Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr15 63631137 . G A CCDS10185.1:NM_001218.3:c.755gCt>gTt_NP_001209.1:p.252A>V Homo sapiens carbonic anhydrase XII (CA12), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1jcz 1 O43570 99.62 0.0 X-RAY
 2001-08-17 ALA A:224 A:225 20.0 0.174 H -61.0 -45.0 20.0 0.174 0.0 HOH
 3.734
 CB
 O
ALA B:224 B:225 38.0 0.33 H -60.7 -46.4 38.0 0.33 0.0 HOH
 3.857
 N
 O
1jd0 1 O43570 99.62 0.0 X-RAY
 2001-08-17 ALA A:224 A:225 20.0 0.174 H -62.2 -44.3 20.0 0.174 0.0 HOH
 3.740
 CB
 O
ALA B:224 B:225 39.0 0.339 H -59.8 -46.2 39.0 0.339 0.0 HOH
 3.592
 O
 O
6qn0 1 O43570 99.62 0.0 X-RAY
 2020-02-26 ALA A:224 A:225 34.0 0.296 H -60.8 -50.9 34.0 0.296 0.0 HOH
 3.899
 O
 O
ALA B:224 B:225 37.0 0.322 H -50.2 -54.0 37.0 0.322 0.0 HOH
 4.076
 CB
 O
ALA C:224 C:225 35.0 0.304 H -59.8 -48.2 NA NA NA
ALA D:224 D:225 39.0 0.339 H -61.1 -48.0 NA NA NA
6qng 1 O43570 99.62 0.0 X-RAY
 2020-03-04 ALA A:224 A:225 23.0 0.2 H -62.1 -48.9 23.0 0.2 0.0 HOH
 4.864
 O
 O
ALA B:224 B:225 20.0 0.174 H -58.0 -52.3 20.0 0.174 0.0 HOH
 3.364
 O
 O
ALA C:224 C:225 34.0 0.296 H -62.1 -48.4 NA NA NA
ALA D:224 D:225 35.0 0.304 H -57.2 -49.5 NA NA NA
6qnl 1 O43570 99.62 0.0 X-RAY
 2020-03-04 ALA A:224 A:225 40.0 0.348 H -58.8 -48.5 40.0 0.348 0.0 HOH
 3.806
 CB
 O
ALA B:224 B:225 37.0 0.322 H -58.0 -52.4 37.0 0.322 0.0 HOH
 3.721
 N
 O
ALA C:224 C:225 38.0 0.33 H -59.3 -48.9 NA NA NA
ALA D:224 D:225 36.0 0.313 H -57.6 -48.6 NA NA NA
4ht2 1 O43570 100.0 0.0 X-RAY
 2013-04-10 ALA A:224 A:224 27.0 0.235 H -59.8 -44.1 27.0 0.235 0.0 HOH
 3.582
 N
 O
ALA B:224 B:224 37.0 0.322 H -53.4 -50.1 NA NA NA
ALA C:224 C:224 29.0 0.252 H -61.2 -47.6 NA NA NA
ALA D:224 D:224 38.0 0.33 H -59.2 -45.3 NA NA NA
4kp5 1 O43570 100.0 0.0 X-RAY
 2013-11-06 ALA A:224 A:224 40.0 0.348 H -62.7 -46.3 40.0 0.348 0.0 EDO
HOH
 3.897
3.395
 CB
CA
 C2
O
ALA B:224 B:224 34.0 0.296 H -60.5 -48.1 34.0 0.296 0.0 HOH
 3.654
 CA
 O
ALA C:224 C:224 28.0 0.243 H -56.4 -52.9 NA NA NA
ALA D:224 D:224 39.0 0.339 H -62.5 -47.2 NA NA NA
4kp8 1 O43570 100.0 0.0 X-RAY
 2013-11-06 ALA A:224 A:224 28.0 0.243 H -63.9 -42.3 28.0 0.243 0.0 HOH
