Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr14 | 90451505 | . | G | A | CCDS9888.1:NM_001008744.1:c.1082cGc>cAc_NP_001008744.1:p.361R>H | Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 1qzq | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2004-05-11 | ARG | A:236 | A:361 | 137.0 | 0.609 | E | -128.4 | 108.4 | 137.0 | 0.609 | 0.0 |
HOH |
2.575 |
NE |
O |
||
| ARG | B:236 | B:361 | 133.0 | 0.591 | E | -122.2 | 102.8 | 133.0 | 0.591 | 0.0 |
HOH |
3.510 |
O |
O |
|||||||||
| 6dhu | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:214 | A:361 | 141.0 | 0.627 | E | -121.6 | 114.5 | 141.0 | 0.627 | 0.0 |
HOH |
3.291 |
NH2 |
O |
||
| ARG | B:214 | B:361 | 140.0 | 0.622 | E | -124.9 | 109.3 | NA | NA | NA | |||||||||||||
| 6die | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:214 | A:361 | 142.0 | 0.631 | E | -124.9 | 110.9 | 142.0 | 0.631 | 0.0 |
HOH |
2.777 |
NH2 |
O |
||
| ARG | B:214 | B:361 | 137.0 | 0.609 | E | -129.2 | 108.5 | NA | NA | NA | |||||||||||||
| 6dih | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:214 | A:361 | 141.0 | 0.627 | E | -123.3 | 111.4 | 141.0 | 0.627 | 0.0 |
HOH |
3.790 |
O |
O |
||
| ARG | B:214 | B:361 | 139.0 | 0.618 | E | -125.3 | 105.5 | NA | NA | NA | |||||||||||||
| 6dim | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:214 | A:361 | 132.0 | 0.587 | E | -125.1 | 109.7 | 132.0 | 0.587 | 0.0 |
HOH |
3.166 |
NH2 |
O |
||
| ARG | B:214 | B:361 | 136.0 | 0.604 | E | -130.6 | 99.0 | NA | NA | NA | |||||||||||||
| 6djd | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:214 | A:361 | 138.0 | 0.613 | E | -126.9 | 108.6 | 138.0 | 0.613 | 0.0 |
HOH |
3.226 |
NH1 |
O |
||
| ARG | B:214 | B:361 | 136.0 | 0.604 | E | -126.3 | 112.2 | NA | NA | NA | |||||||||||||
| 6dje | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:214 | A:361 | 136.0 | 0.604 | E | -123.7 | 109.4 | 136.0 | 0.604 | 0.0 |
HOH |
2.910 |
O |
O |
||
| ARG | B:214 | B:361 | 143.0 | 0.636 | E | -127.0 | 106.1 | NA | NA | NA | |||||||||||||
| 6djf | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:214 | A:361 | 143.0 | 0.636 | E | -121.9 | 113.0 | 143.0 | 0.636 | 0.0 |
HOH |
3.786 |
O |
O |
||
| ARG | B:214 | B:361 | 140.0 | 0.622 | E | -122.8 | 115.5 | NA | NA | NA | |||||||||||||
| 6djg | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:214 | A:361 | 140.0 | 0.622 | E | -119.6 | 108.6 | 140.0 | 0.622 | 0.0 |
HOH |
3.163 |
N |
O |
||
| ARG | B:214 | B:361 | 131.0 | 0.582 | E | -125.7 | 113.2 | NA | NA | NA | |||||||||||||
| 6djh | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:214 | A:361 | 143.0 | 0.636 | E | -123.6 | 109.6 | 143.0 | 0.636 | 0.0 |
HOH |
3.054 |
NH1 |
O |
||
| ARG | B:214 | B:361 | 134.0 | 0.596 | E | -124.7 | 113.8 | NA | NA | NA | |||||||||||||
| 6dji | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:214 | A:361 | 140.0 | 0.622 | E | -124.3 | 110.2 | 140.0 | 0.622 | 0.0 |
HOH |
2.933 |
N |
O |
||
| ARG | B:214 | B:361 | 138.0 | 0.613 | E | -126.4 | 108.1 | NA | NA | NA | |||||||||||||
| 6djj | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:214 | A:361 | 141.0 | 0.627 | E | -123.1 | 109.8 | 141.0 | 0.627 | 0.0 |
HOH |
2.779 |
O |
O |
||
| ARG | B:214 | B:361 | 138.0 | 0.613 | E | -126.4 | 108.4 | NA | NA | NA | |||||||||||||
| 6myz | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:214 | A:361 | 135.0 | 0.6 | E | -124.9 | 110.7 | 135.0 | 0.6 | 0.0 |
HOH |
3.733 |
O |
O |
||
| ARG | B:214 | B:361 | 142.0 | 0.631 | E | -127.8 | 106.2 | NA | NA | NA | |||||||||||||
