Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr15 99482586 . G A CCDS10378.1:NM_000875.3:c.3454Gga>Aga_NP_000866.1:p.1152G>R Homo sapiens insulin-like growth factor 1 receptor (IGF1R), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6jk8 1 P08069 100.0 0.0 EM
 2020-03-04 GLY A:1152 NA:NA DO NA DO DO DO NA NA NA
GLY B:1152 NA:NA DO NA DO DO DO NA NA NA
6pyh 1 Q60751 95.96 0.0 EM
 2019-10-23 GLY A:1124 NA:NA DO NA DO DO DO NA NA NA
GLY C:1124 NA:NA DO NA DO DO DO NA NA NA
3lvp 1 P08069 100.0 0.0 X-RAY
 2010-07-21 GLY A:202 A:1152 17.0 0.227 -121.1 43.1 17.0 0.227 0.0 PDR
 5.257
 O
 C15
GLY B:202 B:1152 6.0 0.08 -100.7 -42.0 NA NA NA
GLY C:202 C:1152 15.0 0.2 -128.3 8.6 NA NA NA
GLY D:202 D:1152 2.0 0.027 -106.9 166.9 NA NA NA
1m7n 1 P08069 100.0 0.0 X-RAY
 2003-01-07 GLY A:180 A:1149 15.0 0.2 -63.6 150.6 15.0 0.2 0.0 HOH
 2.839
 O
 O
GLY B:180 B:1149 18.0 0.24 -73.5 167.8 NA NA NA
1p4o 1 P08069 99.38 0.0 X-RAY
 2003-04-29 GLY A:180 A:1122 15.0 0.2 -75.6 161.8 15.0 0.2 0.0 HOH
 2.596
 O
 O
GLY B:180 B:1122 15.0 0.2 -75.0 163.7 NA NA NA
5fxq 1 P08069 100.0 0.0 X-RAY
 2016-10-19 GLY A:174 A:1152 2.0 0.027 -75.2 161.2 2.0 0.027 0.0 GD5
HOH
 7.231
2.684
 C
O
 CL
O
5fxr 1 P08069 100.0 0.0 X-RAY
 2016-10-19 GLY A:174 A:1152 2.0 0.027 -71.1 158.4 2.0 0.027 0.0 8LN
HOH
 7.180
2.711
 C
O
 CL
O
1jqh 1 P08069 100.0 0.0 X-RAY
 2002-04-19 GLY A:174 A:1152 8.0 0.107 -66.7 163.9 8.0 0.107 0.0 MG
ANP
HOH
 6.282
6.994
2.808
 C
CA
O
 MG
N6
O
GLY B:174 B:1152 8.0 0.107 -65.8 164.4 NA NA NA
GLY C:174 C:1152 8.0 0.107 -65.5 162.7 NA NA NA
2zm3 1 P08069 100.0 0.0 X-RAY
 2008-06-10 GLY A:174 A:1152 20.0 0.267 -126.6 3.0 20.0 0.267 0.0 575
HOH
 4.832
2.522
 O
O
 C18
O
GLY B:174 B:1152 11.0 0.147 -122.2 -30.5 NA NA NA
GLY C:174 C:1152 9.0 0.12 -152.1 35.0 NA NA NA
GLY D:174 D:1152 14.0 0.187 -111.4 -39.6 NA NA NA
3f5p 1 P08069 100.0 0.0 X-RAY
 2008-12-30 GLY A:174 A:1152 17.0 0.227 -138.1 -25.6 17.0 0.227 0.0 741
 5.145
 O
 N33
GLY B:174 B:1152 18.0 0.24 -147.8 -6.8 NA NA NA
GLY C:174 C:1152 18.0 0.24 -131.3 -29.7 NA NA NA
GLY D:174 D:1152 14.0 0.187 -123.5 -41.4 NA NA NA
GLY E:174 E:1152 15.0 0.2 -135.5 -29.1 NA NA NA
GLY F:174 F:1152 14.0 0.187 -133.6 -29.1 NA NA NA
GLY G:174 G:1152 18.0 0.24 -142.8 -22.6 NA NA NA
GLY H:174 H:1152 15.0 0.2 -135.2 -37.6 NA NA NA
GLY I:174 I:1152 16.0 0.213 -144.3 -12.5 NA NA NA
GLY J:174 J:1152 18.0 0.24 -137.3 -22.1 NA NA NA
