Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr15 | 99478269 | . | A | C | CCDS10378.1:NM_000875.3:c.3173aAt>aCt_NP_000866.1:p.1058N>T | Homo sapiens insulin-like growth factor 1 receptor (IGF1R), mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 6jk8 | 1 | P08069 | 100.0 | 0.0 |
EM |
2020-03-04 | ASN | A:1058 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ASN | B:1058 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 6pyh | 1 | Q60751 | 95.96 | 0.0 |
EM |
2019-10-23 | ASN | A:1029 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ASN | C:1029 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 3lvp | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2010-07-21 | ASN | A:108 | A:1058 | 90.0 | 0.562 | -167.8 | 85.8 | 90.0 | 0.562 | 0.0 | |||||||
| ASN | B:108 | B:1058 | 96.0 | 0.6 | -154.3 | 78.4 | NA | NA | NA | ||||||||||||||
| ASN | C:108 | C:1058 | 98.0 | 0.613 | -173.7 | 100.2 | NA | NA | NA | ||||||||||||||
| ASN | D:108 | D:1058 | 90.0 | 0.562 | -169.6 | 114.5 | NA | NA | NA | ||||||||||||||
| 1m7n | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2003-01-07 | ASN | A:86 | A:1055 | 89.0 | 0.556 | -156.9 | 67.1 | 89.0 | 0.556 | 0.0 |
HOH |
3.363 |
C |
O |
|||
| ASN | B:86 | B:1055 | 104.0 | 0.65 | -175.4 | 67.4 | NA | NA | NA | ||||||||||||||
| 1p4o | 1 | P08069 | 99.38 | 0.0 |
X-RAY |
2003-04-29 | ASN | A:86 | A:1028 | 101.0 | 0.631 | -148.3 | 74.7 | 101.0 | 0.631 | 0.0 |
HOH |
3.028 |
O |
O |
|||
| ASN | B:86 | B:1028 | 123.0 | 0.769 | -153.5 | 73.4 | NA | NA | NA | ||||||||||||||
| 5fxq | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2016-10-19 | ASN | A:80 | A:1058 | 114.0 | 0.713 | -136.5 | 82.7 | 114.0 | 0.713 | 0.0 |
HOH |
3.602 |
CA |
O |
|||
| 5fxr | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2016-10-19 | ASN | A:80 | A:1058 | 114.0 | 0.713 | -137.5 | 85.0 | 114.0 | 0.713 | 0.0 |
HOH |
3.645 |
CA |
O |
|||
| 1jqh | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2002-04-19 | ASN | A:80 | A:1058 | 96.0 | 0.6 | -148.6 | 90.4 | 96.0 | 0.6 | 0.0 |
HOH |
3.154 |
CA |
O |
|||
| ASN | B:80 | B:1058 | 96.0 | 0.6 | -149.2 | 91.0 | NA | NA | NA | ||||||||||||||
| ASN | C:80 | C:1058 | 96.0 | 0.6 | -149.1 | 91.5 | NA | NA | NA | ||||||||||||||
| 2zm3 | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2008-06-10 | ASN | A:80 | A:1058 | 100.0 | 0.625 | -123.2 | 85.6 | 100.0 | 0.625 | 0.0 |
HOH |
3.330 |
CA |
O |
|||
| ASN | B:80 | B:1058 | 113.0 | 0.706 | -123.0 | 88.5 | NA | NA | NA | ||||||||||||||
| ASN | C:80 | C:1058 | 119.0 | 0.744 | -114.5 | 84.5 | NA | NA | NA | ||||||||||||||