| 6mz0 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:214 | A:361 | 141.0 | 0.627 | E | -121.9 | 113.2 | 141.0 | 0.627 | 0.0 |
HOH |
3.109 |
N |
O |
||
| ARG | B:214 | B:361 | 136.0 | 0.604 | E | -126.5 | 112.1 | NA | NA | NA | |||||||||||||
| 6n0d | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | ARG | A:214 | A:361 | 138.0 | 0.613 | E | -125.3 | 107.2 | 138.0 | 0.613 | 0.0 |
HOH |
3.740 |
O |
O |
||
| ARG | B:214 | B:361 | 136.0 | 0.604 | E | -125.1 | 103.6 | NA | NA | NA | |||||||||||||
| 6n0n | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | ARG | A:214 | A:361 | 139.0 | 0.618 | E | -126.6 | 103.4 | 139.0 | 0.618 | 0.0 |
HOH |
2.971 |
N |
O |
||
| ARG | B:214 | B:361 | 141.0 | 0.627 | E | -127.5 | 106.7 | NA | NA | NA | |||||||||||||
| 6n0o | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | ARG | A:214 | A:361 | 135.0 | 0.6 | E | -124.8 | 111.9 | 135.0 | 0.6 | 0.0 |
HOH |
3.276 |
NH2 |
O |
||
| ARG | B:214 | B:361 | 132.0 | 0.587 | E | -124.3 | 106.7 | NA | NA | NA | |||||||||||||
| 6n0r | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | ARG | A:214 | A:361 | 142.0 | 0.631 | E | -122.8 | 112.5 | 142.0 | 0.631 | 0.0 |
HOH |
4.243 |
NH2 |
O |
||
| ARG | B:214 | B:361 | 141.0 | 0.627 | E | -123.6 | 110.3 | NA | NA | NA | |||||||||||||
| 6n17 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | ARG | A:214 | A:361 | 137.0 | 0.609 | E | -120.9 | 114.9 | 137.0 | 0.609 | 0.0 |
HOH |
2.497 |
NH2 |
O |
||
| ARG | B:214 | B:361 | 132.0 | 0.587 | E | -125.5 | 109.5 | NA | NA | NA | |||||||||||||
| 6n19 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | ARG | A:214 | A:361 | 144.0 | 0.64 | E | -124.1 | 110.4 | 144.0 | 0.64 | 0.0 |
HOH |
2.797 |
NH2 |
O |
||
| ARG | B:214 | B:361 | 156.0 | 0.693 | E | -125.4 | 109.6 | NA | NA | NA | |||||||||||||
| 6w4r | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-17 | ARG | A:214 | A:361 | 141.0 | 0.627 | E | -127.1 | 109.6 | 141.0 | 0.627 | 0.0 |
HOH |
2.776 |
NH2 |
O |
||
| ARG | B:214 | B:361 | 130.0 | 0.578 | E | -121.6 | 110.0 | NA | NA | NA | |||||||||||||
| 6w7j | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | ARG | A:214 | A:361 | 146.0 | 0.649 | E | -124.8 | 109.2 | 146.0 | 0.649 | 0.0 |
HOH |
3.244 |
NH1 |
O |
||
| ARG | B:214 | B:361 | 139.0 | 0.618 | E | -125.8 | 104.3 | NA | NA | NA | |||||||||||||
| 6w7k | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | ARG | A:214 | A:361 | 144.0 | 0.64 | E | -122.0 | 111.5 | 144.0 | 0.64 | 0.0 |
HOH |
3.731 |
O |
O |
||
| ARG | B:214 | B:361 | 137.0 | 0.609 | E | -128.0 | 105.9 | NA | NA | NA | |||||||||||||
| 6w7l | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | ARG | A:214 | A:361 | 143.0 | 0.636 | E | -124.6 | 110.9 | 143.0 | 0.636 | 0.0 |
HOH |
2.863 |
NH2 |
O |
||
| ARG | B:214 | B:361 | 141.0 | 0.627 | E | -120.3 | 113.4 | NA | NA | NA | |||||||||||||
| 6mj5 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | ARG | A:213 | A:361 | 144.0 | 0.64 | E | -123.1 | 113.8 | 144.0 | 0.64 | 0.0 |
HOH |
3.064 |
N |
O |
||
| ARG | B:213 | B:361 | 148.0 | 0.658 | E | -123.7 | 115.0 | NA | NA | NA | |||||||||||||
| 1jy1 | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2002-02-20 | ARG | A:217 | A:361 | 140.0 | 0.622 | E | -124.8 | 111.8 | 140.0 | 0.622 | 0.0 |
HOH |
2.758 |
O |
O |
||
| 1mu7 | 1 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-01-07 | ARG | A:238 | A:361 | 159.0 | 0.707 | E | -123.3 | 115.1 | 159.0 | 0.707 | 0.0 |
HOH |
4.018 |
NH2 |
O |
||