GLY K:174 K:1152 14.0 0.187 -137.4 -28.8 NA NA NA
GLY L:174 M:1152 14.0 0.187 -128.6 -42.5 NA NA NA
GLY M:174 L:1152 15.0 0.2 -130.1 -30.5 NA NA NA
GLY N:174 R:1152 14.0 0.187 -139.0 -20.9 NA NA NA
GLY O:174 S:1152 17.0 0.227 -137.7 -25.3 NA NA NA
GLY P:174 T:1152 17.0 0.227 -141.3 -19.5 NA NA NA
3i81 1 P08069 99.67 0.0 X-RAY
 2009-12-22 GLY A:173 A:1122 3.0 0.04 -69.6 174.6 3.0 0.04 0.0 EBI
HOH
 3.092
2.820
 CA
O
 F34
O
5fxs 1 P08069 99.35 0.0 X-RAY
 2016-10-19 GLY A:174 A:1152 1.0 0.013 -84.3 164.5 1.0 0.013 0.0 OZN
HOH
 6.939
2.820
 C
O
 CL36
O
2oj9 1 P08069 100.0 0.0 X-RAY
 2007-05-01 GLY A:173 A:1122 5.0 0.067 -109.1 -162.4 5.0 0.067 0.0 BMI
HOH
 7.478
6.206
 CA
C
 C2
O
3nw5 1 P08069 100.0 0.0 X-RAY
 2010-07-28 GLY A:173 A:1122 3.0 0.04 -72.7 167.9 3.0 0.04 0.0 LGX
HOH
 6.903
2.585
 C
O
 C16
O
3nw6 1 P08069 100.0 0.0 X-RAY
 2010-07-28 GLY A:173 A:1122 4.0 0.053 -74.9 163.3 4.0 0.053 0.0 LGW
HOH
 3.448
2.627
 CA
O
 F32
O
3nw7 1 P08069 100.0 0.0 X-RAY
 2010-07-28 GLY A:173 A:1122 1.0 0.013 -79.8 -167.5 1.0 0.013 0.0 LGV
HOH
 3.442
3.071
 CA
O
 F29
O
3o23 1 P08069 99.67 0.0 X-RAY
 2011-05-04 GLY A:171 A:1152 15.0 0.2 -141.0 -145.1 15.0 0.2 0.0 MQY
HOH
 3.603
6.574
 CA
C
 O8
O
3lw0 1 P08069 99.34 0.0 X-RAY
 2010-09-29 GLY A:170 A:1152 9.0 0.12 170.0 149.4 9.0 0.12 0.0 CCX
HOH
 3.644
2.975
 CA
O
 C8
O
GLY B:170 B:1152 10.0 0.133 170.4 151.1 NA NA NA
GLY C:170 C:1152 10.0 0.133 171.4 152.6 NA NA NA
GLY D:170 D:1152 10.0 0.133 167.7 152.0 NA NA NA
5hzn 1 P08069 99.34 0.0 X-RAY
 2016-04-06 GLY A:170 A:1149 13.0 0.173 -122.7 -134.0 13.0 0.173 0.0 66A
HOH
 3.727
3.750
 CA
CA
 C14
O
GLY B:170 B:1149 12.0 0.16 -120.2 -145.7 NA NA NA
GLY C:170 C:1149 11.0 0.147 -117.5 -144.2 NA NA NA
GLY D:170 D:1149 12.0 0.16 -120.2 -138.3 NA NA NA
GLY E:170 E:1149 13.0 0.173 -123.0 -133.9 NA NA NA
GLY F:170 F:1149 11.0 0.147 -119.9 -143.9 NA NA NA
GLY G:170 G:1149 12.0 0.16 -115.2 -143.9 NA NA NA
GLY H:170 H:1149 13.0 0.173 -117.5 -139.8 NA NA NA
4d2r 1 P08069 100.0 0.0 X-RAY
 2015-04-22 GLY A:168 A:1152 3.0 0.04 -69.7 163.1 3.0 0.04 0.0 DYK
HOH
 7.723
2.704
 CA
O
 C15
O
3d94 1 P08069 99.67 0.0 X-RAY
 2008-07-29 GLY A:167 A:1122 12.0 0.16 -113.8 -141.3 12.0 0.16 0.0 D94
HOH
 3.651
2.857
 CA
O
 C9
O
3qqu 1 P08069 100.0 0.0 X-RAY
 2011-04-20 GLY A:167 A:1149 0.0 0.0 -115.3 159.6 0.0 0.0 0.0 01P
HOH
 6.127
8.884
 C
C
 C1
O
GLY B:167 B:1149 0.0 0.0 -33.4 160.5 NA NA NA
GLY C:167 C:1149 4.0 0.053 -97.0 150.3 NA NA NA
