Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr14 90499510 . A C CCDS9888.1:NM_001008744.1:c.1705Acc>Ccc_NP_001008744.1:p.569T>P Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1qzq 1 Q9NUW8 100.0 0.0 X-RAY
 2004-05-11 THR A:444 A:569 81.0 0.579 360.0 136.6 81.0 0.579 0.0 HOH
 9.530
 OG1
 O
THR B:444 B:569 30.0 0.214 E -106.3 117.6 30.0 0.214 0.0 HOH
 9.604
 CB
 O
6dhu 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 THR A:422 A:569 40.0 0.286 E -104.4 136.2 40.0 0.286 0.0 EDO
HOH
 9.913
2.950
 OG1
O
 C1
O
THR B:422 B:569 23.0 0.164 E -120.1 124.9 NA NA NA
6die 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 THR A:422 A:569 18.0 0.129 E -113.9 128.7 18.0 0.129 0.0 EDO
HOH
 8.507
2.962
 CG2
O
 C2
O
THR B:422 B:569 23.0 0.164 E -114.2 130.1 NA NA NA
6dih 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 THR A:422 A:569 22.0 0.157 E -105.6 137.4 22.0 0.157 0.0 HOH
 2.961
 O
 O
THR B:422 B:569 31.0 0.221 E -116.5 132.1 NA NA NA
6dim 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 THR A:422 A:569 20.0 0.143 E -105.4 139.4 20.0 0.143 0.0 HOH
 3.064
 O
 O
THR B:422 B:569 26.0 0.186 E -119.0 131.6 NA NA NA
6djd 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 THR A:422 A:569 22.0 0.157 E -110.2 135.5 22.0 0.157 0.0 HOH
 3.090
 O
 O
THR B:422 B:569 34.0 0.243 E -114.0 131.1 NA NA NA
6dje 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 THR A:422 A:569 39.0 0.279 E -107.8 137.0 39.0 0.279 0.0 EDO
HOH
 9.486
2.978
 OG1
O
 C2
O
THR B:422 B:569 57.0 0.407 E -118.3 132.0 NA NA NA
6djf 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 THR A:422 A:569 22.0 0.157 E -110.2 137.4 22.0 0.157 0.0 HOH
 2.941
 O
 O
THR B:422 B:569 20.0 0.143 E -108.2 138.9 NA NA NA
6djg 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 THR A:422 A:569 19.0 0.136 E -112.1 137.3 19.0 0.136 0.0 HOH
 4.447
 OG1
 O
THR B:422 B:569 26.0 0.186 E -111.2 136.0 NA NA NA
6djh 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 THR A:422 A:569 27.0 0.193 E -110.4 139.5 27.0 0.193 0.0 EDO
HOH
 9.855
2.954
 OG1
O
 C2
O
THR B:422 B:569 25.0 0.179 E -118.0 132.2 NA NA NA
6dji 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 THR A:422 A:569 25.0 0.179 E -110.3 140.2 25.0 0.179 0.0 EDO
HOH
 9.864
2.903
 OG1
O
 C1
O
THR B:422 B:569 29.0 0.207 E -113.7 136.6 NA NA NA
6djj 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 THR A:422 A:569 18.0 0.129 E -112.0 136.0 18.0 0.129 0.0 EDO
HOH
 9.406
2.851
 OG1
O
 C2
O
THR B:422 B:569 29.0 0.207 E -118.9 129.4 NA NA NA
6myz 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-06 THR A:422 A:569 18.0 0.129 E -108.3 138.1 18.0 0.129 0.0 HOH
 3.026
 O
 O
THR B:422 B:569 25.0 0.179 E -117.9 136.6 NA NA NA
6mz0 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-06 THR A:422 A:569 21.0 0.15 E -106.5 140.1 21.0 0.15 0.0 HOH
 2.763
 O
 O
THR B:422 B:569 28.0 0.2 E -113.4 132.3 NA NA NA
6n0d 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 THR A:422 A:569 28.0 0.2 E -102.5 136.4 28.0 0.2 0.0 HOH
 2.699
 O
 O
THR B:422 B:569 26.0 0.186 E -120.7 115.3 NA NA NA
6n0n 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 THR A:422 A:569 25.0 0.179 E -115.4 126.3 25.0 0.179 0.0 HOH
 2.709
 O
 O
THR B:422 B:569 21.0 0.15 E -105.6 134.4 NA NA NA
6n0o 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 THR A:422 A:569 14.0 0.1 E -108.9 141.3 14.0 0.1 0.0 HOH
 3.002
 O
 O
THR B:422 B:569 28.0 0.2 E -107.8 140.6 NA NA NA
6n0r 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 THR A:422 A:569 19.0 0.136 E -103.9 138.1 19.0 0.136 0.0 HOH
 2.901
 O
 O
THR B:422 B:569 26.0 0.186 E -112.6 136.9 NA NA NA
