Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr15 | 99491829 | . | T | A | CCDS10378.1:NM_000875.3:c.3614aTc>aAc_NP_000866.1:p.1205I>N | Homo sapiens insulin-like growth factor 1 receptor (IGF1R), mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 6jk8 | 1 | P08069 | 100.0 | 0.0 |
EM |
2020-03-04 | ILE | A:1205 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ILE | B:1205 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 6pyh | 1 | Q60751 | 95.96 | 0.0 |
EM |
2019-10-23 | ILE | A:1177 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ILE | C:1177 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 3lvp | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2010-07-21 | ILE | A:255 | A:1205 | 0.0 | 0.0 | H | -50.4 | -53.9 | 0.0 | 0.0 | 0.0 |
HOH |
8.267 |
N |
O |
||
| ILE | B:255 | B:1205 | 1.0 | 0.006 | H | -65.6 | -43.2 | NA | NA | NA | |||||||||||||
| ILE | C:255 | C:1205 | 1.0 | 0.006 | H | -85.0 | -51.6 | NA | NA | NA | |||||||||||||
| ILE | D:255 | D:1205 | 0.0 | 0.0 | H | -66.4 | -44.8 | NA | NA | NA | |||||||||||||
| 1m7n | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2003-01-07 | ILE | A:233 | A:1202 | 2.0 | 0.011 | H | -53.8 | -45.4 | 2.0 | 0.011 | 0.0 |
HOH |
4.562 |
CG2 |
O |
||
| ILE | B:233 | B:1202 | 5.0 | 0.029 | H | -43.2 | -44.3 | NA | NA | NA | |||||||||||||
| 1p4o | 1 | P08069 | 99.38 | 0.0 |
X-RAY |
2003-04-29 | ILE | A:233 | A:1175 | 5.0 | 0.029 | H | -59.6 | -44.5 | 5.0 | 0.029 | 0.0 |
HOH |
2.657 |
O |
O |
||
| ILE | B:233 | B:1175 | 4.0 | 0.023 | H | -60.8 | -44.2 | NA | NA | NA | |||||||||||||
| 5fxq | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2016-10-19 | ILE | A:227 | A:1205 | 2.0 | 0.011 | H | -61.0 | -44.1 | 2.0 | 0.011 | 0.0 |
HOH |
3.233 |
O |
O |
||
| 5fxr | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2016-10-19 | ILE | A:227 | A:1205 | 1.0 | 0.006 | H | -63.1 | -44.9 | 1.0 | 0.006 | 0.0 |
HOH |
2.989 |
O |
O |
||
| 1jqh | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2002-04-19 | ILE | A:227 | A:1205 | 2.0 | 0.011 | H | -55.2 | -55.3 | 2.0 | 0.011 | 0.0 |
HOH |
7.220 |
CG2 |
O |
||
| ILE | B:227 | B:1205 | 1.0 | 0.006 | H | -55.5 | -54.2 | NA | NA | NA | |||||||||||||
| ILE | C:227 | C:1205 | 1.0 | 0.006 | H | -55.1 | -56.0 | NA | NA | NA | |||||||||||||
| 2zm3 | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2008-06-10 | ILE | A:227 | A:1205 | 4.0 | 0.023 | H | -65.4 | -38.4 | 4.0 | 0.023 | 0.0 |
HOH |
6.999 |
N |
O |
||
| ILE | B:227 | B:1205 | 2.0 | 0.011 | H | -70.5 | -41.2 | NA | NA | NA | |||||||||||||
| ILE | C:227 | C:1205 | 1.0 | 0.006 | H | -67.4 | -41.8 | NA | NA | NA | |||||||||||||
