Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr14 | 90459746 | . | G | A | CCDS9888.1:NM_001008744.1:c.1460cGc>cAc_NP_001008744.1:p.487R>H | Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 1qzq | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2004-05-11 | ARG | A:362 | A:487 | 4.0 | 0.018 | -121.9 | 28.0 | 4.0 | 0.018 | 0.0 |
HOH |
2.975 |
NE |
O |
|||
| ARG | B:362 | B:487 | 3.0 | 0.013 | -118.0 | 25.1 | 3.0 | 0.013 | 0.0 |
HOH |
2.801 |
NE |
O |
||||||||||
| 6dhu | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:340 | A:487 | 0.0 | 0.0 | -120.1 | 22.0 | 0.0 | 0.0 | 0.0 |
HOH |
2.912 |
NE |
O |
|||
| ARG | B:340 | B:487 | 0.0 | 0.0 | -120.9 | 23.1 | NA | NA | NA | ||||||||||||||
| 6die | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:340 | A:487 | 0.0 | 0.0 | -121.4 | 23.1 | 0.0 | 0.0 | 0.0 |
HOH |
2.955 |
NE |
O |
|||
| ARG | B:340 | B:487 | 0.0 | 0.0 | -124.7 | 22.4 | NA | NA | NA | ||||||||||||||
| 6dih | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:340 | A:487 | 0.0 | 0.0 | -120.5 | 23.2 | 0.0 | 0.0 | 0.0 |
HOH |
2.914 |
NE |
O |
|||
| ARG | B:340 | B:487 | 0.0 | 0.0 | -122.7 | 22.4 | NA | NA | NA | ||||||||||||||
| 6dim | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:340 | A:487 | 0.0 | 0.0 | -121.2 | 22.4 | 0.0 | 0.0 | 0.0 |
HOH |
3.001 |
NE |
O |
|||
| ARG | B:340 | B:487 | 1.0 | 0.004 | -119.9 | 23.9 | NA | NA | NA | ||||||||||||||
| 6djd | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:340 | A:487 | 0.0 | 0.0 | -122.3 | 22.9 | 0.0 | 0.0 | 0.0 |
HOH |
2.927 |
NE |
O |
|||
| ARG | B:340 | B:487 | 0.0 | 0.0 | -122.2 | 23.0 | NA | NA | NA | ||||||||||||||
| 6dje | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:340 | A:487 | 0.0 | 0.0 | -120.8 | 22.4 | 0.0 | 0.0 | 0.0 |
HOH |
3.004 |
NE |
O |
|||
| ARG | B:340 | B:487 | 0.0 | 0.0 | -118.7 | 25.1 | NA | NA | NA | ||||||||||||||
| 6djf | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:340 | A:487 | 0.0 | 0.0 | -119.5 | 22.8 | 0.0 | 0.0 | 0.0 |
HOH |
2.962 |
NE |
O |
|||
| ARG | B:340 | B:487 | 0.0 | 0.0 | -120.5 | 24.6 | NA | NA | NA | ||||||||||||||
| 6djg | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:340 | A:487 | 1.0 | 0.004 | -121.7 | 23.3 | 1.0 | 0.004 | 0.0 |
HOH |
2.903 |
NE |
O |
|||
| ARG | B:340 | B:487 | 0.0 | 0.0 | -121.6 | 20.2 | NA | NA | NA | ||||||||||||||
| 6djh | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:340 | A:487 | 1.0 | 0.004 | -120.3 | 23.4 | 1.0 | 0.004 | 0.0 |
HOH |
2.935 |
NE |
O |
|||
| ARG | B:340 | B:487 | 0.0 | 0.0 | -121.7 | 19.4 | NA | NA | NA | ||||||||||||||
| 6dji | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:340 | A:487 | 0.0 | 0.0 | -120.9 | 21.9 | 0.0 | 0.0 | 0.0 |
HOH |
2.912 |
NE |
O |
|||
| ARG | B:340 | B:487 | 0.0 | 0.0 | -121.0 | 24.2 | NA | NA | NA | ||||||||||||||
| 6djj | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | ARG | A:340 | A:487 | 0.0 | 0.0 | -121.7 | 22.7 | 0.0 | 0.0 | 0.0 |
HOH |
2.954 |
NE |
O |
|||
| ARG | B:340 | B:487 | 0.0 | 0.0 | -124.0 | 22.5 | NA | NA | NA | ||||||||||||||
| 6myz | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:340 | A:487 | 1.0 | 0.004 | -120.9 | 22.3 | 1.0 | 0.004 | 0.0 |
HOH |
2.971 |
NE |
O |
|||