| ASN | D:80 | D:1058 | 101.0 | 0.631 | -110.1 | 92.4 | NA | NA | NA | ||||||||||||||
| 3f5p | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2008-12-30 | ASN | A:80 | A:1058 | 97.0 | 0.606 | -136.7 | 85.2 | 97.0 | 0.606 | 0.0 |
HOH |
4.825 |
CA |
O |
|||
| ASN | B:80 | B:1058 | 95.0 | 0.594 | -132.3 | 83.1 | NA | NA | NA | ||||||||||||||
| ASN | C:80 | C:1058 | 96.0 | 0.6 | -123.6 | 80.3 | NA | NA | NA | ||||||||||||||
| ASN | D:80 | D:1058 | 80.0 | 0.5 | -126.7 | 92.4 | NA | NA | NA | ||||||||||||||
| ASN | E:80 | E:1058 | 88.0 | 0.55 | -126.9 | 82.7 | NA | NA | NA | ||||||||||||||
| ASN | F:80 | F:1058 | 90.0 | 0.562 | -130.7 | 81.5 | NA | NA | NA | ||||||||||||||
| ASN | G:80 | G:1058 | 94.0 | 0.588 | -132.3 | 70.6 | NA | NA | NA | ||||||||||||||
| ASN | H:80 | H:1058 | 95.0 | 0.594 | -129.3 | 82.1 | NA | NA | NA | ||||||||||||||
| ASN | I:80 | I:1058 | 92.0 | 0.575 | -133.3 | 75.4 | NA | NA | NA | ||||||||||||||
| ASN | J:80 | J:1058 | 93.0 | 0.581 | -137.7 | 77.6 | NA | NA | NA | ||||||||||||||
| ASN | K:80 | K:1058 | 90.0 | 0.562 | -134.2 | 73.5 | NA | NA | NA | ||||||||||||||
| ASN | L:80 | M:1058 | 80.0 | 0.5 | -130.5 | 67.0 | NA | NA | NA | ||||||||||||||
| ASN | M:80 | L:1058 | 88.0 | 0.55 | -130.6 | 71.1 | NA | NA | NA | ||||||||||||||
| ASN | N:80 | R:1058 | 87.0 | 0.544 | -123.2 | 81.1 | NA | NA | NA | ||||||||||||||
| ASN | O:80 | S:1058 | 93.0 | 0.581 | -115.7 | 75.4 | NA | NA | NA | ||||||||||||||
| ASN | P:80 | T:1058 | 92.0 | 0.575 | -137.5 | 74.7 | NA | NA | NA | ||||||||||||||
| 3i81 | 1 | P08069 | 99.67 | 0.0 |
X-RAY |
2009-12-22 | ASN | A:79 | A:1028 | 116.0 | 0.725 | -140.7 | 80.3 | 116.0 | 0.725 | 0.0 |
HOH |
3.003 |
OD1 |
O |
|||
| 5fxs | 1 | P08069 | 99.35 | 0.0 |
X-RAY |
2016-10-19 | ASN | A:80 | A:1058 | 115.0 | 0.719 | -143.7 | 83.5 | 115.0 | 0.719 | 0.0 |
HOH |
2.826 |
OD1 |
O |
|||
| 2oj9 | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2007-05-01 | ASN | A:79 | A:1028 | 119.0 | 0.744 | -144.2 | 84.0 | 119.0 | 0.744 | 0.0 |
HOH |
3.011 |
O |
O |
|||
| 3nw5 | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2010-07-28 | ASN | A:79 | A:1028 | 108.0 | 0.675 | -153.1 | 88.3 | 108.0 | 0.675 | 0.0 |
HOH |
3.286 |
OD1 |
O |
|||
| 3nw6 | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2010-07-28 | ASN | A:79 | A:1028 | 111.0 | 0.694 | -149.7 | 86.6 | 111.0 | 0.694 | 0.0 |
HOH |
2.703 |
O |
O |
|||
| 3nw7 | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2010-07-28 | ASN | A:79 | A:1028 | 95.0 | 0.594 | -154.4 | 88.6 | 95.0 | 0.594 | 0.0 |
HOH |
3.331 |
ND2 |
O |
|||
| 3o23 | 1 | P08069 | 99.67 | 0.0 |
X-RAY |