| ILE | D:227 | D:1205 | 1.0 | 0.006 | H | -66.7 | -36.1 | NA | NA | NA | |||||||||||||
| 3f5p | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2008-12-30 | ILE | A:227 | A:1205 | 1.0 | 0.006 | H | -54.5 | -44.4 | 1.0 | 0.006 | 0.0 | ||||||
| ILE | B:227 | B:1205 | 1.0 | 0.006 | H | -49.3 | -48.3 | NA | NA | NA | |||||||||||||
| ILE | C:227 | C:1205 | 0.0 | 0.0 | H | -64.0 | -45.0 | NA | NA | NA | |||||||||||||
| ILE | D:227 | D:1205 | 1.0 | 0.006 | H | -55.3 | -45.6 | NA | NA | NA | |||||||||||||
| ILE | E:227 | E:1205 | 1.0 | 0.006 | H | -61.1 | -45.8 | NA | NA | NA | |||||||||||||
| ILE | F:227 | F:1205 | 1.0 | 0.006 | H | -67.4 | -39.1 | NA | NA | NA | |||||||||||||
| ILE | G:227 | G:1205 | 0.0 | 0.0 | H | -57.8 | -42.1 | NA | NA | NA | |||||||||||||
| ILE | H:227 | H:1205 | 1.0 | 0.006 | H | -58.5 | -44.7 | NA | NA | NA | |||||||||||||
| ILE | I:227 | I:1205 | 1.0 | 0.006 | H | -62.1 | -41.2 | NA | NA | NA | |||||||||||||
| ILE | J:227 | J:1205 | 1.0 | 0.006 | H | -77.9 | -41.3 | NA | NA | NA | |||||||||||||
| ILE | K:227 | K:1205 | 1.0 | 0.006 | H | -68.2 | -42.0 | NA | NA | NA | |||||||||||||
| ILE | L:227 | M:1205 | 0.0 | 0.0 | H | -56.2 | -47.6 | NA | NA | NA | |||||||||||||
| ILE | M:227 | L:1205 | 1.0 | 0.006 | H | -52.7 | -49.7 | NA | NA | NA | |||||||||||||
| ILE | N:227 | R:1205 | 2.0 | 0.011 | H | -65.1 | -31.9 | NA | NA | NA | |||||||||||||
| ILE | O:227 | S:1205 | 2.0 | 0.011 | H | -67.2 | -34.8 | NA | NA | NA | |||||||||||||
| ILE | P:227 | T:1205 | 1.0 | 0.006 | H | -63.4 | -42.4 | NA | NA | NA | |||||||||||||
| 3i81 | 1 | P08069 | 99.67 | 0.0 |
X-RAY |
2009-12-22 | ILE | A:226 | A:1175 | 3.0 | 0.017 | H | -63.2 | -45.3 | 3.0 | 0.017 | 0.0 |
HOH |
2.962 |
O |
O |
||
| 5fxs | 1 | P08069 | 99.35 | 0.0 |
X-RAY |
2016-10-19 | ILE | A:227 | A:1205 | 2.0 | 0.011 | H | -61.2 | -44.1 | 2.0 | 0.011 | 0.0 |
HOH |
3.159 |
O |
O |
||
| 2oj9 | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2007-05-01 | ILE | A:226 | A:1175 | 3.0 | 0.017 | H | -63.8 | -45.6 | 3.0 | 0.017 | 0.0 |
HOH |
2.859 |
O |
O |
||
| 3nw5 | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2010-07-28 | ILE | A:226 | A:1175 | 2.0 | 0.011 | H | -57.4 | -47.4 | 2.0 | 0.011 | 0.0 |
HOH |
3.094 |
O |
O |
||
| 3nw6 | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2010-07-28 | ILE | A:226 | A:1175 | 3.0 | 0.017 | H | -62.9 | -44.2 | 3.0 | 0.017 | 0.0 |
HOH |
3.556 |
O |
O |
||
| 3nw7 | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2010-07-28 | ILE | A:226 | A:1175 | 3.0 | 0.017 | H | -60.7 | -47.8 | 3.0 | 0.017 | 0.0 |
HOH |
2.950 |
O |
O |
||
