Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr14 | 90455282 | . | G | A | CCDS9888.1:NM_001008744.1:c.1165Gca>Aca_NP_001008744.1:p.389A>T | Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1, mRNA. |
|---|---|---|---|---|---|---|---|
|
|
|
|
|
PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 1qzq | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2004-05-11 | ALA | A:264 | A:389 | 15.0 | 0.13 | G | -57.3 | -36.2 | 15.0 | 0.13 | 0.0 |
HOH |
2.881 |
N |
O |
||
| ALA | B:264 | B:389 | 15.0 | 0.13 | G | -52.6 | -33.1 | 15.0 | 0.13 | 0.0 |
HOH |
3.703 |
CB |
O |
|||||||||
| 6dhu | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ALA | A:242 | A:389 | 17.0 | 0.148 | G | -56.2 | -30.9 | 17.0 | 0.148 | 0.0 |
HOH |
3.021 |
N |
O |
||
| ALA | B:242 | B:389 | 11.0 | 0.096 | G | -61.2 | -31.2 | NA | NA | NA | |||||||||||||
| 6die | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ALA | A:242 | A:389 | 10.0 | 0.087 | G | -56.0 | -30.8 | 10.0 | 0.087 | 0.0 |
HOH |
3.676 |
CB |
O |
||
| ALA | B:242 | B:389 | 14.0 | 0.122 | G | -60.8 | -31.3 | NA | NA | NA | |||||||||||||
| 6dih | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ALA | A:242 | A:389 | 17.0 | 0.148 | G | -59.0 | -27.4 | 17.0 | 0.148 | 0.0 |
HOH |
3.042 |
N |
O |
||
| ALA | B:242 | B:389 | 10.0 | 0.087 | G | -56.4 | -33.5 | NA | NA | NA | |||||||||||||
| 6dim | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ALA | A:242 | A:389 | 11.0 | 0.096 | G | -58.2 | -30.6 | 11.0 | 0.096 | 0.0 |
HOH |
3.082 |
N |
O |
||
| ALA | B:242 | B:389 | 12.0 | 0.104 | G | -60.4 | -27.3 | NA | NA | NA | |||||||||||||
| 6djd | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ALA | A:242 | A:389 | 17.0 | 0.148 | G | -60.6 | -27.9 | 17.0 | 0.148 | 0.0 |
HOH |
2.946 |
N |
O |
||
| ALA | B:242 | B:389 | 16.0 | 0.139 | G | -62.0 | -25.3 | NA | NA | NA | |||||||||||||
| 6dje | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ALA | A:242 | A:389 | 16.0 | 0.139 | G | -57.0 | -32.7 | 16.0 | 0.139 | 0.0 |
HOH |
3.265 |
N |
O |
||
| ALA | B:242 | B:389 | 16.0 | 0.139 | G | -59.2 | -27.8 | NA | NA | NA | |||||||||||||
| 6djf | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ALA | A:242 | A:389 | 17.0 | 0.148 | G | -57.4 | -29.2 | 17.0 | 0.148 | 0.0 |
HOH |
3.566 |
CB |
O |
||
| ALA | B:242 | B:389 | 17.0 | 0.148 | G | -60.8 | -24.7 | NA | NA | NA | |||||||||||||
| 6djg | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ALA | A:242 | A:389 | 17.0 | 0.148 | G | -57.1 | -28.8 | 17.0 | 0.148 | 0.0 |
HOH |
3.036 |
N |
O |
||
| ALA | B:242 | B:389 | 15.0 | 0.13 | G | -60.2 | -23.9 | NA | NA | NA | |||||||||||||
| 6djh | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ALA | A:242 | A:389 | 10.0 | 0.087 | G | -61.5 | -28.1 | 10.0 | 0.087 | 0.0 |
HOH |
3.720 |
CB |
O |
||
| ALA | B:242 | B:389 | 17.0 | 0.148 | G | -61.8 | -31.6 | NA | NA | NA | |||||||||||||
| 6dji | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ALA | A:242 | A:389 | 19.0 | 0.165 | G | -60.6 | -29.1 | 19.0 | 0.165 | 0.0 |
HOH |
3.221 |
N |
O |
||
| ALA | B:242 | B:389 | 10.0 | 0.087 | G | -57.0 | -27.7 | NA | NA | NA | |||||||||||||
| 6djj | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ALA | A:242 | A:389 | 9.0 | 0.078 | G | -57.8 | -29.0 | 9.0 | 0.078 | 0.0 |
