Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr15 99482523 . T A CCDS10378.1:NM_000875.3:c.3391Ttc>Atc_NP_000866.1:p.1131F>I Homo sapiens insulin-like growth factor 1 receptor (IGF1R), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6jk8 1 P08069 100.0 0.0 EM
 2020-03-04 PHE A:1131 NA:NA DO NA DO DO DO NA NA NA
PHE B:1131 NA:NA DO NA DO DO DO NA NA NA
6pyh 1 Q60751 95.96 0.0 EM
 2019-10-23 PHE A:1103 NA:NA DO NA DO DO DO NA NA NA
PHE C:1103 NA:NA DO NA DO DO DO NA NA NA
3lvp 1 P08069 100.0 0.0 X-RAY
 2010-07-21 PHE A:181 A:1131 23.0 0.11 E -133.0 151.5 23.0 0.11 0.0
PHE B:181 B:1131 24.0 0.114 E -117.1 135.8 NA NA NA
PHE C:181 C:1131 21.0 0.1 E -152.4 147.6 NA NA NA
PHE D:181 D:1131 18.0 0.086 E -129.0 144.9 NA NA NA
1m7n 1 P08069 100.0 0.0 X-RAY
 2003-01-07 PHE A:159 A:1128 75.0 0.357 -126.3 123.3 75.0 0.357 0.0 HOH
 7.502
 O
 O
PHE B:159 B:1128 79.0 0.376 -131.6 129.2 NA NA NA
1p4o 1 P08069 99.38 0.0 X-RAY
 2003-04-29 PHE A:159 A:1101 77.0 0.367 -113.3 142.3 77.0 0.367 0.0 HOH
 3.257
 CE1
 O
PHE B:159 B:1101 72.0 0.343 -110.3 145.9 NA NA NA
5fxq 1 P08069 100.0 0.0 X-RAY
 2016-10-19 PHE A:153 A:1131 62.0 0.295 -87.9 139.0 62.0 0.295 0.0 HOH
 3.184
 O
 O
5fxr 1 P08069 100.0 0.0 X-RAY
 2016-10-19 PHE A:153 A:1131 75.0 0.357 -88.4 143.2 75.0 0.357 0.0 HOH
 3.079
 O
 O
1jqh 1 P08069 100.0 0.0 X-RAY
 2002-04-19 PHE A:153 A:1131 0.0 0.0 E -130.5 130.9 0.0 0.0 0.0 HOH
 7.061
 CE1
 O
PHE B:153 B:1131 0.0 0.0 E -131.6 130.2 NA NA NA
PHE C:153 C:1131 0.0 0.0 E -131.7 130.2 NA NA NA
2zm3 1 P08069 100.0 0.0 X-RAY
 2008-06-10 PHE A:153 A:1131 35.0 0.167 E -125.3 144.7 35.0 0.167 0.0 HOH
 3.441
 CE2
 O
PHE B:153 B:1131 41.0 0.195 E -127.8 139.4 NA NA NA
PHE C:153 C:1131 15.0 0.071 E -118.5 143.6 NA NA NA
PHE D:153 D:1131 26.0 0.124 E -131.4 139.4 NA NA NA
3f5p 1 P08069 100.0 0.0 X-RAY
 2008-12-30 PHE A:153 A:1131 17.0 0.081 E -124.4 153.2 17.0 0.081 0.0 HOH
 9.131
 O
 O
PHE B:153 B:1131 14.0 0.067 E -133.8 146.9 NA NA NA
PHE C:153 C:1131 24.0 0.114 E -136.9 153.9 NA NA NA
PHE D:153 D:1131 21.0 0.1 E -123.3 148.1 NA NA NA
PHE E:153 E:1131 14.0 0.067 E -122.4 153.5 NA NA NA
PHE F:153 F:1131 15.0 0.071 E -134.2 144.6 NA NA NA
PHE G:153 G:1131 13.0 0.062 E -124.9 157.0 NA NA NA
PHE H:153 H:1131 11.0 0.052 E -133.8 145.6 NA NA NA
PHE I:153 I:1131 13.0 0.062 E -126.4 137.6 NA NA NA
