Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr14 90455369 . G A CCDS9888.1:NM_001008744.1:c.1252Gag>Aag_NP_001008744.1:p.418E>K Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1qzq 1 Q9NUW8 100.0 0.0 X-RAY
 2004-05-11 GLU A:293 A:418 90.0 0.474 H -57.2 -37.8 90.0 0.474 0.0 HOH
 3.686
 CB
 O
GLU B:293 B:418 96.0 0.505 H -57.5 -46.4 96.0 0.505 0.0 HOH
 3.489
 CB
 O
6dhu 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 GLU A:271 A:418 102.0 0.537 H -60.6 -40.5 102.0 0.537 0.0 HOH
 3.177
 OE1
 O
GLU B:271 B:418 109.0 0.574 H -60.9 -42.6 NA NA NA
6die 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 GLU A:271 A:418 85.0 0.447 H -60.8 -40.1 85.0 0.447 0.0 HOH
 2.855
 OE2
 O
GLU B:271 B:418 103.0 0.542 H -58.1 -43.9 NA NA NA
6dih 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 GLU A:271 A:418 90.0 0.474 H -61.8 -40.3 90.0 0.474 0.0 HOH
 2.571
 OE2
 O
GLU B:271 B:418 100.0 0.526 H -60.1 -42.6 NA NA NA
6dim 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 GLU A:271 A:418 92.0 0.484 H -61.0 -41.9 92.0 0.484 0.0 HOH
 3.246
 OE1
 O
GLU B:271 B:418 94.0 0.495 H -60.4 -41.4 NA NA NA
6djd 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 GLU A:271 A:418 105.0 0.553 H -60.2 -43.2 105.0 0.553 0.0 HOH
 3.650
 OE2
 O
GLU B:271 B:418 110.0 0.579 H -61.6 -41.3 NA NA NA
6dje 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 GLU A:271 A:418 107.0 0.563 H -62.2 -40.6 107.0 0.563 0.0 HOH
 2.116
 OE1
 O
GLU B:271 B:418 105.0 0.553 H -54.4 -49.8 NA NA NA
6djf 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 GLU A:271 A:418 88.0 0.463 H -63.3 -41.2 88.0 0.463 0.0 HOH
 3.791
 CB
 O
GLU B:271 B:418 113.0 0.595 H -57.7 -47.5 NA NA NA
6djg 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 GLU A:271 A:418 90.0 0.474 H -62.6 -39.5 90.0 0.474 0.0 HOH
 3.671
 CB
 O
GLU B:271 B:418 105.0 0.553 H -59.0 -45.3 NA NA NA
6djh 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 GLU A:271 A:418 93.0 0.489 H -62.1 -39.0 93.0 0.489 0.0 HOH
 3.866
 CB
 O
GLU B:271 B:418 111.0 0.584 H -62.1 -41.1 NA NA NA
6dji 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 GLU A:271 A:418 90.0 0.474 H -60.0 -43.0 90.0 0.474 0.0 HOH
 2.965
 OE2
 O
GLU B:271 B:418 102.0 0.537 H -61.3 -41.1 NA NA NA
6djj 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 GLU A:271 A:418 88.0 0.463 H -62.1 -41.2 88.0 0.463 0.0 HOH
 2.963
 OE2
 O
GLU B:271 B:418 100.0 0.526 H -56.9 -45.1 NA NA NA
6myz 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-06 GLU A:271 A:418 92.0 0.484 H -62.3 -41.4 92.0 0.484 0.0 HOH
 2.873
 OE2
 O
GLU B:271 B:418 106.0 0.558 H -62.9 -40.6 NA NA NA
6mz0 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-06 GLU A:271 A:418 100.0 0.526 H -63.9 -39.3 100.0 0.526 0.0 HOH
 3.990
 CB
 O
GLU B:271 B:418 93.0 0.489 H -59.7 -43.6 NA NA NA
6n0d 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 GLU A:271 A:418 87.0 0.458 H -61.0 -41.8 87.0 0.458 0.0 HOH
 2.639
 OE1
 O
GLU B:271 B:418 96.0 0.505 H -60.1 -39.9 NA NA NA
6n0n 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 GLU A:271 A:418 101.0 0.532 H -58.9 -42.0 101.0 0.532 0.0 HOH
 2.909
 OE1
 O
GLU B:271 B:418 85.0 0.447 H -60.1 -40.6 NA NA NA
6n0o 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 GLU A:271 A:418 90.0 0.474 H -60.1 -40.8 90.0 0.474 0.0 HOH
 3.848
 CB
 O
GLU B:271 B:418 89.0 0.468 H -60.6 -42.9 NA NA NA
6n0r 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 GLU A:271 A:418 88.0 0.463 H -59.8 -40.3 88.0 0.463 0.0 HOH
 2.678
 OE1
 O
GLU B:271 B:418 87.0 0.458 H -55.7 -48.3 NA NA NA