 3.941
 CB
 O
ALA B:224 B:224 36.0 0.313 H -60.4 -44.5 36.0 0.313 0.0 EDO
HOH
 3.966
3.041
 CB
O
 O1
O
ALA C:224 C:224 30.0 0.261 H -60.6 -50.0 NA NA NA
ALA D:224 D:224 36.0 0.313 H -63.3 -41.0 NA NA NA
4q0l 1 O43570 100.0 0.0 X-RAY
 2015-01-28 ALA A:224 A:224 27.0 0.235 H -60.8 -45.6 27.0 0.235 0.0 HOH
 5.445
 O
 O
ALA B:224 B:224 27.0 0.235 H -57.5 -46.5 27.0 0.235 0.0 HOH
 3.871
 N
 O
ALA C:224 C:224 36.0 0.313 H -68.3 -42.8 NA NA NA
ALA D:224 D:224 27.0 0.235 H -60.4 -46.7 NA NA NA
4qj0 1 O43570 100.0 0.0 X-RAY
 2015-04-15 ALA A:224 A:224 39.0 0.339 H -57.3 -48.3 39.0 0.339 0.0 EDO
HOH
 3.864
3.425
 CB
CA
 C1
O
ALA B:224 B:224 42.0 0.365 H -60.3 -45.3 42.0 0.365 0.0 HOH
 3.736
 N
 O
ALA C:224 C:224 38.0 0.33 H -56.5 -51.1 NA NA NA
ALA D:224 D:224 34.0 0.296 H -65.0 -43.3 NA NA NA
4qjo 1 O43570 100.0 0.0 X-RAY
 2015-04-15 ALA A:224 A:224 38.0 0.33 H -58.8 -45.8 38.0 0.33 0.0 HOH
 4.262
 CB
 O
ALA B:224 B:224 35.0 0.304 H -60.1 -43.5 35.0 0.304 0.0 EDO
HOH
 3.780
3.463
 CB
CA
 C2
O
ALA C:224 C:224 33.0 0.287 H -60.2 -45.9 NA NA NA
ALA D:224 D:224 34.0 0.296 H -63.1 -46.5 NA NA NA
4qjw 1 O43570 100.0 0.0 X-RAY
 2015-04-15 ALA A:224 A:224 29.0 0.252 H -64.5 -40.4 29.0 0.252 0.0 HOH
 4.196
 CB
 O
ALA B:224 B:224 37.0 0.322 H -59.3 -45.4 37.0 0.322 0.0 EDO
HOH
 3.840
3.000
 CB
O
 C1
O
ALA C:224 C:224 31.0 0.27 H -59.8 -46.4 NA NA NA
ALA D:224 D:224 36.0 0.313 H -59.2 -44.9 NA NA NA
4ww8 1 O43570 100.0 0.0 X-RAY
 2015-07-01 ALA A:224 A:224 39.0 0.339 H -61.5 -46.8 39.0 0.339 0.0 EDO
HOH
 3.839
3.318
 CB
CA
 C1
O
ALA B:224 B:224 36.0 0.313 H -57.0 -51.4 36.0 0.313 0.0 EDO
HOH
 3.449
3.715
 CB
CA
 C1
O
ALA C:224 C:224 41.0 0.357 H -57.5 -47.9 NA NA NA
ALA D:224 D:224 42.0 0.365 H -64.5 -46.2 NA NA NA
5ll5 1 O43570 100.0 0.0 X-RAY
 2017-08-16 ALA A:224 A:224 32.0 0.278 H -63.9 -42.9 32.0 0.278 0.0 EDO
HOH
 3.854
3.381
 CB
CA
 C1
O
ALA B:224 B:224 35.0 0.304 H -60.6 -47.4 35.0 0.304 0.0 HOH
 3.705
 CA
 O
ALA C:224 C:224 36.0 0.313 H -58.7 -48.7 NA NA NA
ALA D:224 D:224 37.0 0.322 H -62.7 -46.0 NA NA NA
5ll9 1 O43570 100.0 0.0 X-RAY
 2017-08-16 ALA A:224 A:224 38.0 0.33 H -61.2 -46.0 38.0 0.33 0.0 EDO
