Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr15 63634224 . C A CCDS10185.1:NM_001218.3:c.502Gct>Tct_NP_001209.1:p.168A>S Homo sapiens carbonic anhydrase XII (CA12), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1jcz 1 O43570 99.62 0.0 X-RAY
 2001-08-17 ALA A:140 A:142 1.0 0.009 E -141.1 127.2 1.0 0.009 0.0 ACY
HOH
 6.912
3.853
 C
CB
 CH3
O
ALA B:140 B:142 2.0 0.017 E -140.5 127.5 2.0 0.017 0.0 ACY
HOH
 6.855
3.867
 C
CB
 CH3
O
1jd0 1 O43570 99.62 0.0 X-RAY
 2001-08-17 ALA A:140 A:142 3.0 0.026 E -141.8 122.6 3.0 0.026 0.0 AZM
HOH
 7.561
3.869
 O
CB
 O1
O
ALA B:140 B:142 2.0 0.017 E -143.6 123.4 2.0 0.017 0.0 AZM
HOH
 7.556
3.814
 O
CB
 O1
O
6qn0 1 O43570 99.62 0.0 X-RAY
 2020-02-26 ALA A:140 A:142 1.0 0.009 E -140.6 128.2 1.0 0.009 0.0 ZN
J8Q
HOH
 9.988
6.106
3.766
 O
O
CB
 ZN
CL1
O
ALA B:140 B:142 3.0 0.026 E -136.9 128.3 3.0 0.026 0.0 ZN
J8Q
HOH
 9.857
5.997
3.897
 O
O
CB
 ZN
CL1
O
ALA C:140 C:142 1.0 0.009 E -142.5 124.7 NA NA NA
ALA D:140 D:142 2.0 0.017 E -140.6 130.1 NA NA NA
6qng 1 O43570 99.62 0.0 X-RAY
 2020-03-04 ALA A:140 A:142 2.0 0.017 E -131.6 131.0 2.0 0.017 0.0 J95
HOH
 6.310
3.607
 C
CB
 CL1
O
ALA B:140 B:142 1.0 0.009 E -137.9 129.5 1.0 0.009 0.0 J95
HOH
 6.259
3.867
 C
CB
 CL1
O
ALA C:140 C:142 1.0 0.009 E -131.7 133.4 NA NA NA
ALA D:140 D:142 2.0 0.017 E -132.9 124.9 NA NA NA
6qnl 1 O43570 99.62 0.0 X-RAY
 2020-03-04 ALA A:140 A:142 2.0 0.017 E -137.1 131.6 2.0 0.017 0.0 J92
HOH
 6.172
3.661
 O
CB
 CL1
O
ALA B:140 B:142 2.0 0.017 E -134.6 126.9 2.0 0.017 0.0 J92
HOH
 6.349
3.722
 C
CB
 CL1
O
ALA C:140 C:142 2.0 0.017 E -137.9 129.8 NA NA NA
ALA D:140 D:142 2.0 0.017 E -139.8 130.2 NA NA NA
4ht2 1 O43570 100.0 0.0 X-RAY
 2013-04-10 ALA A:140 A:140 1.0 0.009 E -137.0 123.5 1.0 0.009 0.0 V50
EDO
HOH
 6.509
9.075
3.658
 C
CB
CB
 F11
O2
O
ALA B:140 B:140 2.0 0.017 E -137.6 125.4 NA NA NA
ALA C:140 C:140 2.0 0.017 E -138.9 125.0 NA NA NA
ALA D:140 D:140 1.0 0.009 E -141.9 124.4 NA NA NA
4kp5 1 O43570 100.0 0.0 X-RAY
 2013-11-06 ALA A:140 A:140 1.0 0.009 E -143.2 127.8 1.0 0.009 0.0 E1F
HOH
 6.094
3.729
 C
CB
 CL1
O
ALA B:140 B:140 2.0 0.017 E -140.8 128.6 2.0 0.017 0.0 E1F
EDO
HOH
 6.185
9.177
3.653
 C
CB
CB
 CL1
O1
O
ALA C:140 C:140 3.0 0.026 E -143.8 132.5 NA NA NA
ALA D:140 D:140 2.0 0.017 E -142.4 133.4 NA NA NA
4kp8 1 O43570 100.0 0.0 X-RAY
 2013-11-06 ALA A:140 A:140 1.0 0.009 E -128.3 134.4 1.0 0.009 0.0 E1G
