Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr15 99486158 . G A CCDS10378.1:NM_000875.3:c.3464gGt>gAt_NP_000866.1:p.1155G>D Homo sapiens insulin-like growth factor 1 receptor (IGF1R), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6jk8 1 P08069 100.0 0.0 EM
 2020-03-04 GLY A:1155 NA:NA DO NA DO DO DO NA NA NA
GLY B:1155 NA:NA DO NA DO DO DO NA NA NA
6pyh 1 Q60751 95.96 0.0 EM
 2019-10-23 GLY A:1127 NA:NA DO NA DO DO DO NA NA NA
GLY C:1127 NA:NA DO NA DO DO DO NA NA NA
3lvp 1 P08069 100.0 0.0 X-RAY
 2010-07-21 GLY A:205 A:1155 45.0 0.6 S -58.6 -41.2 45.0 0.6 0.0
GLY B:205 B:1155 32.0 0.427 T -51.1 -10.4 NA NA NA
GLY C:205 C:1155 22.0 0.293 T -60.5 -40.1 NA NA NA
GLY D:205 D:1155 34.0 0.453 T -46.2 -39.9 NA NA NA
1m7n 1 P08069 100.0 0.0 X-RAY
 2003-01-07 GLY A:183 A:1152 15.0 0.2 S 65.0 31.0 15.0 0.2 0.0 HOH
 2.853
 C
 O
GLY B:183 B:1152 16.0 0.213 S 55.2 47.2 NA NA NA
1p4o 1 P08069 99.38 0.0 X-RAY
 2003-04-29 GLY A:183 A:1125 15.0 0.2 T 58.7 28.2 15.0 0.2 0.0 HOH
 2.752
 N
 O
GLY B:183 B:1125 14.0 0.187 T 59.3 26.8 NA NA NA
5fxq 1 P08069 100.0 0.0 X-RAY
 2016-10-19 GLY A:177 A:1155 39.0 0.52 T 87.6 25.8 39.0 0.52 0.0 GD5
HOH
 6.818
3.075
 C
N
 N7
O
5fxr 1 P08069 100.0 0.0 X-RAY
 2016-10-19 GLY A:177 A:1155 37.0 0.493 T 93.0 19.7 37.0 0.493 0.0 8LN
HOH
 6.974
3.237
 C
N
 N7
O
1jqh 1 P08069 100.0 0.0 X-RAY
 2002-04-19 GLY A:177 A:1155 9.0 0.12 -106.8 173.1 9.0 0.12 0.0 MG
ANP
HOH
 8.034
7.297
3.946
 N
N
CA
 MG
O1G
O
GLY B:177 B:1155 6.0 0.08 -109.7 -174.8 NA NA NA
GLY C:177 C:1155 6.0 0.08 -110.2 -177.7 NA NA NA
2zm3 1 P08069 100.0 0.0 X-RAY
 2008-06-10 GLY A:177 A:1155 28.0 0.373 T -55.9 -25.1 28.0 0.373 0.0 575
HOH
 9.860
2.968
 N
O
 C17
O
GLY B:177 B:1155 25.0 0.333 T -63.5 -21.7 NA NA NA
GLY C:177 C:1155 23.0 0.307 T -67.2 -1.5 NA NA NA
GLY D:177 D:1155 14.0 0.187 T -65.5 -19.6 NA NA NA
3f5p 1 P08069 100.0 0.0 X-RAY
 2008-12-30 GLY A:177 A:1155 27.0 0.36 S -78.8 -11.1 27.0 0.36 0.0 741
 6.541
 N
 C29
GLY B:177 B:1155 26.0 0.347 T -63.9 -6.6 NA NA NA
GLY C:177 C:1155 30.0 0.4 T -71.3 -4.5 NA NA NA
GLY D:177 D:1155 25.0 0.333 T -67.9 -13.4 NA NA NA
GLY E:177 E:1155 26.0 0.347 T -57.6 -18.1 NA NA NA
GLY F:177 F:1155 32.0 0.427 T -62.1 -21.1 NA NA NA
GLY G:177 G:1155 31.0 0.413 T -73.8 -11.8 NA NA NA
GLY H:177 H:1155 25.0 0.333 T -57.5 -9.9 NA NA NA
GLY I:177 I:1155 24.0 0.32 T -62.2 -14.2 NA NA NA
GLY J:177 J:1155 30.0 0.4 T -61.9 -18.8 NA NA NA