| ARG | B:340 | B:487 | 0.0 | 0.0 | -120.4 | 24.2 | NA | NA | NA | ||||||||||||||
| 6mz0 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:340 | A:487 | 1.0 | 0.004 | -122.4 | 24.8 | 1.0 | 0.004 | 0.0 |
HOH |
2.891 |
NE |
O |
|||
| ARG | B:340 | B:487 | 1.0 | 0.004 | -126.5 | 20.8 | NA | NA | NA | ||||||||||||||
| 6n0d | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | ARG | A:340 | A:487 | 0.0 | 0.0 | -120.7 | 21.8 | 0.0 | 0.0 | 0.0 |
HOH |
2.949 |
NE |
O |
|||
| ARG | B:340 | B:487 | 0.0 | 0.0 | -121.6 | 20.5 | NA | NA | NA | ||||||||||||||
| 6n0n | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | ARG | A:340 | A:487 | 0.0 | 0.0 | -121.3 | 20.6 | 0.0 | 0.0 | 0.0 |
HOH |
2.927 |
NE |
O |
|||
| ARG | B:340 | B:487 | 1.0 | 0.004 | -121.2 | 22.2 | NA | NA | NA | ||||||||||||||
| 6n0o | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | ARG | A:340 | A:487 | 0.0 | 0.0 | -119.5 | 21.4 | 0.0 | 0.0 | 0.0 |
HOH |
2.968 |
NE |
O |
|||
| ARG | B:340 | B:487 | 0.0 | 0.0 | -124.7 | 22.2 | NA | NA | NA | ||||||||||||||
| 6n0r | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | ARG | A:340 | A:487 | 0.0 | 0.0 | -121.3 | 23.3 | 0.0 | 0.0 | 0.0 |
HOH |
2.969 |
NE |
O |
|||
| ARG | B:340 | B:487 | 0.0 | 0.0 | -121.3 | 22.6 | NA | NA | NA | ||||||||||||||
| 6n17 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | ARG | A:340 | A:487 | 0.0 | 0.0 | -121.4 | 21.7 | 0.0 | 0.0 | 0.0 |
HOH |
2.981 |
NE |
O |
|||
| ARG | B:340 | B:487 | 0.0 | 0.0 | -121.9 | 23.8 | NA | NA | NA | ||||||||||||||
| 6n19 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | ARG | A:340 | A:487 | 0.0 | 0.0 | -122.2 | 22.5 | 0.0 | 0.0 | 0.0 |
HOH |
2.943 |
NE |
O |
|||
| ARG | B:340 | B:487 | 0.0 | 0.0 | -122.7 | 22.1 | NA | NA | NA | ||||||||||||||
| 6w4r | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-17 | ARG | A:340 | A:487 | 1.0 | 0.004 | -124.7 | 23.3 | 1.0 | 0.004 | 0.0 |
HOH |
2.945 |
NE |
O |
|||
| ARG | B:340 | B:487 | 1.0 | 0.004 | -124.5 | 20.8 | NA | NA | NA | ||||||||||||||
| 6w7j | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | ARG | A:340 | A:487 | 0.0 | 0.0 | -119.9 | 22.8 | 0.0 | 0.0 | 0.0 |
HOH |
2.946 |
NE |
O |
|||
| ARG | B:340 | B:487 | 0.0 | 0.0 | -120.2 | 21.0 | NA | NA | NA | ||||||||||||||
| 6w7k | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | ARG | A:340 | A:487 | 1.0 | 0.004 | -122.2 | 21.6 | 1.0 | 0.004 | 0.0 |
HOH |
2.944 |
NE |
O |
|||
| ARG | B:340 | B:487 | 0.0 | 0.0 | -122.6 | 21.3 | NA | NA | NA | ||||||||||||||
| 6w7l | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | ARG | A:340 | A:487 | 1.0 | 0.004 | -122.2 | 25.9 | 1.0 | 0.004 | 0.0 |
HOH |
2.917 |
NE |
O |
|||
| ARG | B:340 | B:487 | 0.0 | 0.0 | -118.9 | 20.5 | NA | NA | NA | ||||||||||||||
| 6mj5 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | ARG | A:339 | A:487 | 1.0 | 0.004 | -121.6 | 24.5 | 1.0 | 0.004 | 0.0 |
HOH |
2.903 |
NE |
O |
|||
| ARG | B:339 | B:487 | 0.0 | 0.0 | -120.8 | 20.7 | NA | NA | NA | ||||||||||||||
| 1jy1 | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2002-02-20 | ARG | A:343 | A:487 | 5.0 | 0.022 | -118.2 | 21.3 | 5.0 | 0.022 | 0.0 |
HOH |
2.924 |
NE |
O |
|||
