Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr14 | 90455420 | . | G | A | CCDS9888.1:NM_001008744.1:c.1303Gtt>Att_NP_001008744.1:p.435V>I | Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 1qzq | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2004-05-11 | VAL | A:310 | A:435 | 4.0 | 0.026 | -57.6 | 135.5 | 4.0 | 0.026 | 0.0 |
HOH |
3.295 |
N |
O |
|||
| VAL | B:310 | B:435 | 12.0 | 0.077 | -75.6 | 132.7 | 12.0 | 0.077 | 0.0 |
HOH |
7.703 |
CG2 |
O |
||||||||||
| 6dhu | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | VAL | A:288 | A:435 | 6.0 | 0.039 | -68.0 | 125.4 | 6.0 | 0.039 | 0.0 |
HOH |
3.569 |
CG2 |
O |
|||
| VAL | B:288 | B:435 | 7.0 | 0.045 | -74.7 | 131.1 | NA | NA | NA | ||||||||||||||
| 6die | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | VAL | A:288 | A:435 | 5.0 | 0.032 | -64.2 | 127.4 | 5.0 | 0.032 | 0.0 |
HOH |
3.511 |
CG2 |
O |
|||
| VAL | B:288 | B:435 | 6.0 | 0.039 | -64.8 | 129.6 | NA | NA | NA | ||||||||||||||
| 6dih | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | VAL | A:288 | A:435 | 6.0 | 0.039 | -64.8 | 124.1 | 6.0 | 0.039 | 0.0 |
HOH |
3.497 |
CG2 |
O |
|||
| VAL | B:288 | B:435 | 6.0 | 0.039 | -70.2 | 126.6 | NA | NA | NA | ||||||||||||||
| 6dim | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | VAL | A:288 | A:435 | 6.0 | 0.039 | -64.3 | 125.0 | 6.0 | 0.039 | 0.0 |
HOH |
4.049 |
O |
O |
|||
| VAL | B:288 | B:435 | 7.0 | 0.045 | -74.6 | 128.7 | NA | NA | NA | ||||||||||||||
| 6djd | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | VAL | A:288 | A:435 | 7.0 | 0.045 | -63.6 | 126.5 | 7.0 | 0.045 | 0.0 |
HOH |
3.810 |
CG2 |
O |
|||
| VAL | B:288 | B:435 | 5.0 | 0.032 | -76.4 | 129.6 | NA | NA | NA | ||||||||||||||
| 6dje | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | VAL | A:288 | A:435 | 10.0 | 0.065 | -69.0 | 132.5 | 10.0 | 0.065 | 0.0 |
HOH |
3.067 |
N |
O |
|||
| VAL | B:288 | B:435 | 8.0 | 0.052 | -85.7 | 131.4 | NA | NA | NA | ||||||||||||||
| 6djf | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | VAL | A:288 | A:435 | 7.0 | 0.045 | -63.0 | 124.3 | 7.0 | 0.045 | 0.0 |
HOH |
3.845 |
O |
O |
|||
| VAL | B:288 | B:435 | 2.0 | 0.013 | -74.1 | 128.7 | NA | NA | NA | ||||||||||||||
| 6djg | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | VAL | A:288 | A:435 | 7.0 | 0.045 | -65.7 | 124.3 | 7.0 | 0.045 | 0.0 |
HOH |
4.003 |
O |
O |
|||
| VAL | B:288 | B:435 | 7.0 | 0.045 | -75.2 | 127.4 | NA | NA | NA | ||||||||||||||
| 6djh | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | VAL | A:288 | A:435 | 6.0 | 0.039 | -68.0 | 122.9 | 6.0 | 0.039 | 0.0 |
HOH |
3.986 |
O |
O |
|||
| VAL | B:288 | B:435 | 6.0 | 0.039 | -79.7 | 125.2 | NA | NA | NA | ||||||||||||||
| 6dji | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | VAL | A:288 | A:435 | 4.0 | 0.026 | -63.1 | 123.4 | 4.0 | 0.026 | 0.0 |
HOH |
3.568 |
CG2 |
O |
|||
| VAL | B:288 | B:435 | 6.0 | 0.039 | -72.3 | 128.0 | NA | NA | NA | ||||||||||||||
| 6djj | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | VAL | A:288 | A:435 | 6.0 | 0.039 | -62.9 | 126.1 | 6.0 | 0.039 | 0.0 |
HOH |
3.580 |
CG2 |
O |
|||
| VAL | B:288 | B:435 | 5.0 | 0.032 | -64.9 | 128.0 | NA | NA | NA | ||||||||||||||
| 6myz | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-06 | VAL | A:288 | A:435 | 8.0 | 0.052 | -63.8 | 128.0 | 8.0 | 0.052 | 0.0 |
