Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr14 90499538 . C A CCDS9888.1:NM_001008744.1:c.1733cCa>cAa_NP_001008744.1:p.578P>Q Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1qzq 1 Q9NUW8 100.0 0.0 X-RAY
 2004-05-11 PRO A:453 A:578 12.0 0.083 -74.5 146.5 12.0 0.083 0.0 HOH
 3.743
 CA
 O
PRO B:453 B:578 14.0 0.097 -72.5 144.2 14.0 0.097 0.0 HOH
 4.196
 CA
 O
6dhu 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 PRO A:431 A:578 15.0 0.103 -67.2 152.0 15.0 0.103 0.0 EDO
HOH
 7.790
2.557
 N
O
 O2
O
PRO B:431 B:578 13.0 0.09 -68.3 148.1 NA NA NA
6die 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 PRO A:431 A:578 13.0 0.09 -67.3 150.4 13.0 0.09 0.0 EDO
HOH
 7.646
2.557
 N
O
 O1
O
PRO B:431 B:578 19.0 0.131 -66.0 147.8 NA NA NA
6dih 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 PRO A:431 A:578 15.0 0.103 -66.4 152.7 15.0 0.103 0.0 HOH
 2.559
 O
 O
PRO B:431 B:578 14.0 0.097 -66.3 148.4 NA NA NA
6dim 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 PRO A:431 A:578 14.0 0.097 -69.9 149.9 14.0 0.097 0.0 HOH
 3.661
 CA
 O
PRO B:431 B:578 14.0 0.097 -68.0 147.3 NA NA NA
6djd 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 PRO A:431 A:578 15.0 0.103 -66.6 151.9 15.0 0.103 0.0 HOH
 2.621
 O
 O
PRO B:431 B:578 14.0 0.097 -66.3 151.2 NA NA NA
6dje 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 PRO A:431 A:578 15.0 0.103 -67.0 151.0 15.0 0.103 0.0 EDO
HOH
 7.612
2.488
 N
O
 O1
O
PRO B:431 B:578 14.0 0.097 -65.8 147.0 NA NA NA
6djf 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 PRO A:431 A:578 15.0 0.103 -67.2 150.1 15.0 0.103 0.0 HOH
 3.650
 CA
 O
PRO B:431 B:578 14.0 0.097 -65.4 147.2 NA NA NA
6djg 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 PRO A:431 A:578 14.0 0.097 -65.7 151.2 14.0 0.097 0.0 HOH
 2.600
 O
 O
PRO B:431 B:578 13.0 0.09 -61.8 145.7 NA NA NA
6djh 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 PRO A:431 A:578 15.0 0.103 -70.7 148.3 15.0 0.103 0.0 EDO
HOH
 7.566
3.595
 N
CA
 O1
O
PRO B:431 B:578 13.0 0.09 -68.8 147.6 NA NA NA
6dji 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 PRO A:431 A:578 14.0 0.097 -67.0 153.0 14.0 0.097 0.0 EDO
HOH
 7.703
2.875
 N
O
 O2
O
PRO B:431 B:578 13.0 0.09 -71.3 150.9 NA NA NA
6djj 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 PRO A:431 A:578 13.0 0.09 -66.6 150.9 13.0 0.09 0.0 EDO
HOH
 7.661
2.523
 N
O
 O1
O
PRO B:431 B:578 13.0 0.09 -63.6 150.1 NA NA NA
6myz 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-06 PRO A:431 A:578 15.0 0.103 -65.4 152.7 15.0 0.103 0.0 HOH
 2.681
 O
 O
PRO B:431 B:578 14.0 0.097 -65.2 146.5 NA NA NA
6mz0 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-06 PRO A:431 A:578 13.0 0.09 -62.9 154.6 13.0 0.09 0.0 HOH
 3.684
 CA
 O
PRO B:431 B:578 14.0 0.097 -66.0 146.5 NA NA NA
6n0d 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 PRO A:431 A:578 13.0 0.09 -66.9 149.4 13.0 0.09 0.0 HOH
 2.586
 O
 O
PRO B:431 B:578 12.0 0.083 -67.1 148.0 NA NA NA
6n0n 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 PRO A:431 A:578 15.0 0.103 -68.4 148.1 15.0 0.103 0.0 HOH
 2.632
 O
 O
PRO B:431 B:578 15.0 0.103 -65.8 149.0 NA NA NA
6n0o 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 PRO A:431 A:578 14.0 0.097 -69.8 147.7 14.0 0.097 0.0 HOH
 3.605
 CA
 O
PRO B:431 B:578 12.0 0.083 -64.5 147.9 NA NA NA
6n0r 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 PRO A:431 A:578 14.0 0.097 -66.3 149.0 14.0 0.097 0.0 HOH
 3.664
 CA
 O
PRO B:431 B:578 14.0 0.097 -65.6 149.0 NA NA NA
