Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr15 99486152 . A C CCDS10378.1:NM_000875.3:c.3458gAt>gCt_NP_000866.1:p.1153D>A Homo sapiens insulin-like growth factor 1 receptor (IGF1R), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6jk8 1 P08069 100.0 0.0 EM
 2020-03-04 ASP A:1153 NA:NA DO NA DO DO DO NA NA NA
ASP B:1153 NA:NA DO NA DO DO DO NA NA NA
6pyh 1 Q60751 95.96 0.0 EM
 2019-10-23 ASP A:1125 NA:NA DO NA DO DO DO NA NA NA
ASP C:1125 NA:NA DO NA DO DO DO NA NA NA
3lvp 1 P08069 100.0 0.0 X-RAY
 2010-07-21 ASP A:203 A:1153 45.0 0.3 -157.4 127.3 45.0 0.3 0.0 PDR
EPE
HOH
 7.393
8.301
9.628
 CB
OD1
OD1
 CL
C5
O
ASP B:203 B:1153 32.0 0.213 -105.2 149.9 NA NA NA
ASP C:203 C:1153 39.0 0.26 -136.7 135.2 NA NA NA
ASP D:203 D:1153 42.0 0.28 53.4 123.0 NA NA NA
1m7n 1 P08069 100.0 0.0 X-RAY
 2003-01-07 ASP A:181 A:1150 13.0 0.087 -83.7 162.0 13.0 0.087 0.0 HOH
 4.641
 N
 O
ASP B:181 B:1150 20.0 0.133 -87.9 168.4 NA NA NA
1p4o 1 P08069 99.38 0.0 X-RAY
 2003-04-29 ASP A:181 A:1123 18.0 0.12 -88.2 167.6 18.0 0.12 0.0 HOH
 2.658
 OD1
 O
ASP B:181 B:1123 17.0 0.113 -90.4 168.6 NA NA NA
5fxq 1 P08069 100.0 0.0 X-RAY
 2016-10-19 ASP A:175 A:1153 14.0 0.093 -49.5 127.0 14.0 0.093 0.0 GD5
HOH
 3.666
2.670
 OD2
O
 CL
O
5fxr 1 P08069 100.0 0.0 X-RAY
 2016-10-19 ASP A:175 A:1153 10.0 0.067 -48.3 129.2 10.0 0.067 0.0 8LN
HOH
 3.840
2.412
 OD2
O
 CL
O
1jqh 1 P08069 100.0 0.0 X-RAY
 2002-04-19 ASP A:175 A:1153 54.0 0.36 -59.4 151.3 54.0 0.36 0.0 MG
ANP
HOH
 4.219
4.559
2.587
 OD1
OD1
OD2
 MG
O1B
O
ASP B:175 B:1153 52.0 0.347 -60.0 151.9 NA NA NA
ASP C:175 C:1153 53.0 0.353 -58.8 151.6 NA NA NA
2zm3 1 P08069 100.0 0.0 X-RAY
 2008-06-10 ASP A:175 A:1153 50.0 0.333 -143.7 130.0 50.0 0.333 0.0 575
HOH
 5.718
2.555
 OD1
OD2
 C17
O
ASP B:175 B:1153 36.0 0.24 -117.4 117.6 NA NA NA
ASP C:175 C:1153 55.0 0.367 -157.7 111.6 NA NA NA
ASP D:175 D:1153 46.0 0.307 -105.5 131.7 NA NA NA
3f5p 1 P08069 100.0 0.0 X-RAY
 2008-12-30 ASP A:175 A:1153 63.0 0.42 -129.6 107.7 63.0 0.42 0.0 741
 6.281
 OD1
 C29
ASP B:175 B:1153 66.0 0.44 -126.4 106.7 NA NA NA
ASP C:175 C:1153 60.0 0.4 -123.2 122.2 NA NA NA
ASP D:175 D:1153 62.0 0.413 -120.4 119.0 NA NA NA
ASP E:175 E:1153 65.0 0.433 -118.8 122.1 NA NA NA
ASP F:175 F:1153 63.0 0.42 -124.9 116.8 NA NA NA
ASP G:175 G:1153 64.0 0.427 -124.4 117.7 NA NA NA
ASP H:175 H:1153 70.0 0.467 -123.1 112.9 NA NA NA
ASP I:175 I:1153 68.0 0.453 -125.2 113.8 NA NA NA
ASP J:175 J:1153 61.0 0.407 -131.8 119.1 NA NA NA
ASP K:175 K:1153 58.0 0.387 -125.0 120.2 NA NA NA
