Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr15 99478548 . C A CCDS10378.1:NM_000875.3:c.3190Cga>Aga_NP_000866.1:p.1064R>R Homo sapiens insulin-like growth factor 1 receptor (IGF1R), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6jk8 1 P08069 100.0 0.0 EM
 2020-03-04 ARG A:1064 NA:NA DO NA DO DO DO NA NA NA
ARG B:1064 NA:NA DO NA DO DO DO NA NA NA
6pyh 1 Q60751 95.96 0.0 EM
 2019-10-23 ARG A:1035 NA:NA DO NA DO DO DO NA NA NA
ARG C:1035 NA:NA DO NA DO DO DO NA NA NA
3lvp 1 P08069 100.0 0.0 X-RAY
 2010-07-21 ARG A:114 A:1064 92.0 0.409 -81.1 143.9 92.0 0.409 0.0 PDR
 6.754
 O
 C16
ARG B:114 B:1064 109.0 0.484 -83.3 137.7 NA NA NA
ARG C:114 C:1064 111.0 0.493 -68.0 144.3 NA NA NA
ARG D:114 D:1064 77.0 0.342 -75.1 145.3 NA NA NA
1m7n 1 P08069 100.0 0.0 X-RAY
 2003-01-07 ARG A:92 A:1061 91.0 0.404 -86.3 146.8 91.0 0.404 0.0 HOH
 2.852
 CG
 O
ARG B:92 B:1061 78.0 0.347 -81.5 142.2 NA NA NA
1p4o 1 P08069 99.38 0.0 X-RAY
 2003-04-29 ARG A:92 A:1034 77.0 0.342 -85.7 140.9 77.0 0.342 0.0 HOH
 2.594
 NH2
 O
ARG B:92 B:1034 116.0 0.516 -85.3 138.6 NA NA NA
5fxq 1 P08069 100.0 0.0 X-RAY
 2016-10-19 ARG A:86 A:1064 67.0 0.298 -90.0 143.6 67.0 0.298 0.0 GD5
HOH
 6.442
2.739
 O
NH1
 CL
O
5fxr 1 P08069 100.0 0.0 X-RAY
 2016-10-19 ARG A:86 A:1064 70.0 0.311 -87.0 149.4 70.0 0.311 0.0 8LN
HOH
 6.368
2.507
 O
NH1
 CL
O
1jqh 1 P08069 100.0 0.0 X-RAY
 2002-04-19 ARG A:86 A:1064 83.0 0.369 -96.0 142.9 83.0 0.369 0.0 ANP
HOH
 6.374
3.442
 O
CG
 N6
O
ARG B:86 B:1064 86.0 0.382 -95.5 142.1 NA NA NA
ARG C:86 C:1064 87.0 0.387 -94.8 141.8 NA NA NA
2zm3 1 P08069 100.0 0.0 X-RAY
 2008-06-10 ARG A:86 A:1064 70.0 0.311 -84.2 140.0 70.0 0.311 0.0 575
HOH
 5.870
3.450
 O
NH2
 O1
O
ARG B:86 B:1064 75.0 0.333 -88.5 143.3 NA NA NA
ARG C:86 C:1064 67.0 0.298 -91.4 146.2 NA NA NA
ARG D:86 D:1064 85.0 0.378 -89.1 144.7 NA NA NA
3f5p 1 P08069 100.0 0.0 X-RAY
 2008-12-30 ARG A:86 A:1064 64.0 0.284 -99.7 145.4 64.0 0.284 0.0 741
HOH
 5.787
3.666
 O
NE
 N33
O
ARG B:86 B:1064 66.0 0.293 -107.9 138.7 NA NA NA
ARG C:86 C:1064 71.0 0.316 -101.4 141.8 NA NA NA
ARG D:86 D:1064 76.0 0.338 -91.2 136.1 NA NA NA
ARG E:86 E:1064 63.0 0.28 -98.2 144.8 NA NA NA
ARG F:86 F:1064 66.0 0.293 -96.6 145.8 NA NA NA
ARG G:86 G:1064 61.0 0.271 -99.1 139.2 NA NA NA
ARG H:86 H:1064 55.0 0.244 -84.5 142.7 NA NA NA
ARG I:86 I:1064 64.0 0.284 -93.0 144.2 NA NA NA
ARG J:86 J:1064 80.0 0.356 -97.2 137.6 NA NA NA
