Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr14 | 90499547 | . | A | C | CCDS9888.1:NM_001008744.1:c.1742tAt>tCt_NP_001008744.1:p.581Y>S | Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 1qzq | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2004-05-11 | TYR | A:456 | A:581 | 24.0 | 0.104 | -56.7 | 146.1 | 24.0 | 0.104 | 0.0 |
HOH |
3.505 |
CB |
O |
|||
| TYR | B:456 | B:581 | 22.0 | 0.096 | -53.8 | 138.8 | 22.0 | 0.096 | 0.0 |
HOH |
3.560 |
CB |
O |
||||||||||
| 6dhu | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TYR | A:434 | A:581 | 25.0 | 0.109 | -50.2 | 140.1 | 25.0 | 0.109 | 0.0 |
HOH |
3.473 |
O |
O |
|||
| TYR | B:434 | B:581 | 24.0 | 0.104 | -50.8 | 141.6 | NA | NA | NA | ||||||||||||||
| 6die | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TYR | A:434 | A:581 | 25.0 | 0.109 | -52.0 | 146.3 | 25.0 | 0.109 | 0.0 |
HOH |
2.946 |
O |
O |
|||
| TYR | B:434 | B:581 | 23.0 | 0.1 | -50.6 | 140.6 | NA | NA | NA | ||||||||||||||
| 6dih | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TYR | A:434 | A:581 | 24.0 | 0.104 | -50.7 | 139.1 | 24.0 | 0.104 | 0.0 |
HOH |
3.458 |
O |
O |
|||
| TYR | B:434 | B:581 | 23.0 | 0.1 | -49.9 | 140.0 | NA | NA | NA | ||||||||||||||
| 6dim | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TYR | A:434 | A:581 | 26.0 | 0.113 | -50.9 | 139.0 | 26.0 | 0.113 | 0.0 |
HOH |
3.484 |
CB |
O |
|||
| TYR | B:434 | B:581 | 23.0 | 0.1 | -52.0 | 140.1 | NA | NA | NA | ||||||||||||||
| 6djd | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TYR | A:434 | A:581 | 25.0 | 0.109 | -52.9 | 141.6 | 25.0 | 0.109 | 0.0 |
HOH |
3.509 |
CB |
O |
|||
| TYR | B:434 | B:581 | 23.0 | 0.1 | -52.9 | 142.9 | NA | NA | NA | ||||||||||||||
| 6dje | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TYR | A:434 | A:581 | 25.0 | 0.109 | -50.2 | 136.6 | 25.0 | 0.109 | 0.0 |
HOH |
3.102 |
O |
O |
|||
| TYR | B:434 | B:581 | 24.0 | 0.104 | -50.1 | 135.2 | NA | NA | NA | ||||||||||||||
| 6djf | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TYR | A:434 | A:581 | 24.0 | 0.104 | -50.9 | 140.8 | 24.0 | 0.104 | 0.0 |
HOH |
3.534 |
O |
O |
|||
| TYR | B:434 | B:581 | 23.0 | 0.1 | -52.4 | 142.0 | NA | NA | NA | ||||||||||||||
| 6djg | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TYR | A:434 | A:581 | 25.0 | 0.109 | -51.7 | 139.7 | 25.0 | 0.109 | 0.0 |
HOH |
3.531 |
CB |
O |
|||
| TYR | B:434 | B:581 | 23.0 | 0.1 | -52.0 | 138.4 | NA | NA | NA | ||||||||||||||
| 6djh | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TYR | A:434 | A:581 | 26.0 | 0.113 | -51.9 | 139.7 | 26.0 | 0.113 | 0.0 |
HOH |
3.557 |
CB |
O |
|||
| TYR | B:434 | B:581 | 24.0 | 0.104 | -57.2 | 139.9 | NA | NA | NA | ||||||||||||||
| 6dji | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TYR | A:434 | A:581 | 24.0 | 0.104 | -51.8 | 139.3 | 24.0 | 0.104 | 0.0 |
HOH |
3.156 |
O |
O |
|||
| TYR | B:434 | B:581 | 24.0 | 0.104 | -53.1 | 142.8 | NA | NA | NA | ||||||||||||||
| 6djj | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-05-29 | TYR | A:434 | A:581 | 23.0 | 0.1 | -50.4 | 142.7 | 23.0 | 0.1 | 0.0 |
HOH |
3.318 |
O |
O |
|||
| TYR | B:434 | B:581 | 23.0 | 0.1 | -49.1 | 139.9 | NA | NA | NA | ||||||||||||||
| 6myz | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-06 | TYR | A:434 | A:581 | 24.0 | 0.104 | -50.7 | 139.3 | 24.0 | 0.104 | 0.0 |