2011-05-04 | ASN | A:77 | A:1058 | 114.0 | 0.713 | -156.2 | 84.3 | 114.0 | 0.713 | 0.0 |
MQY HOH |
7.808 3.485 |
N CA |
O21 O |
|||
| 3lw0 | 1 | P08069 | 99.34 | 0.0 |
X-RAY |
2010-09-29 | ASN | A:76 | A:1058 | 94.0 | 0.588 | -148.0 | 93.7 | 94.0 | 0.588 | 0.0 |
CCX HOH |
9.027 2.849 |
N O |
N9 O |
|||
| ASN | B:76 | B:1058 | 97.0 | 0.606 | -150.9 | 90.0 | NA | NA | NA | ||||||||||||||
| ASN | C:76 | C:1058 | 108.0 | 0.675 | -151.8 | 93.7 | NA | NA | NA | ||||||||||||||
| ASN | D:76 | D:1058 | 105.0 | 0.656 | -152.5 | 88.5 | NA | NA | NA | ||||||||||||||
| 5hzn | 1 | P08069 | 99.34 | 0.0 |
X-RAY |
2016-04-06 | ASN | A:76 | A:1055 | 95.0 | 0.594 | -143.7 | 87.4 | 95.0 | 0.594 | 0.0 |
HOH |
3.796 |
C |
O |
|||
| ASN | B:76 | B:1055 | 91.0 | 0.569 | -130.7 | 85.9 | NA | NA | NA | ||||||||||||||
| ASN | C:76 | C:1055 | 103.0 | 0.644 | -135.9 | 89.6 | NA | NA | NA | ||||||||||||||
| ASN | D:76 | D:1055 | 96.0 | 0.6 | -142.4 | 85.5 | NA | NA | NA | ||||||||||||||
| ASN | E:76 | E:1055 | 97.0 | 0.606 | -144.1 | 87.3 | NA | NA | NA | ||||||||||||||
| ASN | F:76 | F:1055 | 88.0 | 0.55 | -132.3 | 85.6 | NA | NA | NA | ||||||||||||||
| ASN | G:76 | G:1055 | 100.0 | 0.625 | -136.4 | 88.5 | NA | NA | NA | ||||||||||||||
| ASN | H:76 | H:1055 | 96.0 | 0.6 | -143.5 | 85.5 | NA | NA | NA | ||||||||||||||
| 4d2r | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2015-04-22 | ASN | A:74 | A:1058 | 107.0 | 0.669 | -143.7 | 82.0 | 107.0 | 0.669 | 0.0 |
HOH |
3.705 |
O |
O |
|||
| 3d94 | 1 | P08069 | 99.67 | 0.0 |
X-RAY |
2008-07-29 | ASN | A:73 | A:1028 | 105.0 | 0.656 | -147.2 | 84.4 | 105.0 | 0.656 | 0.0 |
HOH |
3.482 |
O |
O |
|||
| 3qqu | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2011-04-20 | ASN | A:73 | A:1055 | 111.0 | 0.694 | -174.1 | 79.7 | 111.0 | 0.694 | 0.0 |
HOH |
3.723 |
OD1 |
O |
|||
| ASN | B:73 | B:1055 | 96.0 | 0.6 | -167.9 | 83.1 | NA | NA | NA | ||||||||||||||
| ASN | C:73 | C:1055 | 112.0 | 0.7 | -116.3 | 73.3 | NA | NA | NA | ||||||||||||||
| ASN | D:73 | D:1055 | 97.0 | 0.606 | -130.3 | 87.7 | NA | NA | NA | ||||||||||||||
| 1k3a | 1 | P08069 | 99.67 | 0.0 |
X-RAY |
2001-11-28 | ASN | A:71 | A:1028 | 106.0 | 0.662 | -143.7 | 82.2 | 106.0 | 0.662 | 0.0 |
HOH |
3.500 |
CA |
O |
|||
| 2z8c | 1 | P06213 | 80.2 | 1e-175 |
X-RAY |
2008-08-12 | THR | A:75 | A:1055 | 82.0 | 0.586 | -108.6 | 90.8 | 82.0 | 0.586 | 0.0 | |||||||
| 1gag | 1 | P06213 | 80.2 | 2e-175 |
X-RAY |
2001-01-17 | THR | A:78 | A:1055 | 118.0 | 0.843 | -158.5 | 90.9 | 118.0 | 0.843 | 0.0 |
HOH |
4.162 |
N |
O |
|||
| 1ir3 | 1 | P06213 | 80.2 | 2e-175 |
X-RAY |