HOH
 7.469
3.510
 O
CB
 O18
O
ALA B:140 B:140 2.0 0.017 E -139.1 118.6 2.0 0.017 0.0 E1G
HOH
 7.622
3.805
 C
CB
 O18
O
ALA C:140 C:140 3.0 0.026 E -136.9 128.2 NA NA NA
ALA D:140 D:140 2.0 0.017 E -140.2 128.0 NA NA NA
4q0l 1 O43570 100.0 0.0 X-RAY
 2015-01-28 ALA A:140 A:140 1.0 0.009 E -144.4 126.2 1.0 0.009 0.0 ZN
V14
HOH
 9.938
7.176
3.978
 O
O
CB
 ZN
O9
O
ALA B:140 B:140 0.0 0.0 E -135.8 126.9 0.0 0.0 0.0 V14
HOH
 7.562
3.639
 O
CB
 O9
O
ALA C:140 C:140 0.0 0.0 E -136.6 122.6 NA NA NA
ALA D:140 D:140 1.0 0.009 E -140.6 125.1 NA NA NA
4qj0 1 O43570 100.0 0.0 X-RAY
 2015-04-15 ALA A:140 A:140 2.0 0.017 E -136.5 129.4 2.0 0.017 0.0 WWX
HOH
 6.423
3.681
 C
CB
 F11
O
ALA B:140 B:140 1.0 0.009 E -135.1 124.9 1.0 0.009 0.0 EDO
WWX
HOH
 9.010
7.597
3.570
 CB
C
CB
 O1
O2
O
ALA C:140 C:140 1.0 0.009 E -137.5 127.3 NA NA NA
ALA D:140 D:140 1.0 0.009 E -135.7 128.6 NA NA NA
4qjo 1 O43570 100.0 0.0 X-RAY
 2015-04-15 ALA A:140 A:140 0.0 0.0 E -132.9 127.3 0.0 0.0 0.0 V1F
HOH
 7.368
3.502
 O
CB
 O9
O
ALA B:140 B:140 1.0 0.009 E -131.8 123.5 1.0 0.009 0.0 V1F
HOH
 7.448
3.706
 C
CB
 O9
O
ALA C:140 C:140 1.0 0.009 E -137.3 124.8 NA NA NA
ALA D:140 D:140 2.0 0.017 E -139.6 127.5 NA NA NA
4qjw 1 O43570 100.0 0.0 X-RAY
 2015-04-15 ALA A:140 A:140 1.0 0.009 E -137.3 127.4 1.0 0.009 0.0 WWO
EDO
HOH
 7.390
9.060
3.654
 O
CB
CB
 O9
O2
O
ALA B:140 B:140 2.0 0.017 E -137.4 124.5 2.0 0.017 0.0 WWO
HOH
 7.275
3.742
 O
CB
 O9
O
ALA C:140 C:140 2.0 0.017 E -139.7 127.4 NA NA NA
ALA D:140 D:140 2.0 0.017 E -139.6 127.8 NA NA NA
4ww8 1 O43570 100.0 0.0 X-RAY
 2015-07-01 ALA A:140 A:140 1.0 0.009 E -140.4 128.2 1.0 0.009 0.0 VD9
HOH
 7.387
3.733
 O
CB
 O1
O
ALA B:140 B:140 1.0 0.009 E -130.9 124.1 1.0 0.009 0.0 EDO
VD9
HOH
 8.899
7.602
3.621
 CB
O
CB
 O2
O1
O
ALA C:140 C:140 1.0 0.009 E -140.4 129.7 NA NA NA
ALA D:140 D:140 3.0 0.026 E -138.4 128.4 NA NA NA
5ll5 1 O43570 100.0 0.0 X-RAY
 2017-08-16 ALA A:140 A:140 1.0 0.009 E -138.0 129.3 1.0 0.009 0.0 6YH
HOH
 7.374
3.729
 O
CB
 O8
O
ALA B:140 B:140 1.0 0.009 E -132.3 126.3 1.0 0.009 0.0 6YH
EDO
HOH
 7.468
8.933
3.524
 O
CB
CB
 O8
O1
O
ALA C:140 C:140 1.0 0.009 E -138.7 127.4 NA NA NA
ALA D:140 D:140 1.0 0.009 E -136.5 128.1 NA NA NA
5ll9 1 O43570 100.0 0.0 X-RAY
 2017-08-16 ALA A:140 A:140 1.0 0.009 E -140.8 129.4 1.0 0.009 0.0 6YQ
EDO
HOH
 6.094
9.148
3.731
 O
CB
CB
 CL1
O1
O
