Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr15 63637678 . C A CCDS10185.1:NM_001218.3:c.427Gag>Tag_NP_001209.1:p.143E>* Homo sapiens carbonic anhydrase XII (CA12), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1jcz 1 O43570 99.62 0.0 X-RAY
 2001-08-17 GLU A:115 A:117 0.0 0.0 E -150.9 135.6 0.0 0.0 0.0 ZN
ACY
HOH
 6.308
7.482
6.975
 O
OE1
OE2
 ZN
O
O
GLU B:115 B:117 0.0 0.0 E -150.8 137.7 0.0 0.0 0.0 ZN
ACY
HOH
 6.307
7.324
7.001
 O
OE1
OE2
 ZN
O
O
1jd0 1 O43570 99.62 0.0 X-RAY
 2001-08-17 GLU A:115 A:117 0.0 0.0 E -149.6 134.0 0.0 0.0 0.0 ZN
AZM
HOH
 6.173
7.652
7.024
 O
OE1
OE2
 ZN
N1
O
GLU B:115 B:117 0.0 0.0 E -149.8 135.8 0.0 0.0 0.0 ZN
AZM
HOH
 6.207
7.640
6.999
 O
OE1
OE2
 ZN
N1
O
6qn0 1 O43570 99.62 0.0 X-RAY
 2020-02-26 GLU A:115 A:117 0.0 0.0 E -153.8 135.2 0.0 0.0 0.0 ZN
J8Q
HOH
 6.456
7.266
6.980
 O
OE1
OE2
 ZN
O5
O
GLU B:115 B:117 0.0 0.0 E -146.9 131.1 0.0 0.0 0.0 ZN
J8Q
HOH
 6.176
7.314
7.091
 O
OE1
OE2
 ZN
O5
O
GLU C:115 C:117 0.0 0.0 E -152.7 134.2 NA NA NA
GLU D:115 D:117 0.0 0.0 E -137.7 129.8 NA NA NA
6qng 1 O43570 99.62 0.0 X-RAY
 2020-03-04 GLU A:115 A:117 0.0 0.0 E -145.3 132.5 0.0 0.0 0.0 ZN
J95
HOH
 6.241
7.586
6.978
 O
OE1
OE2
 ZN
O5
O
GLU B:115 B:117 0.0 0.0 E -147.8 137.4 0.0 0.0 0.0 ZN
J95
HOH
 6.285
7.407
7.048
 O
OE1
CG
 ZN
O6
O
GLU C:115 C:117 0.0 0.0 E -150.8 135.5 NA NA NA
GLU D:115 D:117 0.0 0.0 E -151.0 136.2 NA NA NA
6qnl 1 O43570 99.62 0.0 X-RAY
 2020-03-04 GLU A:115 A:117 0.0 0.0 E -152.4 133.6 0.0 0.0 0.0 ZN
J92
HOH
 6.145
7.425
7.083
 O
OE1
OE2
 ZN
O6
O
GLU B:115 B:117 0.0 0.0 E -149.3 133.3 0.0 0.0 0.0 ZN
J92
HOH
 6.275
7.513
7.017
 O
OE1
OE2
 ZN
O6
O
GLU C:115 C:117 0.0 0.0 E -151.5 133.8 NA NA NA
GLU D:115 D:117 0.0 0.0 E -148.3 133.3 NA NA NA
4ht2 1 O43570 100.0 0.0 X-RAY
 2013-04-10 GLU A:115 A:115 0.0 0.0 E -151.2 137.3 0.0 0.0 0.0 ZN
V50
EDO
HOH
 6.251
7.393
8.337
7.043
 O
OE1
O
OE2
 ZN
O9
O2
O
GLU B:115 B:115 0.0 0.0 E -149.8 138.0 NA NA NA
GLU C:115 C:115 0.0 0.0 E -151.2 137.7 NA NA NA
