Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr14 90456086 . G A CCDS9888.1:NM_001008744.1:c.1343cGg>cAg_NP_001008744.1:p.448R>Q Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1qzq 1 Q9NUW8 100.0 0.0 X-RAY
 2004-05-11 ARG A:323 A:448 57.0 0.253 H -58.4 -43.7 14.0 0.062 0.191 B:Q9NUW8:0.191
 HOH
 4.670
 NH2
 O
ARG B:323 B:448 62.0 0.276 H -50.3 -45.6 62.0 0.276 0.0 HOH
 5.460
 C
 O
6dhu 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 ARG A:301 A:448 56.0 0.249 H -55.9 -43.2 56.0 0.249 0.0 HOH
 3.763
 NH2
 O
ARG B:301 B:448 58.0 0.258 H -58.3 -41.2 NA NA NA
6die 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 ARG A:301 A:448 57.0 0.253 H -58.1 -43.9 57.0 0.253 0.0 HOH
 3.665
 NH2
 O
ARG B:301 B:448 57.0 0.253 H -56.5 -40.1 NA NA NA
6dih 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 ARG A:301 A:448 56.0 0.249 H -56.7 -45.1 56.0 0.249 0.0 HOH
 4.551
 CD
 O
ARG B:301 B:448 57.0 0.253 H -57.8 -40.9 NA NA NA
6dim 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 ARG A:301 A:448 58.0 0.258 H -58.8 -43.8 58.0 0.258 0.0 HOH
 3.472
 NH2
 O
ARG B:301 B:448 57.0 0.253 H -57.1 -44.2 NA NA NA
6djd 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 ARG A:301 A:448 56.0 0.249 H -56.9 -46.3 56.0 0.249 0.0 HOH
 3.398
 NH2
 O
ARG B:301 B:448 59.0 0.262 H -55.2 -44.9 NA NA NA
6dje 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 ARG A:301 A:448 56.0 0.249 H -57.0 -45.9 56.0 0.249 0.0 HOH
 3.586
 NH2
 O
ARG B:301 B:448 56.0 0.249 H -57.9 -43.5 NA NA NA
6djf 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 ARG A:301 A:448 56.0 0.249 H -56.9 -44.0 56.0 0.249 0.0 HOH
 3.635
 NH2
 O
ARG B:301 B:448 58.0 0.258 H -56.6 -41.4 NA NA NA
6djg 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 ARG A:301 A:448 56.0 0.249 H -58.5 -45.0 56.0 0.249 0.0 HOH
 3.247
 NH2
 O
ARG B:301 B:448 56.0 0.249 H -55.2 -45.0 NA NA NA
6djh 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 ARG A:301 A:448 58.0 0.258 H -58.0 -43.0 58.0 0.258 0.0 HOH
 3.079
 NH2
 O
ARG B:301 B:448 65.0 0.289 H -54.5 -44.6 NA NA NA
6dji 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 ARG A:301 A:448 56.0 0.249 H -57.8 -44.3 56.0 0.249 0.0 HOH
 3.238
 NH2
 O
ARG B:301 B:448 55.0 0.244 H -56.6 -42.9 NA NA NA
6djj 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 ARG A:301 A:448 55.0 0.244 H -57.4 -45.3 55.0 0.244 0.0 HOH
 3.392
 NH2
 O
ARG B:301 B:448 56.0 0.249 H -58.4 -40.9 NA NA NA
6myz 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-06 ARG A:301 A:448 57.0 0.253 H -54.7 -44.9 57.0 0.253 0.0 HOH
 3.326
 NH2
 O
ARG B:301 B:448 60.0 0.267 H -57.5 -43.1 NA NA NA
6mz0 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-06 ARG A:301 A:448 55.0 0.244 H -56.8 -41.4 55.0 0.244 0.0 HOH
 4.408
 CD
 O
ARG B:301 B:448 58.0 0.258 H -54.3 -44.6 NA NA NA
6n0d 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 ARG A:301 A:448 55.0 0.244 H -55.8 -42.1 55.0 0.244 0.0 HOH
 3.677
 NH2
 O
ARG B:301 B:448 57.0 0.253 H -57.8 -39.8 NA NA NA
6n0n 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 ARG A:301 A:448 56.0 0.249 H -58.1 -39.3 56.0 0.249 0.0 HOH
 3.631
 NE
 O
ARG B:301 B:448 55.0 0.244 H -55.4 -43.2 NA NA NA
6n0o 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 ARG A:301 A:448 57.0 0.253 H -55.9 -45.8 57.0 0.253 0.0 HOH
 3.562
 NH2
 O
ARG B:301 B:448 58.0 0.258 H -53.9 -43.4 NA NA NA
6n0r 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 ARG A:301 A:448 54.0 0.24 H -57.3 -42.3 54.0 0.24 0.0 HOH
 3.484
 NH2
 O
ARG B:301 B:448 58.0 0.258 H -58.2 -39.4 NA NA NA