ALA B:140 B:140 2.0 0.017 E -139.5 130.6 2.0 0.017 0.0 6YQ
EDO
HOH
 6.146
9.186
3.624
 C
CB
CB
 CL1
O1
O
ALA C:140 C:140 1.0 0.009 E -141.5 129.5 NA NA NA
ALA D:140 D:140 2.0 0.017 E -139.6 131.2 NA NA NA
5llo 1 O43570 100.0 0.0 X-RAY
 2017-08-16 ALA A:140 A:140 2.0 0.017 E -138.6 130.7 2.0 0.017 0.0 ZN
5EF
HOH
 9.981
7.344
3.722
 O
O
CB
 ZN
O3
O
ALA B:140 B:140 2.0 0.017 E -131.7 128.2 2.0 0.017 0.0 EDO
5EF
HOH
 8.799
7.602
3.602
 CB
O
CB
 O2
O3
O
ALA C:140 C:140 1.0 0.009 E -140.3 130.0 NA NA NA
ALA D:140 D:140 1.0 0.009 E -133.4 131.2 NA NA NA
5llp 1 O43570 100.0 0.0 X-RAY
 2017-08-16 ALA A:140 A:140 2.0 0.017 E -138.6 129.1 2.0 0.017 0.0 ZN
6Z9
HOH
 9.990
7.393
3.685
 O
O
CB
 ZN
O30
O
ALA B:140 B:140 1.0 0.009 E -131.8 122.8 1.0 0.009 0.0 6Z9
HOH
 7.590
3.581
 C
CB
 O30
O
ALA C:140 C:140 1.0 0.009 E -139.2 128.7 NA NA NA
ALA D:140 D:140 1.0 0.009 E -135.1 128.0 NA NA NA
5msa 1 O43570 100.0 0.0 X-RAY
 2018-01-17 ALA A:140 A:140 2.0 0.017 E -137.4 130.2 2.0 0.017 0.0 3TV
HOH
 6.452
3.711
 C
CB
 F17
O
ALA B:140 B:140 1.0 0.009 E -134.6 124.7 1.0 0.009 0.0 3TV
EDO
HOH
 6.601
8.974
3.633
 C
CB
CB
 F16
O2
O
ALA C:140 C:140 1.0 0.009 E -140.0 130.6 NA NA NA
ALA D:140 D:140 1.0 0.009 E -136.2 124.4 NA NA NA
5msb 1 O43570 100.0 0.0 X-RAY
 2018-01-17 ALA A:140 A:140 1.0 0.009 E -136.2 129.1 1.0 0.009 0.0 V13
HOH
 6.468
3.714
 C
CB
 F13
O
ALA B:140 B:140 1.0 0.009 E -133.4 123.3 1.0 0.009 0.0 V13
HOH
 6.519
3.631
 C
CB
 F13
O
ALA C:140 C:140 1.0 0.009 E -142.3 127.9 NA NA NA
ALA D:140 D:140 2.0 0.017 E -137.1 127.2 NA NA NA
6g5l 1 O43570 100.0 0.0 X-RAY
 2019-03-13 ALA A:140 A:140 1.0 0.009 E -138.9 133.7 1.0 0.009 0.0 EM5
HOH
 6.231
3.703
 C
CB
 CL1
O
ALA B:140 B:140 1.0 0.009 E -135.4 127.2 1.0 0.009 0.0 EM5
EDO
HOH
 6.400
9.036
3.666
 C
CB
CB
 CL1
O1
O
ALA C:140 C:140 1.0 0.009 E -140.6 134.2 NA NA NA
ALA D:140 D:140 3.0 0.026 E -138.8 131.8 NA NA NA
6g7a 1 O43570 100.0 0.0 X-RAY
 2019-03-13 ALA A:140 A:140 1.0 0.009 E -142.5 131.3 1.0 0.009 0.0 EOQ
HOH
 6.122
3.673
 C
CB
 CL1
O
ALA B:140 B:140 1.0 0.009 E -135.7 129.2 1.0 0.009 0.0 EDO
EOQ
HOH
 9.007
6.316
3.588
 CB
C
CB
 O2
CL1
O
ALA C:140 C:140 1.0 0.009 E -142.8 134.1 NA NA NA
ALA D:140 D:140 1.0 0.009 E -140.1 131.6 NA NA NA
6r6y 1 O43570 100.0 0.0 X-RAY
 2020-04-08 ALA A:140 A:140 2.0 0.017 E -140.7 132.3 2.0 0.017 0.0 EA3
HOH
 6.294
3.684
 C
CB
 CL1
O
ALA B:140 B:140 1.0 0.009 E -135.1 129.7 1.0 0.009 0.0 EDO
