Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr15 99482512 . A C CCDS10378.1:NM_000875.3:c.3380aAc>aCc_NP_000866.1:p.1127N>T Homo sapiens insulin-like growth factor 1 receptor (IGF1R), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6jk8 1 P08069 100.0 0.0 EM
 2020-03-04 ASN A:1127 NA:NA DO NA DO DO DO NA NA NA
ASN B:1127 NA:NA DO NA DO DO DO NA NA NA
6pyh 1 Q60751 95.96 0.0 EM
 2019-10-23 ASN A:1099 NA:NA DO NA DO DO DO NA NA NA
ASN C:1099 NA:NA DO NA DO DO DO NA NA NA
3lvp 1 P08069 100.0 0.0 X-RAY
 2010-07-21 ASN A:177 A:1127 56.0 0.35 H -62.6 -40.0 56.0 0.35 0.0
ASN B:177 B:1127 30.0 0.188 H -67.7 -29.5 NA NA NA
ASN C:177 C:1127 53.0 0.331 H -64.4 -30.8 NA NA NA
ASN D:177 D:1127 18.0 0.113 H -59.8 -30.5 NA NA NA
1m7n 1 P08069 100.0 0.0 X-RAY
 2003-01-07 ASN A:155 A:1124 24.0 0.15 H -56.8 -38.6 24.0 0.15 0.0 HOH
 2.686
 OD1
 O
ASN B:155 B:1124 29.0 0.181 H -58.2 -33.8 NA NA NA
1p4o 1 P08069 99.38 0.0 X-RAY
 2003-04-29 ASN A:155 A:1097 30.0 0.188 H -61.6 -38.0 30.0 0.188 0.0 HOH
 3.029
 OD1
 O
ASN B:155 B:1097 32.0 0.2 H -63.5 -37.4 NA NA NA
5fxq 1 P08069 100.0 0.0 X-RAY
 2016-10-19 ASN A:149 A:1127 71.0 0.444 H -64.7 -41.3 71.0 0.444 0.0 HOH
 2.763
 ND2
 O
5fxr 1 P08069 100.0 0.0 X-RAY
 2016-10-19 ASN A:149 A:1127 68.0 0.425 H -63.1 -44.9 68.0 0.425 0.0 HOH
 2.776
 ND2
 O
1jqh 1 P08069 100.0 0.0 X-RAY
 2002-04-19 ASN A:149 A:1127 10.0 0.062 H -61.6 -37.3 10.0 0.062 0.0 HOH
 3.384
 OD1
 O
ASN B:149 B:1127 12.0 0.075 H -61.9 -38.2 NA NA NA
ASN C:149 C:1127 12.0 0.075 H -61.8 -37.7 NA NA NA
2zm3 1 P08069 100.0 0.0 X-RAY
 2008-06-10 ASN A:149 A:1127 22.0 0.138 H -58.5 -30.6 22.0 0.138 0.0 HOH
 3.140
 OD1
 O
ASN B:149 B:1127 18.0 0.113 H -67.7 -28.7 NA NA NA
ASN C:149 C:1127 23.0 0.144 H -65.7 -33.9 NA NA NA
ASN D:149 D:1127 21.0 0.131 H -64.6 -33.9 NA NA NA
3f5p 1 P08069 100.0 0.0 X-RAY
 2008-12-30 ASN A:149 A:1127 29.0 0.181 H -68.0 -30.7 29.0 0.181 0.0 HOH
 4.532
 CB
 O
ASN B:149 B:1127 20.0 0.125 H -68.2 -19.4 NA NA NA
ASN C:149 C:1127 26.0 0.163 H -62.6 -33.6 NA NA NA
ASN D:149 D:1127 26.0 0.163 H -65.5 -26.3 NA NA NA
ASN E:149 E:1127 22.0 0.138 H -68.5 -29.6 NA NA NA
ASN F:149 F:1127 25.0 0.156 H -64.2 -26.0 NA NA NA
ASN G:149 G:1127 23.0 0.144 H -72.4 -20.9 NA NA NA
ASN H:149 H:1127 22.0 0.138 H -64.2 -30.3 NA NA NA
ASN I:149 I:1127 20.0 0.125 H -63.3 -37.6 NA NA NA