PHE J:153 J:1131 18.0 0.086 E -124.6 137.2 NA NA NA
PHE K:153 K:1131 12.0 0.057 E -123.6 139.5 NA NA NA
PHE L:153 M:1131 12.0 0.057 E -123.0 142.2 NA NA NA
PHE M:153 L:1131 25.0 0.119 E -130.6 134.0 NA NA NA
PHE N:153 R:1131 13.0 0.062 E -128.5 142.2 NA NA NA
PHE O:153 S:1131 9.0 0.043 E -134.7 142.5 NA NA NA
PHE P:153 T:1131 17.0 0.081 E -130.2 144.0 NA NA NA
3i81 1 P08069 99.67 0.0 X-RAY
 2009-12-22 PHE A:152 A:1101 64.0 0.305 -105.4 144.8 64.0 0.305 0.0 HOH
 2.868
 O
 O
5fxs 1 P08069 99.35 0.0 X-RAY
 2016-10-19 PHE A:153 A:1131 76.0 0.362 -96.5 146.2 76.0 0.362 0.0 HOH
 3.053
 O
 O
2oj9 1 P08069 100.0 0.0 X-RAY
 2007-05-01 PHE A:152 A:1101 58.0 0.276 -98.7 132.6 58.0 0.276 0.0 HOH
 3.345
 CE1
 O
3nw5 1 P08069 100.0 0.0 X-RAY
 2010-07-28 PHE A:152 A:1101 58.0 0.276 -102.7 143.7 58.0 0.276 0.0 HOH
 2.994
 O
 O
3nw6 1 P08069 100.0 0.0 X-RAY
 2010-07-28 PHE A:152 A:1101 63.0 0.3 -106.1 140.1 63.0 0.3 0.0 HOH
 2.799
 O
 O
3nw7 1 P08069 100.0 0.0 X-RAY
 2010-07-28 PHE A:152 A:1101 64.0 0.305 -99.6 149.8 64.0 0.305 0.0 HOH
 2.992
 O
 O
3o23 1 P08069 99.67 0.0 X-RAY
 2011-05-04 PHE A:150 A:1131 67.0 0.319 -114.2 121.2 67.0 0.319 0.0 MQY
HOH
 3.462
6.036
 CE1
CE2
 F26
O
3lw0 1 P08069 99.34 0.0 X-RAY
 2010-09-29 PHE A:149 A:1131 52.0 0.248 -106.1 113.2 52.0 0.248 0.0 CCX
HOH
 4.202
3.599
 CZ
CA
 C14
O
PHE B:149 B:1131 53.0 0.252 -106.3 113.7 NA NA NA
PHE C:149 C:1131 54.0 0.257 -109.3 113.4 NA NA NA
PHE D:149 D:1131 53.0 0.252 -109.9 113.1 NA NA NA
5hzn 1 P08069 99.34 0.0 X-RAY
 2016-04-06 PHE A:149 A:1128 16.0 0.076 -110.2 127.0 16.0 0.076 0.0 66A
HOH
 7.965
6.856
 CZ
O
 C23
O
PHE B:149 B:1128 17.0 0.081 -108.8 130.5 NA NA NA
PHE C:149 C:1128 16.0 0.076 -118.1 130.0 NA NA NA
PHE D:149 D:1128 19.0 0.09 -112.9 122.0 NA NA NA
PHE E:149 E:1128 17.0 0.081 -109.8 127.3 NA NA NA
PHE F:149 F:1128 17.0 0.081 -109.0 129.7 NA NA NA
PHE G:149 G:1128 16.0 0.076 -116.8 130.5 NA NA NA
PHE H:149 H:1128 18.0 0.086 -111.0 122.3 NA NA NA
4d2r 1 P08069 100.0 0.0 X-RAY
 2015-04-22 PHE A:147 A:1131 61.0 0.29 -93.3 150.4 61.0 0.29 0.0 CL
HOH
 8.752
2.837
 O
O
 CL
O
3d94 1 P08069 99.67 0.0 X-RAY
 2008-07-29 PHE A:146 A:1101 17.0 0.081 -103.7 125.3 17.0 0.081 0.0 D94
HOH
 7.279
3.702
 CZ
CA
 C17
O
3qqu 1 P08069 100.0 0.0 X-RAY
 2011-04-20 PHE A:146 A:1128 54.0 0.257 -104.5 140.3 54.0 0.257 0.0 HOH
