Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr15 99500313 . G A CCDS10378.1:NM_000875.3:c.3746tGg>tAg_NP_000866.1:p.1249W>* Homo sapiens insulin-like growth factor 1 receptor (IGF1R), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6jk8 1 P08069 100.0 0.0 EM
 2020-03-04 TRP A:1249 NA:NA DO NA DO DO DO NA NA NA
TRP B:1249 NA:NA DO NA DO DO DO NA NA NA
6pyh 1 Q60751 95.96 0.0 EM
 2019-10-23 TRP A:1221 NA:NA DO NA DO DO DO NA NA NA
TRP C:1221 NA:NA DO NA DO DO DO NA NA NA
3lvp 1 P08069 100.0 0.0 X-RAY
 2010-07-21 TRP A:299 A:1249 8.0 0.031 T -103.9 14.3 8.0 0.031 0.0
TRP B:299 B:1249 8.0 0.031 T -92.4 17.7 NA NA NA
TRP C:299 C:1249 5.0 0.02 T -99.6 27.7 NA NA NA
TRP D:299 D:1249 9.0 0.035 -102.2 50.6 NA NA NA
1m7n 1 P08069 100.0 0.0 X-RAY
 2003-01-07 TRP A:277 A:1246 6.0 0.024 T -97.3 34.1 6.0 0.024 0.0 HOH
 2.889
 O
 O
TRP B:277 B:1246 5.0 0.02 T -106.6 19.9 NA NA NA
1p4o 1 P08069 99.38 0.0 X-RAY
 2003-04-29 TRP A:277 A:1219 5.0 0.02 T -103.5 23.0 5.0 0.02 0.0 HOH
 2.776
 O
 O
TRP B:277 B:1219 6.0 0.024 T -102.9 23.1 NA NA NA
5fxq 1 P08069 100.0 0.0 X-RAY
 2016-10-19 TRP A:271 A:1249 7.0 0.027 T -102.1 14.4 7.0 0.027 0.0 HOH
 2.841
 O
 O
5fxr 1 P08069 100.0 0.0 X-RAY
 2016-10-19 TRP A:271 A:1249 6.0 0.024 S -97.8 17.5 6.0 0.024 0.0 HOH
 2.663
 O
 O
1jqh 1 P08069 100.0 0.0 X-RAY
 2002-04-19 TRP A:271 A:1249 6.0 0.024 T -102.9 20.9 6.0 0.024 0.0 HOH
 3.214
 O
 O
TRP B:271 B:1249 6.0 0.024 T -101.6 23.0 NA NA NA
TRP C:271 C:1249 6.0 0.024 T -102.8 22.0 NA NA NA
2zm3 1 P08069 100.0 0.0 X-RAY
 2008-06-10 TRP A:271 A:1249 7.0 0.027 T -101.9 25.8 7.0 0.027 0.0 HOH
 2.949
 O
 O
TRP B:271 B:1249 5.0 0.02 T -93.6 21.3 NA NA NA
TRP C:271 C:1249 7.0 0.027 T -104.5 20.7 NA NA NA
TRP D:271 D:1249 8.0 0.031 T -103.8 21.3 NA NA NA
3f5p 1 P08069 100.0 0.0 X-RAY
 2008-12-30 TRP A:271 A:1249 6.0 0.024 T -108.3 13.8 6.0 0.024 0.0
TRP B:271 B:1249 6.0 0.024 T -101.0 13.4 NA NA NA
TRP C:271 C:1249 4.0 0.016 T -106.2 14.3 NA NA NA
TRP D:271 D:1249 6.0 0.024 T -100.0 14.7 NA NA NA
TRP E:271 E:1249 5.0 0.02 T -105.3 12.8 NA NA NA
TRP F:271 F:1249 6.0 0.024 T -109.6 14.9 NA NA NA
TRP G:271 G:1249 7.0 0.027 T -109.8 14.4 NA NA NA
TRP H:271 H:1249 6.0 0.024 T -112.7 21.1 NA NA NA
TRP I:271 I:1249 6.0 0.024 T -101.4 6.1 NA NA NA