ASN J:149 J:1127 26.0 0.163 H -60.1 -34.5 NA NA NA
ASN K:149 K:1127 25.0 0.156 H -67.6 -34.6 NA NA NA
ASN L:149 M:1127 22.0 0.138 H -73.0 -20.6 NA NA NA
ASN M:149 L:1127 21.0 0.131 H -68.4 -27.4 NA NA NA
ASN N:149 R:1127 22.0 0.138 H -63.8 -37.8 NA NA NA
ASN O:149 S:1127 21.0 0.131 H -69.8 -20.3 NA NA NA
ASN P:149 T:1127 28.0 0.175 H -71.9 -25.4 NA NA NA
3i81 1 P08069 99.67 0.0 X-RAY
 2009-12-22 ASN A:148 A:1097 61.0 0.381 H -64.2 -41.1 61.0 0.381 0.0 HOH
 2.836
 OD1
 O
5fxs 1 P08069 99.35 0.0 X-RAY
 2016-10-19 ASN A:149 A:1127 66.0 0.412 H -59.6 -41.6 66.0 0.412 0.0 HOH
 2.653
 OD1
 O
2oj9 1 P08069 100.0 0.0 X-RAY
 2007-05-01 ASN A:148 A:1097 29.0 0.181 H -62.0 -36.0 29.0 0.181 0.0 HOH
 2.847
 ND2
 O
3nw5 1 P08069 100.0 0.0 X-RAY
 2010-07-28 ASN A:148 A:1097 63.0 0.394 H -62.5 -44.9 63.0 0.394 0.0 HOH
 2.669
 ND2
 O
3nw6 1 P08069 100.0 0.0 X-RAY
 2010-07-28 ASN A:148 A:1097 68.0 0.425 H -62.0 -44.5 68.0 0.425 0.0 HOH
 2.801
 O
 O
3nw7 1 P08069 100.0 0.0 X-RAY
 2010-07-28 ASN A:148 A:1097 67.0 0.419 H -64.1 -38.4 67.0 0.419 0.0 HOH
 2.667
 OD1
 O
3o23 1 P08069 99.67 0.0 X-RAY
 2011-05-04 ASN A:146 A:1127 27.0 0.169 H -62.3 -35.2 27.0 0.169 0.0 MQY
HOH
 8.137
3.229
 N
OD1
 F26
O
3lw0 1 P08069 99.34 0.0 X-RAY
 2010-09-29 ASN A:145 A:1127 26.0 0.163 H -61.4 -36.3 26.0 0.163 0.0 HOH
 2.956
 OD1
 O
ASN B:145 B:1127 25.0 0.156 H -59.7 -37.5 NA NA NA
ASN C:145 C:1127 27.0 0.169 H -61.2 -34.9 NA NA NA
ASN D:145 D:1127 25.0 0.156 H -61.5 -36.7 NA NA NA
5hzn 1 P08069 99.34 0.0 X-RAY
 2016-04-06 ASN A:145 A:1124 24.0 0.15 H -56.6 -48.9 24.0 0.15 0.0 HOH
 3.143
 CB
 O
ASN B:145 B:1124 28.0 0.175 H -61.6 -38.8 NA NA NA
ASN C:145 C:1124 26.0 0.163 H -58.5 -42.1 NA NA NA
ASN D:145 D:1124 24.0 0.15 H -63.3 -43.5 NA NA NA
ASN E:145 E:1124 24.0 0.15 H -56.9 -46.7 NA NA NA
ASN F:145 F:1124 27.0 0.169 H -60.3 -39.6 NA NA NA
ASN G:145 G:1124 24.0 0.15 H -60.3 -42.3 NA NA NA
ASN H:145 H:1124 22.0 0.138 H -63.6 -43.4 NA NA NA
4d2r 1 P08069 100.0 0.0 X-RAY
 2015-04-22 ASN A:143 A:1127 69.0 0.431 H -63.9 -42.9 69.0 0.431 0.0 CL
HOH
 3.352
2.722
 ND2
OD1
 CL
O
3d94 1 P08069 99.67 0.0 X-RAY
 2008-07-29 ASN A:142 A:1097 24.0 0.15 H -58.0 -33.9 24.0 0.15 0.0 HOH
 3.057
 OD1
 O
3qqu 1 P08069 100.0 0.0 X-RAY
 2011-04-20 ASN A:142 A:1124 29.0 0.181 H -47.1 -38.4 29.0 0.181 0.0 HOH