HOH
 3.860
3.359
 CB
CA
 C1
O
ALA B:224 B:224 35.0 0.304 H -60.9 -46.7 35.0 0.304 0.0 HOH
 3.616
 CA
 O
ALA C:224 C:224 35.0 0.304 H -56.1 -49.4 NA NA NA
ALA D:224 D:224 39.0 0.339 H -63.2 -46.0 NA NA NA
5llo 1 O43570 100.0 0.0 X-RAY
 2017-08-16 ALA A:224 A:224 39.0 0.339 H -61.4 -48.3 39.0 0.339 0.0 EDO
HOH
 3.702
3.460
 CB
CA
 C1
O
ALA B:224 B:224 37.0 0.322 H -57.4 -53.1 37.0 0.322 0.0 HOH
 3.723
 N
 O
ALA C:224 C:224 42.0 0.365 H -57.2 -48.8 NA NA NA
ALA D:224 D:224 42.0 0.365 H -64.2 -41.1 NA NA NA
5llp 1 O43570 100.0 0.0 X-RAY
 2017-08-16 ALA A:224 A:224 39.0 0.339 H -63.7 -45.5 39.0 0.339 0.0 HOH
 3.385
 CA
 O
ALA B:224 B:224 53.0 0.461 H -67.3 -44.3 53.0 0.461 0.0 HOH
 2.978
 O
 O
ALA C:224 C:224 47.0 0.409 H -57.6 -47.3 NA NA NA
ALA D:224 D:224 42.0 0.365 H -65.8 -42.1 NA NA NA
5msa 1 O43570 100.0 0.0 X-RAY
 2018-01-17 ALA A:224 A:224 38.0 0.33 H -59.5 -47.3 38.0 0.33 0.0 EDO
EDO
HOH
 3.752
3.402
3.641
 CB
CA
N
 C2
C2
O
ALA B:224 B:224 40.0 0.348 H -58.9 -50.3 40.0 0.348 0.0 HOH
 2.992
 O
 O
ALA C:224 C:224 46.0 0.4 H -55.1 -49.8 NA NA NA
ALA D:224 D:224 44.0 0.383 H -59.4 -49.1 NA NA NA
5msb 1 O43570 100.0 0.0 X-RAY
 2018-01-17 ALA A:224 A:224 39.0 0.339 H -58.0 -51.7 39.0 0.339 0.0 HOH
 3.366
 CA
 O
ALA B:224 B:224 43.0 0.374 H -61.2 -48.8 43.0 0.374 0.0 HOH
 2.904
 O
 O
ALA C:224 C:224 44.0 0.383 H -57.5 -49.5 NA NA NA
ALA D:224 D:224 44.0 0.383 H -64.5 -45.1 NA NA NA
6g5l 1 O43570 100.0 0.0 X-RAY
 2019-03-13 ALA A:224 A:224 39.0 0.339 H -62.4 -42.1 39.0 0.339 0.0 HOH
 3.406
 CA
 O
ALA B:224 B:224 38.0 0.33 H -60.0 -45.6 38.0 0.33 0.0 HOH
 3.610
 CB
 O
ALA C:224 C:224 39.0 0.339 H -46.4 -48.9 NA NA NA
ALA D:224 D:224 39.0 0.339 H -59.4 -47.5 NA NA NA
6g7a 1 O43570 100.0 0.0 X-RAY
 2019-03-13 ALA A:224 A:224 39.0 0.339 H -63.9 -44.4 39.0 0.339 0.0 EDO
HOH
 3.853
3.400
 CB
CA
 C1
O
ALA B:224 B:224 36.0 0.313 H -59.8 -50.2 36.0 0.313 0.0 EDO
HOH
 3.573
3.733
 CB
CA
 C1
O
ALA C:224 C:224 37.0 0.322 H -49.9 -52.5 NA NA NA
ALA D:224 D:224 37.0 0.322 H -61.1 -47.1 NA NA NA
6r6y 1 O43570 100.0 0.0 X-RAY
 2020-04-08 ALA A:224 A:224 39.0 0.339 H -59.1 -51.1 39.0 0.339 0.0 EDO
HOH
 3.867
3.387
