Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr15 99500375 . A C CCDS10378.1:NM_000875.3:c.3808Atg>Ctg_NP_000866.1:p.1270M>L Homo sapiens insulin-like growth factor 1 receptor (IGF1R), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6jk8 1 P08069 100.0 0.0 EM
 2020-03-04 MET A:1270 NA:NA DO NA DO DO DO NA NA NA
MET B:1270 NA:NA DO NA DO DO DO NA NA NA
6pyh 1 Q60751 95.96 0.0 EM
 2019-10-23 MET A:1242 NA:NA DO NA DO DO DO NA NA NA
MET C:1242 NA:NA DO NA DO DO DO NA NA NA
3lvp 1 P08069 100.0 0.0 X-RAY
 2010-07-21 MET A:320 A:1270 20.0 0.108 S -73.2 -178.6 20.0 0.108 0.0
MET B:320 B:1270 15.0 0.081 S -63.1 163.8 NA NA NA
MET C:320 C:1270 24.0 0.13 S -74.9 178.1 NA NA NA
MET D:320 D:1270 15.0 0.081 S -79.7 171.2 NA NA NA
1m7n 1 P08069 100.0 0.0 X-RAY
 2003-01-07 MET A:298 A:1267 17.0 0.092 S -74.3 146.9 17.0 0.092 0.0 HOH
 3.492
 O
 O
MET B:298 B:1267 15.0 0.081 S -83.8 147.9 NA NA NA
1p4o 1 P08069 99.38 0.0 X-RAY
 2003-04-29 MET A:298 A:1240 19.0 0.103 S -85.6 158.0 19.0 0.103 0.0 HOH
 3.788
 CB
 O
MET B:298 B:1240 19.0 0.103 S -83.6 159.4 NA NA NA
5fxq 1 P08069 100.0 0.0 X-RAY
 2016-10-19 MET A:292 A:1270 18.0 0.097 S -88.7 143.8 18.0 0.097 0.0 HOH
 3.356
 O
 O
5fxr 1 P08069 100.0 0.0 X-RAY
 2016-10-19 MET A:292 A:1270 16.0 0.086 S -77.6 145.5 16.0 0.086 0.0 HOH
 4.346
 C
 O
1jqh 1 P08069 100.0 0.0 X-RAY
 2002-04-19 MET A:292 A:1270 20.0 0.108 S -92.1 165.0 20.0 0.108 0.0 HOH
 4.261
 CA
 O
MET B:292 B:1270 18.0 0.097 S -91.0 165.1 NA NA NA
MET C:292 C:1270 19.0 0.103 S -91.5 165.2 NA NA NA
2zm3 1 P08069 100.0 0.0 X-RAY
 2008-06-10 MET A:292 A:1270 17.0 0.092 S -73.5 151.4 17.0 0.092 0.0 HOH
 3.863
 CB
 O
MET B:292 B:1270 17.0 0.092 S -72.8 155.8 NA NA NA
MET C:292 C:1270 14.0 0.076 S -75.6 147.9 NA NA NA
MET D:292 D:1270 18.0 0.097 S -81.6 154.3 NA NA NA
3f5p 1 P08069 100.0 0.0 X-RAY
 2008-12-30 MET A:292 A:1270 19.0 0.103 S -95.5 136.6 19.0 0.103 0.0 HOH
 4.900
 O
 O
MET B:292 B:1270 19.0 0.103 S -97.2 141.4 NA NA NA
MET C:292 C:1270 20.0 0.108 S -90.9 142.1 NA NA NA
MET D:292 D:1270 20.0 0.108 S -82.7 146.6 NA NA NA
MET E:292 E:1270 18.0 0.097 S -105.9 143.5 NA NA NA
MET F:292 F:1270 19.0 0.103 S -96.0 148.4 NA NA NA
MET G:292 G:1270 18.0 0.097 S -86.5 150.4 NA NA NA
MET H:292 H:1270 15.0 0.081 S -94.4 131.5 NA NA NA