GLY K:177 K:1155 25.0 0.333 T -59.3 -20.5 NA NA NA
GLY L:177 M:1155 23.0 0.307 S -73.2 -23.1 NA NA NA
GLY M:177 L:1155 23.0 0.307 T -62.1 -19.5 NA NA NA
GLY N:177 R:1155 29.0 0.387 T -58.6 -20.2 NA NA NA
GLY O:177 S:1155 29.0 0.387 T -47.7 -27.8 NA NA NA
GLY P:177 T:1155 21.0 0.28 T -51.0 -21.4 NA NA NA
3i81 1 P08069 99.67 0.0 X-RAY
 2009-12-22 GLY A:176 A:1125 48.0 0.64 T 70.7 14.2 48.0 0.64 0.0 EBI
HOH
 6.347
3.483
 N
N
 F34
O
5fxs 1 P08069 99.35 0.0 X-RAY
 2016-10-19 GLY A:177 A:1155 37.0 0.493 T 82.7 11.9 37.0 0.493 0.0 OZN
HOH
 6.877
2.727
 C
O
 N29
O
2oj9 1 P08069 100.0 0.0 X-RAY
 2007-05-01 GLY A:176 A:1125 3.0 0.04 S 65.2 -124.9 3.0 0.04 0.0 BMI
HOH
 7.527
4.245
 O
C
 C6
O
3nw5 1 P08069 100.0 0.0 X-RAY
 2010-07-28 GLY A:176 A:1125 52.0 0.693 T 38.8 22.8 52.0 0.693 0.0 LGX
HOH
 9.881
3.907
 C
N
 C17
O
3nw6 1 P08069 100.0 0.0 X-RAY
 2010-07-28 GLY A:176 A:1125 48.0 0.64 T 60.4 24.7 48.0 0.64 0.0 LGW
HOH
 6.215
3.045
 N
N
 F32
O
3nw7 1 P08069 100.0 0.0 X-RAY
 2010-07-28 GLY A:176 A:1125 25.0 0.333 T 55.3 50.2 25.0 0.333 0.0 LGV
HOH
 6.401
2.996
 N
N
 F29
O
3o23 1 P08069 99.67 0.0 X-RAY
 2011-05-04 GLY A:174 A:1155 36.0 0.48 38.6 39.1 36.0 0.48 0.0 MQY
HOH
 4.814
3.187
 O
CA
 C14
O
3lw0 1 P08069 99.34 0.0 X-RAY
 2010-09-29 GLY A:173 A:1155 14.0 0.187 90.3 111.8 14.0 0.187 0.0 CCX
HOH
 7.040
2.883
 CA
O
 C21
O
GLY B:173 B:1155 11.0 0.147 88.8 109.4 NA NA NA
GLY C:173 C:1155 12.0 0.16 88.6 109.6 NA NA NA
GLY D:173 D:1155 13.0 0.173 89.3 110.6 NA NA NA
5hzn 1 P08069 99.34 0.0 X-RAY
 2016-04-06 GLY A:173 A:1152 7.0 0.093 -80.2 -12.6 7.0 0.093 0.0 66A
MES
HOH
 4.237
3.401
2.711
 N
O
O
 C23
C3
O
GLY B:173 B:1152 7.0 0.093 -86.8 -17.8 NA NA NA
GLY C:173 C:1152 8.0 0.107 -83.8 -13.7 NA NA NA
GLY D:173 D:1152 7.0 0.093 -80.5 -21.3 NA NA NA
GLY E:173 E:1152 7.0 0.093 -81.9 -14.0 NA NA NA
GLY F:173 F:1152 7.0 0.093 -86.5 -19.7 NA NA NA
GLY G:173 G:1152 7.0 0.093 -84.3 -13.9 NA NA NA
GLY H:173 H:1152 7.0 0.093 -79.1 -20.2 NA NA NA
4d2r 1 P08069 100.0 0.0 X-RAY
 2015-04-22 GLY A:171 A:1155 48.0 0.64 T 61.3 29.8 48.0 0.64 0.0 DYK
HOH
 7.528
3.345
 C
N
 N4
O
3d94 1 P08069 99.67 0.0 X-RAY
 2008-07-29 GLY A:170 A:1125 3.0 0.04 G -78.6 -17.4 3.0 0.04 0.0 CA
D94
HOH
 7.663
3.772
3.474
 O
N
N
 CA
C17
O
3qqu 1 P08069 100.0 0.0 X-RAY
 2011-04-20 GLY A:170 A:1152 25.0 0.333 S 68.3 -45.8 25.0 0.333 0.0 01P
HOH
 6.630
7.005
 C
N
 N3
O
GLY B:170 B:1152 15.0 0.2 T 61.2 -16.3 NA NA NA
GLY C:170 C:1152 13.0 0.173 T -140.1 16.5 NA NA NA