GLU D:115 D:115 0.0 0.0 E -148.1 137.0 NA NA NA
4kp5 1 O43570 100.0 0.0 X-RAY
 2013-11-06 GLU A:115 A:115 0.0 0.0 E -148.6 138.3 0.0 0.0 0.0 ZN
E1F
EDO
HOH
 6.238
7.401
9.477
7.043
 O
OE2
O
OE1
 ZN
O17
C2
O
GLU B:115 B:115 0.0 0.0 E -148.7 138.0 0.0 0.0 0.0 ZN
E1F
EDO
HOH
 6.319
7.440
9.362
7.007
 O
OE1
O
OE2
 ZN
O17
C2
O
GLU C:115 C:115 0.0 0.0 E -149.0 140.1 NA NA NA
GLU D:115 D:115 0.0 0.0 E -149.4 134.4 NA NA NA
4kp8 1 O43570 100.0 0.0 X-RAY
 2013-11-06 GLU A:115 A:115 0.0 0.0 E -154.1 133.2 0.0 0.0 0.0 ZN
E1G
HOH
 6.217
7.538
7.047
 O
OE1
OE2
 ZN
N20
O
GLU B:115 B:115 0.0 0.0 E -153.6 135.2 0.0 0.0 0.0 ZN
E1G
PEG
HOH
 6.260
7.469
9.089
7.057
 O
OE1
O
OE2
 ZN
N20
O2
O
GLU C:115 C:115 0.0 0.0 E -145.6 140.2 NA NA NA
GLU D:115 D:115 0.0 0.0 E -148.0 136.7 NA NA NA
4q0l 1 O43570 100.0 0.0 X-RAY
 2015-01-28 GLU A:115 A:115 0.0 0.0 E -148.0 137.9 0.0 0.0 0.0 ZN
V14
HOH
 6.122
6.569
7.228
 O
OE1
OE2
 ZN
N10
O
GLU B:115 B:115 0.0 0.0 E -147.7 139.9 0.0 0.0 0.0 ZN
V14
HOH
 6.207
7.135
6.822
 O
OE1
CG
 ZN
N10
O
GLU C:115 C:115 0.0 0.0 E -147.1 134.2 NA NA NA
GLU D:115 D:115 0.0 0.0 E -139.9 135.7 NA NA NA
4qj0 1 O43570 100.0 0.0 X-RAY
 2015-04-15 GLU A:115 A:115 0.0 0.0 E -148.8 135.7 0.0 0.0 0.0 ZN
WWX
HOH
 6.208
7.665
7.098
 O
OE2
OE1
 ZN
O2
O
GLU B:115 B:115 0.0 0.0 E -146.9 137.8 0.0 0.0 0.0 ZN
WWX
HOH
 6.301
7.224
7.007
 O
OE1
OE2
 ZN
N4
O
GLU C:115 C:115 0.0 0.0 E -147.5 137.1 NA NA NA
GLU D:115 D:115 0.0 0.0 E -150.0 132.6 NA NA NA
4qjo 1 O43570 100.0 0.0 X-RAY
 2015-04-15 GLU A:115 A:115 0.0 0.0 E -150.0 139.3 0.0 0.0 0.0 ZN
V1F
HOH
 6.179
7.017
6.913
 O
OE1
OE2
 ZN
N10
O
GLU B:115 B:115 0.0 0.0 E -151.1 137.4 0.0 0.0 0.0 ZN
V1F
HOH
 6.337
7.322
7.055
 O
OE1
OE2
 ZN
N10
O
GLU C:115 C:115 0.0 0.0 E -151.1 134.9 NA NA NA
GLU D:115 D:115 0.0 0.0 E -143.1 132.8 NA NA NA
4qjw 1 O43570 100.0 0.0 X-RAY
 2015-04-15 GLU A:115 A:115 0.0 0.0 E -152.6 136.9 0.0 0.0 0.0 ZN
WWO
HOH
 6.165
6.839
6.926
 O
OE1
OE2
 ZN
N10
O