6n17 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 THR A:422 A:569 20.0 0.143 E -108.5 137.5 20.0 0.143 0.0 HOH
 3.034
 O
 O
THR B:422 B:569 25.0 0.179 E -114.6 134.9 NA NA NA
6n19 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 THR A:422 A:569 23.0 0.164 E -108.0 134.6 23.0 0.164 0.0 HOH
 2.881
 O
 O
THR B:422 B:569 20.0 0.143 E -112.8 134.6 NA NA NA
6w4r 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-17 THR A:422 A:569 21.0 0.15 E -108.9 138.3 21.0 0.15 0.0 HOH
 2.796
 O
 O
THR B:422 B:569 30.0 0.214 E -119.8 124.3 NA NA NA
6w7j 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 THR A:422 A:569 25.0 0.179 E -97.3 136.6 25.0 0.179 0.0 HOH
 2.807
 O
 O
THR B:422 B:569 35.0 0.25 E -114.1 119.3 NA NA NA
6w7k 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 THR A:422 A:569 14.0 0.1 E -110.5 135.8 14.0 0.1 0.0 HOH
 3.139
 O
 O
THR B:422 B:569 24.0 0.171 E -123.7 121.5 NA NA NA
6w7l 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 THR A:422 A:569 33.0 0.236 E -121.3 112.8 33.0 0.236 0.0 HOH
 2.799
 O
 O
THR B:422 B:569 31.0 0.221 E -123.0 111.8 NA NA NA
6mj5 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 THR A:421 A:569 15.0 0.107 E -113.1 136.7 15.0 0.107 0.0 EDO
HOH
 9.776
2.967
 OG1
O
 C2
O
THR B:421 B:569 20.0 0.143 E -109.7 138.0 NA NA NA
1jy1 1 Q9NUW8 98.92 0.0 X-RAY
 2002-02-20 THR A:425 A:569 72.0 0.514 E -107.4 124.5 72.0 0.514 0.0 HOH
 2.777
 O
 O
1mu7 1 20127586 98.92 0.0 X-RAY
 2003-01-07 THR A:446 A:569 54.0 0.386 E -102.1 127.8 54.0 0.386 0.0 HOH
 2.605
 O
 O
THR B:446 B:569 51.0 0.364 E -100.1 133.5 NA NA NA
1mu9 1 20127586 98.92 0.0 X-RAY
 2003-01-07 THR A:446 A:569 46.0 0.329 E -114.1 131.7 46.0 0.329 0.0 HOH
 2.592
 O
 O
THR B:446 B:569 35.0 0.25 E -101.8 125.5 NA NA NA
1nop 2 20127586 98.92 0.0 X-RAY
 2003-03-11 THR C:446 A:569 44.0 0.314 E -125.7 120.2 44.0 0.314 0.0 HOH
 8.278
 OG1
 O
THR D:446 B:569 37.0 0.264 E -113.7 128.6 NA NA NA
1rff 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 THR C:446 A:569 49.0 0.35 E -114.0 115.3 49.0 0.35 0.0 HOH
 4.798
 O
 O
THR D:446 B:569 85.0 0.607 360.0 132.9 NA NA NA
1rfi 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 THR C:446 A:569 46.0 0.329 E -121.1 123.3 46.0 0.329 0.0 HOH
 6.784
 O
 O
THR D:446 B:569 82.0 0.586 360.0 126.9 NA NA NA
1rg1 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 THR C:446 A:569 92.0 0.657 360.0 124.8 92.0 0.657 0.0 HOH
 6.825
 O
 O
THR D:446 B:569 51.0 0.364 E -112.1 125.9 NA NA NA
1rg2 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 THR C:446 A:569 46.0 0.329 E -120.5 132.8 46.0 0.329 0.0 HOH
 6.813
 O
 O
THR D:446 B:569 34.0 0.243 E -103.9 128.3 NA NA NA
1rgt 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 THR C:446 A:569 88.0 0.629 360.0 130.4 88.0 0.629 0.0 HOH
 6.753
 O
 O
THR D:446 B:569 90.0 0.643 360.0 130.9 NA NA NA
1rgu 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 THR C:446 A:569 48.0 0.343 E -123.7 114.2 48.0 0.343 0.0 HOH
 6.765
 O
 O
THR D:446 B:569 81.0 0.579 360.0 126.7 NA NA NA
1rh0 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 THR C:446 A:569 45.0 0.321 E -117.4 124.0 45.0 0.321 0.0 HOH
 5.357
 OG1
 O
THR D:446 B:569 85.0 0.607 360.0 120.6 NA NA NA
5nw9 1 Q9NUW8 98.92 0.0 X-RAY
 2018-01-10 THR A:446 A:569 47.0 0.336 E -101.0 132.2 47.0 0.336 0.0
THR B:446 B:569 53.0 0.379 E -98.6 129.9 NA NA NA
5nwa 1 Q9NUW8 98.92 0.0 X-RAY
 2018-01-10 THR A:446 A:569 13.0 0.093 -109.1 130.6 13.0 0.093 0.0
THR C:446 B:569 46.0 0.329 E -98.7 134.8 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q9nuw8-f1 1 Q9NUW8 100.0 0.0 THR A:569 A:569 25.0 0.179 E -90.0 107.9