Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr14 90459803 . A C CCDS9888.1:NM_001008744.1:c.1517aAa>aCa_NP_001008744.1:p.506K>T Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1qzq 1 Q9NUW8 100.0 0.0 X-RAY
 2004-05-11 LYS A:381 A:506 76.0 0.38 E -148.7 163.8 76.0 0.38 0.0 HOH
 4.817
 NZ
 O
LYS B:381 B:506 79.0 0.395 E -150.6 168.8 79.0 0.395 0.0 HOH
 5.947
 N
 O
6dhu 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 LYS A:359 A:506 87.0 0.435 E -133.2 163.9 87.0 0.435 0.0 EDO
HOH
 9.149
3.467
 N
CG
 O1
O
LYS B:359 B:506 74.0 0.37 E -134.7 161.7 NA NA NA
6die 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 LYS A:359 A:506 84.0 0.42 E -136.7 163.8 84.0 0.42 0.0 EDO
HOH
 9.178
3.364
 N
CG
 C2
O
LYS B:359 B:506 86.0 0.43 E -136.1 163.2 NA NA NA
6dih 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 LYS A:359 A:506 83.0 0.415 E -133.6 163.5 83.0 0.415 0.0 HOH
 3.561
 CG
 O
LYS B:359 B:506 73.0 0.365 E -137.3 162.3 NA NA NA
6dim 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 LYS A:359 A:506 84.0 0.42 E -131.7 164.5 84.0 0.42 0.0 HOH
 3.384
 CD
 O
LYS B:359 B:506 73.0 0.365 E -136.1 161.1 NA NA NA
6djd 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 LYS A:359 A:506 86.0 0.43 E -129.9 165.9 86.0 0.43 0.0 HOH
 3.550
 CE
 O
LYS B:359 B:506 73.0 0.365 E -133.1 163.5 NA NA NA
6dje 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 LYS A:359 A:506 84.0 0.42 E -130.6 165.2 84.0 0.42 0.0 EDO
HOH
 9.222
3.323
 N
CG
 O2
O
LYS B:359 B:506 81.0 0.405 E -134.1 160.9 NA NA NA
6djf 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 LYS A:359 A:506 87.0 0.435 E -131.7 161.8 87.0 0.435 0.0 HOH
 3.646
 CG
 O
LYS B:359 B:506 88.0 0.44 E -133.4 161.7 NA NA NA
6djg 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 LYS A:359 A:506 82.0 0.41 E -133.3 163.2 82.0 0.41 0.0 HOH
 3.457
 CG
 O
LYS B:359 B:506 72.0 0.36 E -133.8 164.6 NA NA NA
6djh 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 LYS A:359 A:506 76.0 0.38 E -136.9 171.2 76.0 0.38 0.0 EDO
HOH
 9.281
2.900
 N
NZ
 O2
O
LYS B:359 B:506 86.0 0.43 E -132.9 158.4 NA NA NA
6dji 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 LYS A:359 A:506 86.0 0.43 E -130.0 165.2 86.0 0.43 0.0 EDO
HOH
 9.187
3.596
 N
CG
 O1
O
LYS B:359 B:506 76.0 0.38 E -135.3 161.2 NA NA NA
6djj 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 LYS A:359 A:506 82.0 0.41 E -135.0 162.4 82.0 0.41 0.0 EDO
HOH
 9.253
3.406
 N
CG
 O2
O
LYS B:359 B:506 82.0 0.41 E -135.9 164.0 NA NA NA
6myz 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-06 LYS A:359 A:506 84.0 0.42 E -132.3 162.5 84.0 0.42 0.0 HOH
 3.514
 CG
 O
LYS B:359 B:506 84.0 0.42 E -134.6 162.3 NA NA NA
6mz0 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-06 LYS A:359 A:506 85.0 0.425 E -131.8 160.4 85.0 0.425 0.0 HOH
 3.313
 CG
 O
LYS B:359 B:506 76.0 0.38 E -133.7 159.6 NA NA NA
6n0d 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 LYS A:359 A:506 81.0 0.405 E -136.7 162.5 81.0 0.405 0.0 HOH
 3.545
 CG
 O
LYS B:359 B:506 83.0 0.415 E -138.1 161.0 NA NA NA
6n0n 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 LYS A:359 A:506 84.0 0.42 E -137.5 161.7 84.0 0.42 0.0 HOH
 3.457
 CG
 O
LYS B:359 B:506 82.0 0.41 E -135.4 162.4 NA NA NA
6n0o 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 LYS A:359 A:506 85.0 0.425 E -130.5 164.3 85.0 0.425 0.0 HOH
 3.812
 CG
 O
LYS B:359 B:506 74.0 0.37 E -133.1 161.5 NA NA NA
6n0r 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 LYS A:359 A:506 82.0 0.41 E -135.5 162.5 82.0 0.41 0.0 HOH
 3.563
 CD
 O