GLU B:115 B:115 0.0 0.0 E -154.0 134.8 0.0 0.0 0.0 ZN
WWO
HOH
 6.206
7.081
6.979
 O
OE1
OE2
 ZN
N10
O
GLU C:115 C:115 0.0 0.0 E -148.8 137.7 NA NA NA
GLU D:115 D:115 0.0 0.0 E -147.2 132.0 NA NA NA
4ww8 1 O43570 100.0 0.0 X-RAY
 2015-07-01 GLU A:115 A:115 0.0 0.0 E -148.0 134.0 0.0 0.0 0.0 ZN
EDO
VD9
HOH
 6.200
9.057
7.485
7.061
 O
O
OE2
OE1
 ZN
C1
N3
O
GLU B:115 B:115 0.0 0.0 E -147.5 137.0 0.0 0.0 0.0 ZN
EDO
VD9
HOH
 6.298
9.058
7.499
6.991
 O
O
OE2
OE1
 ZN
C2
N3
O
GLU C:115 C:115 0.0 0.0 E -142.4 138.4 NA NA NA
GLU D:115 D:115 0.0 0.0 E -152.0 136.8 NA NA NA
5ll5 1 O43570 100.0 0.0 X-RAY
 2017-08-16 GLU A:115 A:115 0.0 0.0 E -148.8 136.3 0.0 0.0 0.0 ZN
6YH
EDO
HOH
 6.225
7.526
9.061
7.061
 O
OE2
O
OE1
 ZN
O8
C2
O
GLU B:115 B:115 0.0 0.0 E -149.9 137.1 0.0 0.0 0.0 ZN
6YH
EDO
HOH
 6.313
7.560
8.980
7.034
 O
OE1
O
OE2
 ZN
N10
C2
O
GLU C:115 C:115 0.0 0.0 E -144.2 138.8 NA NA NA
GLU D:115 D:115 0.0 0.0 E -152.0 136.7 NA NA NA
5ll9 1 O43570 100.0 0.0 X-RAY
 2017-08-16 GLU A:115 A:115 0.0 0.0 E -150.4 137.0 0.0 0.0 0.0 ZN
6YQ
EDO
HOH
 6.172
7.388
9.581
7.040
 O
OE2
O
OE1
 ZN
O8
C2
O
GLU B:115 B:115 0.0 0.0 E -151.6 135.7 0.0 0.0 0.0 ZN
6YQ
EDO
HOH
 6.304
7.518
9.117
7.024
 O
OE2
O
OE1
 ZN
O8
C2
O
GLU C:115 C:115 0.0 0.0 E -146.3 135.3 NA NA NA
GLU D:115 D:115 0.0 0.0 E -150.8 137.7 NA NA NA
5llo 1 O43570 100.0 0.0 X-RAY
 2017-08-16 GLU A:115 A:115 0.0 0.0 E -152.5 133.7 0.0 0.0 0.0 ZN
5EF
HOH
 6.142
7.291
7.041
 O
OE2
OE1
 ZN
N4
O
GLU B:115 B:115 0.0 0.0 E -147.3 131.8 0.0 0.0 0.0 ZN
5EF
HOH
 6.278
7.233
6.785
 O
OE1
O
 ZN
N4
O
GLU C:115 C:115 0.0 0.0 E -148.5 136.6 NA NA NA
GLU D:115 D:115 0.0 0.0 E -149.5 131.7 NA NA NA
5llp 1 O43570 100.0 0.0 X-RAY
 2017-08-16 GLU A:115 A:115 0.0 0.0 E -150.0 136.1 0.0 0.0 0.0 ZN
6Z9
HOH
 6.126
7.129
6.831
 O
OE2
O
 ZN
N29
O
GLU B:115 B:115 0.0 0.0 E -146.1 137.0 0.0 0.0 0.0 ZN
6Z9
HOH
 6.242
7.203
6.865
 O
OE1
O
 ZN
N29
O
GLU C:115 C:115 0.0 0.0 E -150.3 134.4 NA NA NA
GLU D:115 D:115 0.0 0.0 E -150.7 139.0 NA NA NA
