Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr15 99478141 . A C CCDS10378.1:NM_000875.3:c.3045gaA>gaC_NP_000866.1:p.1015E>D Homo sapiens insulin-like growth factor 1 receptor (IGF1R), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6jk8 1 P08069 100.0 0.0 EM
 2020-03-04 GLU A:1015 NA:NA DO NA DO DO DO NA NA NA
GLU B:1015 NA:NA DO NA DO DO DO NA NA NA
6pyh 1 Q60751 95.96 0.0 EM
 2019-10-23 GLU A:986 NA:NA DO NA DO DO DO NA NA NA
GLU C:986 NA:NA DO NA DO DO DO NA NA NA
3lvp 1 P08069 100.0 0.0 X-RAY
 2010-07-21 GLU A:65 A:1015 25.0 0.132 E -132.6 132.1 25.0 0.132 0.0 PDR
 7.192
 CB
 C8
GLU B:65 B:1015 26.0 0.137 E -145.7 91.9 NA NA NA
GLU C:65 C:1015 22.0 0.116 E -116.9 134.7 NA NA NA
GLU D:65 D:1015 26.0 0.137 E -113.7 153.2 NA NA NA
1m7n 1 P08069 100.0 0.0 X-RAY
 2003-01-07 GLU A:43 A:1012 23.0 0.121 E -123.0 144.2 23.0 0.121 0.0 HOH
 2.804
 CG
 O
GLU B:43 B:1012 15.0 0.079 E -110.8 128.8 NA NA NA
1p4o 1 P08069 99.38 0.0 X-RAY
 2003-04-29 GLU A:43 A:985 20.0 0.105 E -105.5 143.4 20.0 0.105 0.0 HOH
 2.636
 OE2
 O
GLU B:43 B:985 19.0 0.1 E -107.1 142.9 NA NA NA
5fxq 1 P08069 100.0 0.0 X-RAY
 2016-10-19 GLU A:37 A:1015 33.0 0.174 E -92.0 158.6 33.0 0.174 0.0 GD5
HOH
 5.987
2.724
 OE1
OE2
 C1
O
5fxr 1 P08069 100.0 0.0 X-RAY
 2016-10-19 GLU A:37 A:1015 32.0 0.168 E -92.1 153.1 32.0 0.168 0.0 8LN
HOH
 7.141
2.825
 OE1
OE2
 C2
O
1jqh 1 P08069 100.0 0.0 X-RAY
 2002-04-19 GLU A:37 A:1015 14.0 0.074 E -114.6 152.1 14.0 0.074 0.0 ANP
HOH
 7.117
4.155
 CG
OE2
 C2
O
GLU B:37 B:1015 12.0 0.063 E -114.2 152.6 NA NA NA
GLU C:37 C:1015 13.0 0.068 E -114.2 153.2 NA NA NA
2zm3 1 P08069 100.0 0.0 X-RAY
 2008-06-10 GLU A:37 A:1015 20.0 0.105 E -97.3 150.4 20.0 0.105 0.0 575
HOH
 6.014
6.164
 OE1
OE1
 C1
O
GLU B:37 B:1015 19.0 0.1 E -90.3 156.6 NA NA NA
GLU C:37 C:1015 22.0 0.116 E -97.1 162.7 NA NA NA
GLU D:37 D:1015 17.0 0.089 E -80.8 148.3 NA NA NA
3f5p 1 P08069 100.0 0.0 X-RAY
 2008-12-30 GLU A:37 A:1015 27.0 0.142 E -83.2 160.1 27.0 0.142 0.0 741
 5.610
 OE1
 C13
GLU B:37 B:1015 26.0 0.137 E -81.8 153.4 NA NA NA
GLU C:37 C:1015 22.0 0.116 E -95.2 152.4 NA NA NA
GLU D:37 D:1015 30.0 0.158 E -94.5 148.7 NA NA NA
GLU E:37 E:1015 25.0 0.132 E -98.0 153.4 NA NA NA
GLU F:37 F:1015 34.0 0.179 E -87.0 163.1 NA NA NA
GLU G:37 G:1015 30.0 0.158 E -97.9 150.2 NA NA NA
GLU H:37 H:1015 20.0 0.105 E -85.3 133.0 NA NA NA
GLU I:37 I:1015 22.0 0.116 E -88.9 152.8 NA NA NA
GLU J:37 J:1015 21.0 0.111 E -99.0 140.5 NA NA NA