LYS B:359 B:506 81.0 0.405 E -135.4 161.3 NA NA NA
6n17 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 LYS A:359 A:506 82.0 0.41 E -132.7 166.5 82.0 0.41 0.0 HOH
 3.592
 NZ
 O
LYS B:359 B:506 84.0 0.42 E -136.7 162.5 NA NA NA
6n19 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 LYS A:359 A:506 80.0 0.4 E -136.4 161.9 80.0 0.4 0.0 HOH
 3.009
 NZ
 O
LYS B:359 B:506 90.0 0.45 E -135.0 161.4 NA NA NA
6w4r 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-17 LYS A:359 A:506 86.0 0.43 E -134.7 162.7 86.0 0.43 0.0 HOH
 3.391
 CG
 O
LYS B:359 B:506 64.0 0.32 E -130.1 163.7 NA NA NA
6w7j 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 LYS A:359 A:506 82.0 0.41 E -137.5 160.4 82.0 0.41 0.0 HOH
 3.677
 CG
 O
LYS B:359 B:506 80.0 0.4 E -137.7 164.2 NA NA NA
6w7k 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 LYS A:359 A:506 73.0 0.365 E -133.4 161.7 73.0 0.365 0.0 HOH
 2.351
 NZ
 O
LYS B:359 B:506 71.0 0.355 E -134.1 161.7 NA NA NA
6w7l 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 LYS A:359 A:506 86.0 0.43 E -136.2 159.0 86.0 0.43 0.0 HOH
 3.764
 NZ
 O
LYS B:359 B:506 50.0 0.25 E -132.9 159.7 NA NA NA
6mj5 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 LYS A:358 A:506 87.0 0.435 E -132.6 161.8 87.0 0.435 0.0 EDO
HOH
 9.256
2.454
 N
NZ
 O2
O
LYS B:358 B:506 84.0 0.42 E -132.4 162.0 NA NA NA
1jy1 1 Q9NUW8 98.92 0.0 X-RAY
 2002-02-20 LYS A:362 A:506 82.0 0.41 E -143.4 174.3 82.0 0.41 0.0 HOH
 3.681
 NZ
 O
1mu7 1 20127586 98.92 0.0 X-RAY
 2003-01-07 LYS A:383 A:506 83.0 0.415 E -144.4 168.3 83.0 0.415 0.0 HOH
 4.318
 CB
 O
LYS B:383 B:506 84.0 0.42 E -145.7 166.4 NA NA NA
1mu9 1 20127586 98.92 0.0 X-RAY
 2003-01-07 LYS A:383 A:506 84.0 0.42 E -141.3 170.3 84.0 0.42 0.0 HOH
 6.000
 CE
 O
LYS B:383 B:506 87.0 0.435 E -146.0 166.9 NA NA NA
1nop 2 20127586 98.92 0.0 X-RAY
 2003-03-11 LYS C:383 A:506 82.0 0.41 E -141.3 171.6 82.0 0.41 0.0
LYS D:383 B:506 85.0 0.425 E -139.2 162.6 NA NA NA
1rff 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 LYS C:383 A:506 84.0 0.42 E -140.6 171.5 84.0 0.42 0.0 HOH
 9.486
 C
 O
LYS D:383 B:506 83.0 0.415 E -139.1 167.7 NA NA NA
1rfi 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 LYS C:383 A:506 83.0 0.415 E -140.2 169.9 83.0 0.415 0.0 HOH
 9.511
 C
 O
LYS D:383 B:506 82.0 0.41 E -144.2 164.1 NA NA NA
1rg1 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 LYS C:383 A:506 88.0 0.44 E -136.5 169.2 88.0 0.44 0.0
LYS D:383 B:506 77.0 0.385 E -140.9 170.0 NA NA NA
1rg2 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 LYS C:383 A:506 82.0 0.41 E -143.8 170.2 82.0 0.41 0.0
LYS D:383 B:506 85.0 0.425 E -141.0 169.3 NA NA NA
1rgt 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 LYS C:383 A:506 84.0 0.42 E -144.4 168.4 84.0 0.42 0.0
LYS D:383 B:506 86.0 0.43 E -143.3 168.1 NA NA NA
1rgu 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 LYS C:383 A:506 89.0 0.445 E -143.5 169.3 89.0 0.445 0.0
LYS D:383 B:506 85.0 0.425 E -145.2 168.0 NA NA NA
1rh0 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 LYS C:383 A:506 84.0 0.42 E -140.5 168.2 84.0 0.42 0.0 HOH
 9.357
 N
 O
LYS D:383 B:506 85.0 0.425 E -139.2 164.4 NA NA NA
5nw9 1 Q9NUW8 98.92 0.0 X-RAY
 2018-01-10 LYS A:383 A:506 75.0 0.375 E -143.5 167.1 75.0 0.375 0.0
LYS B:383 B:506 71.0 0.355 E -143.6 168.2 NA NA NA
5nwa 1 Q9NUW8 98.92 0.0 X-RAY
 2018-01-10 LYS A:383 A:506 78.0 0.39 E -142.2 156.3 78.0 0.39 0.0
LYS C:383 B:506 72.0 0.36 E -152.8 170.0 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q9nuw8-f1 1 Q9NUW8 100.0 0.0 LYS A:506 A:506 90.0 0.45 E -132.0 160.2