Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr15 63638833 . T A CCDS10185.1:NM_001218.3:c.182cAc>cTc_NP_001209.1:p.61H>L Homo sapiens carbonic anhydrase XII (CA12), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1jcz 1 O43570 99.62 0.0 X-RAY
 2001-08-17 HIS A:33 A:34 62.0 0.318 -134.7 153.2 34.0 0.174 0.144 B:O43570:0.144
 HOH
 3.135
 NE2
 O
HIS B:33 B:34 47.0 0.241 -131.4 147.9 29.0 0.149 0.092 A:O43570:0.092
 HOH
 3.065
 CE1
 O
1jd0 1 O43570 99.62 0.0 X-RAY
 2001-08-17 HIS A:33 A:34 62.0 0.318 -132.4 156.4 35.0 0.179 0.139 B:O43570:0.138
 HOH
 3.147
 NE2
 O
HIS B:33 B:34 45.0 0.231 -134.1 148.6 27.0 0.138 0.093 A:O43570:0.092
 HOH
 3.100
 CE1
 O
6qn0 1 O43570 99.62 0.0 X-RAY
 2020-02-26 HIS A:33 A:34 55.0 0.282 -145.6 149.2 27.0 0.138 0.144 B:O43570:0.144
 HOH
 2.980
 CE1
 O
HIS B:33 B:34 70.0 0.359 -141.5 152.9 54.0 0.277 0.082 A:O43570:0.082
 HOH
 2.889
 CD2
 O
HIS C:33 C:34 51.0 0.262 -144.9 148.1 NA NA NA
HIS D:33 D:34 66.0 0.338 -134.6 155.0 NA NA NA
6qng 1 O43570 99.62 0.0 X-RAY
 2020-03-04 HIS A:33 A:34 58.0 0.297 -132.2 152.6 33.0 0.169 0.128 B:O43570:0.128
 HOH
 3.247
 CE1
 O
HIS B:33 B:34 60.0 0.308 -134.9 156.3 33.0 0.169 0.139 A:O43570:0.138
 HOH
 3.042
 NE2
 O
HIS C:33 C:34 57.0 0.292 -132.3 158.3 NA NA NA
HIS D:33 D:34 63.0 0.323 -129.6 151.9 NA NA NA
6qnl 1 O43570 99.62 0.0 X-RAY
 2020-03-04 HIS A:33 A:34 59.0 0.303 -129.2 153.4 44.0 0.226 0.077 B:O43570:0.077
 HOH
 2.935
 CE1
 O
HIS B:33 B:34 50.0 0.256 -142.8 156.6 27.0 0.138 0.118 A:O43570:0.118
 HOH
 3.013
 NE2
 O
HIS C:33 C:34 49.0 0.251 -142.7 157.7 NA NA NA
HIS D:33 D:34 62.0 0.318 -141.2 154.5 NA NA NA
4ht2 1 O43570 100.0 0.0 X-RAY
 2013-04-10 HIS A:33 A:33 54.0 0.277 -143.8 161.8 54.0 0.277 0.0 HOH
 2.951
 CE1
 O
HIS B:33 B:33 57.0 0.292 -149.6 162.5 NA NA NA
HIS C:33 C:33 59.0 0.303 -140.9 161.9 NA NA NA
HIS D:33 D:33 51.0 0.262 -144.9 158.3 NA NA NA
4kp5 1 O43570 100.0 0.0 X-RAY
 2013-11-06 HIS A:33 A:33 55.0 0.282 -124.1 162.7 42.0 0.215 0.067 B:O43570:0.067
 HOH
 2.904
 CE1
 O
HIS B:33 B:33 56.0 0.287 -141.8 158.5 32.0 0.164 0.123 A:O43570:0.123
 HOH
 3.082
 CE1
 O
HIS C:33 C:33 56.0 0.287 -141.1 160.1 NA NA NA
HIS D:33 D:33 48.0 0.246 -138.4 160.7 NA NA NA
4kp8 1 O43570 100.0 0.0 X-RAY
 2013-11-06 HIS A:33 A:33 55.0 0.282 -145.2 155.9 32.0 0.164 0.118 B:O43570:0.118
