Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr14 90459764 . A C CCDS9888.1:NM_001008744.1:c.1478cAt>cCt_NP_001008744.1:p.493H>P Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1qzq 1 Q9NUW8 100.0 0.0 X-RAY
 2004-05-11 HIS A:368 A:493 10.0 0.051 -120.9 -6.7 10.0 0.051 0.0 HOH
 3.283
 CE1
 O
HIS B:368 B:493 10.0 0.051 -123.9 -5.5 10.0 0.051 0.0 HOH
 3.019
 NE2
 O
6dhu 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:346 A:493 15.0 0.077 -116.0 -7.6 15.0 0.077 0.0 GHM
HOH
 2.744
3.437
 NE2
CB
 O4
O
HIS B:346 B:493 16.0 0.082 -115.2 -10.3 NA NA NA
6die 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:346 A:493 15.0 0.077 -115.5 -6.0 15.0 0.077 0.0 GHM
HOH
 2.757
3.462
 NE2
NE2
 O3
O
HIS B:346 B:493 16.0 0.082 -113.4 -7.7 NA NA NA
6dih 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:346 A:493 15.0 0.077 -115.6 -8.1 15.0 0.077 0.0 GJS
HOH
 2.703
3.447
 NE2
CB
 O01
O
HIS B:346 B:493 16.0 0.082 -113.3 -8.6 NA NA NA
6dim 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:346 A:493 16.0 0.082 -117.9 -8.4 16.0 0.082 0.0 GJP
HOH
 2.686
3.394
 NE2
NE2
 O3
O
HIS B:346 B:493 16.0 0.082 -114.5 -9.2 NA NA NA
6djd 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:346 A:493 15.0 0.077 -118.2 -8.0 15.0 0.077 0.0 GJP
HOH
 2.614
3.475
 NE2
NE2
 O3
O
HIS B:346 B:493 16.0 0.082 -116.0 -7.3 NA NA NA
6dje 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:346 A:493 14.0 0.072 -116.5 -8.1 14.0 0.072 0.0 GNY
HOH
 2.854
3.356
 NE2
NE2
 O10
O
HIS B:346 B:493 15.0 0.077 -114.0 -11.0 NA NA NA
6djf 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:346 A:493 15.0 0.077 -116.4 -8.1 15.0 0.077 0.0 GNV
HOH
 2.784
3.448
 NE2
NE2
 O17
O
HIS B:346 B:493 16.0 0.082 -117.6 -8.3 NA NA NA
6djg 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:346 A:493 16.0 0.082 -117.8 -7.2 16.0 0.082 0.0 GNJ
HOH
 2.689
3.455
 NE2
CB
 O18
O
HIS B:346 B:493 16.0 0.082 -112.5 -7.7 NA NA NA
6djh 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:346 A:493 17.0 0.087 -115.4 -5.9 17.0 0.087 0.0 GNM
HOH
 2.785
3.414
 NE2
CB
 O15
O
HIS B:346 B:493 16.0 0.082 -114.1 -4.5 NA NA NA
6dji 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:346 A:493 15.0 0.077 -116.8 -7.5 15.0 0.077 0.0 GOG
HOH
 2.836
2.743
 NE2
NE2
 O01
O
HIS B:346 B:493 17.0 0.087 -115.2 -9.0 NA NA NA
6djj 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 HIS A:346 A:493 16.0 0.082 -116.2 -5.2 16.0 0.082 0.0 GM7
HOH
 2.671
3.404
 NE2
CB
 O12
O
HIS B:346 B:493 17.0 0.087 -113.1 -9.6 NA NA NA
6myz 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-06 HIS A:346 A:493 15.0 0.077 -116.3 -8.4 15.0 0.077 0.0 K7D
HOH
 2.865
3.388
 NE2
NE2
 O20
O
