Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr14 90509459 . C A CCDS9888.1:NM_001008744.1:c.1799aCg>aAg_NP_001008744.1:p.600T>K Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1qzq 1 Q9NUW8 100.0 0.0 X-RAY
 2004-05-11 THR A:475 A:600 73.0 0.521 T -60.2 -8.2 12.0 0.086 0.435 B:Q9NUW8:0.436
 HOH
 2.966
 O
 O
THR B:475 B:600 67.0 0.479 T -60.7 -16.4 67.0 0.479 0.0 HOH
 4.331
 OG1
 O
6dhu 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 THR A:453 A:600 78.0 0.557 T -69.0 -8.9 78.0 0.557 0.0 HOH
 2.759
 O
 O
THR B:453 B:600 70.0 0.5 T -48.8 -35.6 NA NA NA
6die 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 THR A:453 A:600 79.0 0.564 T -68.6 -11.8 79.0 0.564 0.0 HOH
 2.740
 O
 O
THR B:453 B:600 71.0 0.507 T -51.7 -32.0 NA NA NA
6dih 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 THR A:453 A:600 77.0 0.55 T -68.2 -10.9 77.0 0.55 0.0 HOH
 2.771
 O
 O
THR B:453 B:600 68.0 0.486 T -50.0 -34.9 NA NA NA
6dim 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 THR A:453 A:600 76.0 0.543 T -66.2 -11.4 76.0 0.543 0.0 HOH
 2.655
 O
 O
THR B:453 B:600 69.0 0.493 T -49.1 -36.0 NA NA NA
6djd 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 THR A:453 A:600 76.0 0.543 T -68.1 -12.8 76.0 0.543 0.0 HOH
 2.747
 O
 O
THR B:453 B:600 68.0 0.486 T -47.1 -38.0 NA NA NA
6dje 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 THR A:453 A:600 77.0 0.55 T -66.8 -11.1 77.0 0.55 0.0 HOH
 2.671
 O
 O
THR B:453 B:600 69.0 0.493 T -51.3 -33.1 NA NA NA
6djf 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 THR A:453 A:600 77.0 0.55 T -66.5 -9.6 77.0 0.55 0.0 HOH
 3.610
 CG2
 O
THR B:453 B:600 69.0 0.493 T -49.7 -36.4 NA NA NA
6djg 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 THR A:453 A:600 78.0 0.557 T -66.7 -11.6 78.0 0.557 0.0 HOH
 2.716
 O
 O
THR B:453 B:600 67.0 0.479 T -52.9 -34.2 NA NA NA
6djh 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 THR A:453 A:600 75.0 0.536 T -68.3 -10.6 75.0 0.536 0.0 HOH
 2.699
 O
 O
THR B:453 B:600 68.0 0.486 T -48.4 -38.0 NA NA NA
6dji 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 THR A:453 A:600 76.0 0.543 T -69.7 -8.4 76.0 0.543 0.0 HOH
 2.755
 O
 O
THR B:453 B:600 69.0 0.493 T -43.8 -38.3 NA NA NA
6djj 1 Q9NUW8 100.0 0.0 X-RAY
 2019-05-29 THR A:453 A:600 76.0 0.543 T -67.7 -10.9 76.0 0.543 0.0 HOH
 2.771
 O
 O
THR B:453 B:600 69.0 0.493 T -46.9 -35.8 NA NA NA
6myz 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-06 THR A:453 A:600 78.0 0.557 T -68.7 -9.4 78.0 0.557 0.0 HOH
 2.793
 O
 O
THR B:453 B:600 69.0 0.493 T -50.1 -37.0 NA NA NA
6mz0 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-06 THR A:453 A:600 77.0 0.55 T -66.9 -13.5 77.0 0.55 0.0 HOH
 2.681
 O
 O
THR B:453 B:600 64.0 0.457 T -63.8 -19.2 NA NA NA
6n0d 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 THR A:453 A:600 78.0 0.557 T -66.8 -9.4 78.0 0.557 0.0 HOH
 2.823
 O
 O
THR B:453 B:600 71.0 0.507 T -48.3 -33.9 NA NA NA
6n0n 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 THR A:453 A:600 70.0 0.5 T -49.0 -34.1 70.0 0.5 0.0 HOH
 2.756
 OG1
 O
THR B:453 B:600 76.0 0.543 T -66.0 -9.6 NA NA NA
6n0o 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 THR A:453 A:600 78.0 0.557 T -68.1 -9.8 78.0 0.557 0.0 HOH
 2.719
 O
 O
THR B:453 B:600 68.0 0.486 T -53.4 -35.0 NA NA NA
6n0r 1 Q9NUW8 100.0 0.0 X-RAY
 2019-11-13 THR A:453 A:600 76.0 0.543 T -66.9 -9.4 76.0 0.543 0.0 HOH
 3.271
 O
 O
THR B:453 B:600 68.0 0.486 T -49.4 -35.4 NA NA NA