HOH |
3.342 |
O |
O |
|||
| TYR | B:434 | B:581 | 26.0 | 0.113 | -52.1 | 141.3 | NA | NA | NA | ||||||||||||||
| 6mz0 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-06 | TYR | A:434 | A:581 | 23.0 | 0.1 | -52.3 | 144.1 | 23.0 | 0.1 | 0.0 |
HOH |
3.555 |
CB |
O |
|||
| TYR | B:434 | B:581 | 24.0 | 0.104 | -47.9 | 138.0 | NA | NA | NA | ||||||||||||||
| 6n0d | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | TYR | A:434 | A:581 | 23.0 | 0.1 | -48.8 | 142.8 | 23.0 | 0.1 | 0.0 |
HOH |
3.490 |
CB |
O |
|||
| TYR | B:434 | B:581 | 22.0 | 0.096 | -48.2 | 142.1 | NA | NA | NA | ||||||||||||||
| 6n0n | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | TYR | A:434 | A:581 | 24.0 | 0.104 | -48.3 | 142.5 | 24.0 | 0.104 | 0.0 |
HOH |
3.240 |
O |
O |
|||
| TYR | B:434 | B:581 | 23.0 | 0.1 | -49.1 | 142.3 | NA | NA | NA | ||||||||||||||
| 6n0o | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | TYR | A:434 | A:581 | 25.0 | 0.109 | -52.3 | 140.6 | 25.0 | 0.109 | 0.0 |
HOH |
3.420 |
O |
O |
|||
| TYR | B:434 | B:581 | 24.0 | 0.104 | -54.8 | 145.3 | NA | NA | NA | ||||||||||||||
| 6n0r | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-11-13 | TYR | A:434 | A:581 | 24.0 | 0.104 | -49.1 | 140.2 | 24.0 | 0.104 | 0.0 |
DMS HOH |
3.635 3.523 |
CD2 CB |
C1 O |
|||
| TYR | B:434 | B:581 | 23.0 | 0.1 | -48.5 | 138.7 | NA | NA | NA | ||||||||||||||
| 6n17 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | TYR | A:434 | A:581 | 25.0 | 0.109 | -51.0 | 140.9 | 25.0 | 0.109 | 0.0 |
DMS HOH |
3.917 2.323 |
CD2 O |
S O |
|||
| TYR | B:434 | B:581 | 23.0 | 0.1 | -51.3 | 141.2 | NA | NA | NA | ||||||||||||||
| 6n19 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | TYR | A:434 | A:581 | 24.0 | 0.104 | -49.5 | 142.5 | 24.0 | 0.104 | 0.0 |
HOH |
3.336 |
O |
O |
|||
| TYR | B:434 | B:581 | 23.0 | 0.1 | -49.1 | 141.6 | NA | NA | NA | ||||||||||||||
| 6w4r | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-17 | TYR | A:434 | A:581 | 23.0 | 0.1 | -50.3 | 141.4 | 23.0 | 0.1 | 0.0 |
HOH |
3.162 |
O |
O |
|||
| TYR | B:434 | B:581 | 24.0 | 0.104 | -50.9 | 147.0 | NA | NA | NA | ||||||||||||||
| 6w7j | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | TYR | A:434 | A:581 | 23.0 | 0.1 | -49.6 | 141.6 | 23.0 | 0.1 | 0.0 |
HOH |
2.548 |
O |
O |
|||
| TYR | B:434 | B:581 | 23.0 | 0.1 | -50.1 | 142.1 | NA | NA | NA | ||||||||||||||
| 6w7k | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | TYR | A:434 | A:581 | 26.0 | 0.113 | -49.2 | 139.7 | 26.0 | 0.113 | 0.0 |
HOH |
3.485 |
O |
O |
|||
| TYR | B:434 | B:581 | 24.0 | 0.104 | -54.7 | 143.3 | NA | NA | NA | ||||||||||||||
| 6w7l | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2021-03-24 | TYR | A:434 | A:581 | 26.0 | 0.113 | -54.0 | 140.5 | 26.0 | 0.113 | 0.0 |
HOH |
3.521 |
CB |
O |
|||
| TYR | B:434 | B:581 | 25.0 | 0.109 | -54.3 | 144.0 | NA | NA | NA | ||||||||||||||
| 6mj5 | 1 | Q9NUW8 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | TYR | A:433 | A:581 | 25.0 | 0.109 | -56.2 | 139.8 | 25.0 | 0.109 | 0.0 |
HOH |
3.588 |
CB |
O |
|||
| TYR | B:433 | B:581 | 24.0 | 0.104 | -52.7 | 143.1 | NA | NA | NA | ||||||||||||||
| 1jy1 | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2002-02-20 | TYR | A:437 | A:581 | 26.0 | 0.113 | -55.8 | 152.3 | 26.0 | 0.113 | 0.0 |