ARG K:86 K:1064 84.0 0.373 -105.7 139.1 NA NA NA
ARG L:86 M:1064 91.0 0.404 -94.6 150.1 NA NA NA
ARG M:86 L:1064 61.0 0.271 -98.1 149.2 NA NA NA
ARG N:86 R:1064 79.0 0.351 -82.9 150.2 NA NA NA
ARG O:86 S:1064 59.0 0.262 -100.6 136.8 NA NA NA
ARG P:86 T:1064 70.0 0.311 -99.0 148.6 NA NA NA
3i81 1 P08069 99.67 0.0 X-RAY
 2009-12-22 ARG A:85 A:1034 69.0 0.307 -84.2 146.0 69.0 0.307 0.0 EBI
HOH
 6.636
3.146
 O
NE
 C7
O
5fxs 1 P08069 99.35 0.0 X-RAY
 2016-10-19 ARG A:86 A:1064 86.0 0.382 -87.7 143.7 86.0 0.382 0.0 OZN
HOH
 6.644
2.814
 O
NH1
 CL36
O
2oj9 1 P08069 100.0 0.0 X-RAY
 2007-05-01 ARG A:85 A:1034 97.0 0.431 -85.6 140.0 97.0 0.431 0.0 BMI
HOH
 6.185
2.532
 O
NH1
 C3
O
3nw5 1 P08069 100.0 0.0 X-RAY
 2010-07-28 ARG A:85 A:1034 61.0 0.271 -86.1 144.6 61.0 0.271 0.0 LGX
HOH
 6.264
3.302
 O
CG
 C16
O
3nw6 1 P08069 100.0 0.0 X-RAY
 2010-07-28 ARG A:85 A:1034 68.0 0.302 -86.5 142.9 68.0 0.302 0.0 LGW
HOH
 6.310
2.871
 O
CD
 C16
O
3nw7 1 P08069 100.0 0.0 X-RAY
 2010-07-28 ARG A:85 A:1034 83.0 0.369 -82.1 138.7 83.0 0.369 0.0 LGV
HOH
 6.515
2.873
 O
NH2
 C18
O
3o23 1 P08069 99.67 0.0 X-RAY
 2011-05-04 ARG A:83 A:1064 65.0 0.289 -88.1 145.5 65.0 0.289 0.0 MQY
HOH
 5.768
2.994
 N
NH1
 C12
O
3lw0 1 P08069 99.34 0.0 X-RAY
 2010-09-29 ARG A:82 A:1064 109.0 0.484 -86.6 138.8 109.0 0.484 0.0 CCX
HOH
 4.197
2.737
 C
NH2
 C4
O
ARG B:82 B:1064 109.0 0.484 -86.6 139.2 NA NA NA
ARG C:82 C:1064 100.0 0.444 -86.7 138.0 NA NA NA
ARG D:82 D:1064 97.0 0.431 -85.8 138.1 NA NA NA
5hzn 1 P08069 99.34 0.0 X-RAY
 2016-04-06 ARG A:82 A:1061 92.0 0.409 -89.8 142.1 92.0 0.409 0.0 66A
HOH
 6.179
2.815
 O
NH2
 N24
O
ARG B:82 B:1061 88.0 0.391 -90.1 138.5 NA NA NA
ARG C:82 C:1061 86.0 0.382 -91.2 141.8 NA NA NA
ARG D:82 D:1061 85.0 0.378 -89.0 144.0 NA NA NA
ARG E:82 E:1061 91.0 0.404 -88.6 142.4 NA NA NA
ARG F:82 F:1061 91.0 0.404 -85.0 139.1 NA NA NA
ARG G:82 G:1061 86.0 0.382 -87.9 141.6 NA NA NA
ARG H:82 H:1061 86.0 0.382 -86.5 141.8 NA NA NA
4d2r 1 P08069 100.0 0.0 X-RAY
 2015-04-22 ARG A:80 A:1064 77.0 0.342 -85.9 143.3 77.0 0.342 0.0 DYK
HOH
 7.674
6.726
 O
N
 C14
O
3d94 1 P08069 99.67 0.0 X-RAY
 2008-07-29 ARG A:79 A:1034 78.0 0.347 -84.2 140.6 78.0 0.347 0.0 D94
HOH
 6.145
2.526
 O
NH2
 N5
O
3qqu 1 P08069 100.0 0.0 X-RAY
 2011-04-20 ARG A:79 A:1061 86.0 0.382 -86.0 148.1 86.0 0.382 0.0 01P
HOH
 6.331
3.763
 O
NH2
 C23
O
ARG B:79 B:1061 77.0 0.342 -81.7 148.8 NA NA NA