 HOH
 3.117
 NE2
 O
HIS B:33 B:33 53.0 0.272 -141.5 161.3 30.0 0.154 0.118 A:O43570:0.118
 HOH
 3.277
 CE1
 O
HIS C:33 C:33 58.0 0.297 -144.0 161.5 NA NA NA
HIS D:33 D:33 56.0 0.287 -141.8 156.2 NA NA NA
4q0l 1 O43570 100.0 0.0 X-RAY
 2015-01-28 HIS A:33 A:33 59.0 0.303 -142.5 155.2 29.0 0.149 0.154 B:O43570:0.154
 HOH
 3.792
 CA
 O
HIS B:33 B:33 48.0 0.246 -132.3 158.4 25.0 0.128 0.118 A:O43570:0.118
 HOH
 3.729
 CA
 O
HIS C:33 C:33 59.0 0.303 -141.6 152.9 NA NA NA
HIS D:33 D:33 54.0 0.277 -138.9 159.0 NA NA NA
4qj0 1 O43570 100.0 0.0 X-RAY
 2015-04-15 HIS A:33 A:33 59.0 0.303 -136.5 158.1 46.0 0.236 0.067 B:O43570:0.067
 HOH
 2.810
 CE1
 O
HIS B:33 B:33 58.0 0.297 -142.3 159.1 33.0 0.169 0.128 A:O43570:0.128
 HOH
 3.077
 CE1
 O
HIS C:33 C:33 61.0 0.313 -144.4 156.8 NA NA NA
HIS D:33 D:33 48.0 0.246 -145.0 158.7 NA NA NA
4qjo 1 O43570 100.0 0.0 X-RAY
 2015-04-15 HIS A:33 A:33 59.0 0.303 -141.3 157.4 34.0 0.174 0.129 B:O43570:0.128
 HOH
 3.163
 CE1
 O
HIS B:33 B:33 54.0 0.277 -141.0 155.2 32.0 0.164 0.113 A:O43570:0.113
 HOH
 2.919
 CE1
 O
HIS C:33 C:33 61.0 0.313 -147.2 157.4 NA NA NA
HIS D:33 D:33 54.0 0.277 -143.6 158.0 NA NA NA
4qjw 1 O43570 100.0 0.0 X-RAY
 2015-04-15 HIS A:33 A:33 56.0 0.287 -140.2 160.7 34.0 0.174 0.113 B:O43570:0.113
 HOH
 3.111
 NE2
 O
HIS B:33 B:33 54.0 0.277 -146.3 165.5 30.0 0.154 0.123 A:O43570:0.123
 HOH
 3.227
 CE1
 O
HIS C:33 C:33 57.0 0.292 -138.0 156.0 NA NA NA
HIS D:33 D:33 55.0 0.282 -140.9 155.7 NA NA NA
4ww8 1 O43570 100.0 0.0 X-RAY
 2015-07-01 HIS A:33 A:33 62.0 0.318 -134.2 158.5 47.0 0.241 0.077 B:O43570:0.077
 HOH
 2.849
 NE2
 O
HIS B:33 B:33 59.0 0.303 -142.5 162.2 37.0 0.19 0.113 A:O43570:0.113
 HOH
 3.044
 CE1
 O
HIS C:33 C:33 59.0 0.303 -140.4 154.5 NA NA NA
HIS D:33 D:33 49.0 0.251 -140.4 158.5 NA NA NA
5ll5 1 O43570 100.0 0.0 X-RAY
 2017-08-16 HIS A:33 A:33 57.0 0.292 -136.7 160.8 45.0 0.231 0.061 B:O43570:0.062
 HOH
 2.914
 CE1
 O
HIS B:33 B:33 47.0 0.241 -144.3 159.7 25.0 0.128 0.113 A:O43570:0.113
 HOH
 3.047
 CE1
 O
HIS C:33 C:33 55.0 0.282 -138.5 161.6 NA NA NA
HIS D:33 D:33 51.0 0.262 -144.7 159.8 NA NA NA
5ll9 1 O43570 100.0 0.0 X-RAY
 2017-08-16 HIS A:33 A:33 58.0 0.297 -134.1 162.1 47.0 0.241 0.056 B:O43570:0.056
 HOH
 2.925
 CE1
 O