HOH |
3.268 |
O |
O |
|||
| 1mu7 | 1 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-01-07 | TYR | A:458 | A:581 | 23.0 | 0.1 | -59.7 | 140.5 | 23.0 | 0.1 | 0.0 |
HOH |
5.320 |
O |
O |
|||
| TYR | B:458 | B:581 | 24.0 | 0.104 | -58.4 | 148.8 | NA | NA | NA | ||||||||||||||
| 1mu9 | 1 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-01-07 | TYR | A:458 | A:581 | 23.0 | 0.1 | -58.1 | 137.1 | 23.0 | 0.1 | 0.0 |
HOH |
3.502 |
O |
O |
|||
| TYR | B:458 | B:581 | 24.0 | 0.104 | -54.8 | 149.6 | NA | NA | NA | ||||||||||||||
| 1nop | 2 | 20127586 | 98.92 | 0.0 |
X-RAY |
2003-03-11 | TYR | C:458 | A:581 | 25.0 | 0.109 | -57.9 | 132.2 | 25.0 | 0.109 | 0.0 |
HOH |
3.298 |
CB |
O |
|||
| TYR | D:458 | B:581 | 25.0 | 0.109 | -53.4 | 148.5 | NA | NA | NA | ||||||||||||||
| 1rff | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | TYR | C:458 | A:581 | 25.0 | 0.109 | -52.4 | 138.1 | 25.0 | 0.109 | 0.0 |
HOH |
3.474 |
CB |
O |
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| TYR | D:458 | B:581 | 24.0 | 0.104 | -49.6 | 142.3 | NA | NA | NA | ||||||||||||||
| 1rfi | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | TYR | C:458 | A:581 | 23.0 | 0.1 | -47.4 | 128.8 | 23.0 | 0.1 | 0.0 |
HOH |
3.494 |
CB |
O |
|||
| TYR | D:458 | B:581 | 25.0 | 0.109 | -53.8 | 148.9 | NA | NA | NA | ||||||||||||||
| 1rg1 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | TYR | C:458 | A:581 | 25.0 | 0.109 | -51.7 | 136.2 | 25.0 | 0.109 | 0.0 |
HOH |
3.653 |
CB |
O |
|||
| TYR | D:458 | B:581 | 24.0 | 0.104 | -57.0 | 142.6 | NA | NA | NA | ||||||||||||||
| 1rg2 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | TYR | C:458 | A:581 | 27.0 | 0.117 | -57.1 | 137.4 | 27.0 | 0.117 | 0.0 |
HOH |
3.224 |
CB |
O |
|||
| TYR | D:458 | B:581 | 27.0 | 0.117 | -58.5 | 150.1 | NA | NA | NA | ||||||||||||||
| 1rgt | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | TYR | C:458 | A:581 | 23.0 | 0.1 | -56.9 | 135.8 | 23.0 | 0.1 | 0.0 |
HOH |
3.353 |
CB |
O |
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| TYR | D:458 | B:581 | 25.0 | 0.109 | -57.1 | 140.5 | NA | NA | NA | ||||||||||||||
| 1rgu | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | TYR | C:458 | A:581 | 25.0 | 0.109 | -49.7 | 133.9 | 25.0 | 0.109 | 0.0 |
HOH |
3.522 |
CB |
O |
|||
| TYR | D:458 | B:581 | 24.0 | 0.104 | -54.5 | 150.3 | NA | NA | NA | ||||||||||||||
| 1rh0 | 2 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2004-03-02 | TYR | C:458 | A:581 | 24.0 | 0.104 | -49.4 | 134.2 | 24.0 | 0.104 | 0.0 |
HOH |
3.350 |
CB |
O |
|||
| TYR | D:458 | B:581 | 26.0 | 0.113 | -56.3 | 146.3 | NA | NA | NA | ||||||||||||||
| 5nw9 | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2018-01-10 | TYR | A:458 | A:581 | 20.0 | 0.087 | -41.6 | 131.2 | 20.0 | 0.087 | 0.0 |
HOH |
3.482 |
CB |
O |
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| TYR | B:458 | B:581 | 25.0 | 0.109 | -43.0 | 130.3 | NA | NA | NA | ||||||||||||||
| 5nwa | 1 | Q9NUW8 | 98.92 | 0.0 |
X-RAY |
2018-01-10 | TYR | A:458 | A:581 | 24.0 | 0.104 | -52.7 | 136.6 | 24.0 | 0.104 | 0.0 | |||||||
| TYR | C:458 | B:581 | 24.0 | 0.104 | -55.8 | 150.6 | NA | NA | NA | ||||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q9nuw8-f1 | 1 | Q9NUW8 | 100.0 | 0.0 | TYR | A:581 | A:581 | 21.0 | 0.091 | -57.5 | 131.8 | ||