MET I:292 I:1270 19.0 0.103 S -87.0 157.9 NA NA NA
MET J:292 J:1270 17.0 0.092 S -82.1 139.8 NA NA NA
MET K:292 K:1270 18.0 0.097 S -83.7 146.0 NA NA NA
MET L:292 M:1270 16.0 0.086 S -80.9 155.2 NA NA NA
MET M:292 L:1270 15.0 0.081 S -69.0 151.0 NA NA NA
MET N:292 R:1270 18.0 0.097 S -77.9 158.4 NA NA NA
MET O:292 S:1270 17.0 0.092 S -86.9 168.5 NA NA NA
MET P:292 T:1270 16.0 0.086 S -87.9 137.5 NA NA NA
3i81 1 P08069 99.67 0.0 X-RAY
 2009-12-22 MET A:291 A:1240 14.0 0.076 S -75.7 152.7 14.0 0.076 0.0 HOH
 3.698
 O
 O
5fxs 1 P08069 99.35 0.0 X-RAY
 2016-10-19 MET A:292 A:1270 18.0 0.097 S -77.5 150.2 18.0 0.097 0.0 HOH
 4.043
 CA
 O
2oj9 1 P08069 100.0 0.0 X-RAY
 2007-05-01 MET A:291 A:1240 16.0 0.086 S -73.8 135.1 16.0 0.086 0.0 HOH
 3.897
 O
 O
3nw5 1 P08069 100.0 0.0 X-RAY
 2010-07-28 MET A:291 A:1240 16.0 0.086 S -77.6 154.4 16.0 0.086 0.0 HOH
 3.846
 CB
 O
3nw6 1 P08069 100.0 0.0 X-RAY
 2010-07-28 MET A:291 A:1240 13.0 0.07 S -72.9 146.8 13.0 0.07 0.0 HOH
 3.148
 O
 O
3nw7 1 P08069 100.0 0.0 X-RAY
 2010-07-28 MET A:291 A:1240 16.0 0.086 S -77.6 147.6 16.0 0.086 0.0 HOH
 2.791
 O
 O
3o23 1 P08069 99.67 0.0 X-RAY
 2011-05-04 MET A:289 A:1270 16.0 0.086 S -78.2 151.8 16.0 0.086 0.0 HOH
 3.602
 CE
 O
3lw0 1 P08069 99.34 0.0 X-RAY
 2010-09-29 MET A:288 A:1270 20.0 0.108 S -78.2 141.4 20.0 0.108 0.0 CCX
HOH
 7.223
2.824
 CE
O
 C14
O
MET B:288 B:1270 21.0 0.114 S -79.8 142.5 NA NA NA
MET C:288 C:1270 20.0 0.108 S -77.7 141.1 NA NA NA
MET D:288 D:1270 20.0 0.108 S -78.7 141.3 NA NA NA
5hzn 1 P08069 99.34 0.0 X-RAY
 2016-04-06 MET A:288 A:1267 19.0 0.103 S -78.5 155.1 19.0 0.103 0.0 HOH
 6.021
 CE
 O
MET B:288 B:1267 16.0 0.086 S -76.8 147.6 NA NA NA
MET C:288 C:1267 19.0 0.103 S -81.8 152.2 NA NA NA
MET D:288 D:1267 18.0 0.097 S -86.3 146.9 NA NA NA
MET E:288 E:1267 18.0 0.097 S -79.0 154.9 NA NA NA
MET F:288 F:1267 16.0 0.086 S -75.9 147.5 NA NA NA
MET G:288 G:1267 18.0 0.097 S -83.2 152.0 NA NA NA
MET H:288 H:1267 19.0 0.103 S -85.9 147.0 NA NA NA
4d2r 1 P08069 100.0 0.0 X-RAY
 2015-04-22 MET A:286 A:1270 20.0 0.108 S -74.2 152.1 20.0 0.108 0.0 HOH
 4.160
 CA
 O
3d94 1 P08069 99.67 0.0 X-RAY
 2008-07-29 MET A:285 A:1240 18.0 0.097 S -84.0 153.9 18.0 0.097 0.0 HOH
 4.068
 CA
 O
3qqu 1 P08069 100.0 0.0 X-RAY
 2011-04-20 MET A:285 A:1267 13.0 0.07 S -103.7 144.0 13.0 0.07 0.0 HOH