HOH |
3.649 |
CG2 |
O |
|||
| VAL | B:288 | B:435 | 8.0 | 0.052 | -85.0 | 130.3 | NA | NA | NA | ||||||||||||||
| 6mz0 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-06 | VAL | A:288 | A:435 | 8.0 | 0.052 | -64.9 | 128.4 | 8.0 | 0.052 | 0.0 |
HOH |
3.824 |
O |
O |
|||
| VAL | B:288 | B:435 | 7.0 | 0.045 | -68.1 | 129.6 | NA | NA | NA | ||||||||||||||
| 6n0d | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | VAL | A:288 | A:435 | 7.0 | 0.045 | -66.1 | 124.8 | 7.0 | 0.045 | 0.0 |
HOH |
3.667 |
CG2 |
O |
|||
| VAL | B:288 | B:435 | 5.0 | 0.032 | -62.4 | 126.7 | NA | NA | NA | ||||||||||||||
| 6n0n | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | VAL | A:288 | A:435 | 7.0 | 0.045 | -66.0 | 127.8 | 7.0 | 0.045 | 0.0 |
HOH |
4.007 |
O |
O |
|||
| VAL | B:288 | B:435 | 6.0 | 0.039 | -67.2 | 127.0 | NA | NA | NA | ||||||||||||||
| 6n0o | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | VAL | A:288 | A:435 | 7.0 | 0.045 | -59.7 | 126.2 | 7.0 | 0.045 | 0.0 |
HOH |
3.374 |
O |
O |
|||
| VAL | B:288 | B:435 | 6.0 | 0.039 | -68.6 | 127.5 | NA | NA | NA | ||||||||||||||
| 6n0r | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | VAL | A:288 | A:435 | 2.0 | 0.013 | -67.3 | 125.8 | 2.0 | 0.013 | 0.0 |
HOH |
3.491 |
O |
O |
|||
| VAL | B:288 | B:435 | 6.0 | 0.039 | -68.2 | 128.1 | NA | NA | NA | ||||||||||||||
| 6n17 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | VAL | A:288 | A:435 | 6.0 | 0.039 | -60.8 | 124.3 | 6.0 | 0.039 | 0.0 |
HOH |
3.702 |
CG2 |
O |
|||
| VAL | B:288 | B:435 | 7.0 | 0.045 | -70.9 | 129.9 | NA | NA | NA | ||||||||||||||
| 6n19 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | VAL | A:288 | A:435 | 6.0 | 0.039 | -65.6 | 126.2 | 6.0 | 0.039 | 0.0 |
HOH |
3.485 |
CG2 |
O |
|||
| VAL | B:288 | B:435 | 7.0 | 0.045 | -65.9 | 126.7 | NA | NA | NA | ||||||||||||||
| 6w4r | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-17 | VAL | A:288 | A:435 | 6.0 | 0.039 | -66.9 | 126.1 | 6.0 | 0.039 | 0.0 |
HOH |
3.700 |
CG2 |
O |
|||
| VAL | B:288 | B:435 | 3.0 | 0.019 | -67.1 | 130.6 | NA | NA | NA | ||||||||||||||
| 6w7j | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | VAL | A:288 | A:435 | 6.0 | 0.039 | -63.1 | 129.1 | 6.0 | 0.039 | 0.0 |
HOH |
3.698 |
CG2 |
O |
|||
| VAL | B:288 | B:435 | 12.0 | 0.077 | -66.0 | 129.4 | NA | NA | NA | ||||||||||||||
| 6w7k | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | VAL | A:288 | A:435 | 8.0 | 0.052 | -67.0 | 123.0 | 8.0 | 0.052 | 0.0 |
HOH |
3.908 |
O |
O |
|||
| VAL | B:288 | B:435 | 10.0 | 0.065 | -71.8 | 130.3 | NA | NA | NA | ||||||||||||||
| 6w7l | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | VAL | A:288 | A:435 | 6.0 | 0.039 | -70.0 | 124.4 | 6.0 | 0.039 | 0.0 |
HOH |
3.536 |
CG2 |
O |
|||
| VAL | B:288 | B:435 | 6.0 | 0.039 | -73.9 | 132.2 | NA | NA | NA | ||||||||||||||
| 6mj5 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | VAL | A:287 | A:435 | 6.0 | 0.039 | -69.8 | 124.2 | 6.0 | 0.039 | 0.0 |
HOH |
3.694 |
CG2 |
O |
|||
| VAL | B:287 | B:435 | 7.0 | 0.045 | -67.4 | 131.4 | NA | NA | NA | ||||||||||||||
| 1jy1 | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2002-02-20 | VAL | A:291 | A:435 | 20.0 | 0.129 | -60.6 | 127.9 | 20.0 | 0.129 | 0.0 |