GLU K:37 K:1015 24.0 0.126 E -96.8 146.6 NA NA NA
GLU L:37 M:1015 22.0 0.116 E -90.0 146.5 NA NA NA
GLU M:37 L:1015 24.0 0.126 E -88.8 151.0 NA NA NA
GLU N:37 R:1015 39.0 0.205 E -86.6 153.6 NA NA NA
GLU O:37 S:1015 17.0 0.089 E -88.1 158.5 NA NA NA
GLU P:37 T:1015 24.0 0.126 E -90.6 155.1 NA NA NA
3i81 1 P08069 99.67 0.0 X-RAY
 2009-12-22 GLU A:36 A:985 24.0 0.126 E -101.5 161.1 24.0 0.126 0.0 EBI
HOH
 7.070
2.832
 OE1
OE1
 C12
O
5fxs 1 P08069 99.35 0.0 X-RAY
 2016-10-19 GLU A:37 A:1015 32.0 0.168 E -83.1 153.5 32.0 0.168 0.0 ACT
ACT
OZN
HOH
 9.064
8.053
6.002
2.600
 O
OE1
OE1
OE2
 CH3
OXT
C19
O
2oj9 1 P08069 100.0 0.0 X-RAY
 2007-05-01 GLU A:36 A:985 51.0 0.268 E -104.9 149.0 51.0 0.268 0.0 BMI
HOH
 7.241
2.587
 CB
OE2
 O
O
3nw5 1 P08069 100.0 0.0 X-RAY
 2010-07-28 GLU A:36 A:985 20.0 0.105 E -99.9 154.3 20.0 0.105 0.0 LGX
HOH
 7.411
2.800
 CG
OE2
 N10
O
3nw6 1 P08069 100.0 0.0 X-RAY
 2010-07-28 GLU A:36 A:985 22.0 0.116 E -97.6 154.9 22.0 0.116 0.0 LGW
HOH
 7.161
2.722
 OE1
OE2
 C3
O
3nw7 1 P08069 100.0 0.0 X-RAY
 2010-07-28 GLU A:36 A:985 22.0 0.116 E -102.6 160.9 22.0 0.116 0.0 LGV
HOH
 7.048
2.678
 CB
OE2
 N26
O
3o23 1 P08069 99.67 0.0 X-RAY
 2011-05-04 GLU A:34 A:1015 22.0 0.116 E -139.9 130.0 22.0 0.116 0.0 MQY
HOH
 6.424
3.365
 OE1
OE2
 C30
O
3lw0 1 P08069 99.34 0.0 X-RAY
 2010-09-29 GLU A:33 A:1015 21.0 0.111 E -93.4 148.6 21.0 0.111 0.0 HOH
 2.619
 OE2
 O
GLU B:33 B:1015 23.0 0.121 E -94.6 147.7 NA NA NA
GLU C:33 C:1015 25.0 0.132 E -92.9 148.4 NA NA NA
GLU D:33 D:1015 29.0 0.153 E -91.0 148.2 NA NA NA
5hzn 1 P08069 99.34 0.0 X-RAY
 2016-04-06 GLU A:33 A:1012 22.0 0.116 E -79.7 139.9 22.0 0.116 0.0 66A
HOH
 7.064
2.861
 CA
OE1
 C04
O
GLU B:33 B:1012 28.0 0.147 E -67.4 139.7 NA NA NA
GLU C:33 C:1012 25.0 0.132 E -68.8 137.6 NA NA NA
GLU D:33 D:1012 30.0 0.158 E -81.9 141.9 NA NA NA
GLU E:33 E:1012 22.0 0.116 E -78.7 140.7 NA NA NA
GLU F:33 F:1012 29.0 0.153 E -68.0 141.3 NA NA NA
GLU G:33 G:1012 23.0 0.121 E -69.0 138.7 NA NA NA
GLU H:33 H:1012 30.0 0.158 E -82.8 140.5 NA NA NA
4d2r 1 P08069 100.0 0.0 X-RAY
 2015-04-22 GLU A:31 A:1015 37.0 0.195 E -92.0 148.6 37.0 0.195 0.0 DYK
HOH
 3.557
2.683
 OE1
OE2
 C12
O
3d94 1 P08069 99.67 0.0 X-RAY
 2008-07-29 GLU A:30 A:985 27.0 0.142 E -74.7 146.4 27.0 0.142 0.0 D94
HOH
 6.970
2.630
 N
OE2
 C1
O
3qqu 1 P08069 100.0 0.0 X-RAY
 2011-04-20 GLU A:30 A:1012 46.0 0.242 E -106.8 126.7 46.0 0.242 0.0 01P
HOH
 6.163
2.980
 OE2
OE1
 C11
O