HIS B:346 B:493 17.0 0.087 -115.5 -10.2 NA NA NA
6mz0 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-06 HIS A:346 A:493 10.0 0.051 -118.7 -11.5 10.0 0.051 0.0 K7A
HOH
 2.641
3.194
 NE2
CE1
 O03
O
HIS B:346 B:493 12.0 0.062 -113.0 -14.1 NA NA NA
6n0d 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 HIS A:346 A:493 13.0 0.067 -114.5 -7.7 13.0 0.067 0.0 K8J
HOH
 2.709
3.357
 NE2
CB
 O03
O
HIS B:346 B:493 12.0 0.062 -112.7 -8.2 NA NA NA
6n0n 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 HIS A:346 A:493 15.0 0.077 -113.0 -7.2 15.0 0.077 0.0 KAY
HOH
 2.700
3.425
 NE2
CB
 O08
O
HIS B:346 B:493 15.0 0.077 -115.1 -6.7 NA NA NA
6n0o 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 HIS A:346 A:493 12.0 0.062 -117.3 -7.2 12.0 0.062 0.0 K8G
HOH
 2.654
3.365
 NE2
CE1
 O01
O
HIS B:346 B:493 13.0 0.067 -114.0 -9.3 NA NA NA
6n0r 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 HIS A:346 A:493 11.0 0.056 -116.3 -8.3 11.0 0.056 0.0 K8D
HOH
 2.540
3.328
 NE2
CE1
 O09
O
HIS B:346 B:493 13.0 0.067 -113.4 -10.1 NA NA NA
6n17 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 HIS A:346 A:493 16.0 0.082 -116.1 -9.3 16.0 0.082 0.0 K8Y
HOH
 2.712
3.404
 NE2
CE1
 O14
O
HIS B:346 B:493 15.0 0.077 -114.2 -8.8 NA NA NA
6n19 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 HIS A:346 A:493 11.0 0.056 -115.2 -7.0 11.0 0.056 0.0 K8V
HOH
 2.659
3.430
 NE2
CB
 O15
O
HIS B:346 B:493 12.0 0.062 -113.5 -8.8 NA NA NA
6w4r 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-17 HIS A:346 A:493 15.0 0.077 -116.8 -9.4 15.0 0.077 0.0 MPO
SZV
HOH
 9.550
2.727
3.143
 NE2
NE2
NE2
 O3
O28
O
HIS B:346 B:493 15.0 0.077 -115.7 -10.4 NA NA NA
6w7j 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 HIS A:346 A:493 12.0 0.062 -116.6 -8.3 12.0 0.062 0.0 TGM
HOH
 2.601
3.406
 NE2
NE2
 O29
O
HIS B:346 B:493 15.0 0.077 -114.0 -7.7 NA NA NA
6w7k 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 HIS A:346 A:493 11.0 0.056 -118.1 -8.8 11.0 0.056 0.0 TG7
HOH
 2.435
3.285
 NE2
NE2
 O28
O
HIS B:346 B:493 16.0 0.082 -115.9 -9.5 NA NA NA
6w7l 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 HIS A:346 A:493 16.0 0.082 -118.0 -7.8 16.0 0.082 0.0 TGV
HOH
 2.863
3.403
 NE2
CB
 O28
O
HIS B:346 B:493 16.0 0.082 -112.7 -9.8 NA NA NA
6mj5 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 HIS A:345 A:493 16.0 0.082 -116.6 -6.9 16.0 0.082 0.0 JTA
HOH
 2.677
3.495
 NE2
CE1
 O17
O
HIS B:345 B:493 15.0 0.077 -117.0 -5.2 NA NA NA
1jy1 1 Q9NUW8 98.92 0.0 X-RAY
 2002-02-20 HIS A:349 A:493 13.0 0.067 -116.7 -12.0 13.0 0.067 0.0 HOH
 2.779
 NE2
 O
1mu7 1 20127586 98.92 0.0 X-RAY
 2003-01-07 HIS A:370 A:493 13.0 0.067 -121.9 -12.3 13.0 0.067 0.0 WO4
GOL
HOH
 2.584