6n17 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 ARG A:301 A:448 56.0 0.249 H -56.3 -43.3 56.0 0.249 0.0 HOH
 3.559
 NH2
 O
ARG B:301 B:448 57.0 0.253 H -56.0 -41.7 NA NA NA
6n19 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 ARG A:301 A:448 55.0 0.244 H -56.1 -43.2 55.0 0.244 0.0 HOH
 3.402
 NH2
 O
ARG B:301 B:448 58.0 0.258 H -58.2 -39.9 NA NA NA
6w4r 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-17 ARG A:301 A:448 55.0 0.244 H -57.1 -46.7 55.0 0.244 0.0 HOH
 3.491
 NH2
 O
ARG B:301 B:448 63.0 0.28 H -55.0 -41.2 NA NA NA
6w7j 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 ARG A:301 A:448 55.0 0.244 H -56.6 -42.4 55.0 0.244 0.0 HOH
 3.247
 NH2
 O
ARG B:301 B:448 59.0 0.262 H -57.1 -39.9 NA NA NA
6w7k 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 ARG A:301 A:448 54.0 0.24 H -56.8 -44.2 54.0 0.24 0.0 HOH
 3.363
 NH2
 O
ARG B:301 B:448 60.0 0.267 H -57.2 -42.3 NA NA NA
6w7l 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 ARG A:301 A:448 54.0 0.24 H -51.6 -46.5 54.0 0.24 0.0 HOH
 3.526
 NH2
 O
ARG B:301 B:448 66.0 0.293 H -57.3 -41.2 NA NA NA
6mj5 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 ARG A:300 A:448 58.0 0.258 H -56.9 -44.4 58.0 0.258 0.0 HOH
 4.754
 CD
 O
ARG B:300 B:448 66.0 0.293 H -54.1 -44.1 NA NA NA
1jy1 1 Q9NUW8 98.92 0.0 X-RAY
 2002-02-20 ARG A:304 A:448 53.0 0.236 H -54.0 -43.9 53.0 0.236 0.0 HOH
 3.697
 NE
 O
1mu7 1 20127586 98.92 0.0 X-RAY
 2003-01-07 ARG A:325 A:448 58.0 0.258 H -50.9 -42.8 58.0 0.258 0.0 HOH
 4.696
 O
 O
ARG B:325 B:448 57.0 0.253 H -53.4 -48.7 NA NA NA
1mu9 1 20127586 98.92 0.0 X-RAY
 2003-01-07 ARG A:325 A:448 59.0 0.262 H -53.2 -44.7 59.0 0.262 0.0 HOH
 2.405
 NH2
 O
ARG B:325 B:448 55.0 0.244 H -59.7 -41.7 NA NA NA
1nop 2 20127586 98.92 0.0 X-RAY
 2003-03-11 ARG C:325 A:448 65.0 0.289 H -58.0 -40.3 65.0 0.289 0.0 HOH
 5.723
 C
 O
ARG D:325 B:448 55.0 0.244 H -50.6 -43.7 NA NA NA
1rff 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 ARG C:325 A:448 57.0 0.253 H -52.0 -42.7 57.0 0.253 0.0 HOH
 4.764
 O
 O
ARG D:325 B:448 55.0 0.244 H -54.6 -42.3 NA NA NA
1rfi 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 ARG C:325 A:448 58.0 0.258 H -50.0 -42.1 58.0 0.258 0.0 HOH
 4.734
 O
 O
ARG D:325 B:448 54.0 0.24 H -58.8 -44.2 NA NA NA
1rg1 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 ARG C:325 A:448 57.0 0.253 H -52.9 -43.2 57.0 0.253 0.0 HOH
 7.455
 O
 O
ARG D:325 B:448 52.0 0.231 H -56.6 -41.5 NA NA NA
1rg2 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 ARG C:325 A:448 60.0 0.267 H -56.2 -40.9 60.0 0.267 0.0 HOH
 5.770
 C
 O
ARG D:325 B:448 54.0 0.24 H -55.8 -41.4 NA NA NA
1rgt 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 ARG C:325 A:448 62.0 0.276 H -55.0 -40.4 62.0 0.276 0.0 HOH
 6.760
 N
 O
ARG D:325 B:448 55.0 0.244 H -61.3 -41.7 NA NA NA
1rgu 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 ARG C:325 A:448 61.0 0.271 H -55.9 -40.8 61.0 0.271 0.0 HOH
 5.907
 C
 O
ARG D:325 B:448 54.0 0.24 H -51.0 -45.5 NA NA NA
1rh0 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 ARG C:325 A:448 59.0 0.262 H -60.2 -40.6 59.0 0.262 0.0 HOH
 5.650
 C
 O
ARG D:325 B:448 54.0 0.24 H -52.8 -46.6 NA NA NA
5nw9 1 Q9NUW8 98.92 0.0 X-RAY
 2018-01-10 ARG A:325 A:448 52.0 0.231 H -53.1 -44.5 52.0 0.231 0.0 HOH
 7.604
 CB
 O
ARG B:325 B:448 55.0 0.244 H -63.4 -44.6 NA NA NA
5nwa 1 Q9NUW8 98.92 0.0 X-RAY
 2018-01-10 ARG A:325 A:448 65.0 0.289 H -60.2 -49.6 65.0 0.289 0.0
ARG C:325 B:448 58.0 0.258 H -47.9 -47.7 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q9nuw8-f1 1 Q9NUW8 100.0 0.0 ARG A:448 A:448 49.0 0.218 H -57.1 -39.3