EA3
HOH
 9.032
6.418
3.616
 CB
C
CB
 O2
CL1
O
ALA C:140 C:140 1.0 0.009 E -139.4 132.8 NA NA NA
ALA D:140 D:140 2.0 0.017 E -140.0 132.2 NA NA NA
6r71 1 O43570 100.0 0.0 X-RAY
 2020-04-08 ALA A:140 A:140 1.0 0.009 E -127.1 127.0 1.0 0.009 0.0 JTW
HOH
 6.363
3.599
 C
CB
 CL1
O
ALA B:140 B:140 2.0 0.017 E -142.6 126.5 2.0 0.017 0.0 ZN
JTW
HOH
 9.951
6.108
3.630
 O
C
CB
 ZN
CL1
O
6t5p 1 O43570 100.0 0.0 X-RAY
 2020-10-14 ALA A:140 A:140 2.0 0.017 E -138.7 128.9 2.0 0.017 0.0 VD8
HOH
 7.623
3.735
 O
CB
 O10
O
ALA B:140 B:140 2.0 0.017 E -134.5 127.2 2.0 0.017 0.0 VD8
EDO
HOH
 7.668
9.021
3.639
 O
CB
CB
 O10
O1
O
ALA C:140 C:140 1.0 0.009 E -139.4 129.3 NA NA NA
ALA D:140 D:140 2.0 0.017 E -136.2 129.3 NA NA NA
6t5q 1 O43570 100.0 0.0 X-RAY
 2020-10-14 ALA A:140 A:140 2.0 0.017 E -136.4 131.1 2.0 0.017 0.0 MKQ
HOH
 7.306
3.789
 O
CB
 O3
O
ALA B:140 B:140 0.0 0.0 E -130.7 132.6 0.0 0.0 0.0 MKQ
EDO
HOH
 7.627
8.921
3.573
 C
CB
CB
 O3
O1
O
ALA C:140 C:140 1.0 0.009 E -133.8 134.9 NA NA NA
ALA D:140 D:140 1.0 0.009 E -133.6 140.1 NA NA NA
7puu 1 O43570 100.0 0.0 X-RAY
 2022-01-12 ALA A:140 A:140 2.0 0.017 E -137.8 131.3 2.0 0.017 0.0 84O
HOH
 6.396
3.757
 C
CB
 CL1
O
ALA B:140 B:140 0.0 0.0 E -134.9 124.7 0.0 0.0 0.0 84O
EDO
HOH
 6.555
8.917
3.605
 C
CB
CB
 CL1
O1
O
ALA C:140 C:140 1.0 0.009 E -141.1 132.6 NA NA NA
ALA D:140 D:140 2.0 0.017 E -134.6 129.4 NA NA NA
7puv 1 O43570 100.0 0.0 X-RAY
 2022-01-12 ALA A:140 A:140 1.0 0.009 E -139.4 134.7 1.0 0.009 0.0 ZN
EDO
84Z
HOH
 9.995
9.103
6.116
3.673
 O
CB
O
CB
 ZN
O1
CL1
O
ALA B:140 B:140 1.0 0.009 E -131.5 130.9 1.0 0.009 0.0 PEG
84Z
HOH
 8.803
6.214
3.556
 CB
C
CB
 O4
CL1
O
ALA C:140 C:140 2.0 0.017 E -136.8 132.9 NA NA NA
ALA D:140 D:140 2.0 0.017 E -137.0 130.4 NA NA NA
7puw 1 O43570 100.0 0.0 X-RAY
 2022-01-12 ALA A:140 A:140 1.0 0.009 E -136.2 132.2 1.0 0.009 0.0 84I
HOH
 7.611
3.743
 O
CB
 O8
O
ALA B:140 B:140 1.0 0.009 E -132.4 126.5 1.0 0.009 0.0 84I
EDO
HOH
 7.714
9.015
3.668
 O
CB
CB
 O8
O2
O
ALA C:140 C:140 2.0 0.017 E -139.8 132.5 NA NA NA
ALA D:140 D:140 2.0 0.017 E -133.6 130.8 NA NA NA
6rps 1 O43570 96.7 0.0 X-RAY
 2019-11-13 ALA A:139 A:142 2.0 0.017 E -131.6 124.6 2.0 0.017 0.0 ACT
 7.315
 C
 CH3
ALA B:139 B:142 2.0 0.017 E -129.6 122.5 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-o43570-f1 1 O43570 100.0 0.0 ALA A:168 A:168 1.0 0.009 E -130.8 131.9