TRP J:271 J:1249 6.0 0.024 T -103.3 8.1 NA NA NA
TRP K:271 K:1249 5.0 0.02 T -96.3 5.4 NA NA NA
TRP L:271 M:1249 7.0 0.027 T -101.1 16.5 NA NA NA
TRP M:271 L:1249 5.0 0.02 T -104.8 10.5 NA NA NA
TRP N:271 R:1249 8.0 0.031 T -105.1 6.0 NA NA NA
TRP O:271 S:1249 7.0 0.027 T -108.1 21.9 NA NA NA
TRP P:271 T:1249 7.0 0.027 T -105.5 17.7 NA NA NA
3i81 1 P08069 99.67 0.0 X-RAY
 2009-12-22 TRP A:270 A:1219 4.0 0.016 T -93.6 19.1 4.0 0.016 0.0 HOH
 2.764
 O
 O
5fxs 1 P08069 99.35 0.0 X-RAY
 2016-10-19 TRP A:271 A:1249 7.0 0.027 T -98.7 22.6 7.0 0.027 0.0 HOH
 2.767
 O
 O
2oj9 1 P08069 100.0 0.0 X-RAY
 2007-05-01 TRP A:270 A:1219 5.0 0.02 T -96.8 23.6 5.0 0.02 0.0 HOH
 2.987
 O
 O
3nw5 1 P08069 100.0 0.0 X-RAY
 2010-07-28 TRP A:270 A:1219 6.0 0.024 T -94.6 16.7 6.0 0.024 0.0 HOH
 2.894
 O
 O
3nw6 1 P08069 100.0 0.0 X-RAY
 2010-07-28 TRP A:270 A:1219 7.0 0.027 T -96.8 21.9 7.0 0.027 0.0 HOH
 2.695
 O
 O
3nw7 1 P08069 100.0 0.0 X-RAY
 2010-07-28 TRP A:270 A:1219 6.0 0.024 T -97.5 20.9 6.0 0.024 0.0 HOH
 2.723
 O
 O
3o23 1 P08069 99.67 0.0 X-RAY
 2011-05-04 TRP A:268 A:1249 6.0 0.024 T -103.3 28.0 6.0 0.024 0.0 HOH
 2.927
 O
 O
3lw0 1 P08069 99.34 0.0 X-RAY
 2010-09-29 TRP A:267 A:1249 8.0 0.031 T -101.1 22.4 8.0 0.031 0.0 HOH
 2.957
 O
 O
TRP B:267 B:1249 7.0 0.027 T -101.4 21.6 NA NA NA
TRP C:267 C:1249 6.0 0.024 T -101.1 22.9 NA NA NA
TRP D:267 D:1249 7.0 0.027 T -100.1 21.7 NA NA NA
5hzn 1 P08069 99.34 0.0 X-RAY
 2016-04-06 TRP A:267 A:1246 8.0 0.031 T -101.4 24.4 8.0 0.031 0.0 HOH
 2.904
 O
 O
TRP B:267 B:1246 8.0 0.031 T -102.4 29.1 NA NA NA
TRP C:267 C:1246 10.0 0.039 T -102.2 26.4 NA NA NA
TRP D:267 D:1246 7.0 0.027 T -102.0 27.6 NA NA NA
TRP E:267 E:1246 9.0 0.035 T -102.2 24.2 NA NA NA
TRP F:267 F:1246 8.0 0.031 T -101.0 27.9 NA NA NA
TRP G:267 G:1246 9.0 0.035 T -101.8 25.5 NA NA NA
TRP H:267 H:1246 8.0 0.031 T -102.4 26.7 NA NA NA
4d2r 1 P08069 100.0 0.0 X-RAY
 2015-04-22 TRP A:265 A:1249 6.0 0.024 T -102.4 27.1 6.0 0.024 0.0 HOH
 2.825
 O
 O
3d94 1 P08069 99.67 0.0 X-RAY
 2008-07-29 TRP A:264 A:1219 15.0 0.059 T -102.7 28.8 15.0 0.059 0.0 HOH
 2.926
 O
 O
3qqu 1 P08069 100.0 0.0 X-RAY
 2011-04-20 TRP A:264 A:1246 6.0 0.024 T -88.9 23.6 6.0 0.024 0.0 HOH
 3.191
 O
 O