HOH |
3.606 |
CB |
O |
||
| ALA | B:242 | B:389 | 12.0 | 0.104 | G | -60.2 | -31.6 | NA | NA | NA | |||||||||||||
| 6myz | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-06 | ALA | A:242 | A:389 | 10.0 | 0.087 | G | -55.8 | -31.8 | 10.0 | 0.087 | 0.0 |
HOH |
3.286 |
N |
O |
||
| ALA | B:242 | B:389 | 12.0 | 0.104 | G | -61.5 | -29.9 | NA | NA | NA | |||||||||||||
| 6mz0 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-06 | ALA | A:242 | A:389 | 13.0 | 0.113 | G | -57.7 | -34.4 | 13.0 | 0.113 | 0.0 |
HOH |
3.581 |
CB |
O |
||
| ALA | B:242 | B:389 | 11.0 | 0.096 | G | -59.5 | -27.6 | NA | NA | NA | |||||||||||||
| 6n0d | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | ALA | A:242 | A:389 | 17.0 | 0.148 | G | -59.0 | -28.8 | 17.0 | 0.148 | 0.0 |
HOH |
3.289 |
N |
O |
||
| ALA | B:242 | B:389 | 16.0 | 0.139 | G | -58.0 | -28.0 | NA | NA | NA | |||||||||||||
| 6n0n | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | ALA | A:242 | A:389 | 14.0 | 0.122 | G | -60.5 | -30.3 | 14.0 | 0.122 | 0.0 |
HOH |
3.825 |
CB |
O |
||
| ALA | B:242 | B:389 | 8.0 | 0.07 | G | -58.3 | -29.4 | NA | NA | NA | |||||||||||||
| 6n0o | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | ALA | A:242 | A:389 | 12.0 | 0.104 | G | -57.8 | -29.6 | 12.0 | 0.104 | 0.0 |
HOH |
3.715 |
CB |
O |
||
| ALA | B:242 | B:389 | 11.0 | 0.096 | G | -58.5 | -36.1 | NA | NA | NA | |||||||||||||
| 6n0r | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | ALA | A:242 | A:389 | 18.0 | 0.157 | G | -58.4 | -30.4 | 18.0 | 0.157 | 0.0 |
HOH |
3.547 |
CB |
O |
||
| ALA | B:242 | B:389 | 11.0 | 0.096 | G | -61.8 | -31.9 | NA | NA | NA | |||||||||||||
| 6n17 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | ALA | A:242 | A:389 | 18.0 | 0.157 | G | -57.1 | -30.3 | 18.0 | 0.157 | 0.0 |
HOH |
3.356 |
N |
O |
||
| ALA | B:242 | B:389 | 10.0 | 0.087 | G | -58.3 | -31.3 | NA | NA | NA | |||||||||||||
| 6n19 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | ALA | A:242 | A:389 | 9.0 | 0.078 | G | -55.6 | -30.5 | 9.0 | 0.078 | 0.0 |
HOH |
3.475 |
CB |
O |
||
| ALA | B:242 | B:389 | 10.0 | 0.087 | G | -58.4 | -29.1 | NA | NA | NA | |||||||||||||
| 6w4r | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-17 | ALA | A:242 | A:389 | 8.0 | 0.07 | G | -53.3 | -30.1 | 8.0 | 0.07 | 0.0 |
HOH |
3.150 |
N |
O |
||
| ALA | B:242 | B:389 | 12.0 | 0.104 | G | -59.0 | -30.5 | NA | NA | NA | |||||||||||||
| 6w7j | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | ALA | A:242 | A:389 | 16.0 | 0.139 | G | -58.6 | -29.9 | 16.0 | 0.139 | 0.0 |
HOH |
3.639 |
CB |
O |
||
| ALA | B:242 | B:389 | 10.0 | 0.087 | G | -58.6 | -24.9 | NA | NA | NA | |||||||||||||
| 6w7k | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | ALA | A:242 | A:389 | 10.0 | 0.087 | G | -57.9 | -31.6 | 10.0 | 0.087 | 0.0 |
HOH |
3.583 |
CB |
O |
||
| ALA | B:242 | B:389 | 13.0 | 0.113 | G | -61.7 | -32.6 | NA | NA | NA | |||||||||||||
| 6w7l | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | ALA | A:242 | A:389 | 9.0 | 0.078 | G | -59.8 | -27.2 | 9.0 | 0.078 | 0.0 |
HOH |
3.607 |
CB |
O |
||
| ALA | B:242 | B:389 | 10.0 | 0.087 | G | -60.3 | -24.6 | NA | NA | NA | |||||||||||||