5msa 1 O43570 100.0 0.0 X-RAY
 2018-01-17 GLU A:115 A:115 0.0 0.0 E -151.9 133.0 0.0 0.0 0.0 ZN
3TV
HOH
 6.158
7.369
7.003
 O
OE2
OE1
 ZN
N2
O
GLU B:115 B:115 0.0 0.0 E -151.1 134.8 0.0 0.0 0.0 ZN
3TV
HOH
 6.274
7.478
6.783
 O
OE2
O
 ZN
N2
O
GLU C:115 C:115 0.0 0.0 E -146.1 137.3 NA NA NA
GLU D:115 D:115 0.0 0.0 E -151.4 136.8 NA NA NA
5msb 1 O43570 100.0 0.0 X-RAY
 2018-01-17 GLU A:115 A:115 0.0 0.0 E -148.1 136.3 0.0 0.0 0.0 ZN
V13
HOH
 6.140
7.431
7.021
 O
OE2
OE1
 ZN
N10
O
GLU B:115 B:115 0.0 0.0 E -146.8 135.8 0.0 0.0 0.0 ZN
V13
HOH
 6.242
7.301
6.772
 O
OE2
O
 ZN
O9
O
GLU C:115 C:115 0.0 0.0 E -147.3 138.1 NA NA NA
GLU D:115 D:115 0.0 0.0 E -149.2 137.8 NA NA NA
6g5l 1 O43570 100.0 0.0 X-RAY
 2019-03-13 GLU A:115 A:115 0.0 0.0 E -150.9 134.1 0.0 0.0 0.0 ZN
EM5
HOH
 6.213
7.417
7.010
 O
OE2
OE1
 ZN
O3
O
GLU B:115 B:115 0.0 0.0 E -149.8 137.1 0.0 0.0 0.0 ZN
EM5
HOH
 6.286
7.426
7.004
 O
OE2
OE1
 ZN
O3
O
GLU C:115 C:115 0.0 0.0 E -146.7 139.6 NA NA NA
GLU D:115 D:115 0.0 0.0 E -151.2 138.7 NA NA NA
6g7a 1 O43570 100.0 0.0 X-RAY
 2019-03-13 GLU A:115 A:115 0.0 0.0 E -149.6 135.8 0.0 0.0 0.0 ZN
EOQ
HOH
 6.220
7.371
7.026
 O
OE2
OE1
 ZN
O3
O
GLU B:115 B:115 0.0 0.0 E -151.0 136.0 0.0 0.0 0.0 ZN
EOQ
HOH
 6.306
7.406
6.982
 O
OE2
OE1
 ZN
O3
O
GLU C:115 C:115 0.0 0.0 E -145.3 137.3 NA NA NA
GLU D:115 D:115 0.0 0.0 E -150.9 138.2 NA NA NA
6r6y 1 O43570 100.0 0.0 X-RAY
 2020-04-08 GLU A:115 A:115 0.0 0.0 E -148.5 138.9 0.0 0.0 0.0 ZN
EA3
HOH
 6.176
7.380
7.041
 O
OE2
OE1
 ZN
O4
O
GLU B:115 B:115 0.0 0.0 E -149.4 137.8 0.0 0.0 0.0 ZN
EA3
HOH
 6.264
7.384
6.982
 O
OE2
OE1
 ZN
O4
O
GLU C:115 C:115 0.0 0.0 E -146.1 137.4 NA NA NA
GLU D:115 D:115 0.0 0.0 E -148.9 140.3 NA NA NA
6r71 1 O43570 100.0 0.0 X-RAY
 2020-04-08 GLU A:115 A:115 0.0 0.0 E -152.9 130.4 0.0 0.0 0.0 ZN
JTW
HOH
 6.257
7.480
6.917
 O
OE1
OE2
 ZN
O4
O
GLU B:115 B:115 0.0 0.0 E -153.2 133.4 0.0 0.0 0.0 ZN
JTW
HOH
 6.143
7.345
6.889
 O
OE1
OE2
 ZN
O4
O
6t5p 1 O43570 100.0 0.0 X-RAY