ASP L:175 M:1153 66.0 0.44 -122.7 116.5 NA NA NA
ASP M:175 L:1153 65.0 0.433 -132.5 115.3 NA NA NA
ASP N:175 R:1153 67.0 0.447 -125.5 103.4 NA NA NA
ASP O:175 S:1153 62.0 0.413 -122.8 115.9 NA NA NA
ASP P:175 T:1153 67.0 0.447 -137.8 101.2 NA NA NA
3i81 1 P08069 99.67 0.0 X-RAY
 2009-12-22 ASP A:174 A:1123 23.0 0.153 -71.0 142.3 23.0 0.153 0.0 EBI
HOH
 3.165
2.687
 O
O
 F34
O
5fxs 1 P08069 99.35 0.0 X-RAY
 2016-10-19 ASP A:175 A:1153 11.0 0.073 S -49.7 126.9 11.0 0.073 0.0 OZN
HOH
 3.548
2.457
 OD2
OD1
 CL36
O
2oj9 1 P08069 100.0 0.0 X-RAY
 2007-05-01 ASP A:174 A:1123 16.0 0.107 -73.0 149.8 16.0 0.107 0.0 BMI
HOH
 5.719
2.950
 OD1
OD1
 C4
O
3nw5 1 P08069 100.0 0.0 X-RAY
 2010-07-28 ASP A:174 A:1123 24.0 0.16 -46.3 134.2 24.0 0.16 0.0 LGX
HOH
 4.349
2.369
 OD2
OD1
 C17
O
3nw6 1 P08069 100.0 0.0 X-RAY
 2010-07-28 ASP A:174 A:1123 19.0 0.127 -46.4 132.3 19.0 0.127 0.0 LGW
HOH
 3.129
2.719
 O
OD1
 F32
O
3nw7 1 P08069 100.0 0.0 X-RAY
 2010-07-28 ASP A:174 A:1123 18.0 0.12 -73.8 143.2 18.0 0.12 0.0 LGV
HOH
 3.129
2.584
 N
O
 N20
O
3o23 1 P08069 99.67 0.0 X-RAY
 2011-05-04 ASP A:172 A:1153 92.0 0.613 -170.6 100.7 92.0 0.613 0.0 MQY
HOH
 2.957
2.862
 N
O
 O8
O
3lw0 1 P08069 99.34 0.0 X-RAY
 2010-09-29 ASP A:171 A:1153 49.0 0.327 -168.4 165.1 49.0 0.327 0.0 CCX
HOH
 3.961
2.646
 OD2
O
 C10
O
ASP B:171 B:1153 46.0 0.307 -165.9 166.3 NA NA NA
ASP C:171 C:1153 32.0 0.213 -167.3 165.1 NA NA NA
ASP D:171 D:1153 48.0 0.32 -167.7 166.6 NA NA NA
5hzn 1 P08069 99.34 0.0 X-RAY
 2016-04-06 ASP A:171 A:1150 33.0 0.22 -48.5 117.1 33.0 0.22 0.0 66A
MES
HOH
 3.617
6.951
2.729
 OD1
OD2
OD2
 O16
O1
O
ASP B:171 B:1150 34.0 0.227 -35.0 114.1 NA NA NA
ASP C:171 C:1150 37.0 0.247 -35.3 118.7 NA NA NA
ASP D:171 D:1150 34.0 0.227 -41.9 115.2 NA NA NA
ASP E:171 E:1150 34.0 0.227 -50.0 120.1 NA NA NA
ASP F:171 F:1150 32.0 0.213 -36.6 117.2 NA NA NA
ASP G:171 G:1150 36.0 0.24 -37.2 121.1 NA NA NA
ASP H:171 H:1150 31.0 0.207 -41.0 115.5 NA NA NA
4d2r 1 P08069 100.0 0.0 X-RAY
 2015-04-22 ASP A:169 A:1153 21.0 0.14 -53.5 135.6 21.0 0.14 0.0 DYK
HOH
 5.376
2.663
 OD2
OD1
 C18
O
3d94 1 P08069 99.67 0.0 X-RAY
 2008-07-29 ASP A:168 A:1123 34.0 0.227 -41.6 115.1 34.0 0.227 0.0 D94
HOH
 3.608
2.610
 N
OD1
 C11
O
3qqu 1 P08069 100.0 0.0 X-RAY
 2011-04-20 ASP A:168 A:1150 26.0 0.173 S 28.2 96.2 26.0 0.173 0.0 01P
HOH
 2.453
4.183
 OD2
OD1
 N2
O
ASP B:168 B:1150 25.0 0.167 S -38.0 116.5 NA NA NA
ASP C:168 C:1150 20.0 0.133 14.5 98.7 NA NA NA
ASP D:168 D:1150 19.0 0.127 -41.6 112.4 NA NA NA