1998-01-07 | THR | A:78 | A:1055 | 118.0 | 0.843 | -143.3 | 91.1 | 118.0 | 0.843 | 0.0 |
HOH |
2.689 |
O |
O |
|||
| 1irk | 1 | P06213 | 80.2 | 2e-175 |
X-RAY |
1995-02-27 | THR | A:78 | A:1055 | 68.0 | 0.486 | -115.6 | 101.6 | 68.0 | 0.486 | 0.0 |
EMC HOH |
4.220 3.235 |
O OG1 |
HG O |
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| 5e1s | 1 | P06213 | 80.2 | 2e-175 |
X-RAY |
2015-10-14 | THR | A:80 | A:1055 | 65.0 | 0.464 | -129.2 | 35.5 | 65.0 | 0.464 | 0.0 |
HOH |
3.217 |
OG1 |
O |
|||
| 1rqq | 1 | P06213 | 80.2 | 3e-175 |
X-RAY |
2003-12-30 | THR | A:78 | A:1055 | 115.0 | 0.821 | -146.1 | 84.9 | 115.0 | 0.821 | 0.0 |
HOH |
3.859 |
C |
O |
|||
| THR | B:78 | B:1055 | 107.0 | 0.764 | -147.1 | 84.9 | 107.0 | 0.764 | 0.0 |
HOH |
3.722 |
C |
O |
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| 2auh | 1 | P06213 | 80.2 | 3e-175 |
X-RAY |
2005-11-01 | THR | A:78 | A:1055 | 115.0 | 0.821 | -158.4 | 92.2 | 115.0 | 0.821 | 0.0 | |||||||
| 2b4s | 2 | P06213 | 80.2 | 3e-175 |
X-RAY |
2005-11-15 | THR | B:78 | B:1055 | 115.0 | 0.821 | -140.9 | 93.5 | 115.0 | 0.821 | 0.0 |
HOH |
2.962 |
O |
O |
|||
| THR | D:78 | D:1055 | 121.0 | 0.864 | -145.7 | 92.1 | 121.0 | 0.864 | 0.0 |
HOH |
3.486 |
CA |
O |
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| 3bu3 | 1 | P06213 | 80.2 | 3e-175 |
X-RAY |
2008-02-19 | THR | A:78 | A:1055 | 117.0 | 0.836 | -141.2 | 99.1 | 117.0 | 0.836 | 0.0 |
HOH |
2.747 |
O |
O |
|||
| 3bu5 | 1 | P06213 | 80.2 | 3e-175 |
X-RAY |
2008-02-19 | THR | A:78 | A:1055 | 114.0 | 0.814 | -135.9 | 100.4 | 114.0 | 0.814 | 0.0 |
HOH |
2.714 |
OG1 |
O |
|||
| 3bu6 | 1 | P06213 | 80.2 | 3e-175 |
X-RAY |
2008-02-19 | THR | A:78 | A:1055 | 121.0 | 0.864 | -133.2 | 97.5 | 121.0 | 0.864 | 0.0 |
HOH |
2.952 |
OG1 |
O |
|||
| 5hhw | 1 | P06213 | 80.2 | 4e-175 |
X-RAY |
2016-04-13 | THR | A:79 | A:1082 | 92.0 | 0.657 | -134.5 | 28.4 | 92.0 | 0.657 | 0.0 |
HOH |
3.384 |
OG1 |
O |
|||
| 4ibm | 1 | P06213 | 80.73 | 8e-175 |
X-RAY |
2013-08-21 | THR | A:78 | A:1055 | 87.0 | 0.621 | -135.4 | 93.2 | 87.0 | 0.621 | 0.0 |
HOH |
2.686 |
O |
O |
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| THR | B:78 | B:1055 | 101.0 | 0.721 | -134.6 | 82.5 | NA | NA | NA | ||||||||||||||
| 3eta | 1 | P06213 | 80.41 | 2e-170 |
X-RAY |
2009-05-26 | THR | A:77 | A:1055 | 87.0 | 0.621 | -132.3 | 101.5 | 87.0 | 0.621 | 0.0 |
351 HOH |
9.800 2.746 |
N OG1 |
C27 O |
|||
| THR | B:77 | B:1055 | 87.0 | 0.621 | -133.3 | 103.4 | NA | NA | NA | ||||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p08069-f1 | 1 | P08069 | 100.0 | 0.0 | ASN | A:1058 | A:1058 | 105.0 | 0.656 | -129.7 | 81.9 | ||