Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr15 67473705 . A C CCDS10222.1:NM_005902.3:c.785gAc>gCc_NP_005893.1:p.262D>A Homo sapiens SMAD family member 3 (SMAD3), transcript variant 1, mRNA.
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1khx 1 Q15796 92.51 1e-157 X-RAY
 2002-02-06 ASP A:64 A:304 52.0 0.347 -78.9 120.9 2.0 0.013 0.334 A:Q15796:0.333
 HOH
 2.632
 O
 O
6zvq 1 Q15796 92.51 1e-157 X-RAY
 2021-06-09 ASP A:64 A:304 55.0 0.367 -85.0 115.3 2.0 0.013 0.354 A:Q15796:0.353
 GOL
GOL
TAR
HOH
 3.398
6.785
9.264
2.755
 O
OD2
O
OD2
 O1
C3
O2
O
1mk2 1 P84022 100.0 4e-154 X-RAY
 2002-10-16 ASP A:43 A:261 75.0 0.5 S -112.0 156.1 75.0 0.5 0.0 ACY
 9.775
 O
 CH3
6m64 1 Q15796 96.1 6e-149 X-RAY
 2020-11-25 ASP A:45 A:304 60.0 0.4 -74.5 121.6 2.0 0.013 0.387 C:Q15796:0.387
 HOH
 2.626
 OD2
 O
ASP C:45 C:304 58.0 0.387 -75.5 122.3 1.0 0.007 0.38 E:Q15796:0.38
 HOH
 2.649
 O
 O
ASP E:45 E:304 57.0 0.38 -74.2 125.3 1.0 0.007 0.373 A:Q15796:0.373
 HOH
 2.569
 OD2
 O
7co1 1 Q15796 96.1 6e-149 X-RAY
 2020-11-25 ASP A:45 A:304 50.0 0.333 -82.0 124.2 4.0 0.027 0.306 C:Q15796:0.307
ASP C:45 C:304 47.0 0.313 -82.8 123.2 3.0 0.02 0.293 E:Q15796:0.293
ASP E:45 E:304 49.0 0.327 -83.4 124.0 3.0 0.02 0.307 A:Q15796:0.307
1u7f 1 P84022 100.0 2e-147 X-RAY
 2004-09-28 ASP A:35 A:262 52.0 0.347 -82.5 119.3 18.0 0.12 0.227 C:P84022:0.227
 HOH
 2.844
 O
 O
ASP C:35 C:262 53.0 0.353 -81.6 116.8 4.0 0.027 0.326 B:Q13485:0.327
 HOH
 2.090
 O
 O
5xoc 1 P84022 100.0 2e-147 X-RAY
 2018-03-28 ASP A:45 A:262 55.0 0.367 -75.8 123.7 17.0 0.113 0.254 A:P84022:0.253
 HOH
 4.215
 O
 O
1mjs 1 P84022 100.0 9e-147 X-RAY
 2002-10-16 ASP A:34 A:261 64.0 0.427 S -94.2 158.4 64.0 0.427 0.0 HOH
 2.764
 O
 O
1u7v 1 Q15796 96.97 6e-145 X-RAY
 2004-09-28 ASP A:35 A:304 52.0 0.347 -77.8 116.9 17.0 0.113 0.234 B:Q15796:0.233
ASP B:35 C:304 58.0 0.387 -79.3 110.4 25.0 0.167 0.22 C:Q13485:0.22
5xod 1 Q15796 97.46 3e-144 X-RAY
 2018-03-28 ASP A:45 A:304 52.0 0.347 -89.6 115.6 1.0 0.007 0.34 A:Q15796:0.34
 HOH
 2.497
 OD2
 O
5zoj 1 Q15796 97.46 4e-144 X-RAY
 2018-10-10 ASP A:46 A:304 55.0 0.367 -88.5 114.6 8.0 0.053 0.314 B:Q15796:0.313
ASP B:46 B:304 50.0 0.333 -89.2 114.8 6.0 0.04 0.293 C:Q15796:0.293
ASP C:46 C:304 57.0 0.38 -88.2 113.2 9.0 0.06 0.32 A:Q15796:0.32
1dev 1 Q15796 97.45 9e-144 X-RAY
 2000-01-21 ASP A:44 A:304 70.0 0.467 S -77.7 161.4 70.0 0.467 0.0
ASP C:44 C:304 75.0 0.5 S -73.2 163.5 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p84022-f1 1 P84022 100.0 0.0 ASP A:262 A:262 42.0 0.28 -90.4 111.3
af-q15796-f1 1 Q15796 83.73 0.0 ASP A:304 A:304 42.0 0.28 -84.3 113.1