TRP B:264 B:1246 6.0 0.024 T -100.7 28.0 NA NA NA
TRP C:264 C:1246 8.0 0.031 T -91.8 21.3 NA NA NA
TRP D:264 D:1246 7.0 0.027 T -85.8 18.4 NA NA NA
1k3a 1 P08069 99.67 0.0 X-RAY
 2001-11-28 TRP A:262 A:1219 15.0 0.059 T -100.7 29.2 15.0 0.059 0.0 HOH
 2.847
 O
 O
2z8c 1 P06213 80.2 1e-175 X-RAY
 2008-08-12 TRP A:266 A:1246 23.0 0.09 -108.0 22.5 23.0 0.09 0.0
1gag 1 P06213 80.2 2e-175 X-RAY
 2001-01-17 TRP A:269 A:1246 14.0 0.055 T -98.8 25.4 14.0 0.055 0.0 HOH
 4.159
 O
 O
1ir3 1 P06213 80.2 2e-175 X-RAY
 1998-01-07 TRP A:269 A:1246 15.0 0.059 T -94.9 18.6 15.0 0.059 0.0 HOH
 2.773
 O
 O
1irk 1 P06213 80.2 2e-175 X-RAY
 1995-02-27 TRP A:269 A:1246 8.0 0.031 T -91.0 20.2 8.0 0.031 0.0 HOH
 2.779
 O
 O
5e1s 1 P06213 80.2 2e-175 X-RAY
 2015-10-14 TRP A:271 A:1246 10.0 0.039 T -94.2 21.7 10.0 0.039 0.0 HOH
 2.934
 O
 O
1rqq 1 P06213 80.2 3e-175 X-RAY
 2003-12-30 TRP A:269 A:1246 15.0 0.059 T -103.6 24.1 15.0 0.059 0.0 HOH
 3.239
 CE2
 O
TRP B:269 B:1246 13.0 0.051 T -102.5 24.6 13.0 0.051 0.0 HOH
 3.194
 CE2
 O
2auh 1 P06213 80.2 3e-175 X-RAY
 2005-11-01 TRP A:269 A:1246 12.0 0.047 T -97.2 13.1 12.0 0.047 0.0
2b4s 2 P06213 80.2 3e-175 X-RAY
 2005-11-15 TRP B:269 B:1246 12.0 0.047 T -101.3 34.5 12.0 0.047 0.0 HOH
 2.945
 O
 O
TRP D:269 D:1246 8.0 0.031 T -103.9 31.4 8.0 0.031 0.0 HOH
 2.815
 O
 O
3bu3 1 P06213 80.2 3e-175 X-RAY
 2008-02-19 TRP A:269 A:1246 11.0 0.043 T -106.3 15.9 11.0 0.043 0.0 HOH
 2.809
 O
 O
3bu5 1 P06213 80.2 3e-175 X-RAY
 2008-02-19 TRP A:269 A:1246 10.0 0.039 T -105.3 20.4 10.0 0.039 0.0 HOH
 2.718
 O
 O
3bu6 1 P06213 80.2 3e-175 X-RAY
 2008-02-19 TRP A:269 A:1246 2.0 0.008 T -105.7 17.4 2.0 0.008 0.0 HOH
 2.802
 O
 O
5hhw 1 P06213 80.2 4e-175 X-RAY
 2016-04-13 TRP A:270 A:1273 10.0 0.039 T -103.6 22.3 10.0 0.039 0.0 HOH
 2.919
 O
 O
4ibm 1 P06213 80.73 8e-175 X-RAY
 2013-08-21 TRP A:269 A:1246 10.0 0.039 T -106.5 23.8 10.0 0.039 0.0 HOH
 2.858
 O
 O
TRP B:269 B:1246 13.0 0.051 T -105.8 20.1 NA NA NA
3eta 1 P06213 80.41 2e-170 X-RAY
 2009-05-26 TRP A:268 A:1246 14.0 0.055 T -103.5 19.8 14.0 0.055 0.0 HOH
 2.937
 O
 O
TRP B:268 B:1246 8.0 0.031 T -102.2 21.7 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p08069-f1 1 P08069 100.0 0.0 TRP A:1249 A:1249 4.0 0.016 T -94.6 25.7