1k3a 1 P08069 99.67 0.0 X-RAY
 2001-11-28 ASP A:166 A:1123 32.0 0.213 -126.9 131.7 32.0 0.213 0.0 ACP
HOH
 2.936
2.602
 OD1
O
 O1G
O
2z8c 1 P06213 80.2 1e-175 X-RAY
 2008-08-12 ASP A:170 A:1150 7.0 0.047 45.5 101.6 6.0 0.04 0.007 B:P35568:0.007
 S91
 5.323
 N
 N2
1gag 1 P06213 80.2 2e-175 X-RAY
 2001-01-17 ASP A:173 A:1150 43.0 0.287 39.4 88.7 43.0 0.287 0.0 MG
MG
112
HOH
 2.060
3.134
2.517
2.954
 OD2
OD2
OD2
OD2
 MG
MG
O2B
O
1ir3 1 P06213 80.2 2e-175 X-RAY
 1998-01-07 ASP A:173 A:1150 47.0 0.313 47.5 85.0 44.0 0.293 0.02 B:None:0.02
 MG
MG
ANP
HOH
 2.052
2.438
2.701
2.725
 OD2
OD2
OD2
OD2
 MG
MG
O2B
O
1irk 1 P06213 80.2 2e-175 X-RAY
 1995-02-27 ASP A:173 A:1150 64.0 0.427 -160.8 149.2 64.0 0.427 0.0 HOH
 2.659
 OD2
 O
5e1s 1 P06213 80.2 2e-175 X-RAY
 2015-10-14 ASP A:175 A:1150 75.0 0.5 S -82.8 146.7 75.0 0.5 0.0 5JA
HOH
 3.490
2.798
 OD2
O
 N14
O
1rqq 1 P06213 80.2 3e-175 X-RAY
 2003-12-30 ASP A:173 A:1150 52.0 0.347 50.8 88.1 51.0 0.34 0.007 E:None:0.007
 MN
112
HOH
 2.105
2.741
2.578
 OD2
OD2
OD2
 MN
O2B
O
ASP B:173 B:1150 53.0 0.353 49.5 88.1 51.0 0.34 0.013 F:None:0.013
 MN
112
HOH
 1.998
2.740
2.957
 OD2
OD2
OD2
 MN
O2B
O
2auh 1 P06213 80.2 3e-175 X-RAY
 2005-11-01 ASP A:173 A:1150 37.0 0.247 -122.4 138.2 37.0 0.247 0.0 CA
CA
 2.316
3.290
 OD2
OD2
 CA
CA
2b4s 2 P06213 80.2 3e-175 X-RAY
 2005-11-15 ASP B:173 B:1150 6.0 0.04 -136.2 138.6 6.0 0.04 0.0 HOH
 3.852
 O
 O
ASP D:173 D:1150 9.0 0.06 -144.6 123.8 9.0 0.06 0.0 HOH
 3.925
 O
 O
3bu3 1 P06213 80.2 3e-175 X-RAY
 2008-02-19 ASP A:173 A:1150 26.0 0.173 49.4 91.3 26.0 0.173 0.0 HOH
 2.284
 O
 O
3bu5 1 P06213 80.2 3e-175 X-RAY
 2008-02-19 ASP A:173 A:1150 43.0 0.287 44.5 89.5 41.0 0.273 0.014 B:P81122:0.013
 MG
ATP
HOH
 2.129
2.622
2.689
 OD2
OD2
N
 MG
O3G
O
3bu6 1 P06213 80.2 3e-175 X-RAY
 2008-02-19 ASP A:173 A:1150 16.0 0.107 -146.8 128.5 13.0 0.087 0.02 B:P81122:0.02
 HOH
 2.657
 O
 O
5hhw 1 P06213 80.2 4e-175 X-RAY
 2016-04-13 ASP A:174 A:1177 62.0 0.413 -75.3 119.0 62.0 0.413 0.0 60O
HOH
 3.350
2.714
 OD1
OD1
 C1
O
4ibm 1 P06213 80.73 8e-175 X-RAY
 2013-08-21 ASP A:173 A:1150 9.0 0.06 S -44.8 128.6 9.0 0.06 0.0 IR1
HOH
 2.545
2.796
 OD2
O
 O28
O
ASP B:173 B:1150 10.0 0.067 S -45.7 125.5 NA NA NA
3eta 1 P06213 80.41 2e-170 X-RAY
 2009-05-26 ASP A:172 A:1150 58.0 0.387 -157.9 103.4 58.0 0.387 0.0 351
HOH
 2.787
2.629
 N
O
 O23
O
ASP B:172 B:1150 58.0 0.387 -152.0 107.0 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p08069-f1 1 P08069 100.0 0.0 ASP A:1153 A:1153 44.0 0.293 49.4 86.3