||||||||||||||
| 6w7k | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | ASP | A:199 | A:346 | 25.0 | 0.167 | -96.2 | 107.6 | 25.0 | 0.167 | 0.0 |
HOH |
2.599 |
OD2 |
O |
|||
| ASP | B:199 | B:346 | 29.0 | 0.193 | -94.9 | 103.9 | NA | NA | NA | ||||||||||||||
| 6w7l | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | ASP | A:199 | A:346 | 49.0 | 0.327 | -101.3 | 106.4 | 49.0 | 0.327 | 0.0 |
HOH |
2.768 |
O |
O |
|||
| ASP | B:199 | B:346 | 28.0 | 0.187 | -100.6 | 102.7 | NA | NA | NA | ||||||||||||||
| 6mj5 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | ASP | A:198 | A:346 | 29.0 | 0.193 | -95.5 | 108.6 | 29.0 | 0.193 | 0.0 |
HOH |
2.593 |
OD2 |
O |
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| ASP | B:198 | B:346 | 32.0 | 0.213 | -98.1 | 104.1 | NA | NA | NA | ||||||||||||||
| 1jy1 | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2002-02-20 | ASP | A:202 | A:346 | 26.0 | 0.173 | -97.0 | 103.3 | 26.0 | 0.173 | 0.0 |
HOH |
2.655 |
OD2 |
O |
|||
| 1mu7 | 1 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-01-07 | ASP | A:223 | A:346 | 25.0 | 0.167 | -97.6 | 107.4 | 25.0 | 0.167 | 0.0 |
HOH |
2.764 |
O |
O |
|||
| ASP | B:223 | B:346 | 31.0 | 0.207 | -97.7 | 107.4 | NA | NA | NA | ||||||||||||||
| 1mu9 | 1 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-01-07 | ASP | A:223 | A:346 | 39.0 | 0.26 | -98.8 | 100.3 | 39.0 | 0.26 | 0.0 |
HOH |
2.521 |
O |
O |
|||
| ASP | B:223 | B:346 | 40.0 | 0.267 | -95.5 | 104.4 | NA | NA | NA | ||||||||||||||
| 1nop | 2 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-03-11 | ASP | C:223 | A:346 | 36.0 | 0.24 | -91.1 | 103.8 | 36.0 | 0.24 | 0.0 |
HOH |
7.255 |
N |
O |
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| ASP | D:223 | B:346 | 24.0 | 0.16 | -101.1 | 108.4 | NA | NA | NA | ||||||||||||||
| 1rff | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ASP | C:223 | A:346 | 36.0 | 0.24 | -96.6 | 104.7 | 36.0 | 0.24 | 0.0 |
HOH |
2.758 |
O |
O |
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| ASP | D:223 | B:346 | 41.0 | 0.273 | -98.6 | 105.4 | NA | NA | NA | ||||||||||||||
| 1rfi | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ASP | C:223 | A:346 | 35.0 | 0.233 | -95.9 | 100.0 | 35.0 | 0.233 | 0.0 |
HOH |
2.509 |
O |
O |
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| ASP | D:223 | B:346 | 41.0 | 0.273 | -98.2 | 108.6 | NA | NA | NA | ||||||||||||||
| 1rg1 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ASP | C:223 | A:346 | 37.0 | 0.247 | -88.2 | 100.2 | 37.0 | 0.247 | 0.0 |
HOH |
2.590 |
O |
O |
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| ASP | D:223 | B:346 | 38.0 | 0.253 | -101.2 | 111.7 | NA | NA | NA | ||||||||||||||
| 1rg2 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ASP | C:223 | A:346 | 37.0 | 0.247 | -99.3 | 105.9 | 37.0 | 0.247 | 0.0 |
HOH |
4.467 |
OD1 |
O |
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| ASP | D:223 | B:346 | 43.0 | 0.287 | -99.1 | 107.2 | NA | NA | NA | ||||||||||||||
| 1rgt | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ASP | C:223 | A:346 | 41.0 | 0.273 | -95.0 | 103.1 | 41.0 | 0.273 | 0.0 |
HOH |
2.678 |
O |
O |
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| ASP | D:223 | B:346 | 40.0 | 0.267 | -99.3 | 103.4 | NA | NA | NA | ||||||||||||||
| 1rgu | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ASP | C:223 | A:346 | 36.0 | 0.24 | -96.4 | 104.3 | 36.0 | 0.24 | 0.0 |
HOH |
4.423 |
OD1 |
O |
|||
| ASP | D:223 | B:346 | 48.0 | 0.32 | -98.2 | 105.7 | NA | NA | NA | ||||||||||||||
| 1rh0 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ASP | C:223 | A:346 | 36.0 | 0.24 | -91.0 | 102.7 | 36.0 | 0.24 | 0.0 |
HOH |
2.551 |
O |
O |
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| ASP | D:223 | B:346 | 37.0 | 0.247 | -98.4 | 110.9 | NA | NA | NA | ||||||||||||||
| 5nw9 | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2018-01-10 | ASP | A:223 | A:346 | 36.0 | 0.24 | -97.3 | 109.2 | 36.0 | 0.24 | 0.0 | |||||||
| ASP | B:223 | B:346 | 35.0 | 0.233 | -90.2 | 109.8 | NA | NA | NA | ||||||||||||||
| 5nwa | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2018-01-10 | ASP | A:223 | A:346 | 40.0 | 0.267 | -93.7 | 109.7 | 40.0 | 0.267 | 0.0 | |||||||
| ASP | C:223 | B:346 | 43.0 | 0.287 | -110.4 | 108.7 | NA | NA | NA | ||||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q9nuw8-f1 | 1 | Q9NUW8 | 100.0 | 0.0 | ASP | A:346 | A:346 | 28.0 | 0.187 | -89.6 | 110.5 | ||