ARG C:79 C:1061 86.0 0.382 -86.6 152.8 NA NA NA
ARG D:79 D:1061 89.0 0.396 -86.8 144.8 NA NA NA
1k3a 1 P08069 99.67 0.0 X-RAY
 2001-11-28 ARG A:77 A:1034 75.0 0.333 -85.3 132.1 75.0 0.333 0.0 ACP
HOH
 6.812
3.260
 O
NH2
 N6
O
2z8c 1 P06213 80.2 1e-175 X-RAY
 2008-08-12 ARG A:81 A:1061 83.0 0.369 -84.1 133.8 83.0 0.369 0.0 S91
 6.601
 O
 N5
1gag 1 P06213 80.2 2e-175 X-RAY
 2001-01-17 ARG A:84 A:1061 130.0 0.578 -89.9 133.9 130.0 0.578 0.0 112
HOH
 6.745
3.712
 O
CA
 N6
O
1ir3 1 P06213 80.2 2e-175 X-RAY
 1998-01-07 ARG A:84 A:1061 137.0 0.609 -84.9 135.3 137.0 0.609 0.0 ANP
HOH
 6.326
2.739
 O
NE
 N6
O
1irk 1 P06213 80.2 2e-175 X-RAY
 1995-02-27 ARG A:84 A:1061 97.0 0.431 -107.3 156.6 97.0 0.431 0.0 HOH
 3.092
 CB
 O
5e1s 1 P06213 80.2 2e-175 X-RAY
 2015-10-14 ARG A:86 A:1061 91.0 0.404 -90.8 147.0 91.0 0.404 0.0 5JA
HOH
 7.089
2.764
 N
NE
 C26
O
1rqq 1 P06213 80.2 3e-175 X-RAY
 2003-12-30 ARG A:84 A:1061 126.0 0.56 -91.2 139.1 126.0 0.56 0.0 112
HOH
 6.570
3.431
 O
CA
 N6
O
ARG B:84 B:1061 118.0 0.524 -90.9 141.5 118.0 0.524 0.0 112
HOH
 6.424
3.637
 O
CG
 N6
O
2auh 1 P06213 80.2 3e-175 X-RAY
 2005-11-01 ARG A:84 A:1061 134.0 0.596 -81.1 135.9 134.0 0.596 0.0
2b4s 2 P06213 80.2 3e-175 X-RAY
 2005-11-15 ARG B:84 B:1061 151.0 0.671 -91.8 138.7 134.0 0.596 0.075 A:P18031:0.076
 HOH
 2.878
 NH1
 O
ARG D:84 D:1061 153.0 0.68 -92.6 140.4 136.0 0.604 0.076 C:P18031:0.076
 HOH
 3.466
 CA
 O
3bu3 1 P06213 80.2 3e-175 X-RAY
 2008-02-19 ARG A:84 A:1061 140.0 0.622 -84.0 134.4 140.0 0.622 0.0 HOH
 2.978
 NE
 O
3bu5 1 P06213 80.2 3e-175 X-RAY
 2008-02-19 ARG A:84 A:1061 135.0 0.6 -81.9 129.0 135.0 0.6 0.0 ATP
HOH
 6.425
3.069
 O
NE
 N6
O
3bu6 1 P06213 80.2 3e-175 X-RAY
 2008-02-19 ARG A:84 A:1061 133.0 0.591 -89.8 132.7 133.0 0.591 0.0 HOH
 3.177
 NH1
 O
5hhw 1 P06213 80.2 4e-175 X-RAY
 2016-04-13 ARG A:85 A:1088 88.0 0.391 -94.7 151.1 88.0 0.391 0.0 60O
HOH
 6.339
2.775
 O
NH1
 N18
O
4ibm 1 P06213 80.73 8e-175 X-RAY
 2013-08-21 ARG A:84 A:1061 86.0 0.382 -94.9 134.1 86.0 0.382 0.0 IR1
HOH
 6.205
2.622
 O
NH2
 N26
O
ARG B:84 B:1061 27.0 NA -99.0 144.9 NA NA NA
3eta 1 P06213 80.41 2e-170 X-RAY
 2009-05-26 ARG A:83 A:1061 79.0 0.351 -85.5 147.8 79.0 0.351 0.0 351
HOH
 5.719
3.355
 O
NH1
 C14
O
ARG B:83 B:1061 82.0 0.364 -95.6 139.4 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p08069-f1 1 P08069 100.0 0.0 ARG A:1064 A:1064 85.0 0.378 -78.4 140.5