| 6mj5 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | ALA | A:241 | A:389 | 17.0 | 0.148 | G | -57.9 | -32.0 | 17.0 | 0.148 | 0.0 |
HOH |
2.922 |
N |
O |
||
| ALA | B:241 | B:389 | 12.0 | 0.104 | G | -58.4 | -28.4 | NA | NA | NA | |||||||||||||
| 1jy1 | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2002-02-20 | ALA | A:245 | A:389 | 71.0 | 0.617 | 360.0 | 74.6 | 71.0 | 0.617 | 0.0 |
HOH |
2.842 |
N |
O |
|||
| 1mu7 | 1 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-01-07 | ALA | A:266 | A:389 | 116.0 | 1.0 | 360.0 | 63.2 | 116.0 | 1.0 | 0.0 |
HOH |
9.597 |
N |
O |
|||
| ALA | B:266 | B:389 | 17.0 | 0.148 | G | -57.8 | -37.9 | NA | NA | NA | |||||||||||||
| 1mu9 | 1 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-01-07 | ALA | A:266 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ALA | B:266 | B:389 | 15.0 | 0.13 | G | -56.5 | -35.1 | NA | NA | NA | |||||||||||||
| 1nop | 2 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-03-11 | ALA | C:266 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ALA | D:266 | B:389 | 17.0 | 0.148 | G | -48.1 | -34.8 | NA | NA | NA | |||||||||||||
| 1rff | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ALA | C:266 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ALA | D:266 | B:389 | 12.0 | 0.104 | G | -49.0 | -34.0 | NA | NA | NA | |||||||||||||
| 1rfi | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ALA | C:266 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ALA | D:266 | B:389 | 17.0 | 0.148 | G | -56.1 | -32.7 | NA | NA | NA | |||||||||||||
| 1rg1 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ALA | C:266 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ALA | D:266 | B:389 | 20.0 | 0.174 | G | -51.4 | -37.2 | NA | NA | NA | |||||||||||||
| 1rg2 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ALA | C:266 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ALA | D:266 | B:389 | 17.0 | 0.148 | G | -50.0 | -36.1 | NA | NA | NA | |||||||||||||
| 1rgt | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ALA | C:266 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ALA | D:266 | B:389 | 17.0 | 0.148 | G | -45.5 | -39.6 | NA | NA | NA | |||||||||||||
| 1rgu | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ALA | C:266 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ALA | D:266 | B:389 | 14.0 | 0.122 | G | -56.5 | -26.6 | NA | NA | NA | |||||||||||||
| 1rh0 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ALA | C:266 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ALA | D:266 | B:389 | 17.0 | 0.148 | G | -51.8 | -38.1 | NA | NA | NA | |||||||||||||
| 5nw9 | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2018-01-10 | ALA | A:266 | A:389 | 24.0 | 0.209 | G | -31.1 | -47.3 | 24.0 | 0.209 | 0.0 |
HOH |
7.718 |
O |
O |
||
| ALA | B:266 | B:389 | 17.0 | 0.148 | G | -48.2 | -39.0 | NA | NA | NA | |||||||||||||
| 5nwa | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2018-01-10 | ALA | A:266 | A:389 | 12.0 | 0.104 | G | -63.4 | -44.2 | 12.0 | 0.104 | 0.0 | ||||||
| ALA | C:266 | B:389 | 24.0 | 0.209 | G | -65.7 | -8.8 | NA | NA | NA | |||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q9nuw8-f1 | 1 | Q9NUW8 | 100.0 | 0.0 | ALA | A:389 | A:389 | 25.0 | 0.217 | G | -51.2 | -27.1 | |