| ARG | B:238 | B:361 | 134.0 | 0.596 | E | -125.3 | 110.1 | NA | NA | NA | |||||||||||||
| 1mu9 | 1 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-01-07 | ARG | A:238 | A:361 | 128.0 | 0.569 | E | -127.3 | 110.9 | 128.0 | 0.569 | 0.0 |
HOH |
7.208 |
C |
O |
||
| ARG | B:238 | B:361 | 141.0 | 0.627 | E | -123.8 | 109.9 | NA | NA | NA | |||||||||||||
| 1nop | 2 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-03-11 | ARG | C:238 | A:361 | 135.0 | 0.6 | E | -123.5 | 118.8 | 135.0 | 0.6 | 0.0 |
DG |
7.838 |
NH2 |
N2 |
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| ARG | D:238 | B:361 | 128.0 | 0.569 | E | -121.7 | 123.6 | NA | NA | NA | |||||||||||||
| 1rff | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:238 | A:361 | 132.0 | 0.587 | E | -121.8 | 118.3 | 132.0 | 0.587 | 0.0 |
HOH |
7.511 |
O |
O |
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| ARG | D:238 | B:361 | 130.0 | 0.578 | E | -127.1 | 116.5 | NA | NA | NA | |||||||||||||
| 1rfi | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:238 | A:361 | 134.0 | 0.596 | E | -125.5 | 115.4 | 134.0 | 0.596 | 0.0 |
HOH |
3.896 |
NH1 |
O |
||
| ARG | D:238 | B:361 | 129.0 | 0.573 | E | -123.4 | 121.9 | NA | NA | NA | |||||||||||||
| 1rg1 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:238 | A:361 | 130.0 | 0.578 | E | -122.8 | 114.0 | 130.0 | 0.578 | 0.0 |
HOH |
7.651 |
O |
O |
||
| ARG | D:238 | B:361 | 131.0 | 0.582 | E | -121.9 | 113.8 | NA | NA | NA | |||||||||||||
| 1rg2 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:238 | A:361 | 134.0 | 0.596 | E | -122.2 | 113.3 | 134.0 | 0.596 | 0.0 |
HOH |
8.184 |
NH2 |
O |
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| ARG | D:238 | B:361 | 131.0 | 0.582 | E | -124.7 | 122.0 | NA | NA | NA | |||||||||||||
| 1rgt | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:238 | A:361 | 134.0 | 0.596 | E | -125.9 | 118.0 | 134.0 | 0.596 | 0.0 |
HOH |
3.009 |
CD |
O |
||
| ARG | D:238 | B:361 | 133.0 | 0.591 | E | -120.4 | 117.9 | NA | NA | NA | |||||||||||||
| 1rgu | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:238 | A:361 | 132.0 | 0.587 | E | -120.5 | 119.0 | 132.0 | 0.587 | 0.0 |
HOH |
8.064 |
NH2 |
O |
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| ARG | D:238 | B:361 | 127.0 | 0.564 | E | -116.2 | 121.2 | NA | NA | NA | |||||||||||||
| 1rh0 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:238 | A:361 | 132.0 | 0.587 | E | -118.8 | 118.3 | 132.0 | 0.587 | 0.0 |
HOH |
7.738 |
O |
O |
||
| ARG | D:238 | B:361 | 134.0 | 0.596 | E | -125.5 | 117.4 | NA | NA | NA | |||||||||||||
| 5nw9 | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2018-01-10 | ARG | A:238 | A:361 | 122.0 | 0.542 | E | -126.1 | 120.7 | 122.0 | 0.542 | 0.0 |
DG DC DA DG DC DA HOH |
9.997 8.911 8.037 9.997 8.911 8.037 6.957 |
NH2 NH2 NH2 NH2 NH2 NH2 C |
N2 O2 C2 N2 O2 C2 O |
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| ARG | B:238 | B:361 | 120.0 | 0.533 | E | -129.2 | 123.1 | NA | NA | NA | |||||||||||||
| 5nwa | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2018-01-10 | ARG | A:238 | A:361 | 123.0 | 0.547 | E | -138.1 | 119.2 | 123.0 | 0.547 | 0.0 |
DG DC DA DT DG DC DG |
9.978 8.774 7.624 6.467 4.139 3.686 7.737 |
NH2 NH2 NH2 NH1 NH1 NH2 NH2 |
N2 O2 C2 O3' C5' C5' P |
||
| ARG | C:238 | B:361 | 132.0 | 0.587 | E | -138.1 | 105.1 | NA | NA | NA | |||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q9nuw8-f1 | 1 | Q9NUW8 | 100.0 | 0.0 | ARG | A:361 | A:361 | 133.0 | 0.591 | E | -120.5 | 112.0 | |