6n17 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 GLU A:271 A:418 86.0 0.453 H -60.4 -40.4 86.0 0.453 0.0 HOH
 2.815
 OE1
 O
GLU B:271 B:418 89.0 0.468 H -57.6 -44.2 NA NA NA
6n19 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 GLU A:271 A:418 85.0 0.447 H -61.7 -39.1 85.0 0.447 0.0 HOH
 3.797
 CB
 O
GLU B:271 B:418 92.0 0.484 H -60.4 -43.8 NA NA NA
6w4r 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-17 GLU A:271 A:418 86.0 0.453 H -62.0 -41.6 86.0 0.453 0.0 HOH
 3.781
 CB
 O
GLU B:271 B:418 95.0 0.5 H -61.5 -44.2 NA NA NA
6w7j 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 GLU A:271 A:418 86.0 0.453 H -61.0 -40.7 86.0 0.453 0.0 HOH
 2.311
 OE1
 O
GLU B:271 B:418 104.0 0.547 H -57.4 -45.3 NA NA NA
6w7k 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 GLU A:271 A:418 91.0 0.479 H -65.3 -36.0 91.0 0.479 0.0 HOH
 3.538
 CG
 O
GLU B:271 B:418 115.0 0.605 H -58.8 -47.5 NA NA NA
6w7l 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 GLU A:271 A:418 91.0 0.479 H -63.8 -40.0 91.0 0.479 0.0 HOH
 3.881
 CB
 O
GLU B:271 B:418 68.0 0.358 H -68.0 -36.8 NA NA NA
6mj5 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 GLU A:270 A:418 84.0 0.442 H -63.3 -40.9 84.0 0.442 0.0 HOH
 3.775
 CB
 O
GLU B:270 B:418 105.0 0.553 H -57.1 -49.0 NA NA NA
1jy1 1 Q9NUW8 98.92 0.0 X-RAY
 2002-02-20 GLU A:274 A:418 91.0 0.479 H -58.2 -41.3 91.0 0.479 0.0 HOH
 2.771
 OE1
 O
1mu7 1 20127586 98.92 0.0 X-RAY
 2003-01-07 GLU A:295 A:418 91.0 0.479 H -56.2 -46.3 91.0 0.479 0.0 HOH
 3.739
 CB
 O
GLU B:295 B:418 90.0 0.474 H -53.4 -46.7 NA NA NA
1mu9 1 20127586 98.92 0.0 X-RAY
 2003-01-07 GLU A:295 A:418 87.0 0.458 H -56.7 -47.8 87.0 0.458 0.0 HOH
 6.809
 O
 O
GLU B:295 B:418 93.0 0.489 H -55.8 -45.8 NA NA NA
1nop 2 20127586 98.92 0.0 X-RAY
 2003-03-11 GLU C:295 A:418 89.0 0.468 H -54.9 -51.4 89.0 0.468 0.0 HOH
 2.722
 OE2
 O
GLU D:295 B:418 87.0 0.458 H -58.3 -45.1 NA NA NA
1rff 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 GLU C:295 A:418 105.0 0.553 H -60.3 -39.6 105.0 0.553 0.0 HOH
 2.738
 OE1
 O
GLU D:295 B:418 90.0 0.474 H -56.8 -42.0 NA NA NA
1rfi 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 GLU C:295 A:418 93.0 0.489 H -65.3 -44.1 93.0 0.489 0.0 HOH
 2.681
 OE1
 O
GLU D:295 B:418 89.0 0.468 H -62.2 -44.3 NA NA NA
1rg1 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 GLU C:295 A:418 87.0 0.458 H -64.3 -43.3 87.0 0.458 0.0 HOH
 3.575
 CB
 O
GLU D:295 B:418 94.0 0.495 H -61.8 -40.4 NA NA NA
1rg2 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 GLU C:295 A:418 87.0 0.458 H -57.6 -41.2 87.0 0.458 0.0 HOH
 6.969
 O
 O
GLU D:295 B:418 93.0 0.489 H -58.3 -40.8 NA NA NA
1rgt 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 GLU C:295 A:418 86.0 0.453 H -63.6 -38.1 86.0 0.453 0.0 HOH
 3.446
 CB
 O
GLU D:295 B:418 93.0 0.489 H -62.5 -40.2 NA NA NA
1rgu 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 GLU C:295 A:418 102.0 0.537 H -55.2 -46.2 102.0 0.537 0.0 HOH
 6.861
 O
 O
GLU D:295 B:418 95.0 0.5 H -57.7 -43.0 NA NA NA
1rh0 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 GLU C:295 A:418 93.0 0.489 H -63.3 -45.4 93.0 0.489 0.0 HOH
 6.674
 O
 O
GLU D:295 B:418 94.0 0.495 H -59.6 -38.2 NA NA NA
5nw9 1 Q9NUW8 98.92 0.0 X-RAY
 2018-01-10 GLU A:295 A:418 78.0 0.411 H -55.1 -50.9 78.0 0.411 0.0 HOH
 6.886
 O
 O
GLU B:295 B:418 77.0 0.405 H -63.0 -48.6 NA NA NA
5nwa 1 Q9NUW8 98.92 0.0 X-RAY
 2018-01-10 GLU A:295 A:418 86.0 0.453 H -51.6 -58.9 86.0 0.453 0.0
GLU C:295 B:418 84.0 0.442 H -54.0 -50.9 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q9nuw8-f1 1 Q9NUW8 100.0 0.0 GLU A:418 A:418 32.0 0.168 H -57.2 -33.7