 4.436
 CB
 O
ASN B:142 B:1124 31.0 0.194 H -66.5 -34.6 NA NA NA
ASN C:142 C:1124 33.0 0.206 H -54.0 -41.5 NA NA NA
ASN D:142 D:1124 36.0 0.225 H -69.6 -37.6 NA NA NA
1k3a 1 P08069 99.67 0.0 X-RAY
 2001-11-28 ASN A:140 A:1097 23.0 0.144 H -61.3 -36.1 23.0 0.144 0.0 HOH
 2.991
 OD1
 O
2z8c 1 P06213 80.2 1e-175 X-RAY
 2008-08-12 ASN A:144 A:1124 21.0 0.131 H -54.2 -29.7 21.0 0.131 0.0
1gag 1 P06213 80.2 2e-175 X-RAY
 2001-01-17 ASN A:147 A:1124 39.0 0.244 H -68.1 -37.6 39.0 0.244 0.0 HOH
 3.242
 OD1
 O
1ir3 1 P06213 80.2 2e-175 X-RAY
 1998-01-07 ASN A:147 A:1124 42.0 0.263 H -61.9 -39.0 42.0 0.263 0.0 HOH
 2.861
 ND2
 O
1irk 1 P06213 80.2 2e-175 X-RAY
 1995-02-27 ASN A:147 A:1124 61.0 0.381 H -63.5 -32.2 61.0 0.381 0.0 HOH
 2.776
 ND2
 O
5e1s 1 P06213 80.2 2e-175 X-RAY
 2015-10-14 ASN A:149 A:1124 67.0 0.419 H -64.0 -41.8 67.0 0.419 0.0 HOH
 2.691
 ND2
 O
1rqq 1 P06213 80.2 3e-175 X-RAY
 2003-12-30 ASN A:147 A:1124 42.0 0.263 H -58.9 -46.7 42.0 0.263 0.0 HOH
 2.837
 OD1
 O
ASN B:147 B:1124 39.0 0.244 H -58.6 -45.5 39.0 0.244 0.0 HOH
 3.164
 CB
 O
2auh 1 P06213 80.2 3e-175 X-RAY
 2005-11-01 ASN A:147 A:1124 46.0 0.287 H -63.4 -40.1 46.0 0.287 0.0
2b4s 2 P06213 80.2 3e-175 X-RAY
 2005-11-15 ASN B:147 B:1124 47.0 0.294 H -70.8 -32.7 47.0 0.294 0.0 HOH
 2.672
 ND2
 O
ASN D:147 D:1124 48.0 0.3 H -66.1 -34.3 48.0 0.3 0.0 HOH
 2.926
 ND2
 O
3bu3 1 P06213 80.2 3e-175 X-RAY
 2008-02-19 ASN A:147 A:1124 39.0 0.244 H -62.7 -42.1 39.0 0.244 0.0 HOH
 2.795
 ND2
 O
3bu5 1 P06213 80.2 3e-175 X-RAY
 2008-02-19 ASN A:147 A:1124 37.0 0.231 H -55.9 -46.4 37.0 0.231 0.0 HOH
 2.695
 ND2
 O
3bu6 1 P06213 80.2 3e-175 X-RAY
 2008-02-19 ASN A:147 A:1124 47.0 0.294 H -66.8 -44.5 47.0 0.294 0.0 HOH
 2.713
 ND2
 O
5hhw 1 P06213 80.2 4e-175 X-RAY
 2016-04-13 ASN A:148 A:1151 68.0 0.425 H -61.6 -43.1 68.0 0.425 0.0 HOH
 2.704
 OD1
 O
4ibm 1 P06213 80.73 8e-175 X-RAY
 2013-08-21 ASN A:147 A:1124 18.0 0.113 H -61.9 -34.1 18.0 0.113 0.0 HOH
 2.853
 OD1
 O
ASN B:147 B:1124 28.0 0.175 H -64.9 -37.4 NA NA NA
3eta 1 P06213 80.41 2e-170 X-RAY
 2009-05-26 ASN A:146 A:1124 57.0 0.356 H -61.4 -39.4 57.0 0.356 0.0 351
HOH
 9.470
3.034
 N
OD1
 C28
O
ASN B:146 B:1124 59.0 0.369 H -63.8 -40.3 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p08069-f1 1 P08069 100.0 0.0 ASN A:1127 A:1127 44.0 0.275 H -63.9 -37.1