HOH |
3.995 |
O |
O |
|||
| 1mu7 | 1 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-01-07 | VAL | A:312 | A:435 | 21.0 | 0.135 | -69.8 | 131.3 | 21.0 | 0.135 | 0.0 |
HOH |
3.800 |
O |
O |
|||
| VAL | B:312 | B:435 | 15.0 | 0.097 | -66.7 | 123.8 | NA | NA | NA | ||||||||||||||
| 1mu9 | 1 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-01-07 | VAL | A:312 | A:435 | 77.0 | 0.497 | 360.0 | 123.9 | 77.0 | 0.497 | 0.0 |
HOH |
3.673 |
O |
O |
|||
| VAL | B:312 | B:435 | 13.0 | 0.084 | -68.2 | 130.2 | NA | NA | NA | ||||||||||||||
| 1nop | 2 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-03-11 | VAL | C:312 | A:435 | 77.0 | 0.497 | 360.0 | 117.9 | 77.0 | 0.497 | 0.0 |
HOH |
7.480 |
O |
O |
|||
| VAL | D:312 | B:435 | 14.0 | 0.09 | -67.6 | 129.1 | NA | NA | NA | ||||||||||||||
| 1rff | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | VAL | C:312 | A:435 | 71.0 | 0.458 | 360.0 | 118.4 | 71.0 | 0.458 | 0.0 |
HOH |
4.802 |
CG2 |
O |
|||
| VAL | D:312 | B:435 | 11.0 | 0.071 | -61.5 | 129.0 | NA | NA | NA | ||||||||||||||
| 1rfi | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | VAL | C:312 | A:435 | 70.0 | 0.452 | 360.0 | 111.4 | 70.0 | 0.452 | 0.0 |
HOH |
6.445 |
CB |
O |
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| VAL | D:312 | B:435 | 12.0 | 0.077 | -68.4 | 129.3 | NA | NA | NA | ||||||||||||||
| 1rg1 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | VAL | C:312 | A:435 | 77.0 | 0.497 | 360.0 | 113.2 | 77.0 | 0.497 | 0.0 |
HOH |
7.755 |
CG1 |
O |
|||
| VAL | D:312 | B:435 | 55.0 | 0.355 | 360.0 | 120.7 | NA | NA | NA | ||||||||||||||
| 1rg2 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | VAL | C:312 | A:435 | 73.0 | 0.471 | 360.0 | 117.5 | 73.0 | 0.471 | 0.0 |
HOH |
7.985 |
CG1 |
O |
|||
| VAL | D:312 | B:435 | 13.0 | 0.084 | -54.4 | 129.3 | NA | NA | NA | ||||||||||||||
| 1rgt | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | VAL | C:312 | A:435 | 71.0 | 0.458 | 360.0 | 113.3 | 71.0 | 0.458 | 0.0 |
HOH |
4.655 |
CG2 |
O |
|||
| VAL | D:312 | B:435 | 11.0 | 0.071 | -64.0 | 128.3 | NA | NA | NA | ||||||||||||||
| 1rgu | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | VAL | C:312 | A:435 | 81.0 | 0.523 | 360.0 | 115.4 | 81.0 | 0.523 | 0.0 |
HOH |
8.033 |
CG1 |
O |
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| VAL | D:312 | B:435 | 13.0 | 0.084 | -64.2 | 127.3 | NA | NA | NA | ||||||||||||||
| 1rh0 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | VAL | C:312 | A:435 | 76.0 | 0.49 | 360.0 | 131.8 | 76.0 | 0.49 | 0.0 |
HOH |
8.139 |
CG2 |
O |
|||
| VAL | D:312 | B:435 | 13.0 | 0.084 | -68.5 | 129.7 | NA | NA | NA | ||||||||||||||
| 5nw9 | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2018-01-10 | VAL | A:312 | A:435 | 7.0 | 0.045 | -61.0 | 111.3 | 7.0 | 0.045 | 0.0 |
HOH |
7.563 |
CG1 |
O |
|||
| VAL | B:312 | B:435 | 5.0 | 0.032 | -66.4 | 112.1 | NA | NA | NA | ||||||||||||||
| 5nwa | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2018-01-10 | VAL | A:312 | A:435 | 3.0 | 0.019 | -93.1 | 111.0 | 3.0 | 0.019 | 0.0 | |||||||
| VAL | C:312 | B:435 | 7.0 | 0.045 | -96.9 | 110.4 | NA | NA | NA | ||||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q9nuw8-f1 | 1 | Q9NUW8 | 100.0 | 0.0 | VAL | A:435 | A:435 | 1.0 | 0.006 | -52.6 | 126.5 | ||