 2020-10-14 GLU A:115 A:115 0.0 0.0 E -148.9 137.8 0.0 0.0 0.0 ZN
VD8
HOH
 6.197
7.578
7.056
 O
OE2
OE1
 ZN
N8
O
GLU B:115 B:115 0.0 0.0 E -148.8 134.5 0.0 0.0 0.0 ZN
VD8
HOH
 6.283
7.453
6.963
 O
OE2
OE1
 ZN
N8
O
GLU C:115 C:115 0.0 0.0 E -144.6 138.2 NA NA NA
GLU D:115 D:115 0.0 0.0 E -149.2 136.8 NA NA NA
6t5q 1 O43570 100.0 0.0 X-RAY
 2020-10-14 GLU A:115 A:115 0.0 0.0 E -146.9 139.9 0.0 0.0 0.0 ZN
MKQ
HOH
 6.339
7.336
7.019
 O
OE2
OE1
 ZN
N1
O
GLU B:115 B:115 0.0 0.0 E -142.2 136.7 0.0 0.0 0.0 ZN
MKQ
HOH
 6.379
7.305
7.119
 O
OE2
OE1
 ZN
O3
O
GLU C:115 C:115 0.0 0.0 E -145.7 137.1 NA NA NA
GLU D:115 D:115 0.0 0.0 E -149.2 135.7 NA NA NA
7puu 1 O43570 100.0 0.0 X-RAY
 2022-01-12 GLU A:115 A:115 0.0 0.0 E -148.9 133.4 0.0 0.0 0.0 ZN
84O
HOH
 6.198
7.464
7.034
 O
OE2
OE1
 ZN
O12
O
GLU B:115 B:115 0.0 0.0 E -149.5 136.0 0.0 0.0 0.0 ZN
84O
HOH
 6.248
7.406
7.002
 O
OE2
OE1
 ZN
N14
O
GLU C:115 C:115 0.0 0.0 E -148.8 135.6 NA NA NA
GLU D:115 D:115 0.0 0.0 E -150.3 135.6 NA NA NA
7puv 1 O43570 100.0 0.0 X-RAY
 2022-01-12 GLU A:115 A:115 0.0 0.0 E -151.4 135.4 0.0 0.0 0.0 ZN
84Z
HOH
 6.191
7.244
6.800
 O
OE2
O
 ZN
N10
O
GLU B:115 B:115 0.0 0.0 E -150.7 138.3 0.0 0.0 0.0 ZN
84Z
HOH
 6.310
7.524
6.937
 O
OE2
O
 ZN
O8
O
GLU C:115 C:115 0.0 0.0 E -140.8 142.0 NA NA NA
GLU D:115 D:115 0.0 0.0 E -145.7 137.7 NA NA NA
7puw 1 O43570 100.0 0.0 X-RAY
 2022-01-12 GLU A:115 A:115 0.0 0.0 E -148.7 133.1 0.0 0.0 0.0 ZN
84I
HOH
 6.155
7.446
7.009
 O
OE2
OE1
 ZN
N10
O
GLU B:115 B:115 0.0 0.0 E -150.8 136.5 0.0 0.0 0.0 ZN
84I
HOH
 6.252
7.418
6.956
 O
OE2
OE1
 ZN
N10
O
GLU C:115 C:115 0.0 0.0 E -146.5 134.6 NA NA NA
GLU D:115 D:115 0.0 0.0 E -151.4 134.9 NA NA NA
6rps 1 O43570 96.7 0.0 X-RAY
 2019-11-13 GLU A:114 A:117 0.0 0.0 E -147.3 137.0 0.0 0.0 0.0 ZN
ACT
HOH
 6.500
7.428
7.348
 O
OE2
N
 ZN
OXT
O
GLU B:114 B:117 0.0 0.0 E -148.3 136.8 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-o43570-f1 1 O43570 100.0 0.0 GLU A:143 A:143 0.0 0.0 E -141.7 131.2