HIS B:33 B:33 48.0 0.246 -142.0 160.8 27.0 0.138 0.108 A:O43570:0.108
 HOH
 3.018
 CE1
 O
HIS C:33 C:33 58.0 0.297 -135.6 159.4 NA NA NA
HIS D:33 D:33 48.0 0.246 -141.0 159.4 NA NA NA
5llo 1 O43570 100.0 0.0 X-RAY
 2017-08-16 HIS A:33 A:33 55.0 0.282 -134.8 166.0 44.0 0.226 0.056 B:O43570:0.056
 HOH
 3.009
 CD2
 O
HIS B:33 B:33 47.0 0.241 -139.6 158.2 26.0 0.133 0.108 A:O43570:0.108
 HOH
 3.048
 CE1
 O
HIS C:33 C:33 62.0 0.318 -142.1 159.9 NA NA NA
HIS D:33 D:33 48.0 0.246 -140.0 156.9 NA NA NA
5llp 1 O43570 100.0 0.0 X-RAY
 2017-08-16 HIS A:33 A:33 63.0 0.323 -146.7 159.4 50.0 0.256 0.067 B:O43570:0.067
 HOH
 2.854
 CD2
 O
HIS B:33 B:33 58.0 0.297 -145.1 165.0 34.0 0.174 0.123 A:O43570:0.123
 HOH
 3.010
 CE1
 O
HIS C:33 C:33 62.0 0.318 -145.6 163.6 NA NA NA
HIS D:33 D:33 60.0 0.308 -140.5 162.4 NA NA NA
5msa 1 O43570 100.0 0.0 X-RAY
 2018-01-17 HIS A:33 A:33 62.0 0.318 -133.8 163.1 48.0 0.246 0.072 B:O43570:0.072
 EDO
HOH
 3.246
2.766
 CB
CD2
 O2
O
HIS B:33 B:33 55.0 0.282 -144.7 157.8 33.0 0.169 0.113 A:O43570:0.113
 HOH
 3.047
 CE1
 O
HIS C:33 C:33 62.0 0.318 -144.3 159.5 NA NA NA
HIS D:33 D:33 47.0 0.241 -140.8 160.3 NA NA NA
5msb 1 O43570 100.0 0.0 X-RAY
 2018-01-17 HIS A:33 A:33 57.0 0.292 -133.5 158.4 44.0 0.226 0.066 B:O43570:0.067
 HOH
 2.718
 CD2
 O
HIS B:33 B:33 55.0 0.282 -144.4 160.7 32.0 0.164 0.118 A:O43570:0.118
 PEG
EDO
EDO
HOH
 8.232
7.910
9.957
2.953
 CA
CE1
CA
CE1
 O4
O1
O1
O
HIS C:33 C:33 60.0 0.308 -140.5 160.5 NA NA NA
HIS D:33 D:33 59.0 0.303 -141.1 160.8 NA NA NA
6g5l 1 O43570 100.0 0.0 X-RAY
 2019-03-13 HIS A:33 A:33 57.0 0.292 -126.3 163.3 44.0 0.226 0.066 B:O43570:0.067
 HOH
 3.013
 CE1
 O
HIS B:33 B:33 57.0 0.292 -143.8 160.5 34.0 0.174 0.118 A:O43570:0.118
 HOH
 2.978
 NE2
 O
HIS C:33 C:33 57.0 0.292 -135.4 155.8 NA NA NA
HIS D:33 D:33 48.0 0.246 -145.8 156.0 NA NA NA
6g7a 1 O43570 100.0 0.0 X-RAY
 2019-03-13 HIS A:33 A:33 53.0 0.272 -142.0 162.1 42.0 0.215 0.057 B:O43570:0.056
 HOH
 2.990
 CD2
 O
HIS B:33 B:33 58.0 0.297 -143.6 158.9 34.0 0.174 0.123 A:O43570:0.123
 HOH
 3.022
 CE1
 O
HIS C:33 C:33 60.0 0.308 -144.3 159.6 NA NA NA
HIS D:33 D:33 46.0 0.236 -142.4 159.0 NA NA NA
6r6y 1 O43570 100.0 0.0 X-RAY
 2020-04-08 HIS A:33 A:33 59.0 0.303 -135.5 161.2 45.0 0.231 0.072 B:O43570:0.072
 HOH
 2.779
 CE1
 O