 5.284
 CZ
 O
PHE B:146 B:1128 50.0 0.238 -128.0 112.3 NA NA NA
PHE C:146 C:1128 57.0 0.271 -129.6 139.7 NA NA NA
PHE D:146 D:1128 68.0 0.324 -145.2 134.8 NA NA NA
1k3a 1 P08069 99.67 0.0 X-RAY
 2001-11-28 PHE A:144 A:1101 26.0 0.124 E -125.1 137.8 26.0 0.124 0.0 HOH
 5.659
 CE1
 O
2z8c 1 P06213 80.2 1e-175 X-RAY
 2008-08-12 PHE A:148 A:1128 22.0 0.105 E -148.7 143.8 22.0 0.105 0.0
1gag 1 P06213 80.2 2e-175 X-RAY
 2001-01-17 PHE A:151 A:1128 36.0 0.171 E -133.4 135.8 36.0 0.171 0.0 HOH
 3.677
 CE2
 O
1ir3 1 P06213 80.2 2e-175 X-RAY
 1998-01-07 PHE A:151 A:1128 37.0 0.176 E -134.3 150.2 22.0 0.105 0.071 A:P06213:0.071
 HOH
 2.730
 O
 O
1irk 1 P06213 80.2 2e-175 X-RAY
 1995-02-27 PHE A:151 A:1128 74.0 0.352 -94.8 129.7 74.0 0.352 0.0 HOH
 3.005
 O
 O
5e1s 1 P06213 80.2 2e-175 X-RAY
 2015-10-14 PHE A:153 A:1128 41.0 0.195 -108.3 139.8 41.0 0.195 0.0 HOH
 2.920
 O
 O
1rqq 1 P06213 80.2 3e-175 X-RAY
 2003-12-30 PHE A:151 A:1128 31.0 0.148 E -131.2 144.7 31.0 0.148 0.0 HOH
 3.579
 O
 O
PHE B:151 B:1128 30.0 0.143 E -129.3 143.8 30.0 0.143 0.0 HOH
 3.578
 O
 O
2auh 1 P06213 80.2 3e-175 X-RAY
 2005-11-01 PHE A:151 A:1128 33.0 0.157 E -157.2 138.5 33.0 0.157 0.0
2b4s 2 P06213 80.2 3e-175 X-RAY
 2005-11-15 PHE B:151 B:1128 40.0 0.19 E -127.3 149.4 40.0 0.19 0.0 HOH
 2.644
 O
 O
PHE D:151 D:1128 41.0 0.195 E -131.6 146.1 41.0 0.195 0.0 HOH
 3.848
 CZ
 O
3bu3 1 P06213 80.2 3e-175 X-RAY
 2008-02-19 PHE A:151 A:1128 37.0 0.176 E -123.0 146.0 37.0 0.176 0.0 HOH
 2.608
 O
 O
3bu5 1 P06213 80.2 3e-175 X-RAY
 2008-02-19 PHE A:151 A:1128 38.0 0.181 E -124.9 149.5 38.0 0.181 0.0 HOH
 2.410
 O
 O
3bu6 1 P06213 80.2 3e-175 X-RAY
 2008-02-19 PHE A:151 A:1128 35.0 0.167 E -125.5 146.8 35.0 0.167 0.0 HOH
 2.632
 O
 O
5hhw 1 P06213 80.2 4e-175 X-RAY
 2016-04-13 PHE A:152 A:1155 70.0 0.333 -104.8 132.0 70.0 0.333 0.0 HOH
 3.154
 O
 O
4ibm 1 P06213 80.73 8e-175 X-RAY
 2013-08-21 PHE A:151 A:1128 42.0 0.2 -100.3 122.4 42.0 0.2 0.0 HOH
 3.645
 CA
 O
PHE B:151 B:1128 79.0 0.376 -102.5 135.3 NA NA NA
3eta 1 P06213 80.41 2e-170 X-RAY
 2009-05-26 PHE A:150 A:1128 65.0 0.31 -104.8 135.2 65.0 0.31 0.0 351
HOH
 3.634
2.789
 CE1
O
 C34
O
PHE B:150 B:1128 66.0 0.314 -98.7 130.3 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p08069-f1 1 P08069 100.0 0.0 PHE A:1131 A:1131 31.0 0.148 -86.2 149.8