GLY D:167 D:1149 3.0 0.04 -72.3 173.4 NA NA NA
1k3a 1 P08069 99.67 0.0 X-RAY
 2001-11-28 GLY A:165 A:1122 11.0 0.147 -128.4 -4.9 11.0 0.147 0.0 ACP
HOH
 5.958
5.068
 O
C
 O2A
O
2z8c 1 P06213 80.2 1e-175 X-RAY
 2008-08-12 GLY A:169 A:1149 1.0 0.013 -126.3 -180.0 1.0 0.013 0.0 S91
 5.927
 CA
 C11
1gag 1 P06213 80.2 2e-175 X-RAY
 2001-01-17 GLY A:172 A:1149 1.0 0.013 -139.8 -163.3 1.0 0.013 0.0 MG
MG
112
HOH
 6.566
8.033
6.852
4.398
 C
C
C
C
 MG
MG
O2A
O
1ir3 1 P06213 80.2 2e-175 X-RAY
 1998-01-07 GLY A:172 A:1149 2.0 0.027 -133.7 -168.2 2.0 0.027 0.0 MG
MG
ANP
HOH
 6.490
7.430
6.834
3.502
 C
C
C
CA
 MG
MG
O2A
O
1irk 1 P06213 80.2 2e-175 X-RAY
 1995-02-27 GLY A:172 A:1149 12.0 0.16 170.3 146.4 12.0 0.16 0.0 HOH
 2.735
 O
 O
5e1s 1 P06213 80.2 2e-175 X-RAY
 2015-10-14 GLY A:174 A:1149 9.0 0.12 -82.6 -126.5 9.0 0.12 0.0 5JA
HOH
 4.442
2.687
 CA
O
 C26
O
1rqq 1 P06213 80.2 3e-175 X-RAY
 2003-12-30 GLY A:172 A:1149 2.0 0.027 -139.3 -172.2 2.0 0.027 0.0 MN
112
HOH
 6.577
6.955
5.688
 O
C
C
 MN
O2A
O
GLY B:172 B:1149 2.0 0.027 -137.5 -169.3 2.0 0.027 0.0 MN
112
HOH
 6.549
7.040
5.740
 C
C
C
 MN
O2A
O
2auh 1 P06213 80.2 3e-175 X-RAY
 2005-11-01 GLY A:172 A:1149 3.0 0.04 -136.6 -4.6 3.0 0.04 0.0 CA
CA
 7.198
6.982
 O
O
 CA
CA
2b4s 2 P06213 80.2 3e-175 X-RAY
 2005-11-15 GLY B:172 B:1149 0.0 0.0 -125.8 6.4 0.0 0.0 0.0 HOH
 7.740
 O
 O
GLY D:172 D:1149 2.0 0.027 -130.7 15.4 2.0 0.027 0.0 HOH
 5.810
 O
 O
3bu3 1 P06213 80.2 3e-175 X-RAY
 2008-02-19 GLY A:172 A:1149 4.0 0.053 -125.3 -173.1 4.0 0.053 0.0 HOH
 4.401
 CA
 O
3bu5 1 P06213 80.2 3e-175 X-RAY
 2008-02-19 GLY A:172 A:1149 2.0 0.027 -128.6 -166.6 2.0 0.027 0.0 MG
ATP
HOH
 6.668
5.442
3.594
 C
C
C
 MG
O1A
O
3bu6 1 P06213 80.2 3e-175 X-RAY
 2008-02-19 GLY A:172 A:1149 10.0 0.133 -127.5 -6.1 10.0 0.133 0.0 HOH
 2.561
 O
 O
5hhw 1 P06213 80.2 4e-175 X-RAY
 2016-04-13 GLY A:173 A:1176 12.0 0.16 -94.0 -126.9 12.0 0.16 0.0 60O
HOH
 3.752
3.008
 C
O
 C5
O
4ibm 1 P06213 80.73 8e-175 X-RAY
 2013-08-21 GLY A:172 A:1149 0.0 0.0 -76.0 163.9 0.0 0.0 0.0 IR1
HOH
 6.320
2.744
 C
O
 N26
O
GLY B:172 B:1149 3.0 0.04 -69.6 155.6 NA NA NA
3eta 1 P06213 80.41 2e-170 X-RAY
 2009-05-26 GLY A:171 A:1149 9.0 0.12 -132.1 -174.2 9.0 0.12 0.0 351
HOH
 3.324
5.892
 CA
O
 O23
O
GLY B:171 B:1149 9.0 0.12 -133.1 -176.7 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p08069-f1 1 P08069 100.0 0.0 GLY A:1152 A:1152 4.0 0.053 -151.3 -167.9