 5.782
 CE
 O
MET B:285 B:1267 19.0 0.103 S -86.7 164.2 NA NA NA
MET C:285 C:1267 18.0 0.097 S -128.4 137.4 NA NA NA
MET D:285 D:1267 20.0 0.108 S -125.4 148.8 NA NA NA
1k3a 1 P08069 99.67 0.0 X-RAY
 2001-11-28 MET A:283 A:1240 18.0 0.097 S -78.0 151.6 18.0 0.097 0.0 HOH
 4.127
 CB
 O
2z8c 1 P06213 80.2 1e-175 X-RAY
 2008-08-12 LEU A:287 A:1267 29.0 0.171 S -85.2 -164.6 29.0 0.171 0.0
1gag 1 P06213 80.2 2e-175 X-RAY
 2001-01-17 LEU A:290 A:1267 25.0 0.147 S -127.1 163.5 25.0 0.147 0.0 HOH
 4.186
 CD1
 O
1ir3 1 P06213 80.2 2e-175 X-RAY
 1998-01-07 LEU A:290 A:1267 29.0 0.171 S -121.3 168.3 29.0 0.171 0.0 HOH
 2.964
 N
 O
1irk 1 P06213 80.2 2e-175 X-RAY
 1995-02-27 LEU A:290 A:1267 28.0 0.165 S -117.4 168.6 28.0 0.165 0.0 HOH
 2.708
 N
 O
5e1s 1 P06213 80.2 2e-175 X-RAY
 2015-10-14 LEU A:292 A:1267 28.0 0.165 S -121.1 164.0 28.0 0.165 0.0 HOH
 3.127
 O
 O
1rqq 1 P06213 80.2 3e-175 X-RAY
 2003-12-30 LEU A:290 A:1267 22.0 0.129 S -125.6 159.2 22.0 0.129 0.0 HOH
 5.898
 CB
 O
LEU B:290 B:1267 23.0 0.135 S -127.8 160.1 23.0 0.135 0.0 HOH
 7.737
 CD1
 O
2auh 1 P06213 80.2 3e-175 X-RAY
 2005-11-01 LEU A:290 A:1267 25.0 0.147 S -123.7 165.1 25.0 0.147 0.0
2b4s 2 P06213 80.2 3e-175 X-RAY
 2005-11-15 LEU B:290 B:1267 28.0 0.165 S -116.7 165.0 28.0 0.165 0.0 HOH
 2.968
 N
 O
LEU D:290 D:1267 31.0 0.182 S -115.3 173.0 31.0 0.182 0.0 HOH
 3.013
 N
 O
3bu3 1 P06213 80.2 3e-175 X-RAY
 2008-02-19 LEU A:290 A:1267 28.0 0.165 S -125.4 161.7 28.0 0.165 0.0 HOH
 3.032
 N
 O
3bu5 1 P06213 80.2 3e-175 X-RAY
 2008-02-19 LEU A:290 A:1267 26.0 0.153 S -125.7 160.7 26.0 0.153 0.0 HOH
 3.205
 O
 O
3bu6 1 P06213 80.2 3e-175 X-RAY
 2008-02-19 LEU A:290 A:1267 27.0 0.159 S -124.3 165.8 27.0 0.159 0.0 HOH
 3.148
 N
 O
5hhw 1 P06213 80.2 4e-175 X-RAY
 2016-04-13 LEU A:291 A:1294 31.0 0.182 S -121.5 165.2 31.0 0.182 0.0 HOH
 2.995
 N
 O
4ibm 1 P06213 80.73 8e-175 X-RAY
 2013-08-21 LEU A:290 A:1267 29.0 0.171 S -128.9 166.4 29.0 0.171 0.0 HOH
 2.985
 N
 O
LEU B:290 B:1267 26.0 0.153 S -116.3 166.5 NA NA NA
3eta 1 P06213 80.41 2e-170 X-RAY
 2009-05-26 LEU A:289 A:1267 20.0 0.118 S -90.6 168.3 20.0 0.118 0.0 HOH
 2.810
 O
 O
LEU B:289 B:1267 17.0 0.1 S -93.0 161.6 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p08069-f1 1 P08069 100.0 0.0 MET A:1270 A:1270 20.0 0.108 S -88.0 155.2