6n17 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 THR A:453 A:600 77.0 0.55 T -69.6 -8.8 77.0 0.55 0.0 HOH
 2.775
 O
 O
THR B:453 B:600 70.0 0.5 T -47.8 -35.2 NA NA NA
6n19 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 THR A:453 A:600 77.0 0.55 T -65.7 -11.1 77.0 0.55 0.0 HOH
 2.765
 O
 O
THR B:453 B:600 71.0 0.507 T -49.9 -32.8 NA NA NA
6w4r 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-17 THR A:453 A:600 74.0 0.529 T -68.6 -10.9 74.0 0.529 0.0 HOH
 2.699
 O
 O
THR B:453 B:600 68.0 0.486 T -48.6 -33.1 NA NA NA
6w7j 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 THR A:453 A:600 78.0 0.557 T -66.2 -10.7 78.0 0.557 0.0 HOH
 2.800
 O
 O
THR B:453 B:600 70.0 0.5 T -48.4 -34.3 NA NA NA
6w7k 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 THR A:453 A:600 77.0 0.55 T -66.8 -11.0 77.0 0.55 0.0 HOH
 2.745
 O
 O
THR B:453 B:600 68.0 0.486 T -46.7 -36.5 NA NA NA
6w7l 1 Q9NUW8 100.0 0.0 X-RAY
 2021-03-24 THR A:453 A:600 75.0 0.536 T -68.8 -12.5 75.0 0.536 0.0 HOH
 2.653
 O
 O
THR B:453 B:600 68.0 0.486 T -51.0 -36.0 NA NA NA
6mj5 1 Q9NUW8 100.0 0.0 X-RAY
 2019-07-03 THR A:452 A:600 76.0 0.543 T -69.3 -11.2 76.0 0.543 0.0 HOH
 2.694
 O
 O
THR B:452 B:600 70.0 0.5 T -48.1 -41.4 NA NA NA
1jy1 1 Q9NUW8 98.92 0.0 X-RAY
 2002-02-20 THR A:456 A:600 73.0 0.521 T -55.4 -25.1 73.0 0.521 0.0 HOH
 2.747
 OG1
 O
1mu7 1 20127586 98.92 0.0 X-RAY
 2003-01-07 THR A:477 A:600 72.0 0.514 T -48.9 -30.6 72.0 0.514 0.0 HOH
 2.654
 OG1
 O
THR B:477 B:600 75.0 0.536 T -62.0 -11.4 NA NA NA
1mu9 1 20127586 98.92 0.0 X-RAY
 2003-01-07 THR A:477 A:600 71.0 0.507 T -52.8 -37.1 71.0 0.507 0.0 HOH
 3.952
 CG2
 O
THR B:477 B:600 71.0 0.507 T -57.0 -16.6 NA NA NA
1nop 2 20127586 98.92 0.0 X-RAY
 2003-03-11 THR C:477 A:600 73.0 0.521 T -38.4 -39.1 73.0 0.521 0.0 HOH
 4.937
 O
 O
THR D:477 B:600 80.0 0.571 T -60.8 -12.7 NA NA NA
1rff 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 THR C:477 A:600 72.0 0.514 T -48.6 -32.1 72.0 0.514 0.0 HOH
 2.803
 OG1
 O
THR D:477 B:600 77.0 0.55 T -68.6 -8.8 NA NA NA
1rfi 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 THR C:477 A:600 72.0 0.514 T -52.5 -30.9 72.0 0.514 0.0 HOH
 2.946
 OG1
 O
THR D:477 B:600 77.0 0.55 T -67.4 -7.2 NA NA NA
1rg1 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 THR C:477 A:600 70.0 0.5 T -47.5 -33.3 70.0 0.5 0.0 HOH
 4.742
 O
 O
THR D:477 B:600 78.0 0.557 T -61.1 -12.0 NA NA NA
1rg2 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 THR C:477 A:600 72.0 0.514 T -49.7 -32.9 72.0 0.514 0.0 HOH
 4.700
 O
 O
THR D:477 B:600 77.0 0.55 T -58.7 -15.3 NA NA NA
1rgt 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 THR C:477 A:600 71.0 0.507 T -49.6 -33.9 71.0 0.507 0.0 HOH
 4.921
 O
 O
THR D:477 B:600 78.0 0.557 T -65.9 -8.9 NA NA NA
1rgu 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 THR C:477 A:600 73.0 0.521 T -42.5 -33.8 73.0 0.521 0.0 HOH
 4.660
 O
 O
THR D:477 B:600 78.0 0.557 T -66.5 -13.0 NA NA NA
1rh0 2 Q9NUW8 98.92 0.0 X-RAY
 2004-03-02 THR C:477 A:600 69.0 0.493 T -43.0 -32.5 69.0 0.493 0.0 HOH
 4.648
 O
 O
THR D:477 B:600 79.0 0.564 T -61.5 -11.5 NA NA NA
5nw9 1 Q9NUW8 98.92 0.0 X-RAY
 2018-01-10 THR A:477 A:600 73.0 0.521 T -42.2 -37.0 73.0 0.521 0.0 HOH
 8.394
 OG1
 O
THR B:477 B:600 74.0 0.529 T -69.1 -17.6 NA NA NA
5nwa 1 Q9NUW8 98.92 0.0 X-RAY
 2018-01-10 THR A:477 A:600 77.0 0.55 T -49.5 -37.4 77.0 0.55 0.0
THR C:477 B:600 88.0 0.629 T -59.9 -20.4 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q9nuw8-f1 1 Q9NUW8 100.0 0.0 THR A:600 A:600 79.0 0.564 T -56.2 -13.6