| 1mu7 | 1 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-01-07 | ARG | A:364 | A:487 | 4.0 | 0.018 | -126.3 | 19.0 | 4.0 | 0.018 | 0.0 |
HOH |
2.804 |
NE |
O |
|||
| ARG | B:364 | B:487 | 5.0 | 0.022 | -120.3 | 24.7 | NA | NA | NA | ||||||||||||||
| 1mu9 | 1 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-01-07 | ARG | A:364 | A:487 | 4.0 | 0.018 | -129.1 | 27.7 | 4.0 | 0.018 | 0.0 |
HOH |
2.896 |
NE |
O |
|||
| ARG | B:364 | B:487 | 5.0 | 0.022 | -120.7 | 22.3 | NA | NA | NA | ||||||||||||||
| 1nop | 2 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-03-11 | ARG | C:364 | A:487 | 4.0 | 0.018 | -132.6 | 20.9 | 4.0 | 0.018 | 0.0 |
HOH |
3.053 |
NE |
O |
|||
| ARG | D:364 | B:487 | 3.0 | 0.013 | -118.3 | 26.7 | NA | NA | NA | ||||||||||||||
| 1rff | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:364 | A:487 | 3.0 | 0.013 | -121.7 | 21.9 | 3.0 | 0.013 | 0.0 |
HOH |
2.979 |
NE |
O |
|||
| ARG | D:364 | B:487 | 0.0 | 0.0 | -121.2 | 23.4 | NA | NA | NA | ||||||||||||||
| 1rfi | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:364 | A:487 | 3.0 | 0.013 | -128.2 | 20.9 | 3.0 | 0.013 | 0.0 |
HOH |
2.898 |
NE |
O |
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| ARG | D:364 | B:487 | 0.0 | 0.0 | -121.0 | 23.6 | NA | NA | NA | ||||||||||||||
| 1rg1 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:364 | A:487 | 3.0 | 0.013 | -127.6 | 21.6 | 3.0 | 0.013 | 0.0 |
HOH |
2.954 |
NE |
O |
|||
| ARG | D:364 | B:487 | 0.0 | 0.0 | -121.4 | 21.0 | NA | NA | NA | ||||||||||||||
| 1rg2 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:364 | A:487 | 3.0 | 0.013 | -130.8 | 21.6 | 3.0 | 0.013 | 0.0 |
HOH |
2.978 |
NE |
O |
|||
| ARG | D:364 | B:487 | 4.0 | 0.018 | -124.6 | 19.4 | NA | NA | NA | ||||||||||||||
| 1rgt | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:364 | A:487 | 3.0 | 0.013 | -125.3 | 22.0 | 3.0 | 0.013 | 0.0 |
HOH |
3.031 |
NE |
O |
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| ARG | D:364 | B:487 | 0.0 | 0.0 | -119.8 | 22.1 | NA | NA | NA | ||||||||||||||
| 1rgu | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:364 | A:487 | 3.0 | 0.013 | -127.4 | 23.6 | 3.0 | 0.013 | 0.0 |
HOH |
2.784 |
NE |
O |
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| ARG | D:364 | B:487 | 0.0 | 0.0 | -125.2 | 21.4 | NA | NA | NA | ||||||||||||||
| 1rh0 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | ARG | C:364 | A:487 | 3.0 | 0.013 | -128.2 | 21.7 | 3.0 | 0.013 | 0.0 |
HOH |
2.916 |
NE |
O |
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| ARG | D:364 | B:487 | 0.0 | 0.0 | -122.0 | 21.3 | NA | NA | NA | ||||||||||||||
| 5nw9 | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2018-01-10 | ARG | A:364 | A:487 | 3.0 | 0.013 | -126.5 | 22.1 | 3.0 | 0.013 | 0.0 |
HOH |
2.946 |
NE |
O |
|||
| ARG | B:364 | B:487 | 4.0 | 0.018 | -124.4 | 26.8 | NA | NA | NA | ||||||||||||||
| 5nwa | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2018-01-10 | ARG | A:364 | A:487 | 0.0 | 0.0 | -122.9 | 9.8 | 0.0 | 0.0 | 0.0 | |||||||
| ARG | C:364 | B:487 | 7.0 | 0.031 | -115.9 | 26.2 | NA | NA | NA | ||||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q9nuw8-f1 | 1 | Q9NUW8 | 100.0 | 0.0 | ARG | A:487 | A:487 | 2.0 | 0.009 | -121.5 | 14.3 | ||