 CB
CA
 C2
O
ALA B:224 B:224 34.0 0.296 H -60.0 -48.7 34.0 0.296 0.0 EDO
HOH
 3.640
3.736
 CB
CA
 C1
O
ALA C:224 C:224 41.0 0.357 H -58.6 -49.1 NA NA NA
ALA D:224 D:224 37.0 0.322 H -61.4 -46.8 NA NA NA
6r71 1 O43570 100.0 0.0 X-RAY
 2020-04-08 ALA A:224 A:224 30.0 0.261 H -58.8 -44.8 30.0 0.261 0.0 HOH
 3.876
 N
 O
ALA B:224 B:224 36.0 0.313 H -65.9 -45.2 36.0 0.313 0.0 HOH
 4.187
 CB
 O
6t5p 1 O43570 100.0 0.0 X-RAY
 2020-10-14 ALA A:224 A:224 39.0 0.339 H -59.0 -47.0 39.0 0.339 0.0 HOH
 3.487
 CA
 O
ALA B:224 B:224 35.0 0.304 H -57.3 -49.3 35.0 0.304 0.0 HOH
 3.632
 CA
 O
ALA C:224 C:224 40.0 0.348 H -59.9 -46.4 NA NA NA
ALA D:224 D:224 36.0 0.313 H -62.6 -46.3 NA NA NA
6t5q 1 O43570 100.0 0.0 X-RAY
 2020-10-14 ALA A:224 A:224 37.0 0.322 H -64.1 -44.1 37.0 0.322 0.0 HOH
 4.717
 O
 O
ALA B:224 B:224 40.0 0.348 H -59.5 -47.3 40.0 0.348 0.0 HOH
 3.549
 CA
 O
ALA C:224 C:224 39.0 0.339 H -61.1 -43.5 NA NA NA
ALA D:224 D:224 40.0 0.348 H -56.6 -48.2 NA NA NA
7puu 1 O43570 100.0 0.0 X-RAY
 2022-01-12 ALA A:224 A:224 40.0 0.348 H -60.4 -45.3 40.0 0.348 0.0 HOH
 3.329
 CA
 O
ALA B:224 B:224 36.0 0.313 H -61.0 -49.4 36.0 0.313 0.0 HOH
 3.618
 CA
 O
ALA C:224 C:224 42.0 0.365 H -56.2 -46.3 NA NA NA
ALA D:224 D:224 46.0 0.4 H -66.5 -43.9 NA NA NA
7puv 1 O43570 100.0 0.0 X-RAY
 2022-01-12 ALA A:224 A:224 41.0 0.357 H -62.9 -46.6 41.0 0.357 0.0 HOH
 3.303
 O
 O
ALA B:224 B:224 52.0 0.452 H -63.5 -47.1 52.0 0.452 0.0 HOH
 2.901
 O
 O
ALA C:224 C:224 45.0 0.391 H -60.8 -49.4 NA NA NA
ALA D:224 D:224 48.0 0.417 H -61.6 -45.0 NA NA NA
7puw 1 O43570 100.0 0.0 X-RAY
 2022-01-12 ALA A:224 A:224 40.0 0.348 H -60.6 -46.6 40.0 0.348 0.0 HOH
 3.334
 CA
 O
ALA B:224 B:224 37.0 0.322 H -58.9 -49.7 37.0 0.322 0.0 EDO
HOH
 3.666
3.557
 CB
CB
 C1
O
ALA C:224 C:224 41.0 0.357 H -57.6 -48.4 NA NA NA
ALA D:224 D:224 46.0 0.4 H -63.9 -45.3 NA NA NA
6rps 1 O43570 96.7 0.0 X-RAY
 2019-11-13 ALA A:223 A:225 41.0 0.357 H -61.6 -48.3 41.0 0.357 0.0 HOH
 9.298
 N
 O
ALA B:223 B:225 42.0 0.365 H -62.0 -47.7 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-o43570-f1 1 O43570 100.0 0.0 ALA A:252 A:252 39.0 0.339 H -62.4 -44.2