HIS B:33 B:33 46.0 0.236 -140.4 162.4 25.0 0.128 0.108 A:O43570:0.108
 HOH
 3.019
 NE2
 O
HIS C:33 C:33 60.0 0.308 -142.1 157.4 NA NA NA
HIS D:33 D:33 48.0 0.246 -138.3 162.8 NA NA NA
6r71 1 O43570 100.0 0.0 X-RAY
 2020-04-08 HIS A:33 A:33 53.0 0.272 -157.4 160.8 30.0 0.154 0.118 B:O43570:0.118
 HOH
 3.383
 CE1
 O
HIS B:33 B:33 60.0 0.308 -124.9 155.6 42.0 0.215 0.093 A:O43570:0.092
 HOH
 3.182
 NE2
 O
6t5p 1 O43570 100.0 0.0 X-RAY
 2020-10-14 HIS A:33 A:33 60.0 0.308 -137.8 161.1 47.0 0.241 0.067 B:O43570:0.067
 HOH
 2.852
 CE1
 O
HIS B:33 B:33 48.0 0.246 -140.2 159.7 26.0 0.133 0.113 A:O43570:0.113
 HOH
 3.449
 CD2
 O
HIS C:33 C:33 59.0 0.303 -142.2 158.7 NA NA NA
HIS D:33 D:33 49.0 0.251 -141.7 161.0 NA NA NA
6t5q 1 O43570 100.0 0.0 X-RAY
 2020-10-14 HIS A:33 A:33 69.0 0.354 -131.6 177.7 49.0 0.251 0.103 B:O43570:0.103
 HOH
 3.727
 CB
 O
HIS B:33 B:33 42.0 0.215 -140.6 163.7 21.0 0.108 0.107 A:O43570:0.108
 HOH
 3.736
 CB
 O
HIS C:33 C:33 88.0 0.451 -155.6 37.7 NA NA NA
HIS D:33 D:33 56.0 0.287 -143.9 158.8 NA NA NA
7puu 1 O43570 100.0 0.0 X-RAY
 2022-01-12 HIS A:33 A:33 61.0 0.313 -121.0 162.6 45.0 0.231 0.082 B:O43570:0.082
 HOH
 3.148
 NE2
 O
HIS B:33 B:33 58.0 0.297 -144.7 162.9 35.0 0.179 0.118 A:O43570:0.118
 HOH
 3.061
 NE2
 O
HIS C:33 C:33 58.0 0.297 -136.6 163.2 NA NA NA
HIS D:33 D:33 48.0 0.246 -142.4 159.2 NA NA NA
7puv 1 O43570 100.0 0.0 X-RAY
 2022-01-12 HIS A:33 A:33 53.0 0.272 -108.4 166.0 40.0 0.205 0.067 B:O43570:0.067
 HOH
 3.332
 CE1
 O
HIS B:33 B:33 60.0 0.308 -149.2 158.0 36.0 0.185 0.123 A:O43570:0.123
 EDO
EDO
HOH
 3.152
2.923
3.164
 CD2
CE1
CE1
 C1
O1
O
HIS C:33 C:33 56.0 0.287 -134.9 162.6 NA NA NA
HIS D:33 D:33 48.0 0.246 -142.6 154.8 NA NA NA
7puw 1 O43570 100.0 0.0 X-RAY
 2022-01-12 HIS A:33 A:33 57.0 0.292 -122.4 164.3 43.0 0.221 0.071 B:O43570:0.072
 HOH
 3.204
 NE2
 O
HIS B:33 B:33 58.0 0.297 -144.7 162.8 35.0 0.179 0.118 A:O43570:0.118
 HOH
 2.951
 NE2
 O
HIS C:33 C:33 60.0 0.308 -136.0 160.4 NA NA NA
HIS D:33 D:33 50.0 0.256 -139.6 158.5 NA NA NA
6rps 1 O43570 96.7 0.0 X-RAY
 2019-11-13 HIS A:32 A:34 55.0 0.282 -145.7 166.9 55.0 0.282 0.0 CD
HOH
 2.254
3.756
 NE2
CB
 CD
O
HIS B:32 B:34 53.0 0.272 -147.3 167.4 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-o43570-f1 1 O43570 100.0 0.0 HIS A:61 A:61 55.0 0.282 -117.8 154.8