GLU B:30 B:1012 48.0 0.253 E -117.3 140.8 NA NA NA
GLU C:30 C:1012 17.0 NA E -104.7 139.4 NA NA NA
GLU D:30 D:1012 59.0 0.311 E -119.7 151.1 NA NA NA
1k3a 1 P08069 99.67 0.0 X-RAY
 2001-11-28 GLU A:28 A:985 20.0 0.105 E -102.0 141.9 20.0 0.105 0.0 ACP
HOH
 6.774
2.554
 CG
OE2
 C2
O
2z8c 1 P06213 80.2 1e-175 X-RAY
 2008-08-12 GLU A:32 A:1012 36.0 0.189 E -102.7 136.6 36.0 0.189 0.0 S91
 6.260
 CG
 C20
1gag 1 P06213 80.2 2e-175 X-RAY
 2001-01-17 GLU A:35 A:1012 30.0 0.158 E -98.2 142.8 30.0 0.158 0.0 112
 6.904
 CB
 C2
1ir3 1 P06213 80.2 2e-175 X-RAY
 1998-01-07 GLU A:35 A:1012 31.0 0.163 E -84.3 140.8 31.0 0.163 0.0 ANP
HOH
 6.838
2.840
 CA
OE2
 C2
O
1irk 1 P06213 80.2 2e-175 X-RAY
 1995-02-27 GLU A:35 A:1012 37.0 0.195 E -94.9 143.0 37.0 0.195 0.0 HOH
 2.648
 OE2
 O
5e1s 1 P06213 80.2 2e-175 X-RAY
 2015-10-14 GLU A:37 A:1012 17.0 0.089 E -96.4 132.4 17.0 0.089 0.0 5JA
HOH
 6.117
2.689
 OE1
OE2
 N30
O
1rqq 1 P06213 80.2 3e-175 X-RAY
 2003-12-30 GLU A:35 A:1012 14.0 0.074 E -100.5 149.2 14.0 0.074 0.0 112
HOH
 7.402
8.495
 CA
OE2
 C2
O
GLU B:35 B:1012 30.0 0.158 E -101.6 151.3 30.0 0.158 0.0 112
HOH
 7.279
8.773
 CB
CG
 C2
O
2auh 1 P06213 80.2 3e-175 X-RAY
 2005-11-01 GLU A:35 A:1012 16.0 0.084 E -107.4 142.7 16.0 0.084 0.0
2b4s 2 P06213 80.2 3e-175 X-RAY
 2005-11-15 GLU B:35 B:1012 39.0 0.205 E -101.6 134.2 39.0 0.205 0.0 HOH
 5.543
 OE2
 O
GLU D:35 D:1012 7.0 0.037 E -96.5 131.8 7.0 0.037 0.0 HOH
 6.156
 OE1
 O
3bu3 1 P06213 80.2 3e-175 X-RAY
 2008-02-19 GLU A:35 A:1012 24.0 0.126 E -91.8 134.5 24.0 0.126 0.0 HOH
 5.278
 OE1
 O
3bu5 1 P06213 80.2 3e-175 X-RAY
 2008-02-19 GLU A:35 A:1012 29.0 0.153 E -85.2 131.6 29.0 0.153 0.0 ATP
HOH
 7.422
5.433
 CB
OE1
 C2
O
3bu6 1 P06213 80.2 3e-175 X-RAY
 2008-02-19 GLU A:35 A:1012 25.0 0.132 E -79.9 135.6 25.0 0.132 0.0 HOH
 6.561
 OE2
 O
5hhw 1 P06213 80.2 4e-175 X-RAY
 2016-04-13 GLU A:36 A:1039 17.0 0.089 E -90.7 136.7 17.0 0.089 0.0 60O
HOH
 6.760
2.761
 CA
OE1
 C15
O
4ibm 1 P06213 80.73 8e-175 X-RAY
 2013-08-21 GLU A:35 A:1012 32.0 0.168 E -84.9 138.5 32.0 0.168 0.0 IR1
HOH
 5.952
2.878
 OE2
OE2
 C10
O
GLU B:35 B:1012 14.0 0.074 E -80.1 135.1 NA NA NA
3eta 1 P06213 80.41 2e-170 X-RAY
 2009-05-26 GLU A:34 A:1012 30.0 0.158 E -90.2 133.7 30.0 0.158 0.0 351
HOH
 7.481
8.460
 CB
CG
 C10
O
GLU B:34 B:1012 43.0 0.226 E -83.0 138.6 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p08069-f1 1 P08069 100.0 0.0 GLU A:1015 A:1015 21.0 0.111 E -74.2 140.2