4.313
3.285
 NE2
NE2
CE1
 O3
O1
O
HIS B:370 B:493 12.0 0.062 -120.0 -12.4 NA NA NA
1mu9 1 20127586 98.92 0.0 X-RAY
 2003-01-07 HIS A:370 A:493 11.0 0.056 -128.7 -4.7 11.0 0.056 0.0 VO4
GOL
HOH
 3.362
2.787
3.389
 CE1
NE2
CB
 O3
O2
O
HIS B:370 B:493 11.0 0.056 -120.9 -9.5 NA NA NA
1nop 2 20127586 98.92 0.0 X-RAY
 2003-03-11 HIS C:370 A:493 12.0 0.062 -115.4 2.0 1.0 0.005 0.057 E:None:0.056
 DT
VO4
HOH
 4.872
2.953
3.706
 NE2
NE2
NE2
 O3'
O1
O
HIS D:370 B:493 11.0 0.056 -118.4 -8.8 NA NA NA
1rff 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 HIS C:370 A:493 11.0 0.056 -118.6 -7.6 1.0 0.005 0.051 E:None:0.051
 DT
VO4
HOH
 5.042
3.116
3.511
 NE2
NE2
CB
 O3'
O1
O
HIS D:370 B:493 12.0 0.062 -119.5 -5.9 NA NA NA
1rfi 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 HIS C:370 A:493 11.0 0.056 -119.6 -8.4 1.0 0.005 0.051 E:None:0.051
 DC
VO4
HOH
 5.077
3.252
3.627
 NE2
NE2
CB
 O3'
O1
O
HIS D:370 B:493 11.0 0.056 -118.9 -12.5 NA NA NA
1rg1 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 HIS C:370 A:493 12.0 0.062 -111.2 -8.3 12.0 0.062 0.0 DT
VO4
OTS
HOH
 5.022
3.125
2.577
3.490
 NE2
NE2
NE2
CB
 O3'
O1
O4
O
HIS D:370 B:493 12.0 0.062 -118.9 -10.4 NA NA NA
1rg2 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 HIS C:370 A:493 11.0 0.056 -116.1 -8.4 11.0 0.056 0.0 DA
VO4
OTS
OTR
HOH
 4.979
3.232
2.582
2.582
3.536
 NE2
NE2
NE2
NE2
CB
 O3'
O1
O4
O4
O
HIS D:370 B:493 13.0 0.067 -122.0 -7.4 NA NA NA
1rgt 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 HIS C:370 A:493 11.0 0.056 -118.7 -5.1 11.0 0.056 0.0 DC
VO4
OTS
OTR
HOH
 4.990
3.196
2.536
2.536
3.484
 NE2
NE2
NE2
NE2
CD2
 O3'
O1
O4
O4
O
HIS D:370 B:493 11.0 0.056 -120.6 -9.3 NA NA NA
1rgu 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 HIS C:370 A:493 12.0 0.062 -117.0 -6.6 12.0 0.062 0.0 DG
VO4
OTS
HOH
 5.017
3.297
2.752
3.352
 NE2
NE2
NE2
CD2
 O3'
O1
O4
O
HIS D:370 B:493 12.0 0.062 -119.4 -5.3 NA NA NA
1rh0 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 HIS C:370 A:493 11.0 0.056 -120.0 0.9 11.0 0.056 0.0 DT
VO4
OTS
HOH
 5.015
3.091
2.785
3.403
 NE2
NE2
NE2
CB
 O3'
O1
O4
O
HIS D:370 B:493 12.0 0.062 -117.6 -5.8 NA NA NA
5nw9 1 Q9NUW8 98.92 0.0 X-RAY
 2018-01-10 HIS A:370 A:493 13.0 0.067 -111.4 -10.4 13.0 0.067 0.0 DT
DA
DT
DA
HOH
 4.860
2.805
4.860
2.805
3.488
 NE2
NE2
NE2
NE2
CB
 O3'
O5'
O3'
O5'
O
HIS B:370 B:493 15.0 0.077 -117.5 -4.5 NA NA NA
5nwa 1 Q9NUW8 98.92 0.0 X-RAY
 2018-01-10 HIS A:370 A:493 12.0 0.062 -113.9 -2.3 12.0 0.062 0.0 DT
DA
 4.910
2.831
 NE2
NE2
 O3'
OP1
HIS C:370 B:493 13.0 0.067 -117.3 9.1 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q9nuw8-f1 1 Q9NUW8 100.0 0.0 HIS A:493 A:493 9.0 0.046 -108.8 16.3