GLY D:170 D:1152 8.0 0.107 T -113.9 14.3 NA NA NA
1k3a 1 P08069 99.67 0.0 X-RAY
 2001-11-28 GLY A:168 A:1125 39.0 0.52 T -55.8 -30.4 39.0 0.52 0.0 ACP
HOH
 6.002
2.917
 CA
O
 O1G
O
2z8c 1 P06213 80.2 1e-175 X-RAY
 2008-08-12 GLY A:172 A:1152 5.0 0.067 T -55.7 -35.8 5.0 0.067 0.0 S91
 9.738
 N
 N2
1gag 1 P06213 80.2 2e-175 X-RAY
 2001-01-17 GLY A:175 A:1152 1.0 0.013 S -68.0 -37.5 1.0 0.013 0.0 MG
MG
112
HOH
 7.334
5.168
7.376
3.650
 N
CA
N
CA
 MG
MG
O2S
O
1ir3 1 P06213 80.2 2e-175 X-RAY
 1998-01-07 GLY A:175 A:1152 2.0 0.027 T -58.8 -39.7 2.0 0.027 0.0 MG
MG
ANP
HOH
 7.311
4.978
7.212
3.579
 N
CA
N
N
 MG
MG
O2B
O
1irk 1 P06213 80.2 2e-175 X-RAY
 1995-02-27 GLY A:175 A:1152 27.0 0.36 S 112.6 49.9 27.0 0.36 0.0 HOH
 4.903
 C
 O
5e1s 1 P06213 80.2 2e-175 X-RAY
 2015-10-14 GLY A:177 A:1152 27.0 0.36 -67.1 97.4 27.0 0.36 0.0 HOH
 5.949
 N
 O
1rqq 1 P06213 80.2 3e-175 X-RAY
 2003-12-30 GLY A:175 A:1152 2.0 0.027 T -57.3 -43.8 2.0 0.027 0.0 MN
112
HOH
 7.457
7.320
3.090
 N
N
O
 MN
O2S
O
GLY B:175 B:1152 12.0 0.16 T -57.3 -45.0 12.0 0.16 0.0 MN
112
HOH
 7.406
7.310
4.465
 N
N
N
 MN
O2S
O
2auh 1 P06213 80.2 3e-175 X-RAY
 2005-11-01 GLY A:175 A:1152 1.0 0.013 T -54.5 -33.9 1.0 0.013 0.0 CA
CA
 5.031
3.873
 N
CA
 CA
CA
2b4s 2 P06213 80.2 3e-175 X-RAY
 2005-11-15 GLY B:175 B:1152 1.0 0.013 T -62.1 -22.3 1.0 0.013 0.0 HOH
 3.266
 N
 O
GLY D:175 D:1152 1.0 0.013 T -64.2 -16.2 1.0 0.013 0.0 HOH
 3.453
 N
 O
3bu3 1 P06213 80.2 3e-175 X-RAY
 2008-02-19 GLY A:175 A:1152 10.0 0.133 T -61.5 -23.5 10.0 0.133 0.0 HOH
 3.350
 N
 O
3bu5 1 P06213 80.2 3e-175 X-RAY
 2008-02-19 GLY A:175 A:1152 15.0 0.2 T -57.5 -34.2 15.0 0.2 0.0 MG
ATP
HOH
 7.356
3.554
3.000
 N
CA
O
 MG
O1G
O
3bu6 1 P06213 80.2 3e-175 X-RAY
 2008-02-19 GLY A:175 A:1152 10.0 0.133 T -62.4 -9.3 10.0 0.133 0.0 HOH
 2.597
 O
 O
5hhw 1 P06213 80.2 4e-175 X-RAY
 2016-04-13 GLY A:176 A:1179 13.0 0.173 -68.5 169.0 13.0 0.173 0.0 60O
HOH
 5.959
2.723
 N
O
 C1
O
4ibm 1 P06213 80.73 8e-175 X-RAY
 2013-08-21 GLY A:175 A:1152 16.0 0.213 T 60.2 44.9 16.0 0.213 0.0 IR1
HOH
 7.195
2.611
 C
O
 C3
O
GLY B:175 B:1152 42.0 0.56 T 78.3 8.8 NA NA NA
3eta 1 P06213 80.41 2e-170 X-RAY
 2009-05-26 GLY A:174 A:1152 18.0 0.24 92.8 -168.3 18.0 0.24 0.0 351
HOH
 5.801
2.703
 N
O
 C19
O
GLY B:174 B:1152 7.0 0.093 126.4 -176.0 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p08069-f1 1 P08069 100.0 0.0 GLY A:1155 A:1155 12.0 0.16 S -92.1 122.2