| 3o23 | 1 | P08069 | 99.67 | 0.0 |
X-RAY |
2011-05-04 | ILE | A:224 | A:1205 | 12.0 | 0.069 | H | -62.8 | -44.1 | 12.0 | 0.069 | 0.0 |
HOH |
6.645 |
O |
O |
||
| 3lw0 | 1 | P08069 | 99.34 | 0.0 |
X-RAY |
2010-09-29 | ILE | A:223 | A:1205 | 4.0 | 0.023 | H | -55.2 | -46.1 | 4.0 | 0.023 | 0.0 |
CCX HOH |
6.026 2.876 |
CG2 O |
N12 O |
||
| ILE | B:223 | B:1205 | 3.0 | 0.017 | H | -57.2 | -45.6 | NA | NA | NA | |||||||||||||
| ILE | C:223 | C:1205 | 3.0 | 0.017 | H | -56.3 | -45.5 | NA | NA | NA | |||||||||||||
| ILE | D:223 | D:1205 | 3.0 | 0.017 | H | -55.6 | -46.2 | NA | NA | NA | |||||||||||||
| 5hzn | 1 | P08069 | 99.34 | 0.0 |
X-RAY |
2016-04-06 | ILE | A:223 | A:1202 | 3.0 | 0.017 | H | -58.1 | -50.0 | 3.0 | 0.017 | 0.0 |
HOH |
6.990 |
N |
O |
||
| ILE | B:223 | B:1202 | 3.0 | 0.017 | H | -55.6 | -48.1 | NA | NA | NA | |||||||||||||
| ILE | C:223 | C:1202 | 1.0 | 0.006 | H | -59.5 | -54.6 | NA | NA | NA | |||||||||||||
| ILE | D:223 | D:1202 | 2.0 | 0.011 | H | -63.7 | -51.5 | NA | NA | NA | |||||||||||||
| ILE | E:223 | E:1202 | 3.0 | 0.017 | H | -57.6 | -50.1 | NA | NA | NA | |||||||||||||
| ILE | F:223 | F:1202 | 3.0 | 0.017 | H | -56.4 | -46.4 | NA | NA | NA | |||||||||||||
| ILE | G:223 | G:1202 | 2.0 | 0.011 | H | -60.8 | -50.8 | NA | NA | NA | |||||||||||||
| ILE | H:223 | H:1202 | 2.0 | 0.011 | H | -66.0 | -52.3 | NA | NA | NA | |||||||||||||
| 4d2r | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2015-04-22 | ILE | A:221 | A:1205 | 2.0 | 0.011 | H | -63.7 | -46.3 | 2.0 | 0.011 | 0.0 |
HOH |
3.171 |
O |
O |
||
| 3d94 | 1 | P08069 | 99.67 | 0.0 |
X-RAY |
2008-07-29 | ILE | A:220 | A:1175 | 1.0 | 0.006 | H | -57.3 | -47.3 | 1.0 | 0.006 | 0.0 |
HOH |
7.274 |
N |
O |
||
| 3qqu | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2011-04-20 | ILE | A:220 | A:1202 | 2.0 | 0.011 | H | -61.9 | -30.4 | 2.0 | 0.011 | 0.0 |
HOH |
3.982 |
O |
O |
||
| ILE | B:220 | B:1202 | 2.0 | 0.011 | H | -64.1 | -45.0 | NA | NA | NA | |||||||||||||
| ILE | C:220 | C:1202 | 2.0 | 0.011 | H | -53.0 | -38.5 | NA | NA | NA | |||||||||||||
| ILE | D:220 | D:1202 | 2.0 | 0.011 | H | -69.6 | -34.7 | NA | NA | NA | |||||||||||||
| 1k3a | 1 | P08069 | 99.67 | 0.0 |
X-RAY |
2001-11-28 | ILE | A:218 | A:1175 | 1.0 | 0.006 | H | -64.3 | -49.8 | 1.0 | 0.006 | 0.0 |
HOH |
7.413 |
N |
O |
||
| 2z8c | 1 | P06213 | 80.2 | 1e-175 |
X-RAY |
2008-08-12 | ILE | A:222 | A:1202 | 3.0 | 0.017 | H | -54.6 | -48.9 | 3.0 | 0.017 | 0.0 | ||||||
| 1gag | 1 | P06213 | 80.2 | 2e-175 |
X-RAY |
2001-01-17 | ILE | A:225 | A:1202 | 4.0 | 0.023 | H | -60.6 | -47.5 | 4.0 | 0.023 | 0.0 |
HOH |
9.669 |
O |
O |
||