6n17 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 PRO A:431 A:578 14.0 0.097 -68.1 152.4 14.0 0.097 0.0 HOH
 2.632
 O
 O
PRO B:431 B:578 12.0 0.083 -67.7 149.6 NA NA NA
6n19 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 PRO A:431 A:578 14.0 0.097 -67.1 148.8 14.0 0.097 0.0 HOH
 3.674
 CA
 O
PRO B:431 B:578 15.0 0.103 -67.6 148.0 NA NA NA
6w4r 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-17 PRO A:431 A:578 15.0 0.103 -66.2 150.6 15.0 0.103 0.0 HOH
 2.802
 O
 O
PRO B:431 B:578 13.0 0.09 -66.1 147.8 NA NA NA
6w7j 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 PRO A:431 A:578 14.0 0.097 -65.7 148.5 14.0 0.097 0.0 HOH
 2.586
 O
 O
PRO B:431 B:578 13.0 0.09 -66.0 148.9 NA NA NA
6w7k 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 PRO A:431 A:578 14.0 0.097 -67.2 150.6 14.0 0.097 0.0 HOH
 2.643
 O
 O
PRO B:431 B:578 13.0 0.09 -67.3 150.5 NA NA NA
6w7l 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 PRO A:431 A:578 14.0 0.097 -66.6 147.7 14.0 0.097 0.0 HOH
 2.674
 O
 O
PRO B:431 B:578 15.0 0.103 -68.9 149.9 NA NA NA
6mj5 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 PRO A:430 A:578 14.0 0.097 -69.0 150.3 14.0 0.097 0.0 EDO
HOH
 7.480
3.743
 N
CA
 O1
O
PRO B:430 B:578 14.0 0.097 -68.4 148.1 NA NA NA
1jy1 1 Q9NUW8 98.92 0.0 X-RAY
 2002-02-20 PRO A:434 A:578 20.0 0.138 -68.4 153.6 20.0 0.138 0.0 HOH
 2.952
 O
 O
1mu7 1 20127586 98.92 0.0 X-RAY
 2003-01-07 PRO A:455 A:578 20.0 0.138 -63.0 147.8 20.0 0.138 0.0 HOH
 2.983
 O
 O
PRO B:455 B:578 19.0 0.131 -65.0 147.5 NA NA NA
1mu9 1 20127586 98.92 0.0 X-RAY
 2003-01-07 PRO A:455 A:578 20.0 0.138 -62.0 146.3 20.0 0.138 0.0 HOH
 2.834
 O
 O
PRO B:455 B:578 14.0 0.097 -69.8 149.9 NA NA NA
1nop 2 20127586 98.92 0.0 X-RAY
 2003-03-11 PRO C:455 A:578 12.0 0.083 -64.4 141.3 12.0 0.083 0.0 HOH
 4.597
 O
 O
PRO D:455 B:578 13.0 0.09 -71.4 145.9 NA NA NA
1rff 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 PRO C:455 A:578 12.0 0.083 -66.3 147.5 12.0 0.083 0.0 HOH
 2.768
 O
 O
PRO D:455 B:578 12.0 0.083 -66.8 147.2 NA NA NA
1rfi 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 PRO C:455 A:578 13.0 0.09 -66.4 146.3 13.0 0.09 0.0 HOH
 4.320
 O
 O
PRO D:455 B:578 14.0 0.097 -69.8 145.0 NA NA NA
1rg1 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 PRO C:455 A:578 13.0 0.09 -59.8 145.6 13.0 0.09 0.0 HOH
 3.302
 CA
 O
PRO D:455 B:578 14.0 0.097 -68.8 150.4 NA NA NA
1rg2 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 PRO C:455 A:578 13.0 0.09 -68.7 142.7 13.0 0.09 0.0 HOH
 4.746
 O
 O
PRO D:455 B:578 13.0 0.09 -68.4 147.8 NA NA NA
1rgt 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 PRO C:455 A:578 13.0 0.09 -66.4 146.5 13.0 0.09 0.0 HOH
 4.613
 O
 O
PRO D:455 B:578 14.0 0.097 -69.5 149.4 NA NA NA
1rgu 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 PRO C:455 A:578 13.0 0.09 -73.2 149.1 13.0 0.09 0.0 HOH
 4.935
 O
 O
PRO D:455 B:578 13.0 0.09 -70.8 146.8 NA NA NA
1rh0 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 PRO C:455 A:578 13.0 0.09 -66.2 143.1 13.0 0.09 0.0 HOH
 4.875
 O
 O
PRO D:455 B:578 15.0 0.103 -68.6 146.3 NA NA NA
5nw9 1 Q9NUW8 98.92 0.0 X-RAY
 2018-01-10 PRO A:455 A:578 18.0 0.124 -72.7 142.2 18.0 0.124 0.0 HOH
 9.443
 O
 O
PRO B:455 B:578 17.0 0.117 -59.8 147.1 NA NA NA
5nwa 1 Q9NUW8 98.92 0.0 X-RAY
 2018-01-10 PRO A:455 A:578 23.0 0.159 -67.7 148.9 23.0 0.159 0.0
PRO C:455 B:578 21.0 0.145 -63.4 141.4 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q9nuw8-f1 1 Q9NUW8 100.0 0.0 PRO A:578 A:578 15.0 0.103 -59.1 139.2