| 1ir3 | 1 | P06213 | 80.2 | 2e-175 |
X-RAY |
1998-01-07 | ILE | A:225 | A:1202 | 3.0 | 0.017 | H | -62.4 | -46.5 | 3.0 | 0.017 | 0.0 |
HOH |
2.940 |
O |
O |
||
| 1irk | 1 | P06213 | 80.2 | 2e-175 |
X-RAY |
1995-02-27 | ILE | A:225 | A:1202 | 4.0 | 0.023 | H | -66.1 | -41.4 | 4.0 | 0.023 | 0.0 |
EMC HOH |
4.598 6.326 |
CG2 C |
C2 O |
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| 5e1s | 1 | P06213 | 80.2 | 2e-175 |
X-RAY |
2015-10-14 | ILE | A:227 | A:1202 | 3.0 | 0.017 | H | -61.5 | -51.1 | 3.0 | 0.017 | 0.0 |
HOH |
6.020 |
O |
O |
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| 1rqq | 1 | P06213 | 80.2 | 3e-175 |
X-RAY |
2003-12-30 | ILE | A:225 | A:1202 | 3.0 | 0.017 | H | -59.2 | -52.0 | 3.0 | 0.017 | 0.0 |
HOH |
7.248 |
N |
O |
||
| ILE | B:225 | B:1202 | 5.0 | 0.029 | H | -61.7 | -51.3 | 5.0 | 0.029 | 0.0 |
HOH |
7.043 |
N |
O |
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| 2auh | 1 | P06213 | 80.2 | 3e-175 |
X-RAY |
2005-11-01 | ILE | A:225 | A:1202 | 4.0 | 0.023 | H | -62.3 | -56.9 | 4.0 | 0.023 | 0.0 | ||||||
| 2b4s | 2 | P06213 | 80.2 | 3e-175 |
X-RAY |
2005-11-15 | ILE | B:225 | B:1202 | 5.0 | 0.029 | H | -66.5 | -43.3 | 5.0 | 0.029 | 0.0 |
HOH |
7.229 |
N |
O |
||
| ILE | D:225 | D:1202 | 4.0 | 0.023 | H | -64.7 | -48.0 | 4.0 | 0.023 | 0.0 |
HOH |
7.436 |
N |
O |
|||||||||
| 3bu3 | 1 | P06213 | 80.2 | 3e-175 |
X-RAY |
2008-02-19 | ILE | A:225 | A:1202 | 2.0 | 0.011 | H | -62.1 | -44.6 | 2.0 | 0.011 | 0.0 |
HOH |
2.742 |
O |
O |
||
| 3bu5 | 1 | P06213 | 80.2 | 3e-175 |
X-RAY |
2008-02-19 | ILE | A:225 | A:1202 | 3.0 | 0.017 | H | -61.2 | -47.2 | 3.0 | 0.017 | 0.0 |
HOH |
2.681 |
O |
O |
||
| 3bu6 | 1 | P06213 | 80.2 | 3e-175 |
X-RAY |
2008-02-19 | ILE | A:225 | A:1202 | 3.0 | 0.017 | H | -57.1 | -45.4 | 3.0 | 0.017 | 0.0 |
HOH |
2.901 |
O |
O |
||
| 5hhw | 1 | P06213 | 80.2 | 4e-175 |
X-RAY |
2016-04-13 | ILE | A:226 | A:1229 | 4.0 | 0.023 | H | -58.3 | -51.0 | 4.0 | 0.023 | 0.0 |
HOH |
2.916 |
O |
O |
||
| 4ibm | 1 | P06213 | 80.73 | 8e-175 |
X-RAY |
2013-08-21 | ILE | A:225 | A:1202 | 3.0 | 0.017 | H | -57.5 | -45.7 | 3.0 | 0.017 | 0.0 |
HOH |
2.796 |
O |
O |
||
| ILE | B:225 | B:1202 | 3.0 | 0.017 | H | -57.7 | -46.7 | NA | NA | NA | |||||||||||||
| 3eta | 1 | P06213 | 80.41 | 2e-170 |
X-RAY |
2009-05-26 | ILE | A:224 | A:1202 | 3.0 | 0.017 | H | -58.4 | -46.1 | 3.0 | 0.017 | 0.0 |
HOH |
2.720 |
O |
O |
||
| ILE | B:224 | B:1202 | 3.0 | 0.017 | H | -57.0 | -48.6 | NA | NA | NA | |||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p08069-f1 | 1 | P08069 | 100.0 | 0.0 | ILE | A:1205 | A:1205 | 0.0 | 0.0 | H | -61.1 | -46.8 | |